LOCUS       NM_001616               5214 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens activin A receptor type 2A (ACVR2A), transcript
            variant 2, mRNA.
ACCESSION   NM_001616
VERSION     NM_001616.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5214)
  AUTHORS   Fei,D., Wang,F., Wang,Y., Chen,J., Chen,S., Fan,L., Yang,L.,
            Ren,Q., Duangmano,S., Du,F., Liu,H., Zhou,J., Sheng,J., Zhao,Y.,
            Wu,X., Li,M., Xiao,Z., Zhang,Z. and Jiang,X.
  TITLE     Circular RNA ACVR2A promotes the progression of hepatocellular
            carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway
  JOURNAL   Mol Cancer 23 (1), 159 (2024)
   PUBMED   39107843
  REMARK    GeneRIF: Circular RNA ACVR2A promotes the progression of
            hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5214)
  AUTHORS   Zhang,H., Ruan,Q., Chen,C., Yu,H., Guan,S., Hu,D., Yang,C., Lin,R.
            and Zhuo,C.
  TITLE     Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition
            in colon cancer by activating SMAD2
  JOURNAL   Mol Carcinog 62 (10), 1585-1598 (2023)
   PUBMED   37378449
  REMARK    GeneRIF: Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal
            transition in colon cancer by activating SMAD2.
REFERENCE   3  (bases 1 to 5214)
  AUTHORS   Yuza,K., Nagahashi,M., Ichikawa,H., Hanyu,T., Nakajima,M.,
            Shimada,Y., Ishikawa,T., Sakata,J., Takeuchi,S., Okuda,S.,
            Matsuda,Y., Abe,M., Sakimura,K., Takabe,K. and Wakai,T.
  TITLE     Activin a Receptor Type 2A Mutation Affects the Tumor Biology of
            Microsatellite Instability-High Gastric Cancer
  JOURNAL   J Gastrointest Surg 25 (9), 2231-2241 (2021)
   PUBMED   33420656
  REMARK    GeneRIF: Activin a Receptor Type 2A Mutation Affects the Tumor
            Biology of Microsatellite Instability-High Gastric Cancer.
REFERENCE   4  (bases 1 to 5214)
  AUTHORS   Yanan,F., Rui,L., Xiaoying,L., Shuang,Z., Feng,Z., Yingnan,W.,
            Tianshuang,J., Xuan,Y., Xiaolei,Y. and Litao,S.
  TITLE     Association between ACVR2A gene polymorphisms and risk of
            hypertensive disorders of pregnancy in the northern Chinese
            population
  JOURNAL   Placenta 90, 1-8 (2020)
   PUBMED   31790936
  REMARK    GeneRIF: Association between ACVR2A gene polymorphisms and risk of
            hypertensive disorders of pregnancy in the northern Chinese
            population.
REFERENCE   5  (bases 1 to 5214)
  AUTHORS   Goebel,E.J., Corpina,R.A., Hinck,C.S., Czepnik,M., Castonguay,R.,
            Grenha,R., Boisvert,A., Miklossy,G., Fullerton,P.T., Matzuk,M.M.,
            Idone,V.J., Economides,A.N., Kumar,R., Hinck,A.P. and Thompson,T.B.
  TITLE     Structural characterization of an activin class ternary receptor
            complex reveals a third paradigm for receptor specificity
  JOURNAL   Proc Natl Acad Sci U S A 116 (31), 15505-15513 (2019)
   PUBMED   31315975
  REMARK    GeneRIF: the structure of an activin class member, GDF11, in
            complex with the type II receptor ActRIIB and the type I receptor
            Alk5, is reported.
REFERENCE   6  (bases 1 to 5214)
  AUTHORS   Xu,J., McKeehan,K., Matsuzaki,K. and McKeehan,W.L.
  TITLE     Inhibin antagonizes inhibition of liver cell growth by activin by a
            dominant-negative mechanism
  JOURNAL   J Biol Chem 270 (11), 6308-6313 (1995)
   PUBMED   7890768
REFERENCE   7  (bases 1 to 5214)
  AUTHORS   Attisano,L., Carcamo,J., Ventura,F., Weis,F.M., Massague,J. and
            Wrana,J.L.
