LOCUS       NM_005721               6589 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens actin related protein 3 (ACTR3), transcript variant 1,
            mRNA.
ACCESSION   NM_005721
VERSION     NM_005721.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6589)
  AUTHORS   Yang,Y., Gong,Y., Ding,Y., Sun,S., Bai,R., Zhuo,S. and Zhang,Z.
  TITLE     LINC01133 promotes pancreatic ductal adenocarcinoma
            epithelial-mesenchymal transition mediated by SPP1 through binding
            to Arp3
  JOURNAL   Cell Death Dis 15 (7), 492 (2024)
   PUBMED   38987572
  REMARK    GeneRIF: LINC01133 promotes pancreatic ductal adenocarcinoma
            epithelial-mesenchymal transition mediated by SPP1 through binding
            to Arp3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6589)
  AUTHORS   van Eeuwen,T., Boczkowska,M., Rebowski,G., Carman,P.J.,
            Fregoso,F.E. and Dominguez,R.
  TITLE     Transition State of Arp2/3 Complex Activation by Actin-Bound
            Dimeric Nucleation-Promoting Factor
  JOURNAL   Proc Natl Acad Sci U S A 120 (33), e2306165120 (2023)
   PUBMED   37549294
  REMARK    GeneRIF: Transition State of Arp2/3 Complex Activation by
            Actin-Bound Dimeric Nucleation-Promoting Factor.
REFERENCE   3  (bases 1 to 6589)
  AUTHORS   Sadhu,L., Tsopoulidis,N., Hasanuzzaman,M., Laketa,V., Way,M. and
            Fackler,O.T.
  TITLE     ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP
            drive distinct Arp2/3-dependent actin remodeling events in CD4 T
            cells
  JOURNAL   Elife 12, e82450 (2023)
   PUBMED   37162507
  REMARK    GeneRIF: ARPC5 isoforms and their regulation by
            calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin
            remodeling events in CD4 T cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6589)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 6589)
  AUTHORS   Zhang,L., Zhang,Y., Lei,Y., Wei,Z., Li,Y., Wang,Y., Bu,Y. and
            Zhang,C.
  TITLE     Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the
            actin-related protein 2/3 complex in human non-small cell lung
            carcinoma
  JOURNAL   J Biol Chem 295 (16), 5335-5349 (2020)
   PUBMED   32169900
  REMARK    GeneRIF: Proline-rich 11 (PRR11) drives F-actin assembly by
            recruiting the actin-related protein 2/3 complex in human non-small
            cell lung carcinoma.
REFERENCE   6  (bases 1 to 6589)
  AUTHORS   Ma,L., Rohatgi,R. and Kirschner,M.W.
  TITLE     The Arp2/3 complex mediates actin polymerization induced by the
            small GTP-binding protein Cdc42
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15362-15367 (1998)
   PUBMED   9860974
REFERENCE   7  (bases 1 to 6589)
  AUTHORS   Machesky,L.M., Reeves,E., Wientjes,F., Mattheyse,F.J., Grogan,A.,
            Totty,N.F., Burlingame,A.L., Hsuan,J.J. and Segal,A.W.
  TITLE     Mammalian actin-related protein 2/3 complex localizes to regions of
            lamellipodial protrusion and is composed of evolutionarily
            conserved proteins
  JOURNAL   Biochem J 328 (Pt 1) (Pt 1), 105-112 (1997)
   PUBMED   9359840
REFERENCE   8  (bases 1 to 6589)
  AUTHORS   Welch,M.D., DePace,A.H., Verma,S., Iwamatsu,A. and Mitchison,T.J.
  TITLE     The human Arp2/3 complex is composed of evolutionarily conserved
            subunits and is localized to cellular regions of dynamic actin
            filament assembly
  JOURNAL   J Cell Biol 138 (2), 375-384 (1997)
   PUBMED   9230079
REFERENCE   9  (bases 1 to 6589)
  AUTHORS   Winter,D., Podtelejnikov,A.V., Mann,M. and Li,R.
