LOCUS       NM_001350943            2032 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens actin related protein 3B (ACTR3B), transcript variant
            6, mRNA.
ACCESSION   NM_001350943
VERSION     NM_001350943.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2032)
  AUTHORS   Julia,A., Domenech,E., Chaparro,M., Garcia-Sanchez,V., Gomollon,F.,
            Panes,J., Manosa,M., Barreiro-De Acosta,M., Gutierrez,A.,
            Garcia-Planella,E., Aguas,M., Munoz,F., Esteve,M., Mendoza,J.L.,
            Vera,M., Marquez,L., Tortosa,R., Lopez-Lasanta,M., Alonso,A.,
            Gelpi,J.L., Garcia-Montero,A.C., Bertranpetit,J., Absher,D.,
            Myers,R.M., Gisbert,J.P. and Marsal,S.
  TITLE     A genome-wide association study identifies a novel locus at 6q22.1
            associated with ulcerative colitis
  JOURNAL   Hum Mol Genet 23 (25), 6927-6934 (2014)
   PUBMED   25082827
REFERENCE   2  (bases 1 to 2032)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 2032)
  AUTHORS   Shin,J.H., Gulesserian,T., Weitzdoerfer,R., Fountoulakis,M. and
            Lubec,G.
  TITLE     Derangement of hypothetical proteins in fetal Down's syndrome brain
  JOURNAL   Neurochem Res 29 (6), 1307-1316 (2004)
   PUBMED   15176487
REFERENCE   4  (bases 1 to 2032)
  AUTHORS   Shindo-Okada,N. and Iigo,M.
  TITLE     Expression of the Arp11 gene suppresses the tumorigenicity of PC-14
            human lung adenocarcinoma cells
  JOURNAL   Biochem Biophys Res Commun 312 (4), 889-896 (2003)
   PUBMED   14651955
  REMARK    GeneRIF: Thus, overexpression of Arp11 may suppress tumorigenicity
            in nude mice.
REFERENCE   5  (bases 1 to 2032)
  AUTHORS   Eckley,D.M. and Schroer,T.A.
  TITLE     Interactions between the evolutionarily conserved, actin-related
            protein, Arp11, actin, and Arp1
  JOURNAL   Mol Biol Cell 14 (7), 2645-2654 (2003)
   PUBMED   12857853
REFERENCE   6  (bases 1 to 2032)
  AUTHORS   Shindo-Okada,N. and Shimizu,K.
  TITLE     Isolation of a novel actin-related gene expressed in low-metastatic
            PC-14 human lung adenocarcinoma
  JOURNAL   Biochem Biophys Res Commun 280 (1), 61-67 (2001)
   PUBMED   11162478
REFERENCE   7  (bases 1 to 2032)
  AUTHORS   Jay,P., Berge-Lefranc,J.L., Massacrier,A., Roessler,E., Wallis,D.,
            Muenke,M., Gastaldi,M., Taviaux,S., Cau,P. and Berta,P.
  TITLE     ARP3beta, the gene encoding a new human actin-related protein, is
            alternatively spliced and predominantly expressed in brain neuronal
            cells
  JOURNAL   Eur J Biochem 267 (10), 2921-2928 (2000)
   PUBMED   10806390
REFERENCE   8  (bases 1 to 2032)
  AUTHORS   Machesky,L.M. and Gould,K.L.
  TITLE     The Arp2/3 complex: a multifunctional actin organizer
  JOURNAL   Curr Opin Cell Biol 11 (1), 117-121 (1999)
   PUBMED   10047519
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092180.5 and AC072057.8.
            
            On Aug 13, 2020 this sequence version replaced NM_001350943.1.
            
            Summary: This gene encodes a member of the actin-related proteins
            (ARP), which form multiprotein complexes and share 35-55% amino
            acid identity with conventional actin. The protein encoded by this
            gene may have a regulatory role in the actin cytoskeleton and
            induce cell-shape change and motility. Pseudogenes of this gene are
            located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing
            results in multiple transcript variants and protein isoforms.
