LOCUS       NM_024855               2547 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens actin related protein 5 (ACTR5), mRNA.
ACCESSION   NM_024855
VERSION     NM_024855.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2547)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2547)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2547)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2547)
  AUTHORS   Ayala,R., Willhoft,O., Aramayo,R.J., Wilkinson,M., McCormack,E.A.,
            Ocloo,L., Wigley,D.B. and Zhang,X.
  TITLE     Structure and regulation of the human INO80-nucleosome complex
  JOURNAL   Nature 556 (7701), 391-395 (2018)
   PUBMED   29643506
REFERENCE   5  (bases 1 to 2547)
  AUTHORS   Zhang,S., Zhou,B., Wang,L., Li,P., Bennett,B.D., Snyder,R.,
            Garantziotis,S., Fargo,D.C., Cox,A.D., Chen,L. and Hu,G.
  TITLE     INO80 is required for oncogenic transcription and tumor growth in
            non-small cell lung cancer
  JOURNAL   Oncogene 36 (10), 1430-1439 (2017)
   PUBMED   27641337
REFERENCE   6  (bases 1 to 2547)
  AUTHORS   Aoyama,N., Oka,A., Kitayama,K., Kurumizaka,H. and Harata,M.
  TITLE     The actin-related protein hArp8 accumulates on the mitotic
            chromosomes and functions in chromosome alignment
  JOURNAL   Exp Cell Res 314 (4), 859-868 (2008)
   PUBMED   18163988
REFERENCE   7  (bases 1 to 2547)
  AUTHORS   Wu,S., Shi,Y., Mulligan,P., Gay,F., Landry,J., Liu,H., Lu,J.,
            Qi,H.H., Wang,W., Nickoloff,J.A., Wu,C. and Shi,Y.
  TITLE     A YY1-INO80 complex regulates genomic stability through homologous
            recombination-based repair
  JOURNAL   Nat Struct Mol Biol 14 (12), 1165-1172 (2007)
   PUBMED   18026119
REFERENCE   8  (bases 1 to 2547)
  AUTHORS   Jin,J., Cai,Y., Yao,T., Gottschalk,A.J., Florens,L., Swanson,S.K.,
            Gutierrez,J.L., Coleman,M.K., Workman,J.L., Mushegian,A.,
            Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     A mammalian chromatin remodeling complex with similarities to the
            yeast INO80 complex
  JOURNAL   J Biol Chem 280 (50), 41207-41212 (2005)
   PUBMED   16230350
REFERENCE   9  (bases 1 to 2547)
  AUTHORS   Lee,S.Y., Obata,Y., Yoshida,M., Stockert,E., Williamson,B.,
            Jungbluth,A.A., Chen,Y.T., Old,L.J. and Scanlan,M.J.
  TITLE     Immunomic analysis of human sarcoma
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2651-2656 (2003)
   PUBMED   12601173
REFERENCE   10 (bases 1 to 2547)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC038402.1, AK022847.1, BF529768.1 and AL133519.28.
