LOCUS       NM_080431               1437 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens actin related protein T2 (ACTRT2), mRNA.
ACCESSION   NM_080431
VERSION     NM_080431.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1437)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1437)
  AUTHORS   Heid,H., Figge,U., Winter,S., Kuhn,C., Zimbelmann,R. and Franke,W.
  TITLE     Novel actin-related proteins Arp-T1 and Arp-T2 as components of the
            cytoskeletal calyx of the mammalian sperm head
  JOURNAL   Exp Cell Res 279 (2), 177-187 (2002)
   PUBMED   12243744
  REMARK    GeneRIF: Describes the discovery of two actin-related proteins as
            major components in a cytoskeletal, nonmotile structure of bull
            spermatozoa, suggesting that certain members of this family of
            proteins may serve functions other than nucleation of actin
            filaments.
REFERENCE   3  (bases 1 to 1437)
  AUTHORS   Harata,M., Nishimori,K. and Hatta,S.
  TITLE     Identification of two cDNAs for human actin-related proteins (Arps)
            that have remarkable similarity to conventional actin
  JOURNAL   Biochim Biophys Acta 1522 (2), 130-133 (2001)
   PUBMED   11750065
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356984.13, BI825639.1,
            AK058153.1, BP370015.1, AF440740.1 and AW016204.1.
            
            On May 17, 2019 this sequence version replaced NM_080431.4.
            
            Summary: The protein encoded by this intronless gene belongs to the
            actin family. Studies have shown that this protein may be involved
            in cytoskeletal organization similar to other cytoplasmic
            actin-related protein (ARP) subfamily members. Antibody raised
            against the human protein has been used to detect the protein by
            immunoblotting and immunofluorescence microscopy, demonstrating its
            specific synthesis in the testis, late in spermatid
            differentiation, and its localization in the calyx. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC029499.1, SRR5189667.147118.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378404.4/ ENSP00000367658.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL356984.13        30680-30694
            16-17               BI825639.1         2-3
            18-28               AK058153.1         2-12
            29-220              BP370015.1         14-205
            221-234             AF440740.1         1-14
            235-1163            AK058153.1         219-1147
            1164-1354           AF440740.1         944-1134
            1355-1437           AW016204.1         16-98               c
FEATURES             Location/Qualifiers
     source          1..1437
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.32"
     gene            1..1437
                     /gene="ACTRT2"
                     /gene_synonym="Arp-T2; ARPM2; ARPT2; HARPM2"
                     /note="actin related protein T2"
                     /db_xref="GeneID:140625"
                     /db_xref="HGNC:HGNC:24026"
                     /db_xref="MIM:608535"
     exon            1..1437
                     /gene="ACTRT2"
                     /gene_synonym="Arp-T2; ARPM2; ARPT2; HARPM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1354
                     /gene="ACTRT2"
                     /gene_synonym="Arp-T2; ARPM2; ARPT2; HARPM2"
                     /note="actin-related protein hArpM2; actin-related protein
                     M2"
                     /codon_start=1
                     /product="actin-related protein T2"
                     /protein_id="NP_536356.3"
                     /db_xref="CCDS:CCDS45.1"
                     /db_xref="GeneID:140625"
                     /db_xref="HGNC:HGNC:24026"
                     /db_xref="MIM:608535"
                     /translation="MFNPHALDSPAVIFDNGSGFCKAGLSGEFGPRHMVSSIVGHLKF
                     QAPSAEANQKKYFVGEEALYKQEALQLHSPFERGLITGWDDVERLWKHLFEWELGVKP
                     SDQPLLATEPSLNPRENREKMAEVMFENFGVPAFYLSDQAVLALYASACVTGLVVDSG
                     DAVTCTVPIFEGYSLPHAVTKLHVAGRDITELLMQLLLASGHTFPCQLDKGLVDDIKK
                     KLCYVALEPEKELSRRPEEVLREYKLPDGNIISLGDPLHQAPEALFVPQQLGSQSPGL
                     SNMVSSSITKCDTDIQKILFGEIVLSGGTTLFHGLDDRLLKELEQLASKDTPIKITAP
                     PDRWFSTWIGASIVTSLSSFKQMWVTAADFKEFGTSVVQRRCF"
     regulatory      1417..1422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTRT2"
                     /gene_synonym="Arp-T2; ARPM2; ARPT2; HARPM2"
                     /note="hexamer: AATAAA"
     polyA_site      1437
                     /gene="ACTRT2"
                     /gene_synonym="Arp-T2; ARPM2; ARPT2; HARPM2"
                     /note="major polyA site"
ORIGIN      
        1 aaccccctgg ccccctggaa gaggcctcag caggcccagg ccacctggag ggagagcaga
       61 cctgcggctg aggatgcagg gctcccgggc acggtgctag ccctgccttg agacaccccg
      121 agagctgtgg gaagagctgt gggatcccct attgcatcac aaagcggccc tggagggctg
      181 gtctttattt tgatgaggct gagaagggaa ggctgcgggc atgtttaatc cgcacgcttt
      241 agactccccg gctgtgattt ttgacaatgg ctcggggttc tgcaaagcgg gcctgtctgg
      301 ggagtttgga ccccggcaca tggtcagctc catcgtgggg cacctgaaat tccaggctcc
      361 ctcagcagag gccaaccaga agaagtactt tgtgggggag gaggccctgt acaagcagga
      421 ggccctgcag ctgcactccc ctttcgagcg tggcctgatc acagggtggg atgacgtgga
      481 gagactctgg aagcacctct ttgagtggga gctaggcgtg aaacccagcg accagcccct
      541 gcttgcaacg gagccctccc tgaaccccag ggagaaccgt gagaagatgg cagaagtcat
      601 gttcgagaac ttcggcgtgc ccgctttcta cctgtcggac caggcggtgc tggctctcta
      661 cgcctctgcc tgtgtcacgg gcctggtggt ggacagcggg gatgcggtca cctgcactgt
      721 ccccatcttt gagggttact ccctgcccca cgcagtcacc aagctccacg tggcgggcag
      781 ggacatcacg gagctcctca tgcagctgct cctggccagc ggccacacct tcccctgcca
      841 gctggacaag ggtctcgtgg acgacatcaa aaagaagctg tgctacgtgg ccttggagcc
      901 cgagaaggag ctttcccgga ggccggagga ggtcctgagg gagtacaagc tgcccgacgg
      961 gaacatcatc agcctcgggg acccgctgca ccaggcgccc gaggccctgt tcgtgcccca
     1021 gcagctgggc agccagagcc ccgggctctc gaatatggtc tccagcagca tcaccaagtg
     1081 tgataccgac atccagaaga tcctctttgg ggagattgtg ctgtcggggg gcactaccct
     1141 gttccacggg ctggatgacc ggcttctcaa ggagctggag cagctggcct ccaaggacac
     1201 ccccatcaag atcacggctc cccccgaccg gtggttctcc acctggattg gagcctccat
     1261 cgtcacctct ctgagtagct tcaagcagat gtgggtcacc gccgcagact tcaaggagtt
     1321 tgggacctcc gtggtgcaga gaagatgctt ctgaaggccg cttctcgttg ggtaccgtgg
     1381 ggggtgaacc ctagccccag ctttgggagg atgttcaata aaggaccaat gccggaa
//
