LOCUS       NM_022496               1737 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens actin related protein 6 (ACTR6), transcript variant 1,
            mRNA.
ACCESSION   NM_022496
VERSION     NM_022496.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1737)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1737)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 1737)
  AUTHORS   Kitamura,H., Matsumori,H., Kalendova,A., Hozak,P., Goldberg,I.G.,
            Nakao,M., Saitoh,N. and Harata,M.
  TITLE     The actin family protein ARP6 contributes to the structure and the
            function of the nucleolus
  JOURNAL   Biochem Biophys Res Commun 464 (2), 554-560 (2015)
   PUBMED   26164235
  REMARK    GeneRIF: under starvation, ARP6 was required for cell survival
            through the repression of rDNA transcription independently of H2A.Z
REFERENCE   4  (bases 1 to 1737)
  AUTHORS   Obri,A., Ouararhni,K., Papin,C., Diebold,M.L., Padmanabhan,K.,
            Marek,M., Stoll,I., Roy,L., Reilly,P.T., Mak,T.W., Dimitrov,S.,
            Romier,C. and Hamiche,A.
  TITLE     ANP32E is a histone chaperone that removes H2A.Z from chromatin
  JOURNAL   Nature 505 (7485), 648-653 (2014)
   PUBMED   24463511
REFERENCE   5  (bases 1 to 1737)
  AUTHORS   Cuadrado,A., Corrado,N., Perdiguero,E., Lafarga,V.,
            Munoz-Canoves,P. and Nebreda,A.R.
  TITLE     Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin
            incorporation in muscle differentiation
  JOURNAL   EMBO J 29 (12), 2014-2025 (2010)
   PUBMED   20473270
REFERENCE   6  (bases 1 to 1737)
  AUTHORS   Ruhl,D.D., Jin,J., Cai,Y., Swanson,S., Florens,L., Washburn,M.P.,
            Conaway,R.C., Conaway,J.W. and Chrivia,J.C.
  TITLE     Purification of a human SRCAP complex that remodels chromatin by
            incorporating the histone variant H2A.Z into nucleosomes
  JOURNAL   Biochemistry 45 (17), 5671-5677 (2006)
   PUBMED   16634648
REFERENCE   7  (bases 1 to 1737)
  AUTHORS   Ohfuchi,E., Kato,M., Sasaki,M., Sugimoto,K., Oma,Y. and Harata,M.
  TITLE     Vertebrate Arp6, a novel nuclear actin-related protein, interacts
            with heterochromatin protein 1
  JOURNAL   Eur J Cell Biol 85 (5), 411-421 (2006)
   PUBMED   16487625
  REMARK    GeneRIF: Results describe the predominant nuclear localization of
            another Arp subfamily, Arp6, in vertebrate cells, and show its
            colocalization with heterochromatin protein 1 orthologs in
            pericentric heterochromatin.
REFERENCE   8  (bases 1 to 1737)
  AUTHORS   Jin,J., Cai,Y., Yao,T., Gottschalk,A.J., Florens,L., Swanson,S.K.,
            Gutierrez,J.L., Coleman,M.K., Workman,J.L., Mushegian,A.,
            Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     A mammalian chromatin remodeling complex with similarities to the
            yeast INO80 complex
  JOURNAL   J Biol Chem 280 (50), 41207-41212 (2005)
   PUBMED   16230350
REFERENCE   9  (bases 1 to 1737)
  AUTHORS   Cai,Y., Jin,J., Florens,L., Swanson,S.K., Kusch,T., Li,B.,
            Workman,J.L., Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60
            histone acetyltransferase and SRCAP complexes
  JOURNAL   J Biol Chem 280 (14), 13665-13670 (2005)
   PUBMED   15647280
REFERENCE   10 (bases 1 to 1737)
  AUTHORS   Kato,M., Sasaki,M., Mizuno,S. and Harata,M.
  TITLE     Novel actin-related proteins in vertebrates: similarities of
            structure and expression pattern to Arp6 localized on Drosophila
            heterochromatin
  JOURNAL   Gene 268 (1-2), 133-140 (2001)
   PUBMED   11368909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK124075.1 and AB038229.1.
