LOCUS       NM_005735               2204 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens actin related protein 1B (ACTR1B), mRNA.
ACCESSION   NM_005735
VERSION     NM_005735.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2204)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2204)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2204)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
REFERENCE   4  (bases 1 to 2204)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   5  (bases 1 to 2204)
  AUTHORS   Appierto,V., Tiberio,P., Cavadini,E., Casalini,P., Cappelletti,G.
            and Formelli,F.
  TITLE     Antimitotic effect of the retinoid 4-oxo-fenretinide through
            inhibition of tubulin polymerization: a novel mechanism of retinoid
            growth-inhibitory activity
  JOURNAL   Mol Cancer Ther 8 (12), 3360-3368 (2009)
   PUBMED   19996280
  REMARK    GeneRIF: Data show that 4-oxo-4-HPR inhibited tubulin
            polymerization and modulated gene expression of spindle aberration
            associated genes Kif 1C, Kif 2A, Eg5, Tara, tankyrase-1,
            centractin, and TOGp.
REFERENCE   6  (bases 1 to 2204)
  AUTHORS   Weng,Y.Q., Qiu,S.J., Liu,Y.K., Fan,J., Gao,Q. and Tang,Z.Y.
  TITLE     Down-regulation of beta-centractin might be involved in dendritic
            cells dysfunction and subsequent hepatocellular carcinoma immune
            escape: a proteomic study
  JOURNAL   J Cancer Res Clin Oncol 134 (2), 179-186 (2008)
   PUBMED   17619203
  REMARK    GeneRIF: Down-regulation of beta-centractin is associated with
            hepatocellular carcinoma immune escape
REFERENCE   7  (bases 1 to 2204)
  AUTHORS   Eckley,D.M. and Schroer,T.A.
  TITLE     Interactions between the evolutionarily conserved, actin-related
            protein, Arp11, actin, and Arp1
  JOURNAL   Mol Biol Cell 14 (7), 2645-2654 (2003)
   PUBMED   12857853
REFERENCE   8  (bases 1 to 2204)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 2204)
  AUTHORS   Elsea,S.H., Clark,I.B., Juyal,R.C., Meyer,D.J., Meyer,D.I. and
            Patel,P.I.
  TITLE     Assignment of beta-centractin (CTRN2) to human chromosome 2 bands
            q11.1-->q11.2 with somatic cell hybrids and in situ hybridization
  JOURNAL   Cytogenet Cell Genet 84 (1-2), 48-49 (1999)
   PUBMED   10343100
REFERENCE   10 (bases 1 to 2204)
  AUTHORS   Clark,S.W., Staub,O., Clark,I.B., Holzbaur,E.L., Paschal,B.M.,
            Vallee,R.B. and Meyer,D.I.
  TITLE     Beta-centractin: characterization and distribution of a new member
            of the centractin family of actin-related proteins
  JOURNAL   Mol Biol Cell 5 (12), 1301-1310 (1994)
   PUBMED   7696711
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC017099.11, BC010090.2 and
            X82207.1.
            
            On May 17, 2019 this sequence version replaced NM_005735.3.
            
            Summary: This gene encodes a 42.3 kD subunit of dynactin, a
            macromolecular complex consisting of 10 subunits ranging in size
            from 22 to 150 kD. Dynactin binds to both microtubules and
            cytoplasmic dynein and is involved in a diverse array of cellular
            functions, including ER-to-Golgi transport, the centripetal
            movement of lysosomes and endosomes, spindle formation, chromosome
            movement, nuclear positioning, and axonogenesis. This subunit, like
            ACTR1A, is an actin-related protein. These two proteins, which are
            of equal length and share 90% amino acid identity, are present in a
            constant ratio of approximately 1:15 in the dynactin complex.