  TITLE     Identification of human activin and TGF beta type I receptors that
            form heteromeric kinase complexes with type II receptors
  JOURNAL   Cell 75 (4), 671-680 (1993)
   PUBMED   8242742
REFERENCE   8  (bases 1 to 5214)
  AUTHORS   Donaldson,C.J., Mathews,L.S. and Vale,W.W.
  TITLE     Molecular cloning and binding properties of the human type II
            activin receptor
  JOURNAL   Biochem Biophys Res Commun 184 (1), 310-316 (1992)
   PUBMED   1314589
REFERENCE   9  (bases 1 to 5214)
  AUTHORS   Matzuk,M.M. and Bradley,A.
  TITLE     Cloning of the human activin receptor cDNA reveals high
            evolutionary conservation
  JOURNAL   Biochim Biophys Acta 1130 (1), 105-108 (1992)
   PUBMED   1311955
  REMARK    Erratum:[Biochim Biophys Acta 1992 Jun 15;1131(2):243]
REFERENCE   10 (bases 1 to 5214)
  AUTHORS   Mathews,L.S. and Vale,W.W.
  TITLE     Expression cloning of an activin receptor, a predicted
            transmembrane serine kinase
  JOURNAL   Cell 65 (6), 973-982 (1991)
   PUBMED   1646080
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X62381.1, BC067417.1,
            DA531622.1, BG616903.1, AW162986.1, BM503220.1, W03601.1,
            DN918410.1, T07746.1 and BU676046.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001616.4.
            
            Summary: This gene encodes a receptor that mediates the functions
            of activins, which are members of the transforming growth
            factor-beta (TGF-beta) superfamily involved in diverse biological
            processes. The encoded protein is a transmembrane serine-threonine
            kinase receptor which mediates signaling by forming heterodimeric
            complexes with various combinations of type I and type II receptors
            and ligands in a cell-specific manner. The encoded type II receptor
            is primarily involved in ligand-binding and includes an
            extracellular ligand-binding domain, a transmembrane domain and a
            cytoplasmic serine-threonine kinase domain. This gene may be
            associated with susceptibility to preeclampsia, a pregnancy-related
            disease which can result in maternal and fetal morbidity and
            mortality. Alternative splicing results in multiple transcript
            variants of this gene. [provided by RefSeq, Jun 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.268933.1,
                                           SRR1803616.12990.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000241416.12/ ENSP00000241416.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-477               X62381.1           22-498
            478-688             BC067417.1         440-650
            689-2335            X62381.1           710-2356
            2336-2631           DA531622.1         310-605
            2632-2991           BG616903.1         193-552
            2992-3247           AW162986.1         1-256               c
            3248-3799           BM503220.1         10-561              c
            3800-4158           W03601.1           8-366
            4159-4348           DN918410.1         70-259
            4349-4407           T07746.1           36-94
            4408-4696           DN918410.1         319-607
            4697-5214           BU676046.1         19-536              c
FEATURES             Location/Qualifiers
     source          1..5214
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q22.3-q23.1"
     gene            1..5214
                     /gene="ACVR2A"
