LOCUS       NM_005736               2830 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens actin related protein 1A (ACTR1A), mRNA.
ACCESSION   NM_005736
VERSION     NM_005736.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2830)
  AUTHORS   Kamal,A.H.M., Aloor,J.J., Fessler,M.B. and Chowdhury,S.M.
  TITLE     Cross-linking Proteomics Indicates Effects of Simvastatin on the
            TLR2 Interactome and Reveals ACTR1A as a Novel Regulator of the
            TLR2 Signal Cascade
  JOURNAL   Mol Cell Proteomics 18 (9), 1732-1744 (2019)
   PUBMED   31221720
  REMARK    GeneRIF: An important role for ACTR1A in induction of
            pro-inflammatory cytokines.TLR2 interacts with alpha-centractin.
REFERENCE   2  (bases 1 to 2830)
  AUTHORS   Huhn,S.C., Liu,J., Ye,C., Lu,H., Jiang,X., Feng,X., Ganesan,S.,
            White,E. and Shen,Z.
  TITLE     Regulation of spindle integrity and mitotic fidelity by BCCIP
  JOURNAL   Oncogene 36 (33), 4750-4766 (2017)
   PUBMED   28394342
REFERENCE   3  (bases 1 to 2830)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2830)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
REFERENCE   5  (bases 1 to 2830)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   6  (bases 1 to 2830)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
REFERENCE   7  (bases 1 to 2830)
  AUTHORS   Clark,S.W., Staub,O., Clark,I.B., Holzbaur,E.L., Paschal,B.M.,
            Vallee,R.B. and Meyer,D.I.
  TITLE     Beta-centractin: characterization and distribution of a new member
            of the centractin family of actin-related proteins
  JOURNAL   Mol Biol Cell 5 (12), 1301-1310 (1994)
   PUBMED   7696711
REFERENCE   8  (bases 1 to 2830)
  AUTHORS   Schafer,D.A., Gill,S.R., Cooper,J.A., Heuser,J.E. and Schroer,T.A.
  TITLE     Ultrastructural analysis of the dynactin complex: an actin-related
            protein is a component of a filament that resembles F-actin
  JOURNAL   J Cell Biol 126 (2), 403-412 (1994)
   PUBMED   7518465
REFERENCE   9  (bases 1 to 2830)
  AUTHORS   Lees-Miller,J.P., Helfman,D.M. and Schroer,T.A.
  TITLE     A vertebrate actin-related protein is a component of a multisubunit
            complex involved in microtubule-based vesicle motility
  JOURNAL   Nature 359 (6392), 244-246 (1992)
   PUBMED   1528266
REFERENCE   10 (bases 1 to 2830)
  AUTHORS   Clark,S.W. and Meyer,D.I.
  TITLE     Centractin is an actin homologue associated with the centrosome
  JOURNAL   Nature 359 (6392), 246-250 (1992)
   PUBMED   1356230
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC384284.1, BC026016.2,
            AL121928.13 and BC000693.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005736.3.