  TITLE     The complex containing actin-related proteins Arp2 and Arp3 is
            required for the motility and integrity of yeast actin patches
  JOURNAL   Curr Biol 7 (7), 519-529 (1997)
   PUBMED   9210376
  REMARK    Erratum:[Curr Biol 1997 Sep 1;7(9):R593]
REFERENCE   10 (bases 1 to 6589)
  AUTHORS   Welch,M.D., Iwamatsu,A. and Mitchison,T.J.
  TITLE     Actin polymerization is induced by Arp2/3 protein complex at the
            surface of Listeria monocytogenes
  JOURNAL   Nature 385 (6613), 265-269 (1997)
   PUBMED   9000076
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB453995.1, BC044590.1,
            AC110769.2 and AI521063.1.
            
            On May 17, 2019 this sequence version replaced NM_005721.4.
            
            Summary: The specific function of this gene has not yet been
            determined; however, the protein it encodes is known to be a major
            constituent of the ARP2/3 complex. This complex is located at the
            cell surface and is essential to cell shape and motility through
            lamellipodial actin assembly and protrusion. Three transcript
            variants encoding two different isoforms have been found for this
            gene. [provided by RefSeq, Mar 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.124907.1,
                                           SRR1660807.233780.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263238.7/ ENSP00000263238.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               DB453995.1         156-296
            142-2583            BC044590.1         271-2712
            2584-5208           AC110769.2         95091-97715
            5209-5547           AI521063.1         7-345               c
            5548-6589           AC110769.2         98055-99096
FEATURES             Location/Qualifiers
     source          1..6589
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..6589
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /note="actin related protein 3"
                     /db_xref="GeneID:10096"
                     /db_xref="HGNC:HGNC:170"
                     /db_xref="MIM:604222"
     exon            1..235
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1448
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     actin-like protein 3; ARP3 actin related protein 3
                     homolog"
                     /codon_start=1
                     /product="actin-related protein 3 isoform 1"
                     /protein_id="NP_005712.1"
                     /db_xref="CCDS:CCDS33277.1"
                     /db_xref="GeneID:10096"
                     /db_xref="HGNC:HGNC:170"
                     /db_xref="MIM:604222"
                     /translation="MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVG
                     DQAQRRVMKGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLR
                     AEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGE
                     RTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPE
                     QSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKKEFSIDVGYERF
                     LGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRR
                     LQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQ
                     VCHTKKDYEEIGPSICRHNPVFGVMS"
     exon            236..291
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            292..416
