LOCUS       NM_145259               8853 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens activin A receptor type 1C (ACVR1C), transcript
            variant 1, mRNA.
ACCESSION   NM_145259
VERSION     NM_145259.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8853)
  AUTHORS   Tangseefa,P., Jin,H., Zhang,H., Xie,M. and Ibanez,C.F.
  TITLE     Human ACVR1C missense variants that correlate with altered body fat
            distribution produce metabolic alterations of graded severity in
            knock-in mutant mice
  JOURNAL   Mol Metab 81, 101890 (2024)
   PUBMED   38307384
  REMARK    GeneRIF: Human ACVR1C missense variants that correlate with altered
            body fat distribution produce metabolic alterations of graded
            severity in knock-in mutant mice.
REFERENCE   2  (bases 1 to 8853)
  AUTHORS   Ibanez,C.F.
  TITLE     Regulation of metabolic homeostasis by the TGF-beta superfamily
            receptor ALK7
  JOURNAL   FEBS J 289 (19), 5776-5797 (2022)
   PUBMED   34173336
  REMARK    GeneRIF: Regulation of metabolic homeostasis by the TGF-beta
            superfamily receptor ALK7.
            Review article
REFERENCE   3  (bases 1 to 8853)
  AUTHORS   Liu,L., Zhou,X., Zhang,Q., Li,L., Shang,Y., Wang,Z., Zhong,M.,
            Chen,Y., Zhang,W. and Tang,M.
  TITLE     Activin receptor-like kinase 7 silencing alleviates cardiomyocyte
            apoptosis, cardiac fibrosis, and dysfunction in diabetic rats
  JOURNAL   Exp Biol Med (Maywood) 247 (16), 1397-1409 (2022)
   PUBMED   35666032
  REMARK    GeneRIF: Activin receptor-like kinase 7 silencing alleviates
            cardiomyocyte apoptosis, cardiac fibrosis, and dysfunction in
            diabetic rats.
REFERENCE   4  (bases 1 to 8853)
  AUTHORS   Tian,Y.D., Chung,M.H., Quan,Q.L., Lee,D.H., Kim,E.J. and Chung,J.H.
  TITLE     UV-Induced Reduction of ACVR1C Decreases SREBP1 and ACC Expression
            by the Suppression of SMAD2 Phosphorylation in Normal Human
            Epidermal Keratinocytes
  JOURNAL   Int J Mol Sci 22 (3), 1101 (2021)
   PUBMED   33499275
  REMARK    GeneRIF: UV-Induced Reduction of ACVR1C Decreases SREBP1 and ACC
            Expression by the Suppression of SMAD2 Phosphorylation in Normal
            Human Epidermal Keratinocytes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8853)
  AUTHORS   Marmol,P., Krapacher,F. and Ibanez,C.F.
  TITLE     Control of brown adipose tissue adaptation to nutrient stress by
            the activin receptor ALK7
  JOURNAL   Elife 9, e54721 (2020)
   PUBMED   32366358
  REMARK    GeneRIF: Control of brown adipose tissue adaptation to nutrient
            stress by the activin receptor ALK7.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8853)
  AUTHORS   Munir,S., Xu,G., Wu,Y., Yang,B., Lala,P.K. and Peng,C.
  TITLE     Nodal and ALK7 inhibit proliferation and induce apoptosis in human
            trophoblast cells
  JOURNAL   J Biol Chem 279 (30), 31277-31286 (2004)
   PUBMED   15150278
  REMARK    GeneRIF: the Nodal-ALK7 pathway inhibits cell proliferation by
            inducing G(1) cell cycle arrest
REFERENCE   7  (bases 1 to 8853)
  AUTHORS   Kim,B.C., van Gelder,H., Kim,T.A., Lee,H.J., Baik,K.G., Chun,H.H.,
            Lee,D.A., Choi,K.S. and Kim,S.J.
  TITLE     Activin receptor-like kinase-7 induces apoptosis through activation
            of MAPKs in a Smad3-dependent mechanism in hepatoma cells
  JOURNAL   J Biol Chem 279 (27), 28458-28465 (2004)
   PUBMED   15107418
  REMARK    GeneRIF: ALK7 induces apoptosis through activation of the
            traditional TGF-beta pathway components
REFERENCE   8  (bases 1 to 8853)
  AUTHORS   Roberts,H.J., Hu,S., Qiu,Q., Leung,P.C., Caniggia,I., Gruslin,A.,
            Tsang,B. and Peng,C.
