LOCUS       NM_198476               3302 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens actin maturation protease (ACTMAP), transcript variant
            1, mRNA.
ACCESSION   NM_198476 XM_209143
VERSION     NM_198476.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3302)
  AUTHORS   Haahr,P., Galli,R.A., van den Hengel,L.G., Bleijerveld,O.B.,
            Kazokaite-Adomaitiene,J., Song,J.Y., Kroese,L.J., Krimpenfort,P.,
            Baltissen,M.P., Vermeulen,M., Ottenheijm,C.A.C. and
            Brummelkamp,T.R.
  TITLE     Actin maturation requires the ACTMAP/C19orf54 protease
  JOURNAL   Science 377 (6614), 1533-1537 (2022)
   PUBMED   36173861
REFERENCE   2  (bases 1 to 3302)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020945.6, BC020262.1, DA073426.1 and AI250667.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198476.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020262.1, SRR1803615.138769.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378313.7/ ENSP00000367564.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-554               AC020945.6         25617-26170
            555-882             BC020262.1         1-328
            883-1211            DA073426.1         232-560
            1212-2718           BC020262.1         658-2164
            2719-3098           AC020945.6         34650-35029
            3099-3302           AI250667.1         22-225              c
FEATURES             Location/Qualifiers
     source          1..3302
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..3302
                     /gene="ACTMAP"
                     /gene_synonym="C19orf54"
                     /note="actin maturation protease"
                     /db_xref="GeneID:284325"
                     /db_xref="HGNC:HGNC:24758"
                     /db_xref="MIM:620093"
     exon            1..997
                     /gene="ACTMAP"
                     /gene_synonym="C19orf54"
                     /inference="alignment:Splign:2.1.0"
     CDS             675..1730
                     /gene="ACTMAP"
                     /gene_synonym="C19orf54"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0692 protein C19orf54; actin aminopeptidase ACTMAP"
                     /codon_start=1
                     /product="actin maturation protease isoform 1"
                     /protein_id="NP_940878.3"
                     /db_xref="CCDS:CCDS12564.2"
                     /db_xref="GeneID:284325"
                     /db_xref="HGNC:HGNC:24758"
                     /db_xref="MIM:620093"
                     /translation="MTSPCSPPLKPPISPPKTPVPQASSIPSPPLPPSPLDFSALPSP
                     PWSQQTPVPPPLPLPPPPAATGPAPRHVFGLEKSQLLKEAFDKAGPVPKGREDVKRLL
                     KLHKDRFRGDLRWILFCADLPSLIQEGPQCGLVALWMAGTLLSPPSGVPLERLIRVAT
                     ERGYTAQGEMFSVADMGRLAQEVLGCQAKLLSGGLGGPNRDLVLQHLVTGHPLLIPYD
                     EDFNHEPCQRKGHKAHWAVSAGVLLGVRAVPSLGYTEDPELPGLFHPVLGTPCQPPSL
                     PEEGSPGAVYLLSKQGKSWHYQLWDYDQVRESNLQLTDFSPSRATDGRVYVVPVGGVR
                     AGLCGQALLLTPQDCSH"
     exon            998..1066
                     /gene="ACTMAP"
                     /gene_synonym="C19orf54"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1191
                     /gene="ACTMAP"
                     /gene_synonym="C19orf54"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1321
                     /gene="ACTMAP"
                     /gene_synonym="C19orf54"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1392
                     /gene="ACTMAP"
                     /gene_synonym="C19orf54"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..3302
                     /gene="ACTMAP"
                     /gene_synonym="C19orf54"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3284..3289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTMAP"
                     /gene_synonym="C19orf54"
                     /note="hexamer: AATAAA"
     polyA_site      3302
                     /gene="ACTMAP"
                     /gene_synonym="C19orf54"
                     /note="major polyA site"
ORIGIN      
