LOCUS       NM_022899               3579 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens actin related protein 8 (ACTR8), transcript variant 1,
            mRNA.
ACCESSION   NM_022899
VERSION     NM_022899.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3579)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3579)
  AUTHORS   Zhang,S., Zhou,B., Wang,L., Li,P., Bennett,B.D., Snyder,R.,
            Garantziotis,S., Fargo,D.C., Cox,A.D., Chen,L. and Hu,G.
  TITLE     INO80 is required for oncogenic transcription and tumor growth in
            non-small cell lung cancer
  JOURNAL   Oncogene 36 (10), 1430-1439 (2017)
   PUBMED   27641337
REFERENCE   3  (bases 1 to 3579)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   4  (bases 1 to 3579)
  AUTHORS   Cao,L., Ding,J., Dong,L., Zhao,J., Su,J., Wang,L., Sui,Y., Zhao,T.,
            Wang,F., Jin,J. and Cai,Y.
  TITLE     Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin
            Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest
            and Abnormal Chromosome Stability
  JOURNAL   PLoS One 10 (9), e0137411 (2015)
   PUBMED   26340092
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3579)
  AUTHORS   Osakabe,A., Takahashi,Y., Murakami,H., Otawa,K., Tachiwana,H.,
            Oma,Y., Nishijima,H., Shibahara,K.I., Kurumizaka,H. and Harata,M.
  TITLE     DNA binding properties of the actin-related protein Arp8 and its
            role in DNA repair
  JOURNAL   PLoS One 9 (10), e108354 (2014)
   PUBMED   25299602
  REMARK    GeneRIF: Plays a regulatory role in the binding of Arp8 to DNA.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3579)
  AUTHORS   Yao,T., Song,L., Jin,J., Cai,Y., Takahashi,H., Swanson,S.K.,
            Washburn,M.P., Florens,L., Conaway,R.C., Cohen,R.E. and
            Conaway,J.W.
  TITLE     Distinct modes of regulation of the Uch37 deubiquitinating enzyme
            in the proteasome and in the Ino80 chromatin-remodeling complex
  JOURNAL   Mol Cell 31 (6), 909-917 (2008)
   PUBMED   18922472
REFERENCE   7  (bases 1 to 3579)
  AUTHORS   Aoyama,N., Oka,A., Kitayama,K., Kurumizaka,H. and Harata,M.
  TITLE     The actin-related protein hArp8 accumulates on the mitotic
            chromosomes and functions in chromosome alignment
  JOURNAL   Exp Cell Res 314 (4), 859-868 (2008)
   PUBMED   18163988
  REMARK    GeneRIF: Expression of truncated hArp8 proteins and depletion of
            endogenous hArp8 by RNA interference caused misalignment of mitotic
            chromosomes, suggesting that chromosome-associated hArp8 has a role
            in chromosome behavior.
REFERENCE   8  (bases 1 to 3579)
  AUTHORS   Wu,S., Shi,Y., Mulligan,P., Gay,F., Landry,J., Liu,H., Lu,J.,
            Qi,H.H., Wang,W., Nickoloff,J.A., Wu,C. and Shi,Y.
  TITLE     A YY1-INO80 complex regulates genomic stability through homologous
            recombination-based repair
  JOURNAL   Nat Struct Mol Biol 14 (12), 1165-1172 (2007)
   PUBMED   18026119
REFERENCE   9  (bases 1 to 3579)
  AUTHORS   Jin,J., Cai,Y., Yao,T., Gottschalk,A.J., Florens,L., Swanson,S.K.,
            Gutierrez,J.L., Coleman,M.K., Workman,J.L., Mushegian,A.,
            Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     A mammalian chromatin remodeling complex with similarities to the
            yeast INO80 complex
  JOURNAL   J Biol Chem 280 (50), 41207-41212 (2005)
   PUBMED   16230350
REFERENCE   10 (bases 1 to 3579)
  AUTHORS   Hassel,S., Eichner,A., Yakymovych,M., Hellman,U., Knaus,P. and
            Souchelnytskyi,S.
  TITLE     Proteins associated with type II bone morphogenetic protein
            receptor (BMPR-II) and identified by two-dimensional gel
            electrophoresis and mass spectrometry
  JOURNAL   Proteomics 4 (5), 1346-1358 (2004)
   PUBMED   15188402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK022996.1 and AC012467.9.
