LOCUS       NM_020445               2213 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens actin related protein 3B (ACTR3B), transcript variant
            1, mRNA.
ACCESSION   NM_020445 XM_937674
VERSION     NM_020445.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2213)
  AUTHORS   Julia,A., Domenech,E., Chaparro,M., Garcia-Sanchez,V., Gomollon,F.,
            Panes,J., Manosa,M., Barreiro-De Acosta,M., Gutierrez,A.,
            Garcia-Planella,E., Aguas,M., Munoz,F., Esteve,M., Mendoza,J.L.,
            Vera,M., Marquez,L., Tortosa,R., Lopez-Lasanta,M., Alonso,A.,
            Gelpi,J.L., Garcia-Montero,A.C., Bertranpetit,J., Absher,D.,
            Myers,R.M., Gisbert,J.P. and Marsal,S.
  TITLE     A genome-wide association study identifies a novel locus at 6q22.1
            associated with ulcerative colitis
  JOURNAL   Hum Mol Genet 23 (25), 6927-6934 (2014)
   PUBMED   25082827
REFERENCE   2  (bases 1 to 2213)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 2213)
  AUTHORS   Shin,J.H., Gulesserian,T., Weitzdoerfer,R., Fountoulakis,M. and
            Lubec,G.
  TITLE     Derangement of hypothetical proteins in fetal Down's syndrome brain
  JOURNAL   Neurochem Res 29 (6), 1307-1316 (2004)
   PUBMED   15176487
REFERENCE   4  (bases 1 to 2213)
  AUTHORS   Shindo-Okada,N. and Iigo,M.
  TITLE     Expression of the Arp11 gene suppresses the tumorigenicity of PC-14
            human lung adenocarcinoma cells
  JOURNAL   Biochem Biophys Res Commun 312 (4), 889-896 (2003)
   PUBMED   14651955
  REMARK    GeneRIF: Thus, overexpression of Arp11 may suppress tumorigenicity
            in nude mice.
REFERENCE   5  (bases 1 to 2213)
  AUTHORS   Eckley,D.M. and Schroer,T.A.
  TITLE     Interactions between the evolutionarily conserved, actin-related
            protein, Arp11, actin, and Arp1
  JOURNAL   Mol Biol Cell 14 (7), 2645-2654 (2003)
   PUBMED   12857853
REFERENCE   6  (bases 1 to 2213)
  AUTHORS   Shindo-Okada,N. and Shimizu,K.
  TITLE     Isolation of a novel actin-related gene expressed in low-metastatic
            PC-14 human lung adenocarcinoma
  JOURNAL   Biochem Biophys Res Commun 280 (1), 61-67 (2001)
   PUBMED   11162478
REFERENCE   7  (bases 1 to 2213)
  AUTHORS   Jay,P., Berge-Lefranc,J.L., Massacrier,A., Roessler,E., Wallis,D.,
            Muenke,M., Gastaldi,M., Taviaux,S., Cau,P. and Berta,P.
  TITLE     ARP3beta, the gene encoding a new human actin-related protein, is
            alternatively spliced and predominantly expressed in brain neuronal
            cells
  JOURNAL   Eur J Biochem 267 (10), 2921-2928 (2000)
   PUBMED   10806390
REFERENCE   8  (bases 1 to 2213)
  AUTHORS   Machesky,L.M. and Gould,K.L.
  TITLE     The Arp2/3 complex: a multifunctional actin organizer
  JOURNAL   Curr Opin Cell Biol 11 (1), 117-121 (1999)
   PUBMED   10047519
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DN601600.1, AK315534.1,
            AB209174.1 and AA559050.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020445.5.
            
            Summary: This gene encodes a member of the actin-related proteins
            (ARP), which form multiprotein complexes and share 35-55% amino
            acid identity with conventional actin. The protein encoded by this
            gene may have a regulatory role in the actin cytoskeleton and
            induce cell-shape change and motility. Pseudogenes of this gene are
            located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing
            results in multiple transcript variants and protein isoforms.