                     /gene_synonym="ACTRII; ACVR2"
                     /note="activin A receptor type 2A"
                     /db_xref="GeneID:92"
                     /db_xref="HGNC:HGNC:173"
                     /db_xref="MIM:102581"
     exon            1..179
                     /gene="ACVR2A"
                     /gene_synonym="ACTRII; ACVR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1666
                     /gene="ACVR2A"
                     /gene_synonym="ACTRII; ACVR2"
                     /EC_number="2.7.11.30"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; activin receptor type-2A; activin A receptor,
                     type IIA"
                     /codon_start=1
                     /product="activin receptor type-2A isoform 1 precursor"
                     /protein_id="NP_001607.1"
                     /db_xref="CCDS:CCDS33301.1"
                     /db_xref="GeneID:92"
                     /db_xref="HGNC:HGNC:173"
                     /db_xref="MIM:102581"
                     /translation="MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQ
                     TGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYF
                     CCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWV
                     YRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAV
                     KIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLS
                     DFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNL
                     TACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGL
                     VLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAG
                     MAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPP
                     KESSL"
     exon            180..387
                     /gene="ACVR2A"
                     /gene_synonym="ACTRII; ACVR2"
                     /inference="alignment:Splign:2.1.0"
     exon            388..497
                     /gene="ACVR2A"
                     /gene_synonym="ACTRII; ACVR2"
                     /inference="alignment:Splign:2.1.0"
     exon            498..652
                     /gene="ACVR2A"
                     /gene_synonym="ACTRII; ACVR2"
                     /inference="alignment:Splign:2.1.0"
     exon            653..796
                     /gene="ACVR2A"
                     /gene_synonym="ACTRII; ACVR2"
                     /inference="alignment:Splign:2.1.0"
     exon            797..940
                     /gene="ACVR2A"
                     /gene_synonym="ACTRII; ACVR2"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1086
                     /gene="ACVR2A"
                     /gene_synonym="ACTRII; ACVR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1201
                     /gene="ACVR2A"
                     /gene_synonym="ACTRII; ACVR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1340
                     /gene="ACVR2A"
                     /gene_synonym="ACTRII; ACVR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1471
                     /gene="ACVR2A"
                     /gene_synonym="ACTRII; ACVR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..5214
                     /gene="ACVR2A"
                     /gene_synonym="ACTRII; ACVR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2312..2317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACVR2A"
                     /gene_synonym="ACTRII; ACVR2"
                     /note="hexamer: AATAAA"
     polyA_site      2339