  TITLE     Identification of novel isoforms of activin receptor-like kinase 7
            (ALK7) generated by alternative splicing and expression of ALK7 and
            its ligand, Nodal, in human placenta
  JOURNAL   Biol Reprod 68 (5), 1719-1726 (2003)
   PUBMED   12606401
  REMARK    GeneRIF: ALK7 and its isoforms are expressed in human placentae of
            different stages of pregnancy and that their expression is
            developmentally regulated
REFERENCE   9  (bases 1 to 8853)
  AUTHORS   Reissmann,E., Jornvall,H., Blokzijl,A., Andersson,O., Chang,C.,
            Minchiotti,G., Persico,M.G., Ibanez,C.F. and Brivanlou,A.H.
  TITLE     The orphan receptor ALK7 and the Activin receptor ALK4 mediate
            signaling by Nodal proteins during vertebrate development
  JOURNAL   Genes Dev 15 (15), 2010-2022 (2001)
   PUBMED   11485994
REFERENCE   10 (bases 1 to 8853)
  AUTHORS   Bondestam,J., Huotari,M.A., Moren,A., Ustinov,J., Kaivo-Oja,N.,
            Kallio,J., Horelli-Kuitunen,N., Aaltonen,J., Fujii,M.,
            Moustakas,A., Ten Dijke,P., Otonkoski,T. and Ritvos,O.
  TITLE     cDNA cloning, expression studies and chromosome mapping of human
            type I serine/threonine kinase receptor ALK7 (ACVR1C)
  JOURNAL   Cytogenet Cell Genet 95 (3-4), 157-162 (2001)
   PUBMED   12063393
  REMARK    GeneRIF: cDNA cloning, expression studies and chromosome mapping
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC019186.9 and AC079750.5.
            
            On Nov 23, 2018 this sequence version replaced NM_145259.2.
            
            Summary: ACVR1C is a type I receptor for the TGFB (see MIM 190180)
            family of signaling molecules. Upon ligand binding, type I
            receptors phosphorylate cytoplasmic SMAD transcription factors,
            which then translocate to the nucleus and interact directly with
            DNA or in complex with other transcription factors (Bondestam et
            al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.4842.1,
                                           SRR1660809.124916.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243349.13/ ENSP00000243349.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               AC019186.9         28597-28889         c
            294-524             AC079750.5         88301-88531         c
            525-764             AC079750.5         57207-57446         c
            765-995             AC079750.5         51276-51506         c
            996-1163            AC079750.5         45559-45726         c
            1164-1320           AC079750.5         43820-43976         c
            1321-1445           AC079750.5         42204-42328         c
            1446-1576           AC079750.5         39687-39817         c
            1577-8853           AC079750.5         27881-35157         c
FEATURES             Location/Qualifiers
     source          1..8853
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.1"
     gene            1..8853
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /note="activin A receptor type 1C"
                     /db_xref="GeneID:130399"
                     /db_xref="HGNC:HGNC:18123"
                     /db_xref="MIM:608981"
     exon            1..293
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1702
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /EC_number="2.7.11.30"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; activin receptor-like kinase 7; activin