            
            Summary: This gene encodes a 42.6 kD subunit of dynactin, a
            macromolecular complex consisting of 10-11 subunits ranging in size
            from 22 to 150 kD. Dynactin binds to both microtubules and
            cytoplasmic dynein. It is involved in a diverse array of cellular
            functions, including ER-to-Golgi transport, the centripetal
            movement of lysosomes and endosomes, spindle formation, chromosome
            movement, nuclear positioning, and axonogenesis. This subunit is
            present in 8-13 copies per dynactin molecule, and is the most
            abundant molecule in the dynactin complex. It is an actin-related
            protein, and is approximately 60% identical at the amino acid level
            to conventional actin. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026016.2, GQ901001.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369905.9/ ENSP00000358921.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                DC384284.1         117-171
            56-1834             BC026016.2         1-1779
            1835-1835           AL121928.13        125590-125590       c
            1836-2830           BC000693.2         1815-2809
FEATURES             Location/Qualifiers
     source          1..2830
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..2830
                     /gene="ACTR1A"
                     /gene_synonym="ARP1; Arp1A; CTRN1"
                     /note="actin related protein 1A"
                     /db_xref="GeneID:10121"
                     /db_xref="HGNC:HGNC:167"
                     /db_xref="MIM:605143"
     exon            1..113
                     /gene="ACTR1A"
                     /gene_synonym="ARP1; Arp1A; CTRN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1196
                     /gene="ACTR1A"
                     /gene_synonym="ARP1; Arp1A; CTRN1"
                     /note="centrosome-associated actin homolog; actin-RPV;
                     centractin; ARP1 actin-related protein 1 homolog A,
                     centractin alpha; epididymis secretory sperm binding
                     protein; ARP1 actin related protein 1 homolog A"
                     /codon_start=1
                     /product="alpha-centractin"
                     /protein_id="NP_005727.1"
                     /db_xref="CCDS:CCDS7536.1"
                     /db_xref="GeneID:10121"
                     /db_xref="HGNC:HGNC:167"
                     /db_xref="MIM:605143"
                     /translation="MESYDVIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKH
                     VRVMAGALEGDIFIGPKAEEHRGLLSIRYPMEHGIVKDWNDMERIWQYVYSKDQLQTF
                     SEEHPVLLTEAPLNPRKNRERAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDS
                     GDGVTHAVPIYEGFAMPHSIMRIDIAGRDVSRFLRLYLRKEGYDFHSSSEFEIVKAIK
                     ERACYLSINPQKDETLETEKAQYYLPDGSTIEIGPSRFRAPELLFRPDLIGEESEGIH
                     EVLVFAIQKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIRISAPQ
                     ERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGARSIHRKTF"
     exon            114..178
                     /gene="ACTR1A"
                     /gene_synonym="ARP1; Arp1A; CTRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            179..254
                     /gene="ACTR1A"
                     /gene_synonym="ARP1; Arp1A; CTRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            255..380
                     /gene="ACTR1A"
                     /gene_synonym="ARP1; Arp1A; CTRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..505
                     /gene="ACTR1A"
                     /gene_synonym="ARP1; Arp1A; CTRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..722
                     /gene="ACTR1A"
                     /gene_synonym="ARP1; Arp1A; CTRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            723..815
                     /gene="ACTR1A"
                     /gene_synonym="ARP1; Arp1A; CTRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..990
                     /gene="ACTR1A"
                     /gene_synonym="ARP1; Arp1A; CTRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1052
                     /gene="ACTR1A"