            [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (6), as well as variants 3, 4, and
            5, encodes isoform 3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.4533124.1,
                                           SRR14038196.1568776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               AC092180.5         81346-81520
            176-286             AC072057.8         100101-100211       c
            287-382             AC072057.8         87187-87282         c
            383-490             AC072057.8         85244-85351         c
            491-634             AC072057.8         81390-81533         c
            635-808             AC072057.8         78317-78490         c
            809-901             AC072057.8         76710-76802         c
            902-1027            AC072057.8         49581-49706         c
            1028-1111           AC072057.8         48255-48338         c
            1112-2032           AC072057.8         46454-47374         c
FEATURES             Location/Qualifiers
     source          1..2032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1-q36.2"
     gene            1..2032
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /note="actin related protein 3B"
                     /db_xref="GeneID:57180"
                     /db_xref="HGNC:HGNC:17256"
     exon            1..175
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            176..286
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1207
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /note="isoform 3 is encoded by transcript variant 6;
                     actin-related protein 3-beta; actin-related protein Arp11;
                     ARP3-beta; actin-like protein 3B; actin-related protein
                     ARP4; ARP3 actin related protein 3 homolog B"
                     /codon_start=1
                     /product="actin-related protein 3B isoform 3"
                     /protein_id="NP_001337872.1"
                     /db_xref="CCDS:CCDS87568.1"
                     /db_xref="GeneID:57180"
                     /db_xref="HGNC:HGNC:17256"
                     /translation="MERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFE
                     SFNVPGLYIAVQAVLALAASWTSRQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCI
                     KHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVKEFAKYDVD
                     PRKWIKQYTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQN
                     CPIDVRRPLYKNVVLSGGSTMFRDFGRRLQRDLKRVVDARLRLSEELSGGRIKPKPVE
                     VQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICRHNPVFGVMS"
     exon            287..382
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            383..490
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            491..634
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            635..808
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            809..901
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1027
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1111
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..2032
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1609..1614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /note="hexamer: AATAAA"
     polyA_site      1636
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /note="major polyA site"
     regulatory      2002..2007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /note="hexamer: AATAAA"
     polyA_site      2032
                     /gene="ACTR3B"
                     /gene_synonym="ARP11; ARP3BETA"
                     /note="major polyA site"
ORIGIN      
        1 atccgggctc ccggcagcgg cgctgcggcg gctcgcggga gacgctgcgc gcggggctag
       61 cgggcggcgg agcggacggc gacggggcgc tctcgggctg ccggcggggc cgagcgccgc
      121 gcgtcccgag catggcaggc tccctgcctc cctgcgtggt ggactgtggc accggtggcc
      181 gatacgacat ggaatcattg aagactggga tcttatggaa aggttcatgg agcaagtggt
      241 ttttaaatat cttcgagctg aacctgagga ccattatttt ttaatgacag aacctccact
      301 caatacacca gaaaacagag agtatcttgc agaaattatg tttgaatcat ttaacgtacc
      361 aggactctac attgcagttc aggcagtgct ggccttggcg gcatcttgga catctcgaca
      421 agtgggtgaa cgtacgttaa cggggatagt cattgacagc ggagatggag tcacccatgt
      481 tatcccagtg gcagaaggtt atgtaattgg aagctgcatc aaacacatcc cgattgcagg
      541 tagagatatt acgtatttca ttcaacagct gctaagggag agggaggtgg gaatccctcc
      601 tgagcagtca ctggagaccg caaaagccat taaggagaaa tactgttaca tttgccccga
      661 tatagtcaag gaatttgcca agtatgatgt ggatccccgg aagtggatca aacagtacac
      721 gggtatcaat gcgatcaacc agaagaagtt tgttatagac gttggttacg aaagattcct
      781 gggacctgaa atattctttc acccggagtt tgccaaccca gactttatgg agtccatctc
      841 agatgttgtt gatgaagtaa tacagaactg ccccatcgat gtgcggcgcc cgctgtataa
      901 gaatgtcgta ctctcaggag gctccaccat gttcagggat ttcggacgcc gactgcagag
      961 ggatttgaag agagtggtgg atgctaggct gaggctcagc gaggagctca gcggcgggag
     1021 gatcaagccg aagcctgtgg aggtccaggt ggtcacgcat cacatgcagc gctacgccgt
     1081 gtggttcgga ggctccatgc tggcctcgac tcccgagttc tttcaggtct gccacaccaa
     1141 gaaggactat gaagagtacg ggcccagcat ctgccgccac aaccccgtct ttggagtcat
     1201 gtcctagtgt ctgcctgaac gcgtcgttcg atggtgtcac gttggggaac aagtgtcctt
     1261 cagaacccag agaaggccgc cgttctgtaa atagcgacgt cggtgttgct gcccagcagc
     1321 gtgcttgcat tgccggtgca tgaggcgcgg cgcgggccct tcagtaaaag ccatttatcc
     1381 gtgtgccgac cgctgtctgc cagcctcctc cttctcccgc cctcctcacc ctcgctctcc
     1441 ctcctcctcc tcctccgagc tgctagctga caaatacaat tctgaaggaa tccaaatgtg
     1501 actttgaaaa ttgttagaga aaacaacatt agaaaatggc gcaaaatcgt taggtcccag
     1561 gagagaatgt gggggcgcaa acccttttcc tcccagccta tttttgtaaa taaaatgttt
     1621 aaacttgaaa tacaaatcga tgtttatatt tcctatcatt ttgtatttta tggtatttgg
     1681 tacaactggc tgatactaag cacgaataga tattgatgtt atggagtgct gtaatccaaa
     1741 gtttttaatt gtgaggcatg ttctgatatg tttataggca aacaaataaa acagcaaact
     1801 tttttgccac atgtttgcta gaaaatgatt atactttatt ggagtgacat gaagtttgaa
     1861 cactaaacag taatgtatga gaattactac agatacatgt atcttttagt tttttttgtt
     1921 tgaactttct ggagctgttt tatagaagat gatggtttgt tgtcggtgag tgttggatga
     1981 aatacttcct tgcaccattg taataaaagc tgttagaata tttgtaaata tc
//