                     receptor type-1C; ALK-7; ACTR-IC; activin receptor type
                     IC; activin A receptor, type IC"
                     /codon_start=1
                     /product="activin receptor type-1C isoform 1 precursor"
                     /protein_id="NP_660302.2"
                     /db_xref="CCDS:CCDS2205.1"
                     /db_xref="GeneID:130399"
                     /db_xref="HGNC:HGNC:18123"
                     /db_xref="MIM:608981"
                     /translation="MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEG
                     ACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTA
                     SPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNL
                     VNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGED
                     VAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQG
                     SLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKC
                     ETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIY
                     SVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQS
                     CEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA"
     exon            294..524
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /inference="alignment:Splign:2.1.0"
     exon            525..764
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /inference="alignment:Splign:2.1.0"
     exon            765..995
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1163
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1320
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1445
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1576
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..8853
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4031..4036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /note="hexamer: AACAAG"
     polyA_site      4059
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /note="major polyA site"
     regulatory      5113..5118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /note="hexamer: AATAAA"
     polyA_site      5132
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /note="major polyA site"
     regulatory      8777..8782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /note="hexamer: AATAAA"
     polyA_site      8798
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
     regulatory      8833..8838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /note="hexamer: AATAAA"
     polyA_site      8853
                     /gene="ACVR1C"
                     /gene_synonym="ACVRLK7; ALK7"
                     /note="major polyA site"
ORIGIN      
        1 agtggcagga gcgccgcgca ccgccagccg cagggggcgt gggatggggg cggccgggga
       61 ggggggcgcc cacactgact agagccaacc gcgcacttca aaagggtgtc ggtgccgcgc
      121 tcccctcccg cggcccggga acttcaaagc gggccgtgct gccccggctg cctcgctctg
      181 ctctggggcc tcgcagcccc ggcgcggccg cctggtggcg atgacccggg cgctctgctc
      241 agcgctccgc caggctctcc tgctgctcgc agcggccgcc gagctctcgc caggactgaa
      301 gtgtgtatgt cttttgtgtg attcttcaaa cttcacctgc caaacagaag gagcatgttg
      361 ggcatcagtc atgctaacca atggaaaaga gcaggtgatc aaatcctgtg tctcccttcc
      421 agaactgaat gctcaagtct tctgtcatag ttccaacaat gttaccaaaa ccgaatgctg
      481 cttcacagat ttttgcaaca acataacact gcaccttcca acagcatcac caaatgcccc
      541 aaaacttgga cccatggagc tggccatcat tattactgtg cctgtttgcc tcctgtccat