            
            On Aug 11, 2020 this sequence version replaced NM_022496.4.
            
            Transcript Variant: This variant (1) encodes a protein of 396aa.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB038229.1, AF175226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000188312.7/ ENSP00000188312.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1736              AK124075.1         729-2464
            1737-1737           AB038229.1         1750-1750
FEATURES             Location/Qualifiers
     source          1..1737
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.1"
     gene            1..1737
                     /gene="ACTR6"
                     /gene_synonym="ARP6; CDA12; hARP6; hARPX; HSPC281;
                     MSTP136"
                     /note="actin related protein 6"
                     /db_xref="GeneID:64431"
                     /db_xref="HGNC:HGNC:24025"
                     /db_xref="MIM:619729"
     exon            1..105
                     /gene="ACTR6"
                     /gene_synonym="ARP6; CDA12; hARP6; hARPX; HSPC281;
                     MSTP136"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1228
                     /gene="ACTR6"
                     /gene_synonym="ARP6; CDA12; hARP6; hARPX; HSPC281;
                     MSTP136"
                     /note="ARP6 actin related protein 6 homolog"
                     /codon_start=1
                     /product="actin-related protein 6"
                     /protein_id="NP_071941.1"
                     /db_xref="CCDS:CCDS9074.1"
                     /db_xref="GeneID:64431"
                     /db_xref="HGNC:HGNC:24025"
                     /db_xref="MIM:619729"
                     /translation="MTTLVLDNGAYNAKIGYSHENVSVIPNCQFRSKTARLKTFTANQ
                     IDEIKDPSGLFYILPFQKGYLVNWDVQRQVWDYLFGKEMYQVDFLDTNIIITEPYFNF
                     TSIQESMNEILFEEYQFQAVLRVNAGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPY
                     CRSKKKKEAIIRINVGGKLLTNHLKEIISYRQLHVMDETHVINQVKEDVCYVSQDFYR
                     DMDIAKLKGEENTVMIDYVLPDFSTIKKGFCKPREEMVLSGKYKSGEQILRLANERFA
                     VPEILFNPSDIGIQEMGIPEAIVYSIQNLPEEMQPHFFKNIVLTGGNSLFPGFRDRVY
                     SEVRCLTPTDYDVSVVLPENPITYAWEGGKLISENDDFEDMVVTREDYEENGHSVCEE
                     KFDI"
     exon            106..223
                     /gene="ACTR6"
                     /gene_synonym="ARP6; CDA12; hARP6; hARPX; HSPC281;
                     MSTP136"
                     /inference="alignment:Splign:2.1.0"
     exon            224..292
                     /gene="ACTR6"
                     /gene_synonym="ARP6; CDA12; hARP6; hARPX; HSPC281;
                     MSTP136"
                     /inference="alignment:Splign:2.1.0"
     exon            293..416
                     /gene="ACTR6"
                     /gene_synonym="ARP6; CDA12; hARP6; hARPX; HSPC281;
                     MSTP136"
                     /inference="alignment:Splign:2.1.0"
     exon            417..552
                     /gene="ACTR6"
                     /gene_synonym="ARP6; CDA12; hARP6; hARPX; HSPC281;
                     MSTP136"
                     /inference="alignment:Splign:2.1.0"
     exon            553..609
                     /gene="ACTR6"
                     /gene_synonym="ARP6; CDA12; hARP6; hARPX; HSPC281;
                     MSTP136"
                     /inference="alignment:Splign:2.1.0"
     exon            610..708
                     /gene="ACTR6"
                     /gene_synonym="ARP6; CDA12; hARP6; hARPX; HSPC281;
                     MSTP136"
                     /inference="alignment:Splign:2.1.0"
     exon            709..787
                     /gene="ACTR6"