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            417..527
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            528..623
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            624..731
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            732..875
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1049
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1142
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1268
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1352
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..6589
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2113..2118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /note="hexamer: AGTAAA"
     polyA_site      2139
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /note="major polyA site"
     regulatory      2226..2231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /note="hexamer: AATAAA"
     polyA_site      2250
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
     regulatory      2568..2573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /note="hexamer: ATTAAA"
     polyA_site      2587
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
     regulatory      3358..3363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /note="hexamer: AATAAA"
     polyA_site      3385
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
     regulatory      5522..5527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /note="hexamer: ATTAAA"
     regulatory      5546..5551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /note="hexamer: AATAAA"
     polyA_site      5547
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
     polyA_site      5575
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
     regulatory      6060..6065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
                     /note="hexamer: AATAAA"
     polyA_site      6084
                     /gene="ACTR3"
                     /gene_synonym="ARP3"
ORIGIN      
        1 gttgcggaag tgatagccgc cgaccgagcc tgctgctttc ttgctactgc ttcggcttcc
       61 cggctacccc ccggacggtg aaggcggccc agctgtggat ggtcagatag cccttgtctc
      121 ccgccgccaa tctctggccc ctagcagcac ggagcagacg gcggcagcag cagcagcagg
      181 cgaggaggaa gatggcggga cggctgccgg cctgtgtggt ggactgtggc acggggtata
      241 caaaactagg atatgctgga aatacagaac cacagtttat catcccttcc tgtattgcta
      301 ttaaggagtc agcaaaagtg ggtgatcaag ctcaaaggag ggtgatgaaa ggtgttgatg
      361 acctagactt cttcattggt gatgaagcaa tagaaaaacc tacatatgca acaaagtggc
      421 caatccgcca tggtatagtt gaagattggg acttaatgga aaggtttatg gagcaagtga
      481 tctttaaata tttaagggca gaacctgaag accattattt tcttttgact gaacctccat
      541 tgaatactcc agaaaacagg gaatatactg ctgaaataat gtttgagtcc ttcaatgttc
      601 caggcttgta cattgctgtg caggctgttc ttgccttagc tgcatcttgg acctcaagac
      661 aagtaggaga acggacgttg accggtacgg taatagacag tggagatggt gtcactcatg
      721 tcattcctgt ggctgaaggg tatgtgattg gcagctgtat taaacacatt ccaatcgcag
      781 gacgagatat aacatatttt attcagcaac tgctgagaga ccgagaagta ggaatccctc
      841 cagaacaatc cttggaaact gctaaggcag taaaggagcg ctatagttat gtctgcccag
      901 atttagtaaa agaatttaac aagtatgata cagatgggtc aaaatggatt aaacagtata
      961 ctggaatcaa tgctatctca aagaaagagt tttctatcga tgttggttat gagagatttt
     1021 tgggacctga aatctttttt catccagagt ttgctaatcc agactttaca caacctatct
     1081 cagaagttgt agatgaagta attcagaatt gtcctattga tgtcagacgt cctctctaca