                     /gene_synonym="ARP1; Arp1A; CTRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1093
                     /gene="ACTR1A"
                     /gene_synonym="ARP1; Arp1A; CTRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..2830
                     /gene="ACTR1A"
                     /gene_synonym="ARP1; Arp1A; CTRN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2804..2809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTR1A"
                     /gene_synonym="ARP1; Arp1A; CTRN1"
                     /note="hexamer: AATAAA"
     polyA_site      2830
                     /gene="ACTR1A"
                     /gene_synonym="ARP1; Arp1A; CTRN1"
                     /note="major polyA site"
ORIGIN      
        1 gtcagtggcg ctagcggcgg acccggctgg gcagttcctt ccccagaagg agagattcct
       61 ctgccatgga gtcctacgat gtgatcgcca accagcctgt cgtgatcgac aacggatccg
      121 gtgtgattaa agctggtttt gctggtgatc agatccccaa atactgcttt ccaaactatg
      181 tgggccgacc caagcacgtt cgtgtcatgg caggagccct tgaaggcgac atcttcattg
      241 gccccaaagc tgaggagcac cgagggctgc tttcaatccg ctatcccatg gagcatggca
      301 tcgtcaagga ttggaacgac atggaacgca tttggcaata tgtctattct aaggaccagc
      361 tgcagacttt ctcagaggag catcctgtgc tcctgactga ggcgccttta aacccacgaa
      421 aaaaccggga acgagctgcc gaagttttct tcgagacctt caatgtgccc gctcttttca
      481 tctccatgca agctgtactc agcctttacg ctacaggcag gaccacaggg gtggtgctgg
      541 attctgggga tggagtcacc catgctgtgc ccatctatga gggctttgcc atgccccact
      601 ccatcatgcg catcgacatc gcgggccggg acgtctctcg cttcctgcgc ctctacctgc
      661 gtaaggaggg ctacgacttc cactcatcct ctgagtttga gattgtcaag gccataaaag
      721 aaagagcctg ttacctatcc ataaaccccc aaaaggatga gacgctagag acagagaaag
      781 ctcagtacta cctgcctgat ggcagcacca ttgagattgg tccttcccga ttccgggccc
      841 ctgagttgct cttcaggcca gatttgattg gagaggagag tgaaggcatc cacgaggtcc
      901 tggtgttcgc cattcagaag tcagacatgg acctgcggcg cacgcttttc tctaacattg
      961 tcctctcagg aggctctacc ctgttcaaag gttttggtga caggctcctg agtgaagtga
     1021 agaaactagc tccaaaagat gtgaagatca ggatatctgc acctcaggag agactgtatt
     1081 ccacgtggat tgggggctcc atccttgcct ccctggacac ctttaagaag atgtgggtct
     1141 ccaaaaagga atatgaggaa gacggtgccc gatccatcca cagaaaaacc ttctaatgtc
     1201 gggacatcat cttcacctct ctctgaagtt aactccactt taaaactcgc tttcttgagt
     1261 cggagtgttt gcgaggaact gcctgtgtgt gagtgcgtgt gtggatatga gtgtgtgtgc
     1321 acatgcgagt gccgtgtggc cctgggaccc tgggcccaga aaggacgatg aactacctgc
     1381 agtggtgatg gcctgaggcc tggggttgac cactaactgg ctcctgacag ggaagagcgc
     1441 tggcagaggc tgtgctccct cctcaggtgg cctctggctg gctgtggggg actccgttta
     1501 ctaccacagg gagacagagg gaggtaagcc atcccccggg agaccttgct gctgaccatc
     1561 ctaggctggg ctggccccac cctcaccccc acccccaggg tgccctgagg ccccaggcag
     1621 ctgctgcctc cactatcgat gcctcctgac tgcacactga ggactgggac tggggttgag
     1681 ttctgtctgg ttttgttgcc attttggttt gggaggctgg aaaagcaccc caagagctat
     1741 tacagagact ggagtcagga gagagcagga ggccctcatg ttcaccaggg aacaggacca
     1801 caccggccac tggaggaggg caggagcagt cctcactctg aatggctgca gagttaatgt
     1861 tcccagccca gtcccctttc gggggccttg ggagagttta aggcacctgc tggttccagg
     1921 acctcgcttt ccatctgttc ttgttgcaat gccatcttca aaccgtttta tttattgaag
     1981 tgtttgttca gttaggggct ggagagaggg agcttgctgc ctcctgcctt gctacactaa
     2041 tgtttacagc acctaagctt agcctccagg gccccacctc tcccagctga tggtgagctg
     2101 acagtgtcca caggttccag gaccatttga gattggaagc tacactcaaa gacactccca
     2161 ccaggctctt tctccctttt cctcttgctc actgccctgg aatcaacagg ctggttgctg
     2221 gttagatttt ctgaaacagg aggtaaaatt tttctttggc agaggcccct aagcaaggga
     2281 ggggtgttgg agagccagtg cccttaagac tggagaaagc tgcaatttac caagttgcct
     2341 tttgccactg tagctgacca ggggactagg ttgtagaggt gggaaggccc cctctgggct
     2401 gatcttgtgc cattcttgac cttggacctg cttggttaag gagggagtgg gccagaccag
     2461 agtgccagga gctaatggag ccaggcctga ctcctaggag tggtccaaag gccttcagcc
     2521 tagatggtgc aaagctgggg ccagcctgtc ttcaccggca ccctcacctg tgacaccaag
     2581 acccacccca atcccagact tcacacagta ttctccccca cgccgtccta tgaccaaagg
     2641 cccctgccag gtgtgggcca cagcagcagg tatgtgtgaa agcaacgtag cgccccgcgg
     2701 actgcagtgc gcttaaccaa ctcacctccc ttctcttagc ccaagcctgt ccctcgcaca
     2761 gcctcgcaca aaccacattg cctggtgggg cccagtgtac tgaaataaag tcgttccgat
     2821 agacacgtca
//