            
            On Nov 23, 2018 this sequence version replaced NM_024855.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.112801.1,
                                           SRR1803611.171891.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243903.6/ ENSP00000243903.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BC038402.1         7-42
            37-1459             AK022847.1         28-1450
            1460-1465           BC038402.1         1466-1471
            1466-2196           AK022847.1         1457-2187
            2197-2218           BC038402.1         2203-2224
            2219-2473           BF529768.1         336-590
            2474-2547           AL133519.28        90246-90319
FEATURES             Location/Qualifiers
     source          1..2547
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..2547
                     /gene="ACTR5"
                     /gene_synonym="Arp5; INO80M"
                     /note="actin related protein 5"
                     /db_xref="GeneID:79913"
                     /db_xref="HGNC:HGNC:14671"
                     /db_xref="MIM:619730"
     exon            1..394
                     /gene="ACTR5"
                     /gene_synonym="Arp5; INO80M"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1843
                     /gene="ACTR5"
                     /gene_synonym="Arp5; INO80M"
                     /note="INO80 complex subunit M; ARP5 actin related protein
                     5 homolog; sarcoma antigen NY-SAR-16; hARP5"
                     /codon_start=1
                     /product="actin-related protein 5"
                     /protein_id="NP_079131.3"
                     /db_xref="CCDS:CCDS13308.1"
                     /db_xref="GeneID:79913"
                     /db_xref="HGNC:HGNC:14671"
                     /db_xref="MIM:619730"
                     /translation="MAANVFPFRDARAAPDPVLEAGPVAHGPLPVPLVLDNGSFQVRA
                     GWACPGQDPGPEPRLQFRAVCARGRGGARGASGPQVGNALGSLEPLRWMLRSPFDRNV
                     PVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCNPLYSRQMMSELLFECYGIPK
                     VAYGIDSLFSFYHNKPKNSMCSGLIISSGYQCTHVLPILEGRLDAKNCKRINLGGSQA
                     AGYLQRLLQLKYPGHLAAITLSRMEEILHEHSYIAEDYVEELHKWRCPDYYENNVHKM
                     QLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELL
                     EDGQMDQFHKALIELNMDSPEELQSYIQKLSIAVEQAKQKILQAEVNLEVDVVDSKPE
                     TPDLEQLEPSLEDVESMNDFDPLFSEETPGVEKPVTTVQPVFNLAAYHQLFVGTERIR
                     APEIIFQPSLIGEEQAGIAETLQYILDRYPKDIQEMLVQNVFLTGGNTMYPGMKARME
                     KELLEMRPFRSSFQVQLASNPVLDAWYGARDWALNHLDDNEVWITRKEYEEKGGEYLK
                     EHCASNIYVPIRLPKQASRSSDAQASSKGSAAGGGGAGEQA"
     exon            395..624
                     /gene="ACTR5"
                     /gene_synonym="Arp5; INO80M"
                     /inference="alignment:Splign:2.1.0"
     exon            625..794
                     /gene="ACTR5"
                     /gene_synonym="Arp5; INO80M"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1012
                     /gene="ACTR5"
                     /gene_synonym="Arp5; INO80M"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1195
                     /gene="ACTR5"
                     /gene_synonym="Arp5; INO80M"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1312
                     /gene="ACTR5"
                     /gene_synonym="Arp5; INO80M"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1452
                     /gene="ACTR5"
                     /gene_synonym="Arp5; INO80M"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1585
                     /gene="ACTR5"
                     /gene_synonym="Arp5; INO80M"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..2547
