LOCUS       NM_030812               1841 bp    mRNA    linear   PRI 19-MAR-2025
DEFINITION  Homo sapiens actin like 8 (ACTL8), mRNA.
ACCESSION   NM_030812 XM_001134367 XM_005246004
VERSION     NM_030812.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1841)
  AUTHORS   Yu,W., Zhang,Q., Ali,M., Chen,B., Sun,Q. and Wang,D.
  TITLE     ACTL8 Promotes the Progression of Gastric Cancer Through
            PI3K/AKT/mTOR Signaling Pathway
  JOURNAL   Dig Dis Sci 69 (10), 3786-3798 (2024)
   PUBMED   39322809
  REMARK    GeneRIF: ACTL8 Promotes the Progression of Gastric Cancer Through
            PI3K/AKT/mTOR Signaling Pathway.
REFERENCE   2  (bases 1 to 1841)
  AUTHORS   Wang,L., Xing,X., Tian,H. and Fan,Q.
  TITLE     Actin-like protein 8, a member of cancer/testis antigens, supports
            the aggressive development of oral squamous cell carcinoma cells
            via activating cell cycle signaling
  JOURNAL   Tissue Cell 75, 101708 (2022)
   PUBMED   35051678
  REMARK    GeneRIF: Actin-like protein 8, a member of cancer/testis antigens,
            supports the aggressive development of oral squamous cell carcinoma
            cells via activating cell cycle signaling.
REFERENCE   3  (bases 1 to 1841)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1841)
  AUTHORS   Ma,S., Wang,X., Zhang,Z. and Liu,D.
  TITLE     Actin-like protein 8 promotes cell proliferation, colony-formation,
            proangiogenesis, migration and invasion in lung adenocarcinoma
            cells
  JOURNAL   Thorac Cancer 11 (3), 526-536 (2020)
   PUBMED   31962007
  REMARK    GeneRIF: Actin-like protein 8 promotes cell proliferation,
            colony-formation, proangiogenesis, migration and invasion in lung
            adenocarcinoma cells.
REFERENCE   5  (bases 1 to 1841)
  AUTHORS   Li,B., Zhu,J. and Meng,L.
  TITLE     High expression of ACTL8 is poor prognosis and accelerates cell
            progression in head and neck squamous cell carcinoma
  JOURNAL   Mol Med Rep 19 (2), 877-884 (2019)
   PUBMED   30535476
REFERENCE   6  (bases 1 to 1841)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   7  (bases 1 to 1841)
  AUTHORS   Buhrke,T., Lengler,I. and Lampen,A.
  TITLE     Analysis of proteomic changes induced upon cellular differentiation
            of the human intestinal cell line Caco-2
  JOURNAL   Dev Growth Differ 53 (3), 411-426 (2011)
   PUBMED   21492153
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK057339.1, BI826094.1 and BC028909.1.
            
            On Nov 22, 2018 this sequence version replaced NM_030812.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR5189661.65593.1, AK057339.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968540, SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375406.2/ ENSP00000364555.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               AK057339.1         21-222
            203-259             BI826094.1         175-231
            260-1841            BC028909.1         244-1825
FEATURES             Location/Qualifiers
     source          1..1841
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..1841
                     /gene="ACTL8"
                     /gene_synonym="CT57"
                     /note="actin like 8"
                     /db_xref="GeneID:81569"
                     /db_xref="HGNC:HGNC:24018"
                     /db_xref="MIM:621132"
     exon            1..172
                     /gene="ACTL8"
                     /gene_synonym="CT57"
                     /inference="alignment:Splign:2.1.0"
     exon            173..544
                     /gene="ACTL8"
                     /gene_synonym="CT57"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1297
                     /gene="ACTL8"