            [provided by RefSeq, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1299651.1,
                                           SRR3476690.465976.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289228.7/ ENSP00000289228.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC017099.11        174381-174426       c
            47-957              BC010090.2         1-911
            958-1577            X82207.1           860-1479
            1578-2204           AC017099.11        166321-166947       c
FEATURES             Location/Qualifiers
     source          1..2204
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..2204
                     /gene="ACTR1B"
                     /gene_synonym="ARP1B; CTRN2; PC3"
                     /note="actin related protein 1B"
                     /db_xref="GeneID:10120"
                     /db_xref="HGNC:HGNC:168"
                     /db_xref="MIM:605144"
     exon            1..202
                     /gene="ACTR1B"
                     /gene_synonym="ARP1B; CTRN2; PC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1285
                     /gene="ACTR1B"
                     /gene_synonym="ARP1B; CTRN2; PC3"
                     /note="centractin beta; ARP1 actin-related protein 1
                     homolog B, centractin beta; ARP1 actin related protein 1
                     homolog B"
                     /codon_start=1
                     /product="beta-centractin"
                     /protein_id="NP_005726.1"
                     /db_xref="CCDS:CCDS2033.1"
                     /db_xref="GeneID:10120"
                     /db_xref="HGNC:HGNC:168"
                     /db_xref="MIM:605144"
                     /translation="MESYDIIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKH
                     MRVMAGALEGDLFIGPKAEEHRGLLTIRYPMEHGVVRDWNDMERIWQYVYSKDQLQTF
                     SEEHPVLLTEAPLNPSKNREKAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDS
                     GDGVTHAVPIYEGFAMPHSIMRVDIAGRDVSRYLRLLLRKEGVDFHTSAEFEVVRTIK
                     ERACYLSINPQKDEALETEKVQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLH
                     EVVAFAIHKSDMDLRRTLFANIVLSGGSTLFKGFGDRLLSEVKKLAPKDIKIKISAPQ
                     ERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGSRAIHRKTF"
     exon            203..267
                     /gene="ACTR1B"
                     /gene_synonym="ARP1B; CTRN2; PC3"
                     /inference="alignment:Splign:2.1.0"
     exon            268..343
                     /gene="ACTR1B"
                     /gene_synonym="ARP1B; CTRN2; PC3"
                     /inference="alignment:Splign:2.1.0"
     exon            344..469
                     /gene="ACTR1B"
                     /gene_synonym="ARP1B; CTRN2; PC3"
                     /inference="alignment:Splign:2.1.0"
     exon            470..594
                     /gene="ACTR1B"
                     /gene_synonym="ARP1B; CTRN2; PC3"
                     /inference="alignment:Splign:2.1.0"
     exon            595..811
                     /gene="ACTR1B"
                     /gene_synonym="ARP1B; CTRN2; PC3"
                     /inference="alignment:Splign:2.1.0"
     exon            812..904
                     /gene="ACTR1B"
                     /gene_synonym="ARP1B; CTRN2; PC3"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1079
                     /gene="ACTR1B"
                     /gene_synonym="ARP1B; CTRN2; PC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1141
                     /gene="ACTR1B"