                     /gene_synonym="ARP6; CDA12; hARP6; hARPX; HSPC281;
                     MSTP136"
                     /inference="alignment:Splign:2.1.0"
     exon            788..959
                     /gene="ACTR6"
                     /gene_synonym="ARP6; CDA12; hARP6; hARPX; HSPC281;
                     MSTP136"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1098
                     /gene="ACTR6"
                     /gene_synonym="ARP6; CDA12; hARP6; hARPX; HSPC281;
                     MSTP136"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1737
                     /gene="ACTR6"
                     /gene_synonym="ARP6; CDA12; hARP6; hARPX; HSPC281;
                     MSTP136"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1482..1487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR6"
                     /gene_synonym="ARP6; CDA12; hARP6; hARPX; HSPC281;
                     MSTP136"
                     /note="hexamer: ATTAAA"
     polyA_site      1502
                     /gene="ACTR6"
                     /gene_synonym="ARP6; CDA12; hARP6; hARPX; HSPC281;
                     MSTP136"
     regulatory      1716..1721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR6"
                     /gene_synonym="ARP6; CDA12; hARP6; hARPX; HSPC281;
                     MSTP136"
                     /note="hexamer: AATAAA"
     polyA_site      1737
                     /gene="ACTR6"
                     /gene_synonym="ARP6; CDA12; hARP6; hARPX; HSPC281;
                     MSTP136"
                     /note="major polyA site"
ORIGIN      
        1 ggaaaacaac tacggctgcg gtgtggttgg tggtgagatg acgaccttag tgctggataa
       61 tggagcttac aacgccaaaa tcggttacag ccatgaaaat gtgtcggtta ttcctaattg
      121 tcagttccgg tcaaaaacag cacgtcttaa aacttttact gccaaccaga tagatgaaat
      181 aaaagaccct tctggactct tttacatcct cccttttcaa aagggctact tggtgaattg
      241 ggatgttcag agacaagttt gggattacct ttttggaaaa gaaatgtatc aggttgattt
      301 tttagatact aatattatta tcactgaacc atactttaac ttcacttcaa ttcaagaatc
      361 aatgaatgaa attctatttg aagaatacca gtttcaagca gtattaagag taaatgctgg
      421 ggctctcagt gcacataggt atttccgaga taatccttcc gaattatgct gtatcattgt
      481 tgatagtgga tattccttta cacatatagt tccttattgt agaagtaaaa agaaaaaaga
      541 agcaattatt cggataaatg tgggaggaaa actcttaacc aatcatctaa aggagatcat
      601 atcttacagg cagctacatg ttatggatga aacacatgtg attaatcaag tgaaagaaga
      661 tgtatgctat gtgtctcagg atttttatag agacatggat attgcaaagt tgaaaggaga
      721 agaaaataca gtaatgatag actatgtctt gcctgacttc agtacaatta aaaagggctt
      781 ttgtaagcca agggaagaga tggtgttgag tggaaaatac aaatctgggg aacaaattct
      841 tcgtttggcc aatgagagat ttgctgttcc ggaaatactc tttaatcctt ctgatatagg
      901 cattcaagaa atgggaattc cagaagctat tgtctattca attcaaaatc tacctgaaga
      961 aatgcagccg cattttttta agaacattgt cttgacagga ggaaattccc ttttcccagg
     1021 atttagggat cgggtttact cagaagttcg atgtcttact ccaacagatt atgatgtttc
     1081 tgttgtgctg cctgaaaacc ctattactta tgcctgggaa ggtggaaaat tgatatcaga
     1141 gaatgatgat tttgaagata tggtggtaac aagagaagat tacgaagaaa atggacatag
     1201 cgtctgtgaa gagaaatttg atatttaagc aacatttttg aatgaaagtt gtgaccataa
     1261 ggtttaattt caaagttcct tttaaaagag gttaaggaac tgtgttacct tttgtcctaa
     1321 gaaaaaggct tgaatttatg taaatacttt gatcgattgc taattttcaa aggcttctta
     1381 ggtaggttac tacagtaaac tgtaactcag tccacatttt catttaggag ctagactacc
     1441 ataacaatgc ttatgctgtt tccaagggta ggttattttt cattaaaaga agaatgaatg
     1501 cattttaagt ttaattcttc atagctgaaa gcacaaattt aacggcttca ctggacagtt
     1561 ttccttagaa ggtagttttg tgtgactgtg actaaactat tttattttaa aatgtcattc
     1621 ttatttatac attctaaagt tggaaagact gatcttatat gtgtataatg tttattttgt
     1681 acctagagta catttaaaag ggtggagact aagctaataa agtttttttg gccacta
//