                     /gene="ACTR5"
                     /gene_synonym="Arp5; INO80M"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2218
                     /gene="ACTR5"
                     /gene_synonym="Arp5; INO80M"
                     /note="major polyA site"
     regulatory      2518..2523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR5"
                     /gene_synonym="Arp5; INO80M"
                     /note="hexamer: AATAAA"
     polyA_site      2547
                     /gene="ACTR5"
                     /gene_synonym="Arp5; INO80M"
ORIGIN      
        1 gctggacgcg cgctccaaga tggcggcgaa cgtgttcccg ttccgcgacg cccgtgccgc
       61 accggaccca gtgctggagg ccggcccggt ggcacacggg ccactgccgg taccgctggt
      121 gctggacaac gggtcgttcc aagtccgcgc tggctgggcg tgtcccgggc aggacccagg
      181 tcccgagccg cgcctgcagt tccgcgcggt gtgcgcccgc ggtcgtggcg gggcacgggg
      241 cgcgtcgggc ccgcaggtgg ggaacgctct gggcagcctg gagccactgc gctggatgct
      301 gcgctcgccc ttcgaccgca acgtgccggt caacctggag cttcaggagt tgctgctgga
      361 ctacagcttc cagcacctgg gtgtctcctc acagggctgt gttgatcatc ccatagtttt
      421 gacagaagct gtgtgcaacc cactgtattc acggcaaatg atgtctgagc ttctttttga
      481 gtgctacggg attcccaagg ttgcctatgg aatagacagc ctcttcagct tctaccacaa
      541 taagccaaag aactcgatgt gcagtgggct aatcatttca tctggatacc agtgtacgca
      601 tgttttaccc atcttagaag ggagattaga tgctaaaaac tgcaagcgca tcaatcttgg
      661 aggaagccaa gcagctggtt acctccagcg tctcctccag ctgaagtacc ctgggcacct
      721 ggcagccatc accctcagcc gcatggagga gattctgcat gagcacagct acatcgctga
      781 ggattatgtg gaagaattac acaaatggcg gtgtcctgat tattatgaga ataatgtcca
      841 caagatgcag ctcccatttt ccagcaagct cctgggcagc actctgacct ctgaggagaa
      901 acaagaaagg cggcagcagc aattgcggcg gctgcaggag ctcaatgccc ggcggcggga
      961 ggagaagctg cagctggatc aggagcgtct ggaccgactg ctatatgtgc aggaacttct
     1021 agaggatggc cagatggatc agtttcacaa agctctgata gagctgaata tggactcccc
     1081 agaagagctg cagtcctaca tccagaagct cagtatagca gtggagcagg ctaagcagaa
     1141 aatcctccaa gcggaagtca acctcgaggt ggatgtggta gacagcaagc cagagacccc
     1201 tgacctggag cagctggagc cgtctttgga agatgtggaa agcatgaatg attttgatcc
     1261 cttgttttca gaggaaacac ctggagtgga gaagccggtc accactgttc agcccgtgtt
     1321 taacttggca gcatatcatc agctatttgt tgggacagaa agaattcgag ctccagagat
     1381 tattttccag ccatctctca taggagaaga acaggctggg attgcagaga ctcttcagta
     1441 cattctggac aggtacccaa aggacattca ggaaatgctg gttcagaacg ttttcctcac
     1501 tggcggcaac acgatgtatc ctggcatgaa agccagaatg gagaaggaac tgttggagat
     1561 gagacccttc cggtcttctt ttcaggttca acttgcctcg aaccctgtgc tggatgcctg
     1621 gtacggtgct cgtgactggg ccttgaacca cctagatgat aatgaagttt ggatcaccag
     1681 gaaagagtat gaagaaaagg gaggagagta cctcaaggag cactgtgctt ccaacatcta
     1741 tgtccccatc cgcctgccga agcaggcctc ccgctcctca gatgcccagg catccagcaa
     1801 gggctccgct gctggtggag gtggtgctgg tgagcaggca tagcagaggc cctccagaga
     1861 gactgccctg cacgccatgc cttgggccac gttggcagtg tgacaggact gtgattgtgc
     1921 tagatgtacc tgcccaagtc tgctggtcac atttggcagc aaaatggatt tctcctgggg
     1981 agaacaaagt taagggacac tgagacctgc ccttcagaat tcggttcact tgggggcttc
     2041 tgtggtagag actaactggc cttctgatgt ctttgttcaa ctgtggccag ctgtggcatc
     2101 agcttcctgg agcagtaaat gaagacagag tggaggacac aaatgtacaa aatgcacaag
     2161 actgatttct taccacattt tagtctttct tgttttaaaa aaaattcttt aaaatttatc
     2221 ttgtccgtgt agatacttta ttcttctgga tgtattcaga aattgcatga atgcccagtg
     2281 aggggaggtc tttcatgcat ataaaaaggt aatgtttatt gccgggcaca gtggcacgtg
     2341 cctgttaagg cccagctttg tgggaggcta aggcaggagg atcgctggag cttaggagtt
     2401 cgaggctatc gtgtgctgtg atcgcacctg tgaataacca ctgcactcca gcctgggcaa
     2461 cataggaaga cattgtctct aaaaagatac atttttcata aaaggtaatg tttattcaat
     2521 aaaagcagtt gcctcaggaa ccggaaa
//