            [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.247181.1,
                                           SRR1660803.17233.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256001.13/ ENSP00000256001.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DN601600.1         4-18
            16-1388             AK315534.1         1-1373
            1389-2206           AB209174.1         4719-5536
            2207-2213           AA559050.1         8-14                c
FEATURES             Location/Qualifiers
     source          1..2213
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1-q36.2"
     gene            1..2213
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /note="actin related protein 3B"
                     /db_xref="GeneID:57180"
                     /db_xref="HGNC:HGNC:17256"
     exon            1..175
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1388
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     actin-related protein 3-beta; actin-related protein Arp11;
                     ARP3-beta; actin-like protein 3B; actin-related protein
                     ARP4; ARP3 actin related protein 3 homolog B"
                     /codon_start=1
                     /product="actin-related protein 3B isoform 1"
                     /protein_id="NP_065178.1"
                     /db_xref="CCDS:CCDS5934.1"
                     /db_xref="GeneID:57180"
                     /db_xref="HGNC:HGNC:17256"
                     /translation="MAGSLPPCVVDCGTGYTKLGYAGNTEPQFIIPSCIAIRESAKVV
                     DQAQRRVLRGVDDLDFFIGDEAIDKPTYATKWPIRHGIIEDWDLMERFMEQVVFKYLR
                     AEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGE
                     RTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPE
                     QSLETAKAIKEKYCYICPDIVKEFAKYDVDPRKWIKQYTGINAINQKKFVIDVGYERF
                     LGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKNVVLSGGSTMFRDFGRR
                     LQRDLKRVVDARLRLSEELSGGRIKPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQ
                     VCHTKKDYEEYGPSICRHNPVFGVMS"
     exon            176..231
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            232..356
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            357..467
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            468..563
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            564..671
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            672..815
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            816..989
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1082
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1208
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1292
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..2213
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1790..1795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /note="hexamer: AATAAA"
     polyA_site      1817
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /note="major polyA site"
     regulatory      2183..2188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /note="hexamer: AATAAA"
     polyA_site      2213
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /note="major polyA site"
ORIGIN      
        1 atccgggctc ccggcagcgg cgctgcggcg gctcgcggga gacgctgcgc gcggggctag
       61 cgggcggcgg agcggacggc gacggggcgc tctcgggctg ccggcggggc cgagcgccgc
      121 gcgtcccgag catggcaggc tccctgcctc cctgcgtggt ggactgtggc accgggtata
      181 ccaagcttgg ctacgcaggc aacactgagc cccagttcat tattccttca tgtattgcca
      241 tcagagagtc agcaaaggta gttgaccaag ctcaaaggag agtgttgagg ggagttgatg
      301 accttgactt tttcatagga gatgaagcca tcgataaacc tacatatgct acaaagtggc
      361 cgatacgaca tggaatcatt gaagactggg atcttatgga aaggttcatg gagcaagtgg
      421 tttttaaata tcttcgagct gaacctgagg accattattt tttaatgaca gaacctccac
      481 tcaatacacc agaaaacaga gagtatcttg cagaaattat gtttgaatca tttaacgtac
      541 caggactcta cattgcagtt caggcagtgc tggccttggc ggcatcttgg acatctcgac
      601 aagtgggtga acgtacgtta acggggatag tcattgacag cggagatgga gtcacccatg
      661 ttatcccagt ggcagaaggt tatgtaattg gaagctgcat caaacacatc ccgattgcag
      721 gtagagatat tacgtatttc attcaacagc tgctaaggga gagggaggtg ggaatccctc
      781 ctgagcagtc actggagacc gcaaaagcca ttaaggagaa atactgttac atttgccccg
      841 atatagtcaa ggaatttgcc aagtatgatg tggatccccg gaagtggatc aaacagtaca
      901 cgggtatcaa tgcgatcaac cagaagaagt ttgttataga cgttggttac gaaagattcc
      961 tgggacctga aatattcttt cacccggagt ttgccaaccc agactttatg gagtccatct
     1021 cagatgttgt tgatgaagta atacagaact gccccatcga tgtgcggcgc ccgctgtata
     1081 agaatgtcgt actctcagga ggctccacca tgttcaggga tttcggacgc cgactgcaga
     1141 gggatttgaa gagagtggtg gatgctaggc tgaggctcag cgaggagctc agcggcggga
     1201 ggatcaagcc gaagcctgtg gaggtccagg tggtcacgca tcacatgcag cgctacgccg
     1261 tgtggttcgg aggctccatg ctggcctcga ctcccgagtt ctttcaggtc tgccacacca
     1321 agaaggacta tgaagagtac gggcccagca tctgccgcca caaccccgtc tttggagtca
     1381 tgtcctagtg tctgcctgaa cgcgtcgttc gatggtgtca cgttggggaa caagtgtcct
     1441 tcagaaccca gagaaggccg ccgttctgta aatagcgacg tcggtgttgc tgcccagcag
     1501 cgtgcttgca ttgccggtgc atgaggcgcg gcgcgggccc ttcagtaaaa gccatttatc
     1561 cgtgtgccga ccgctgtctg ccagcctcct ccttctcccg ccctcctcac cctcgctctc
     1621 cctcctcctc ctcctccgag ctgctagctg acaaatacaa ttctgaagga atccaaatgt
     1681 gactttgaaa attgttagag aaaacaacat tagaaaatgg cgcaaaatcg ttaggtccca
     1741 ggagagaatg tgggggcgca aacccttttc ctcccagcct atttttgtaa ataaaatgtt
     1801 taaacttgaa atacaaatcg atgtttatat ttcctatcat tttgtatttt atggtatttg
     1861 gtacaactgg ctgatactaa gcacgaatag atattgatgt tatggagtgc tgtaatccaa
     1921 agtttttaat tgtgaggcat gttctgatat gtttataggc aaacaaataa aacagcaaac
     1981 ttttttgcca catgtttgct agaaaatgat tatactttat tggagtgaca tgaagtttga
     2041 acactaaaca gtaatgtatg agaattacta cagatacatg tatcttttag ttttttttgt
     2101 ttgaactttc tggagctgtt ttatagaaga tgatggtttg ttgtcggtga gtgttggatg
     2161 aaatacttcc ttgcaccatt gtaataaaag ctgttagaat atttgtaaat atc
//