            
            On Nov 22, 2018 this sequence version replaced NM_022899.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.157625.1,
                                           SRR1660803.228403.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335754.8/ ENSP00000336842.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1837              AK022996.1         1-1837
            1838-3579           AC012467.9         47289-49030
FEATURES             Location/Qualifiers
     source          1..3579
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..3579
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="actin related protein 8"
                     /db_xref="GeneID:93973"
                     /db_xref="HGNC:HGNC:14672"
                     /db_xref="MIM:619716"
     exon            1..174
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1926
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="isoform 1 is encoded by transcript variant 1; INO80
                     complex subunit N; ARP8 actin related protein 8 homolog"
                     /codon_start=1
                     /product="actin-related protein 8 isoform 1"
                     /protein_id="NP_075050.3"
                     /db_xref="CCDS:CCDS2875.1"
                     /db_xref="GeneID:93973"
                     /db_xref="HGNC:HGNC:14672"
                     /db_xref="MIM:619716"
                     /translation="MTQAEKGDTENGKEKGGEKEKEQRGVKRPIVPALVPESLQEQIQ
                     SNFIIVIHPGSTTLRIGRATDTLPASIPHVIARRHKQQGQPLYKDSWLLREGLNKPES
                     NEQRQNGLKMVDQAIWSKKMSNGTRRIPVSPEQARSYNKQMRPAILDHCSGNKWTNTS
                     HHPEYLVGEEALYVNPLDCYNIHWPIRRGQLNIHPGPGGSLTAVLADIEVIWSHAIQK
                     YLEIPLKDLKYYRCILLIPDIYNKQHVKELVNMILMKMGFSGIVVHQESVCATYGSGL
                     SSTCIVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYRECQL
                     TNKMDCLLLQHLKETFCHLDQDISGLQDHEFQIRHPDSPALLYQFRLGDEKLQAPMAL
                     FYPATFGIVGQKMTTLQHRSQGDPEDPHDEHYLLATQSKQEQSAKATADRKSASKPIG
                     FEGDLRGQSSDLPERLHSQEVDLGSAQGDGLMAGNDSEEALTALMSRKTAISLFEGKA
                     LGLDKAILHSIDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRRI
                     IENVDVITRPKDMDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGVRMLRERAAFVW
                     "
     exon            175..345
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            346..456
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            457..561
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            562..735
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            736..829
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            830..962
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1116
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1212
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1353
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1618
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1782
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..3579
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1973..1978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="hexamer: TATAAA"
     polyA_site      1992
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="major polyA site"
     regulatory      2043..2048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="hexamer: AATGAA"
     polyA_site      2059
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
     regulatory      2127..2132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="hexamer: AATAAA"
     polyA_site      2149
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="major polyA site"
     regulatory      3559..3564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="hexamer: AGTAAA"
     polyA_site      3579
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
ORIGIN      
        1 agtcgtggct gcagcgctga ggcgagaggt tggtgggtgt ctccggccat aatgacccag
       61 gctgagaagg gtgatacgga gaacggaaag gagaagggcg gcgagaagga gaaggagcag
      121 cgcggcgtga agcggcccat cgtgcccgcg ctggtgccgg agtcgctgca agagcaaatc
      181 cagagcaact tcatcattgt catacatcca ggttcaacaa ctttaaggat tggtcgagcc