                     /gene_synonym="ARP1B; CTRN2; PC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1182
                     /gene="ACTR1B"
                     /gene_synonym="ARP1B; CTRN2; PC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..2204
                     /gene="ACTR1B"
                     /gene_synonym="ARP1B; CTRN2; PC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2159..2164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR1B"
                     /gene_synonym="ARP1B; CTRN2; PC3"
                     /note="hexamer: AATAAT"
     polyA_site      2175
                     /gene="ACTR1B"
                     /gene_synonym="ARP1B; CTRN2; PC3"
                     /note="major polyA site"
ORIGIN      
        1 agaaagcccc gcggggctcg cgtaggctgc aggctcgggg agggagggca gcggcgccgc
       61 gtcgggagcc gccgccgtcc cggtcctccc gcccgcccgc ccatccggtg cctcctgcag
      121 cccgcctgct gggcagggcc ggcgcggccc ggccatggag tcctacgaca tcatcgccaa
      181 ccagcctgtg gtcatcgaca acggttcggg ggtgattaaa gctggctttg caggagacca
      241 gattcccaaa tactgtttcc caaactatgt cgggcggccg aagcacatgc gggtgatggc
      301 tggagccctg gagggggacc tcttcatcgg accaaaagca gaggagcacc gggggctgct
      361 gaccatccgc taccccatgg agcacggcgt ggtgcgagac tggaacgaca tggaacgcat
      421 ctggcagtac gtctactcca aggatcagct gcagaccttc tcggaggagc atcctgtgct
      481 cctcacggag gccccgctca acccgagtaa gaaccgggag aaggcggcag aggtgttctt
      541 tgagaccttc aacgtgccgg ccctgttcat ctccatgcag gctgtgctca gtctgtacgc
      601 aacaggacgc acgacaggag tggttctaga ctcaggggac ggggtcactc atgctgtgcc
      661 catctatgag ggctttgcca tgcctcactc catcatgcgg gtggacattg ccggccgcga
      721 cgtctcccgc tacctccgac tcctgctgcg caaggaaggg gttgacttcc atacctcggc
      781 tgagtttgag gttgtccgga caatcaaaga gcgagcgtgc tacctgtcca tcaacccaca
      841 gaaggatgag gctctggaga cggagaaggt gcagtacacg ttgccagacg gcagcacgct
      901 tgatgtgggg cctgcacgat tccgggcccc cgagctgctg ttccagccgg accttgtcgg
      961 ggatgagagt gaggggctcc atgaggtggt ggccttcgcc atacacaagt ccgacatgga
     1021 cctgcgccgg acgctgttcg ccaacatcgt gctctcaggt ggctcaacgc ttttcaaagg
     1081 cttcggagac cgattactca gtgaagtgaa gaagcttgcc ccaaaggata tcaaaatcaa
     1141 gatctcagcc ccgcaggaac ggctgtactc cacatggatt ggcggctcca tcctggcctc
     1201 gctggacact tttaagaaga tgtgggtgtc caaaaaggag tatgaagagg atggctcccg
     1261 tgctattcat cgcaaaactt tctagtgccc aaggagggcg gggcatgttg ggagaggggg
     1321 agggagggga gacagagcct ttaacccttt ttggtcttgg ctcgtatact aggcttaggg
     1381 tcccctgcat gccctgaacc cctgggtggg tggcacagca gtgcccccct gcagccttcc
     1441 cctctacaca ggacatgcac acacaagtaa cattgagctg catggacagg agccttgagc
     1501 tggcgtgtgg gaattgagcg ccatgtcagg ctgttgtggg tatccccctg gcagggccag
     1561 ctaggcctgt ggttccctgc tccgactctc agggctgcct ccctgagctc cagggccaga
     1621 atgcctggat gcctgggtag ccagtttggg gagtgggctg caaggggcag ccagcagctc
     1681 ccactggtgt gtcactgcat ccattgccac ctcctgttcg tgacctgaca gggtgacaca
     1741 gcccctttca cactctgtcc tcctatcttc ctgggtagat gccctggtgt agggctgagt
     1801 actgaatggt cttccatccc cagcaagggg gtgcagccca gggtcaggcc cttcagagcc
     1861 agggcagagg atgcacggtg gctagagccg ctgcactatc cttttcagag cacttcatcc
     1921 acttgctcct ccctctaccc tcggcaccct gggtgggaaa gggttgatgc tcatcattta
     1981 ttgaggggaa gccacttaat aaggagtcag acctaaaagg gggtggggga cattttctta
     2041 cctcacccaa gaaagaggtc gtcacttttg ctgtggccag ggccccacct ccctctctca
     2101 gatatgtaca ataatttaac acggttgcct gaaaaaaact tttgtaaatc attatagtaa
     2161 taattatgga caaggcccag tgtgtggctc tgttttcttg tggc
//
