LOCUS       NM_001164458            1157 bp    mRNA    linear   PRI 16-FEB-2024
DEFINITION  Homo sapiens actin related protein 3C (ACTR3C), transcript variant
            1, mRNA.
ACCESSION   NM_001164458 XM_002342793
VERSION     NM_001164458.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1157)
  AUTHORS   Shindo-Okada,N. and Iigo,M.
  TITLE     Expression of the Arp11 gene suppresses the tumorigenicity of PC-14
            human lung adenocarcinoma cells
  JOURNAL   Biochem Biophys Res Commun 312 (4), 889-896 (2003)
   PUBMED   14651955
REFERENCE   2  (bases 1 to 1157)
  AUTHORS   Shindo-Okada,N. and Shimizu,K.
  TITLE     Isolation of a novel actin-related gene expressed in low-metastatic
            PC-14 human lung adenocarcinoma
  JOURNAL   Biochem Biophys Res Commun 280 (1), 61-67 (2001)
   PUBMED   11162478
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA868104.1, DN992136.1, DR004860.1, AB039791.1 and BM674900.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001164458.1.
            
            Transcript Variant: This variant (1), as well as variant 2, encodes
            the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.1061259.1,
                                           SRR18074968.285238.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267755 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683684.1/ ENSP00000507618.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                DA868104.1         125-182
            59-406              DN992136.1         247-594
            407-692             DR004860.1         372-657
            693-979             AB039791.1         755-1041
            980-1157            BM674900.1         18-195              c
FEATURES             Location/Qualifiers
     source          1..1157
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..1157
                     /gene="ACTR3C"
                     /gene_synonym="ARP11"
                     /note="actin related protein 3C"
                     /db_xref="GeneID:653857"
                     /db_xref="HGNC:HGNC:37282"
     exon            1..77
                     /gene="ACTR3C"
                     /gene_synonym="ARP11"
                     /inference="alignment:Splign:2.1.0"
     exon            78..173
                     /gene="ACTR3C"
                     /gene_synonym="ARP11"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..761
                     /gene="ACTR3C"
                     /gene_synonym="ARP11"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; actin-related protein 11; actin-related Arp11;
                     ARP3 actin related protein 3 homolog C"
                     /codon_start=1
                     /product="actin-related protein 3C isoform a precursor"
                     /protein_id="NP_001157930.1"
                     /db_xref="CCDS:CCDS47744.1"
                     /db_xref="GeneID:653857"
                     /db_xref="HGNC:HGNC:37282"
                     /translation="MFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGIVIDSGDG
                     VTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKY
                     CYICPDIVKEFAKYDVDPQKWIKQYTGINAINQKKFVIDVGYERFLGPEIFFHPEFAN
                     PDSMESISDVVDEVIQNCPIDVRRPLYKMEQIPLSYPQGHGFHPLSPPFH"
     exon            174..281
                     /gene="ACTR3C"
                     /gene_synonym="ARP11"
                     /inference="alignment:Splign:2.1.0"
     exon            282..425
                     /gene="ACTR3C"
                     /gene_synonym="ARP11"
                     /inference="alignment:Splign:2.1.0"
     exon            426..599
                     /gene="ACTR3C"
                     /gene_synonym="ARP11"
                     /inference="alignment:Splign:2.1.0"
     exon            600..692
                     /gene="ACTR3C"
                     /gene_synonym="ARP11"
                     /inference="alignment:Splign:2.1.0"
     exon            693..799
                     /gene="ACTR3C"
                     /gene_synonym="ARP11"
                     /inference="alignment:Splign:2.1.0"
     exon            800..1157
                     /gene="ACTR3C"
                     /gene_synonym="ARP11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1137..1142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR3C"
                     /gene_synonym="ARP11"
                     /note="hexamer: AATAAA"
     polyA_site      1157
                     /gene="ACTR3C"
                     /gene_synonym="ARP11"
                     /note="major polyA site"
ORIGIN      
        1 ggcagcctgc ggagccactg gccaagctgg gaagtccggc gcaactccgc accgcagagc
       61 cggcgcctcc tcggcagaca gaacctccac tcaatacacc agaaaacaga gagtatcttg
      121 cagaaattat gttcgaatca tttaacgttc caggactcta cattgcagtt caggcagtgc
      181 tggccttggc ggcatcttgg acatctcgac aagtgggtga acgtacatta acggggatag
      241 tcattgacag cggagatgga gtcacccatg ttatcccagt ggcagaaggt tatgtaattg
      301 gaagctgcat caaacacatc ccgattgcag gtagagatat tacgtatttc attcaacagc
      361 tgctaaggga gagggaggtg ggaatccctc ctgagcagtc actggagacc gcaaaagcca
      421 ttaaggagaa atactgttac atttgccccg atatagtcaa ggaatttgcc aagtatgatg
      481 tggatcccca gaagtggatc aaacagtaca cgggtatcaa tgcgatcaac cagaagaagt
      541 ttgttataga cgttggttac gaaagattcc tgggacctga aatattcttt cacccggagt
      601 ttgccaaccc agactctatg gagtccatct cagatgttgt tgatgaagta atacagaact
      661 gccccatcga tgtgcggcgt ccgctgtata agatggaaca aattccactg agctatcctc
      721 aaggtcacgg attccatcct ctgtcacctc catttcattg agatgatata ttgagcccat
      781 gcgtagcctt ttatttgaga tttccaaggc cagcaatgtt ctcttcctct cccttttctt
      841 tgtataaaaa ttcattctca agaaaaactc tcatatcaat tgtttacatg tcactatggc
      901 taagacacta aaagccctct ccctgcaaaa ctggtggcaa agctctctag agaaccacaa
      961 actgttgcat ccttactacg tggggcagca gcaagcccag gtgaagatgt gcatgttctt
     1021 ggagaaagta ttaataacat accgacactt acatctgggt gaataatttc atcaaatctc
     1081 ttaactcacg cttgcacaaa cttcacctgg agagagagag ggaaagctgt gccagaaata
     1141 aatggttatt gaggtca
//