      601 agctgcgatg ctgacagtat gggcatgcca gggtcgacag tgctcctaca ggaagaaaaa
      661 gagaccaaat gtggaggaac cactctctga gtgcaatctg gtaaatgctg gaaaaactct
      721 gaaagatctg atttatgatg tgaccgcctc tggatctggc tctggtctac ctctgttggt
      781 tcaaaggaca attgcaagga cgattgtgct tcaggaaata gtaggaaaag gtagatttgg
      841 tgaggtgtgg catggaagat ggtgtgggga agatgtggct gtgaaaatat tctcctccag
      901 agatgaaaga tcttggtttc gtgaggcaga aatttaccag acggtcatgc tgcgacatga
      961 aaacatcctt ggtttcattg ctgctgacaa caaagataat ggaacttgga ctcaactttg
     1021 gctggtatct gaatatcatg aacagggctc cttatatgac tatttgaata gaaatatagt
     1081 gaccgtggct ggaatgatca agctggcgct ctcaattgct agtggtctgg cacaccttca
     1141 tatggagatt gttggtacac aaggtaaacc tgctattgct catcgagaca taaaatcaaa
     1201 gaatatctta gtgaaaaagt gtgaaacttg tgccatagcg gacttagggt tggctgtgaa
     1261 gcatgattca atactgaaca ctatcgacat acctcagaat cctaaagtgg gaaccaagag
     1321 gtatatggct cctgaaatgc ttgatgatac aatgaatgtg aatatctttg agtccttcaa
     1381 acgagctgac atctattctg ttggtctggt ttactgggaa atagcccgga ggtgttcagt
     1441 cggaggaatt gttgaggagt accaattgcc ttattatgac atggtgcctt cagatccctc
     1501 gatagaggaa atgagaaagg ttgtttgtga ccagaagttt cgaccaagta tcccaaacca
     1561 gtggcaaagt tgtgaagcac tccgagtcat ggggagaata atgcgtgagt gttggtatgc
     1621 caacggagcg gcccgcctaa ctgctcttcg tattaagaag actatatctc aactttgtgt
     1681 caaagaagac tgcaaagcct aatgatgata attatgttaa aaagaaatct ctcatagctt
     1741 tcttttccat tttccccttt atgtgaatgt ttttgccatt ttttttttgt tctacctcaa
     1801 agataagaca gtacagtatt taagtgccca taaggcagca tgaaaagata actctaaagt
     1861 taagcatggg caggagttga cttcatccaa tctctatgtt atgtttaatt ttattttgaa
     1921 agcaacacct caactcatct ttttatttaa taaggaagaa atatattaca aaagtataaa
     1981 ataagctcta taaaaatgtt atagtcatta agtttttatt ttacttgaac caagagcaca
     2041 tgaatgaaca ggaaaagatg taaaaacatt tttttctgag atgaaaacat attaattaaa
     2101 catgcaaatt agagcatgct atctttaggt gatgcaatct atgtttcccc ctttttaagt
     2161 tagcaggact ttttaaaaat aaatattgct ctaaacttta atatatcgaa cgtgagagtg
     2221 gagctgctta gtggaagatg taagtgaggt gggtgtccca tgtgcttggt ctccccttct
     2281 gctgttctcc tgttcttcat aatccactac tgcagcagtc cctgaaccac taaacttgtt
     2341 cctttcattt acaaaagaga tacctgacat cctgagacac tgagaaatgt cctgaagtca
     2401 cacagctaat ggcagaactg gcactaggtc caaatcttgt gataatgaac accgtaaggt
     2461 tagctagctt cctactttcc cttgaatagt gcttttctcc ctatgtaata tcttttatta
     2521 tgatatttgt ggtttagaag gcatattgag ttattttgca gaatcataat ggacccgcac
     2581 aaaatctcag aaccatatct gttgacattt tttctcatag aaatatcatg gttaccccat
     2641 ttgttaatga gcattaatgt tttctgaaca cttccaaaga ttaatcaaac ataaatattc
     2701 attgtctgaa aatgtcttta agatacaatt cagaggtccc tatttccttt gtacatacac
     2761 acttagaaag aaaagacaga aaaggaagag gaaggaagga aatattttga gaatatattg
     2821 agaagaatta agaaaactct tcaatgaagt gttaacaacc aaaccctaca gacggtatca
     2881 gaaacagcaa atagatattc ctctaccctt tcacagtgag tgagtgagta cagaagaatg
     2941 ctcatgatag ttttgccttc attctacttt ctgtggacac agagtaatga atatttaatg
     3001 ggacattaaa tatgcccttc aaatctataa ttttactttg gtaaacgaga tttaacatga
     3061 tgtcttttat gctcctaaaa catctttttt caaactccat tccttagaac attcttctac
     3121 tgagatgatc caagaccaaa agtgttcttt ggtacttgct tataaagtga tagtacatgt
     3181 tagcatataa tgtattttga agagtgaagt aaatgctatt gataacagta aaaaaaaaaa
     3241 aaaaaactaa taacagtaaa gaaatgctac ttgatttttt tttaaactgg attgctcaga
     3301 ttacctgatc gtggtggaac ccttttatta agaggagggg aaacttttta ctatcccata