        1 agtgggaggt gcactttact tcctgactcc tttccttttt ccagtggtta tcgcggcgcc
       61 caccggcctc tgatctctga gtcttctcca acccacagac gttttttgtt gctctggttc
      121 caggaccttc tccacaacta ggccattttc cctgccaggt gtcctttttg acctcttgac
      181 ctctgactca aaggtcagct caaaggttcc gaactcgggc ctgggatgtg agggggtact
      241 gaacctaagt tctccgaatc tttagccctg ggtccctaag tcgcatcctt aaggcacctc
      301 actctagatc tgagccttca tatcccaaac tcactcatga gtttccacat ccagccccaa
      361 agaatgagtt aactcctact aactctccac ctaagactcc cgaggtaacc caaccggtac
      421 cacagatccg gttccggatt taaggacccc accctgttaa ccgtcaggtg ccttatgact
      481 tgagtcagcc tcgcaattcc tgctcccgtg gtttcaaata ttagccctgg tcctttcaca
      541 cccactgctc agtccccaga ttctggaact cagctcttaa acctttaaaa tctccatccc
      601 tgagaccgtt ctccgttgga ggatccttcc ctccccgctt tctgaacctc tcaacacctc
      661 ctgtagaccc caaaatgact tctccatgct ctcctcccct aaaaccacca atttctcctc
      721 caaaaacccc tgtaccccaa gccagcagca ttccatctcc tcctctaccc ccaagtcccc
      781 tggacttttc agctttacca tcccctccct ggagtcagca gacccctgtt cccccaccgc
      841 tcccactgcc tcctccaccc gctgccacag ggcctgctcc ccgtcatgtc ttcggcctgg
      901 agaagagcca gctcctgaag gaggcctttg ataaggccgg cccggtcccc aagggcagag
      961 aagatgtgaa gaggcttctg aaactacaca aggaccggtt ccgaggtgac ctgcggtgga
     1021 tcctcttctg tgcagacctg ccgtccctca tccaagaagg ccctcaatgc gggctggtgg
     1081 ccttgtggat ggcaggtact ctcctgtcgc cccccagtgg cgtccccctg gagagactca
     1141 tacgggtggc cacggaaaga ggctacacgg cccagggaga gatgttctca gtggccgata
     1201 tgggcaggct ggcccaggag gtgctgggct gccaggccaa gctgctctct ggtggcctgg
     1261 gcggtcccaa cagagacctc gtcctgcagc acctggtcac tggacatccc ctgctcatcc
     1321 cctacgacga ggacttcaac catgagccgt gtcagaggaa gggccacaag gcacactggg
     1381 cggtgagtgc aggggtcctg ctgggtgttc gggctgtgcc cagtctcggc tacactgagg
     1441 accctgagct gccgggcctg ttccacccag tgctgggcac gccctgccaa ccaccatccc
     1501 tgccagagga gggctccccg ggagctgtct acctgctgtc caagcagggc aagagttggc
     1561 actatcagct gtgggactac gaccaggtcc gggagagcaa cctgcagctg acggacttct
     1621 cgccctcacg ggccactgac ggccgggtgt acgtggtgcc cgtgggtggg gtacgggctg
     1681 gcctctgtgg ccaggccctg ctcctcacac cacaggactg cagccattag ctgcggctgc
     1741 ggtctcaggc tgcagcctag ctcggtaacc atttgaagtg tgcctacact tctcccactg
     1801 tgtgatggcg acaagattga agctaggtct caggggtctc cagtcctcct tcatcagggc
     1861 caccccctgc agtattgagc accagctggt ccctctaggg agagattgac aacagcccgg
     1921 accctgcggc ctgcctattc catctgaatg tcgcatcgtc tgtttctcac taggggccgc
     1981 ctctgtcatc tcactagaca tttgaggaac ctcctgcctg ggccctctgc ttctcacagg
     2041 acagggacac tgaactgcgt cagcctcagc tcacccctcc ttagcccaag gtcttcctca
     2101 tgcttgccac ctactagtca tactggcctt ttagatccct gaagtgttgt tcaaatcccc
     2161 ggatcattga gtcccacccc cagccctctg ctgcggatca ctccttaact tttccattgg
     2221 ggctcaggta tcactacctc agggaagagt cctgcagccc cagtcaagac acccctcccc
     2281 cacctcatgt cttcacagtt ttaaagccca tctgggagca gttacctgtg ccagcccctc
     2341 tacctgtgtt agcagatctg gcaaccctgt aaggggggtg ctagatggac ccgatttgac
     2401 agatggcaag actgaggcct ggagaagtgg aatcactggc ctgaggtcac atgactagca
     2461 catggcaagg tcaggattca agctaggtag tcagtatctc agccaggctg tctcctggct
     2521 ccctgaacat tatggtgctg accacaaact ttcctgtcca cttatacaaa cttctagtga
     2581 gtgtgtgtga ttactagctt catgaatacc tgacccctcc actctgaagg aggaacaggc
     2641 ctgtctggat cacttctctg tccctaactg agcccatctc atttagggaa actacagagc
     2701 actgttgctt tttttttttt tagatggagt ctcgttctgt cgtccaggct ggagtgcggt
     2761 ggcgtgatct cagctcactc cagcctccac ttcccaggtt caagtgattc tcctgcctca
     2821 gccccccaag taactgggat tacaggcatg caccaccatg cctggctaat tttttgtatt
     2881 tttagtagag acggggcttt gccatgttgg ccaggctggt ctcgaactcc tgaccttgag
     2941 taatccaccc gcctcggcct cccaaagtgc tgggattaca ggtgtgagcc actgagcccg
     3001 gccacagtgc agtatttcta accagtgatc agggtaaaga ggatgcgtgt ccaccatccc
     3061 agccctgatc agcctgtctg tgcatccccc atcccagcca gggcttggag cagccttgct
     3121 caccactgtg tcccctgcat tgtaacacat ccaggcacaa gaatagccgc ccagtgactg
     3181 ccaagtgagt gaaccagcct gcttggagcc tgcctctttc ccaaactgct cattatcctg
     3241 ttaccccacc cagcccacgt gtccaaatac actccagatg caaaataaaa agctctacga
     3301 ca
//