     1141 agaatattgt cctctctgga ggttcaacca tgttcaggga ctttggacgt cgcttgcaaa
     1201 gagatttgaa aagaactgta gatgcccggc tgaaattaag tgaggaattg agtggtggta
     1261 gattgaagcc aaaacctatt gatgtacaag tcattacaca ccacatgcag cgatatgcag
     1321 tttggtttgg aggatcaatg ctggcttcca cgcctgagtt ctaccaagta tgccacacca
     1381 aaaaggatta tgaagaaatt ggacctagca tttgtcgtca caatccagtg tttggagtca
     1441 tgtcgtaaaa ttggcttcat agttattggg gttagggagg tggggaagag ataatctttc
     1501 tgattacctg ttttgtctgg atggctggtt ttgaggtttt aaacctgact tgaaatagta
     1561 acaccaaaca tgattataca ggaatatttt aataagtgta tcaccatgca gatgtagaag
     1621 agagcgaaag tgattgtgtt tttctttaga ttgaatattt gaatcttatg tgtaacaaaa
     1681 agaagtgggt tttagttctt tctgtgccct gatattttgt atattaatga attatccaag
     1741 attcgatggg atttatcagt gtgtagatag ctctataatg cttgaattgt acacttctaa
     1801 gtgtgcagtg caagagcttg tttatatttc atacttttta tactttgagg aaaaaaagtc
     1861 aaagaaaaat tgtatttgag ggaaaaaacc atgaccaagt aaaggataaa ttcaaaaaat
     1921 agcctcatga gacttggcat acacactcgt gggattccag ttattatgga gtgcttccat
     1981 ccctctccac cccttccccc caaaaggttt tctttgcaag tgcttttgga actaagagct
     2041 agtatcttgg attaactgat gcctgctagt gctttctgat tactcgcatt ctgtttcttg
     2101 ctttaaaaga agagtaaaga caagagtgtt ggaccagtat tgcagttctg tagtgtcatt
     2161 tcttataaaa aacaaaacaa caacaataat ttatcaaaat tggcatattt aaagcctaac
     2221 attctaataa aggcacaaat ttctttttaa tacttgtttc agcctcttta atctctttat
     2281 aagttaacta ataaatctat tttcttcaga cttctgcaat agttctttaa aatcacaaca
     2341 gttagcaagc tgacttttgt aatgtgctca atacaaatac ttgtgaactt ttaatatgtt
     2401 gagtgctttc attttgataa ctggatctcc atttgatatt ttcatttgta taactcattt
     2461 gcagtctgaa aatttttttt agtgccagtc cctgaacata tcattgaaag ttaattttct
     2521 ttgcatttta aaatatctgg attatgaaga aaaagtgatg aaaataaatt aaaactgaat
     2581 taccttttct aatgtttttt ttttttaagt aatgtaattc tattttgttt ttatgtatgt
     2641 gatatctgtt tctgttgaga tttgggagtt attgaaatct ctgtaatgtg tatggtagaa
     2701 aatttcttgt gaccttaaaa ttttaccagt tatttataga aagagaaaat gggaaatgtt
     2761 ttataggctt tttactagca gtatcagtga acacttgaac tccattattc atgaaaataa
     2821 cacgttagga ttggaatacg tctattcaaa agtgaaagaa tataaagtgt ttagtttttt
     2881 gtttttactc taaagataga attggggagt aaacttcagt ttttgtttag agtggatctg
     2941 aatatttaaa atcctataat aatttttgtg aatcttcatt ctttgagtat gggattgtaa
     3001 aagacaaact atatcctaca gtagtatcat catcagtatc aaaggtctcc tttttttact
     3061 tggaaaagta attcacaaac attataaaaa tactattcaa acagtaccaa agagtagatt
     3121 agcaaaagta agtttttttc cctagcctgt ctcatttttc catcattaca cagactactt
     3181 ggaatgtctt agatgtcctt gtattgtaat tttctgtgta ggtagaaata aatgtagctt
     3241 tcttatttta cacaaatagg aacttactgt atatactgtt ctgcactttg cttttattaa
     3301 agatcttttg ataaagaact atattgataa gcagtaaaga tgtcatgctc ctggcccaat
     3361 aaaatattgt tagcattgtc ataaatatgt cttttccacc ggcgatggtt gggtagttaa
     3421 gtgaataagc tagaaagaca tgtttataaa gctatttgat gacaatctca ggcatattta
     3481 tacagagatg ttcttaactg tttgctacaa aaacatgaag atcaaaaact ttcttgaagc
     3541 ttacgcttaa cttatttggg gaaacaaaac tccagccctt cttgtgtatg ttctgatatc
     3601 cctttgctct acttttagag gagtgaaccc taataggatg gtagcagcat tcttgtttct
     3661 ttatatctct cctctgtgat tgtataccgt tttttcaact taaagcaact tcagctggaa
     3721 atatgtagag gttggccaag gtgaactaaa tagtctgtaa cattgattag atatcaagca
     3781 acgtgagcat ggtagcaaaa gcactaactg aagccagtga tttaattttt aattctgatt