     3361 tttaactgtt ctataaagca aagcacagct tgggtaatag cgttctgaag gatatacttc
     3421 tgtattttct catagagtac aatttagtga ttatgcttca tttcactatg gaaatatgtt
     3481 actgaatcta tcttcatttt actgagttga aataaggaag gcaaaaaact gacagctatg
     3541 gagtttgcgt gtacttccat actcgttaat gctctcatcc acttattaaa taatcataga
     3601 gcacccatat cttgcttgcc acaatatcgg gtacaagagg gaatacaaag atagataggt
     3661 cctgccctca gggattttaa agtctaattt gggaatggga atagggatgt gagtgtgtgg
     3721 gggaagagat taaattgaca gataaaatac gaagtgggat gtcttgagtt ctgcatgaca
     3781 gtgggtttct aggataggtc tgaaaattgc tttcatttgc aacacattta gaaagtagct
     3841 ttatttggat attacagaca atctaaatat atcatcagtt tttaaaagtg cctatgtgaa
     3901 gtgattttta aaaagagcct atgtgaaggg gtaatcttgc ttgttcttgt tactaatttc
     3961 tcatagattg tttttctgca tatataagaa cgaaattatt tatttactat ggttgtacgt
     4021 gcctcaaata aacaagaatg atatttcctg ttttatttac ttatgttggg taaatatgct
     4081 tattgaattt ttaagagagg attttttacc atctccattt ttcttgtcat tatgttttgt
     4141 agcttatttg agggtgtcta aatataattt catattttat tggttcaact ttcactctga
     4201 agaaatccgt atgttagtac attttgaggt atttttcttg ttcttgtgtt gtttaactat
     4261 gactcctaac tgagtagtct tatatttcaa ttacaaaata cattttttaa gaaagggaat
     4321 agagcagcaa aaatgataag gaaaatgtta aaagttgtaa tatttccttt actcttaaca
     4381 ggattatata tagaacatgc tcacttacaa aaataggatg atgaagttta gagcataagg
     4441 caggcttctt gtatatactt atgctgtcaa atgttatatt gtttttaatg gagtcccatt
     4501 gtgtaatatt tatttctttt acattttgtt ataagcaaaa aaaaaaaaaa ttctccttag
     4561 gttatgttca gagtatcagt gttctttact ccttacagat attttggctt tggggtataa
     4621 tacaagactt gggaaaacac tattatgaat tttcagtact gtataaagtg gtgatgggat
     4681 ttaaatgcag catcactttc tgaaaataag agaaacatta tttgttgtca gtatttcagc
     4741 atgaacttgt tgccttgtaa attttgcctt taagtttgta attggtacag attctgttgt
     4801 atgctttctt ctatgtctaa aatatttggc atgtcacatc tagaattctt aatttatgtt
     4861 ctgacttgag agttaagtga aacatgactg tcgtgcacta ttttaggcat agcacttgct
     4921 tttcatcttt atactttcaa ttaactttgc attttaaatt tccatgattg tatgaaaata
     4981 gtaacctggt tgcagtatct gaaaaaatta aaattagctt ttatttaaaa atgaaaatct
     5041 acaatagatt cattaggtta gaagttccag aataatttat tattttatta cacctactat
     5101 tgtagaatta ctaataaaac aaaacaaaac tactcctatt ttcctggaat tttgccacca
     5161 tgtgacttat tggggcagag aaaactcagg gttgtctttg agtctgcaca aaagcaccag
     5221 ggaacctgct tagcaaatcg tctgaaaaca gggagctgat gtttgccatt atacaaagtt
     5281 tgagtaaaca acttaaaatt gcttgttagg gcatagtctt tgattgaaat aagtatgaga
     5341 atgtatttgg ctaaataaat gtatttaaaa tatacaaatt ttatttccca ctggaaaatt
     5401 aagaaagtag cagtaccaaa tgaataaaag ctggcagttg atgtcttcaa taatcattcc
     5461 tttaaaataa attcacaaac acatcattac aagctactta gaaatgttta gtattcgtat
     5521 cttaaaatgg caccattgtg gttttcaaag atattttaaa catcttttgt gaaacatact
     5581 atttctgttt gacaatgctt tgttctagct ctgtgtgctg atacctacat ggagtttttc
     5641 tgctatttta gtgaaaacag taattctttt atcttgagag ctgcttctaa ataacaaaaa
     5701 agttaattgg aatgtaagtt tttaaaaaat gttaatatta aatagaattt ttataatatg
     5761 ggcatttttc aaaacatttt aatgaaaata tatagatatt tgactttctt tttttcatct
     5821 agccttgctt tatatttcat tatttttctc actttttttc ttaatattcc ctcactatct
     5881 ttcaacatta tcattagttc ctaattttaa aaataactct tatttaactt aaccgtctgg
     5941 aatttagcct tctaatgaaa gagaatccct tagtactctc agagattata taaagttatt
     6001 ccaattttgt gtagatgacg aaaccaagga tcagagatta aatgactact agttactagc
     6061 agaactctta tgaaagcctg gtggtgacac ccagcactgt tccctgccat atccccaact