      241 acagacactc ttcctgccag cattcctcac gtcattgccc gaagacacaa acaacaaggg
      301 cagcccctat acaaggacag ttggctccta agggagggac taaataaacc agaaagtaat
      361 gaacaaagac aaaatggcct taaaatggtg gatcaagcaa tatggtctaa aaagatgtcc
      421 aatggtacaa gacgcattcc tgtgtcccct gaacaggcac gctcctacaa taagcagatg
      481 cgacctgcaa ttttagatca ctgttcggga aataagtgga caaacacatc tcatcaccct
      541 gagtatttag taggagaaga ggccttgtat gttaatccac tggactgtta caatattcac
      601 tggcctatca gaagaggtca gttaaatatt cacccaggcc ctgggggctc tcttacagct
      661 gttctggcag atattgaagt aatatggtct catgcgatac aaaaatactt ggaaatccca
      721 ctgaaagatt taaagtatta tagatgtatc ttgttaattc ctgatatcta taataagcag
      781 catgtgaaag aactagtgaa tatgatacta atgaagatgg gtttttcagg gattgtggtc
      841 catcaggagt ctgtgtgtgc cacctatgga agtggcttaa gcagcacgtg tattgtagac
      901 gttggggacc agaagacaag tgtatgctgt gtggaggatg gggtgtctca tcggaatact
      961 cggctttgtc tggcatacgg aggatctgat gtgtcaagat gtttttactg gctaatgcag
     1021 cgagctgggt tcccttacag agaatgccag ttaacaaata aaatggattg tcttcttctg
     1081 caacacctta aagaaacttt ttgtcattta gatcaggaca tctctgggct tcaggaccat
     1141 gagtttcaga ttcgacatcc tgattctcct gccctgcttt accagtttcg attaggagat
     1201 gaaaaactgc aggctccaat ggctttgttt taccccgcaa cttttggaat cgttggacag
     1261 aaaatgacga ctttgcagca cagatctcag ggcgatcctg aggatcctca cgatgaacat
     1321 tacctgctgg ccacacagag caaacaagaa cagtctgcaa aagctactgc tgaccgaaag
     1381 tctgcatcca aacctattgg atttgaaggg gatcttcgtg gccagtcctc tgatcttcca
     1441 gaaagactcc attcccagga ggtagatttg gggtctgcac agggagatgg cctgatggcc
     1501 ggcaacgatt ccgaggaggc cctcactgca ctgatgtcca ggaagactgc catctcgctg
     1561 tttgaaggaa aagccctggg cctggataaa gccatcctcc atagcataga ctgctgttca
     1621 tctgacgaca ccaaaaagaa gatgtacagc tccatcctag tggtgggagg tggtttgatg
     1681 tttcataaag ctcaagaatt tctgcagcac agaattctca acaaaatgcc accatccttc
     1741 aggcgaatta ttgaaaatgt ggatgtgatc acaaggccta aggacatgga cccccggctg
     1801 attgcatgga aaggaggggc agtgttggct tgtttggata caacacagga actgtggatt
     1861 tatcagcgag agtggcagcg ctttggtgtc cgcatgttac gagagcgggc tgcgtttgtg
     1921 tggtgaatgg ggaggaaatg tcactgccga agaccaaaaa caagcttctt ggtataaaag
     1981 actcttacag aatatgtgta ttgtaattta ttgatctgga tgcttaagtg tcatggacag
     2041 taaatgaatt tgaactttat gttgaggaca tgacattggt ttgaaaatat aaactgcttt
     2101 tgagcagttt agtcagggca tttgagaata aataggaact ttctcttcag ttgtaaactc
     2161 tcttgccctc tctcagggtc tcataaactc cccagtgatg taaacgttgc tattgaaggt
     2221 tctcatgtgg tgaagccctt catttaagtt ggcttgaatc tcatcagcag gcagcctcat
     2281 gcaaccatga gggatagtat gtgacgaggg agaactgtcc actcatgcca ttttctctct
     2341 tgtctagtat ttcattagga tctaaagttg tctgagttaa atgcacttat gtgactcatg
     2401 tgtcctctta gaatcccaaa tagggggaaa aagttttggt ggtttttgtt ttttttttca
     2461 ttttctgttg gattacagaa aaagaatggg acccattcag gtctcgattt ccaaaggtaa
     2521 agatggaagg ctgggcagac tggcttttgt tacctgacat gccgtagggt gagcttagag
     2581 gaagaaagaa aacaattttt atttggccaa aacagaacaa atgctgaaaa ggaaatcttg
     2641 tttttttcct aaagccaaat agaaatgatt tgggtataat ttaagagtcc ttgtgttgta
     2701 cagatatggt gactgatgta gttattaata ctaccaactt agtcatcaag cctcaatttt
     2761 cctttacctg aaggattaag tgaaagcttt tggagttcat gatgttcagt atgatcagtt
     2821 aaccttaacc tctgagcatc ctgaagcaaa atctaaataa tgcagctatt accactggtg
     2881 gtccaggctc tggtgaagcc ctctgagccc aggaggaaga gaaagcattg tccagaggta
     2941 ggaacacagt ctgggagccc agagctctgg gaggagtggg aaaatgctgc ttcctgctgc
     3001 ttgcttctag gcacctgctt ccgccatctc acttaccatg gctagagatg ggggtgagac
     3061 tggggaagga caaaagcagg gaacagataa gtgatggaaa tcagaaggga atatagaaag
     3121 aactctggat gtggagaaat gccggtacct gagcattttg tatcaatggg agtaccctct
     3181 gtaactgctc agtaggttac aaatgaagag tccaccagta ttagaaacaa tttaaacttg
     3241 ccagtaccaa ctgggatgtg tgccttcaat ttgaaaattg tatgttttat tttttaaatt
     3301 tgttaacagc attaatttat agagtattga tgtcatttat gtttctgagg tgtttcaaca
     3361 caattttgga tcagctgcct gtttgcaaaa acataatata tttctgttaa acagttcttc
     3421 acctaacagc atattgctct tataactggt agagctgttt caaaggaagt tggtttctgg
     3481 tccaagtttt gacctaaacc atgtccatct tctattacca gcacttacaa gcactgtgaa
     3541 aactgatcat gacaaataag taaaatttgc tacattaaa
//