                     /gene_synonym="CT57"
                     /note="cancer/testis antigen 57; actin like protein"
                     /codon_start=1
                     /product="actin-like protein 8"
                     /protein_id="NP_110439.2"
                     /db_xref="CCDS:CCDS183.1"
                     /db_xref="GeneID:81569"
                     /db_xref="HGNC:HGNC:24018"
                     /db_xref="MIM:621132"
                     /translation="MAARTVIIDHGSGFLKAGTAGWNEPQMVFPNIVNYLPCKENPGP
                     SYARRRVSLGIDICHPDTFSYPIERGRILNWEGVQYLWSFVLENHRREQEVPPVIITE
                     TPLREPADRKKMLEILFELLHVPSVLLADQLQMSLYASGLLTGVVVDSGYGLTRVQPF
                     HQGRPLPASGKTLEFAGQDLSAYLLKSLFKEDCDRRCLFQLETVAVTQMNKCYVPQNL
                     GEALDFRERQQSALDESNTYQLPDGSRVELTPMQRVAPEMFFSPQVFEQPGPSIPRAI
                     VESVESCEISLRPLLVSHVMACGGNTLYPGFTKRLFRELMGDHVSSTKATVWEGSNRN
                     FSVWLGASVVAHLSTYQSEWMSREEYGEHMRM"
     exon            545..1841
                     /gene="ACTL8"
                     /gene_synonym="CT57"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1818..1823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTL8"
                     /gene_synonym="CT57"
                     /note="hexamer: AATAAA"
     polyA_site      1841
                     /gene="ACTL8"
                     /gene_synonym="CT57"
                     /note="major polyA site"
ORIGIN      
        1 acagagtagg ctgcggcacc acgtgcagcc gctctcgtgc aggcgtttgc agtgtgcagc
       61 tgagttcggc agctcacaca gcaccccttt caagttgttt tgcagtgggt gcctcttgtg
      121 agacactgtt tctgagagca gcttttgtgg catcttacag ggcagatttc tggtcccacc
      181 cacctctgcc tccgccatgg ctgcaagaac cgttatcatt gaccacgggt ctggcttttt
      241 gaaggctggc acggccggct ggaatgagcc tcagatggtc ttcccgaaca tcgtgaacta
      301 cctaccgtgc aaggagaacc ctggccccag ctatgcccgt aggcgtgtga gcctgggcat
      361 cgacatttgc catcctgaca cctttagcta ccccatcgag cggggccgca tcctcaactg
      421 ggagggtgtg cagtacctct ggtcatttgt gttggagaac cacagacggg agcaagaggt
      481 cccccctgtg atcatcacgg agacaccctt gagggagcct gcggaccgaa agaagatgct
      541 ggagatcctg tttgagttgc tgcatgtccc atcggtcctc ctggccgacc agctgcagat
      601 gtccctgtat gcctctggcc tcctgaccgg agtggtggtt gattctggct atggcctgac
      661 ccgcgtgcag cctttccacc agggccgccc cttgcccgcc agcggcaaga cgctggagtt
      721 cgccggccag gatctctccg cctatctcct caagagtctc tttaaggaag attgcgatag
      781 acgctgcctg tttcagctgg agacagtcgc cgtgactcag atgaacaagt gctacgtgcc
      841 gcagaatctg ggggaggccc tggactttcg tgagaggcag cagagtgcct tggatgagag
      901 caacacctat cagctcccag acggctcccg cgtggagctg acccccatgc agcgggtggc
      961 tcctgagatg ttctttagcc cgcaggtgtt cgagcagccg gggcccagca tcccacgggc
     1021 cattgtggaa tccgtggagt cctgcgagat ctccctgcgc cccctgctgg tctcccacgt
     1081 gatggcctgc gggggcaaca ccctctatcc cgggttcaca aagcgcctgt tcagggagct
     1141 gatgggggat cacgtctcct ccaccaaggc cacagtctgg gagggttcca atagaaactt
     1201 tagtgtctgg ctaggagcgt ccgtggtggc tcacctttct acctaccagt ctgagtggat
     1261 gtcccgagag gagtatggtg agcatatgag gatgtgaccc tactggctca ctcctgagaa
     1321 tgggctcctg ttagatgggc acgggcggat taattttagc aaaatgttct gggtgggggt
     1381 agaatgaggt ggggtggggt gagctggctt tggaattcta ggggcatgag ggtatttttt
     1441 aggttctaag gttttatctt gttgcaagag tgggacctac ccaaggggga agacaagatg
     1501 tcatccttgg aaaccctgca ggggacagtt tttccagggt ggcctatcat tggggtatga
     1561 gtggctgact gccatctcca tgcctgagag ccactgattt ttcattggca tttcccctgg
     1621 tttgtctcat tcttcttggt tgagtaggtt ttaactgggg tagcactcct gctaggagtc
     1681 ccaattattt ttgactaggg gatgggggac agttgacatt tctggtccta caggcccttt
     1741 ctggccaggg aggcattgct gcaggtgagc ctgggatgcc cttgccaccc gtggttggat
     1801 cttgttttat atctgcaaat aaatagcttg tttggaagca a
//