     6121 tttactgatt aaaaattaat tcgcatgcat ctaaacctac cttgaatgca cactaacgta
     6181 atgtgccatt caatgatgat gataaaatcc cacttttctt tgggtttcta ctaaaataat
     6241 ttactcactc agagtgaggt caatgagaaa aactaaacta ggctaagaaa gagttgtaga
     6301 atggttgttg agctaagtag gcaaccactg gggtgctgat aaaattaatg gataaaattt
     6361 aggaactgtg agagtataga atttcttagt gcaagtaatg attagagaag cttcctgaca
     6421 tcccccaccc tttctgtaag gactgttctt tctctttgta ccttggaatg ggggtgaaag
     6481 gtgatttgat agctgaattt gggactatgt ccagtgggat attatctaac ttttctctct
     6541 ttctcttttt tttcccctca gtttctcatt agtttgtctt tggcattcat cttcttttag
     6601 tgcattaaaa aatgtttggc agatctcatc aatcccaagt cactctataa ttcctgtatt
     6661 tctttagttg tcgtttaacc tgtccaaact tctacacaat gaacttctta acaagatttt
     6721 aagttctctg tataagaggt ttcacctcat aacttctcca gtaatccttc atttggcact
     6781 atagagtatt tgttaatggc agagatgatt tttcttttaa aacctaaaaa gactagctgt
     6841 tatttgtatt ctagctttta gctaacatat aaagaatgtc tacttttgct ttaatgctaa
     6901 attccgcttg agaaatagta actgggaaag acaatttgaa atatatgccc cataatgtga
     6961 ttgttaaatt tatttctgct gttccatacc attgctttgt tttgcttttg acaaactaag
     7021 ccattatgct attagtttgg aatataatac tacagcaaaa ttaggtaaca atccctattt
     7081 taaaattccc ctaacaataa tagaactgcc agcatacttt tctctttcag ttgtagatga
     7141 atacattcga gagaatatga gctgtatttc atcctagatt ttaatatttt cagatgtgac
     7201 tgtatttcct gatcattggt ccaagttgtc ctaaaagaaa tttttctctc cagacctaac
     7261 agttttaact gcaagagttt actgtgggtt atgttaatct gaattttaat agggccacta
     7321 agaatctgag tgccttagga gattaccctt atacccactg ccatcacatc cagtcaggcc
     7381 tgttgtgctc tatataaatc ttcccagctg aggggcaggt gcgggctaaa atccaactgc
     7441 aattggctcc cagacataat tttatatttt acagagaagc atcttattgg cttatatgtg
     7501 tttaaagaat ggtctggctt atacatcttc agaaaatgag aattaaaaag tcaaaataat
     7561 tcttgacatc tacagattga acaaagaact tagaagaaat aatactttat cttttcatcc
     7621 tggcattcct gagagaagag aaattgattg tttatcatgt tggtttaatt tttcaaccca
     7681 gacaatctgc agcaaggcac atggacccca attttgatat cgtccataca gttttcattc
     7741 tatgcatgga gctaattact gactttgcct gtaaagagag gattgtgtgc ctaaattttg
     7801 tctaacaaat gcaagcgtag aatgacattt actaatattt ctatttcttc cataggctaa
     7861 ataatagtaa ctaagtattt ttaaggacac agcccttttt ttctctttat acaaaatgag
     7921 agtatctgag ccaaaatatt aaattctagt tcttttccgc aatgactagt gtcaagctca
     7981 tgtactcttc tgattctaga ctggagaaga ttattcaaac ttgatctgtg tttcaggttt
     8041 ttaaatgtcc taaaaacaga aaattagatt cagatctcaa aaaaggaatt ttggattgac
     8101 tttcaaagta ctaatactaa ttatactttt cttttggtag cgtgactctt cttataccta
     8161 agaacatatt acaaatgtca aaaccattgc attttgacat tgcaaaacat gccttgaact
     8221 cttgaactac tgtgaaaaga atcaccgttg taaagacttt ttgtaagcta gctgatactc
     8281 ttaagtatgt aaaaagattg tctttcagcc gacaggccca aaggaatgta tataaggaag
     8341 gaatatgaaa aaataaatta ggttttaaaa taggaattgg gcaataaact gtatcaaaaa
     8401 tatgtagatg gattttagta gttgtaattt aaatgtggaa ggtgaagaga atttcaaact
     8461 ccaaagagaa atgaatgata ttcagatgtt tcattaattt ctagtctgtg aaaatatgca
     8521 ttttatagta atatgtatag acttatttta tttagaaata atagtgtttt agaatttatt
     8581 aaaaactcag tgatagcctt tataccaaaa tgtttaactt taccaacagc aagtcataaa
     8641 agtatttatt ttaaagcttt ttaatattat cgtgtaactt tcatctgtct tcagatgtaa
     8701 ataattatct gcctaaatgt tatattttta tgtatgcatt ttctgaaaat gtattgtttt
     8761 gtaaagtggg aaagataata aatcaagcac ttcttgcact tgtttctgtg aagcatatag
     8821 aactctattt taaataaagg aagatgtgtc gta
//