                     /gene="ACVR2A"
                     /gene_synonym="ACTRII; ACVR2"
                     /note="major polyA site"
     regulatory      5196..5201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACVR2A"
                     /gene_synonym="ACTRII; ACVR2"
                     /note="hexamer: AATAAA"
     polyA_site      5214
                     /gene="ACVR2A"
                     /gene_synonym="ACTRII; ACVR2"
                     /note="major polyA site"
ORIGIN      
        1 gtctgggctt ccgaatatgt tttatgacgg ttgattttac accaggaggt ttgtctccga
       61 ggaagaccca gggaactgga tatctagcga gaacttcctc cggattcccc ggcgcctcgg
      121 gaaaatggga gctgctgcaa agttggcgtt tgccgtcttt cttatctcct gttcttcagg
      181 tgctatactt ggtagatcag aaactcagga gtgtcttttc tttaatgcta attgggaaaa
      241 agacagaacc aatcaaactg gtgttgaacc gtgttatggt gacaaagata aacggcggca
      301 ttgttttgct acctggaaga atatttctgg ttccattgaa atagtgaaac aaggttgttg
      361 gctggatgat atcaactgct atgacaggac tgattgtgta gaaaaaaaag acagccctga
      421 agtatatttt tgttgctgtg agggcaatat gtgtaatgaa aagttttctt attttccgga
      481 gatggaagtc acacagccca cttcaaatcc agttacacct aagccaccct attacaacat
      541 cctgctctat tccttggtgc cacttatgtt aattgcgggg attgtcattt gtgcattttg
      601 ggtgtacagg catcacaaga tggcctaccc tcctgtactt gttccaactc aagacccagg
      661 accaccccca ccttctccat tactaggttt gaaaccactg cagttattag aagtgaaagc
      721 aaggggaaga tttggttgtg tctggaaagc ccagttgctt aacgaatatg tggctgtcaa
      781 aatatttcca atacaggaca aacagtcatg gcaaaatgaa tacgaagtct acagtttgcc
      841 tggaatgaag catgagaaca tattacagtt cattggtgca gaaaaacgag gcaccagtgt
      901 tgatgtggat ctttggctga tcacagcatt tcatgaaaag ggttcactat cagactttct
      961 taaggctaat gtggtctctt ggaatgaact gtgtcatatt gcagaaacca tggctagagg
     1021 attggcatat ttacatgagg atatacctgg cctaaaagat ggccacaaac ctgccatatc
     1081 tcacagggac atcaaaagta aaaatgtgct gttgaaaaac aacctgacag cttgcattgc
     1141 tgactttggg ttggccttaa aatttgaggc tggcaagtct gcaggcgata cccatggaca
     1201 ggttggtacc cggaggtaca tggctccaga ggtattagag ggtgctataa acttccaaag
     1261 ggatgcattt ttgaggatag atatgtatgc catgggatta gtcctatggg aactggcttc
     1321 tcgctgtact gctgcagatg gacctgtaga tgaatacatg ttgccatttg aggaggaaat
     1381 tggccagcat ccatctcttg aagacatgca ggaagttgtt gtgcataaaa aaaagaggcc
     1441 tgttttaaga gattattggc agaaacatgc tggaatggca atgctctgtg aaaccattga
     1501 agaatgttgg gatcacgacg cagaagccag gttatcagct ggatgtgtag gtgaaagaat
     1561 tacccagatg cagagactaa caaatattat taccacagag gacattgtaa cagtggtcac
     1621 aatggtgaca aatgttgact ttcctcccaa agaatctagt ctatgatggt tgcgccatct
     1681 gtgcacacta agaaatggga ctctgaactg gagctgctaa gctaaagaaa ctgcttacag
     1741 tttattttct gtgtaaaatg agtaggatgt ctcttggaaa tgttaagaaa gaagaccctt
     1801 tgttgaaaaa tgttgctctg ggagacttac tgcattgccg acagcacaga tgtgaaggac
     1861 atgagactaa gagaaacctt gcaaactcta taaagaaact tttgaaaaag tgtacatgaa
     1921 gaatgtagcc ctctccaaat caaggatctt ttggacctgg ctaatggagt gtttgaaaac
     1981 tgacatcaga tttcttaatg tctgtcagaa gacactaatt ccttaaatga actactgcta
     2041 ttttttttaa atcaaaaact tttcatttca gattttaaaa agggtaactt gtttttattg
     2101 catttgctgt tgtttctata aatgactatt gtaatgccaa tatgacacag cttgtgaatg
     2161 tttagtgtgc tgctgttctg tgtacataaa gtcatcaaag tggggtacag taaagaggct
     2221 tccaagcatt actttaacct ccctcaacaa ggtatacctc agttccacgg ttgctaaatt
     2281 ataaaattga aaacactaac aaaatttgaa taataaatcg atccatgttt tgtaacaaat
     2341 tcactgtgtt atttaaggaa aaaaaggtaa gctatgctta gtgccaacaa taagtggcca