     3841 ctgataattg atgatatagc tcctcgaact ttgttttttg ttaaaacttg gaaaatatat
     3901 ttgtattatt ttggacaaat tatttgaact ctctggacct tgattcaatt tatatataag
     3961 gtaaaggcat tatactggat tatcctgcaa tttctttgag ttgttagaat ataatgtagc
     4021 ttattaatag caatattagc agtgtagtag attctgactg caaaacctag ccttttctat
     4081 tgattcatta gtggtagtaa aggtattatc tgatttatcc tttttaatag gcagtgcttt
     4141 gatcaagtgg gaaatagtaa tggacaaata aaatcaatga tcattatcta acttgatgcc
     4201 tgcttttcaa aaagtgagca aatttcacat cttcaccctt agacattaat tcatggcacc
     4261 tactataagt actcatcctc ttcttaccta tcttcttttc tataggagat aaagtggtta
     4321 ttcagacccc ccaatacaat tttttggttt gttttcacag ctacttaaaa gattaaaata
     4381 actattcttg cagatatttc taggaatatt tttagaaata atatgaaata cagggataat
     4441 aggccaatta tgatctttat ttttaatttc tacagaaaag tactagagaa tatatctata
     4501 gaaacttctt tcagataacc ctaaagatga tactagaatg tttataaaat tattgagaag
     4561 attatttgtg ttataaagct tatttgtacc atagtaaagg atgtttttgt tcctcttcat
     4621 tctgggctaa tctgtcaata ctgaagtcca gtcttttccc ccttttctta ccagctcaac
     4681 cttgattcct gtgacccatt ctttctgatc tttcgtagtt catagtcacc aggcatgagt
     4741 accttggata gccctctgaa gtctgttacc acccagattt ccaactcggg ttaattggta
     4801 ctaattctat tagctggtat aaataatcca aaatctgtgc agactctggg agcaaaatgt
     4861 tctactcagt ttggaatact gtgccttaaa atatatttca ttgtaacagc accttgtata
     4921 tatagttggc caaggacaga gttgttacaa gttacgtgga actttcatag caaatcttga
     4981 cagtaaatac cttgttcttg tattaggtct atatcctgaa ttgaccttta gcaagaatct
     5041 ttagatctgc tggagggctg ggatggcttt tggacttcag tgaaaaagaa tttctgctac
     5101 tcattgttga taacgcttca gtactgtata aatgtttatc cttttccacg taatttgttt
     5161 tctatgatat gagaactttt attataattt gcctcagtct tgatagaatc ttaacaaaaa
     5221 taaaatctgt ggtcgtctga ggtattctcc atgctataac ccagtttagc tgatgcattt
     5281 ggagcttggg tgctgaaatt aaatataacc tatttgagtt aaggatttat tactagtgct
     5341 ccagtggtca caggaacaat aaaaaaggaa caacgataga aatacgtgat ctaggaaaga
     5401 aggcaactga aaaacctgaa agaaaaaaaa tgaaagatta aaagtatacg atattctatt
     5461 ttgatttagc aattacttgt tttctagtgt tctgtcaatt tttggtgact tttataatta
     5521 cattaaaact aagatgctga attaaaataa agtttctctt ttattcaagc accaacattc
     5581 acttatatta cctatatatt gcatcaagtt ttgagccttc aatcccagaa gcattgattg
     5641 actgtctact gtggttcaag tactgtgcat aaagatgaat aaatattctg tccttggctt
     5701 agtctaatag taaaggcact cttagaggag ggacaaatat tttgcctaga taagatttga
     5761 gagatagtaa gtgcggaatt tctcttcata aaaatggtag tgttagttgt ttagagggag
     5821 aagtccagct atgtaaggtg aaagtggggc ttataaaagt ggatctattg tttaaaaatt
     5881 agtactttgc tcctaaaatt tttacctaag tgttacatcc aacaacagat gaaagtaatt
     5941 cgacagtagc atctgcttta ttcatttcat atttccagtg cctgacatat tgcttggcat
     6001 atagtagttt agtggatgtg tttgatgaat gaatgagtaa aaattatttt tcatgttaaa
     6061 ataaaacttt gaattacatg agtatacaac ttttgttcct tcaaaatacc catatttgtc
     6121 aaatatgacc gaattacgac tttttttctg ttccactagt ttctacctta gaagtgacat
     6181 tctgcgtaag gtagtggggg attactaagt gatcatgact tttctgaagc aggtcttaaa
     6241 taattatcta agccttcagt catttcaaaa tctctgtagt gtaaatgatc acaggctcta
     6301 aatcagattg ttgtacaagg taattgacat gtcctgaaat gtaacattca acattaacag
     6361 tagaaacagg cctcatttct ccctctggct tttattgatc aattttgata ttgtccagat
     6421 cccatgttaa accacttgat ttagagatga cttaattcta aacttcctcc atttttaatt
     6481 aataagattc aaggttgcag taaattgtta atcttatttg gaattatatt agaaagtcga
     6541 tatcggaatt ggaaccacac atctttttct tattgtgggt acatgggat
//