     2401 ttcgtaaagc agtgttttag catttcttgt gctggcttgt aatgtaggga aaaaaagtgc
     2461 tgttttttga aaagatggtg tcatttcccc cttcttccca tgttttaaag ccccatctta
     2521 tatccagttc ccaaaatttg catacttacc taagtatttt ttttaggtgt gctgtgtttg
     2581 gggaatattt gaaaatttaa agcatgattt aaaatttttt aaagtgagct gtgacactgg
     2641 aaagctcttc attttatctt ttaaaataga gttttttcta tttatatatg taaaattgta
     2701 gtgtatttct tttcaccaaa cagtgtgtgg gacattcttt atcactgttt taggatcacc
     2761 tcaggaagtg tcgttaccca gaattcccca ctgtctgcta tgagacttgt aactttatca
     2821 ctatacttct gcttggtgcc atcttgtcag agtaatattt gatgtctgtg atatgtaaag
     2881 aattatccta ggataaagat attaaacttt aagcagattt cagatgttac tgctttaaaa
     2941 caaatcaggg ataacaaatt aaacgtataa cttaaaatat gcaatgacat ttagaggtaa
     3001 ccaatgttga tataggtagc atagcctagc ctcctcccca aaattgcttt tacaactaac
     3061 actgatacta atttaggata gttcatgcct tatccttgct aagaaaatgg aattgatggt
     3121 aggcaggtgc taaagtgctt ttcaaaacaa tattacgtta gaatacaatt ggattcttcc
     3181 tcaaatttat acaggccaaa aagtaaaaca ttaattttct gaatttccag attaccaatc
     3241 aattaatcaa caaatagcca gtattatgct gtgtatttct gtcaggtcat tttaaaatcc
     3301 atgttaattt tataaaagaa ttttttacat gtcactgtca ggagctcact gtgaatgtgt
     3361 tgtcttcaaa tggttattta accacacagt acactacatt ttacatatat gtacgtaatc
     3421 tctgggaata gtaaattaat tatgttattt ataaacaata cataggtcaa cagactttaa
     3481 gcagggagga aaagaagagt aatagcgtct gtgtgctgca gaccattcag aactgtcacg
     3541 tgtgtcccca tggtctcatt cattgtattc ctagcaattc ccttttcaat gttgagttca
     3601 cctctttatt tcacaaagta cttggtctct caatttcttg atctggtttt gcttccattt
     3661 aaaaactaat caagaaggga aaatattgag aatgtgcata caagaaaatc attaatttcc
     3721 tgaagatgaa tttctacctg ttgtgaacat ttaactttct ttttaaaagt taaacaaaaa
     3781 taaacaaggg atattatgat gaatgtttgg cttatgtgag tactagagat aaaattttta
     3841 aacccagtta ttcacaatat aaaatgtttt caagttagaa aaaattttta gaaatcctgg
     3901 gtattgtatt taactgtagc taaccaattt taaaacttgt attcttttga gaactattat
     3961 taatagaaaa actttttata agcagtaaaa taagaatgtt ccagtgacta cctgtcctta
     4021 tacctagtct tgttaaaact ttcttttgca gggtatttag tgtttggttt acagtcagtg
     4081 cagagtgggc aagttaacag aaagtttgag ctagagatac tggaaaaaaa aaagatcaaa
     4141 gaatgagaaa aatggtgatc cattttgggg caaactgaga ccccccaaat aactctttcc
     4201 tcatgtgtat ggtgctcctc atgactcgtc ttgtattttg cctttctgat acccatcaga
     4261 actgctgctg ctctaactta tactctttac cttgcccaga tctccgcgta aggaatgctt
     4321 tatgatcaac ttgccatagg actgatggat taaccagtgt tcggctttat ttgaagtcta
     4381 tgccctgcac agctcttgta tgtattttag atgctagaag tttttttagc atgtgatgtg
     4441 tgattcttgt ttgaattcta ggtaccttgt gaattccaga aaaagagact gtgcttcacg
     4501 attgttagtc ccatgaactt gcactatcta tctttcatgg tgatgttttg aaaatacaat
     4561 caggaaaaaa cccaacacct ttggaattta aaatagaatc atatcatgaa atttaaaaag
     4621 aatctcttct gttgcatttc ctcaccccta agtaacagct acatttaagt aaaatgcagg
     4681 tggtagggga aaaaaaacca tggcgagatg gtggtttagt ggaataaact gattactggt
     4741 ttttttgttt tttttttttt ttttaaagaa agaagcttca tcacagatac tttccagttt
     4801 ctcttttata cttttttgaa agattacttt ttaggaacat ttggtatgat atgcataaaa
     4861 ttatttatcc atttatgggc aaaatgatac aagtagcatc ttgattgaac atcatttacc
     4921 tcagatattc aaccagcagt acgtttttta tgcagtctca acccatatcc catttgttac
     4981 ctctcagaat attggtaagc agttattttc gctttactct gtatttcttg tgttttgggc
     5041 acaggttatt gtactactgt caaatcgtac ttgctatttt ttctgcaagt atttaacaga
     5101 aagcttaaaa tccccataaa accccacctt ggataagtga ttgttaaata ttgtacaaat
     5161 aaaatgtatg ctatccccat tccatcccca agttaaataa aaaaatgaat acgg
//
