LOCUS       NM_004301               1854 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens actin like 6A (ACTL6A), transcript variant 1, mRNA.
ACCESSION   NM_004301
VERSION     NM_004301.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1854)
  AUTHORS   Liu,Y., Liu,Y., Li,Y., Wang,T., Li,B., Kong,X. and Li,C.
  TITLE     High expression of ACTL6A leads to poor prognosis of oral squamous
            cell carcinoma patients through promoting malignant progression
  JOURNAL   Head Neck 46 (6), 1450-1467 (2024)
   PUBMED   38523407
  REMARK    GeneRIF: High expression of ACTL6A leads to poor prognosis of oral
            squamous cell carcinoma patients through promoting malignant
            progression.
REFERENCE   2  (bases 1 to 1854)
  AUTHORS   Liu,F., Liao,Z., Qin,L., Zhang,Z., Zhang,Q., Han,S., Zeng,W.,
            Zhang,H., Liu,Y., Song,J., Chen,W., Zhu,H., Liang,H., Chen,X.,
            Zhang,B. and Zhang,Z.
  TITLE     Targeting VPS72 inhibits ACTL6A/MYC axis activity in HCC
            progression
  JOURNAL   Hepatology 78 (5), 1384-1401 (2023)
   PUBMED   36631007
  REMARK    GeneRIF: Targeting VPS72 inhibits ACTL6A/MYC axis activity in HCC
            progression.
REFERENCE   3  (bases 1 to 1854)
  AUTHORS   Chen,P.M., Wong,C.N., Wong,C.N. and Chu,P.Y.
  TITLE     Actin-like Protein 6A Expression Correlates with Cancer Stem
            Cell-like Features and Poor Prognosis in Ovarian Cancer
  JOURNAL   Int J Mol Sci 24 (3), 2016 (2023)
   PUBMED   36768349
  REMARK    GeneRIF: Actin-like Protein 6A Expression Correlates with Cancer
            Stem Cell-like Features and Poor Prognosis in Ovarian Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1854)
  AUTHORS   Yang,Z., Huang,D., Meng,M., Wang,W., Feng,J., Fang,L., Chen,H. and
            Zou,S.
  TITLE     BAF53A drives colorectal cancer development by regulating
            DUSP5-mediated ERK phosphorylation
  JOURNAL   Cell Death Dis 13 (12), 1049 (2022)
   PUBMED   36526622
  REMARK    GeneRIF: BAF53A drives colorectal cancer development by regulating
            DUSP5-mediated ERK phosphorylation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1854)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 1854)
  AUTHORS   Zhao,K., Wang,W., Rando,O.J., Xue,Y., Swiderek,K., Kuo,A. and
            Crabtree,G.R.
  TITLE     Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF
            complex to chromatin after T lymphocyte receptor signaling
  JOURNAL   Cell 95 (5), 625-636 (1998)
   PUBMED   9845365
REFERENCE   7  (bases 1 to 1854)
  AUTHORS   Cho,H., Orphanides,G., Sun,X., Yang,X.J., Ogryzko,V., Lees,E.,
            Nakatani,Y. and Reinberg,D.
  TITLE     A human RNA polymerase II complex containing factors that modify
            chromatin structure
  JOURNAL   Mol Cell Biol 18 (9), 5355-5363 (1998)
   PUBMED   9710619
REFERENCE   8  (bases 1 to 1854)
  AUTHORS   Reyes,J.C., Muchardt,C. and Yaniv,M.
  TITLE     Components of the human SWI/SNF complex are enriched in active
            chromatin and are associated with the nuclear matrix
  JOURNAL   J Cell Biol 137 (2), 263-274 (1997)
   PUBMED   9128241
REFERENCE   9  (bases 1 to 1854)
  AUTHORS   Wang,W., Cote,J., Xue,Y., Zhou,S., Khavari,P.A., Biggar,S.R.,
            Muchardt,C., Kalpana,G.V., Goff,S.P., Yaniv,M., Workman,J.L. and
            Crabtree,G.R.
  TITLE     Purification and biochemical heterogeneity of the mammalian SWI-SNF
            complex
  JOURNAL   EMBO J 15 (19), 5370-5382 (1996)
   PUBMED   8895581
REFERENCE   10 (bases 1 to 1854)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB041143.1, BC036371.1 and
            AC090425.15.
            
            On Nov 23, 2018 this sequence version replaced NM_004301.4.
            
            Summary: This gene encodes a family member of actin-related
            proteins (ARPs), which share significant amino acid sequence
            identity to conventional actins. Both actins and ARPs have an actin
            fold, which is an ATP-binding cleft, as a common feature. The ARPs
            are involved in diverse cellular processes, including vesicular
            transport, spindle orientation, nuclear migration and chromatin
            remodeling. This gene encodes a 53 kDa subunit protein of the BAF
            (BRG1/brm-associated factor) complex in mammals, which is
            functionally related to SWI/SNF complex in S. cerevisiae and
            Drosophila; the latter is thought to facilitate transcriptional
            activation of specific genes by antagonizing chromatin-mediated
            transcriptional repression. Together with beta-actin, it is
            required for maximal ATPase activity of BRG1, and for the
            association of the BAF complex with chromatin/matrix. Three
            transcript variants that encode two different protein isoforms have
            been described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a), which is also referred to as hArpNbeta/Baf53. Isoform a is
            found mostly in the nucleus.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.157103.1,
                                           SRR5189661.114987.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429709.7/ ENSP00000397552.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DB041143.1         47-64
            19-1852             BC036371.1         4-1837
            1853-1854           AC090425.15        55005-55006         c
FEATURES             Location/Qualifiers
     source          1..1854
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.33"
     gene            1..1854
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /note="actin like 6A"
                     /db_xref="GeneID:86"
                     /db_xref="HGNC:HGNC:24124"
                     /db_xref="MIM:604958"
     exon            1..192
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1457
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /note="isoform 1 is encoded by transcript variant 1; hArpN
                     beta; BAF53; INO80 complex subunit K; actin-related
                     protein 4; BAF complex 53 kDa subunit; actin-like protein
                     6A; arpNbeta; BRG1-associated factor 53A; actin-related
                     protein Baf53a; 53 kDa BRG1-associated factor A"
                     /codon_start=1
                     /product="actin-like protein 6A isoform 1"
                     /protein_id="NP_004292.1"
                     /db_xref="CCDS:CCDS3231.1"
                     /db_xref="GeneID:86"
                     /db_xref="HGNC:HGNC:24124"
                     /db_xref="MIM:604958"
                     /translation="MSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGMV
                     VERDDGSTLMEIDGDKGKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAI
                     LDHTYKMHVKSEASLHPVLMSEAPWNTRAKREKLTELMFEHYNIPAFFLCKTAVLTAF
                     ANGRSTGLILDSGATHTTAIPVHDGYVLQQGIVKSPLAGDFITMQCRELFQEMNIELV
                     PPYMIASKEAVREGSPANWKRKEKLPQVTRSWHNYMCNCVIQDFQASVLQVSDSTYDE
                     QVAAQMPTVHYEFPNGYNCDFGAERLKIPEGLFDPSNVKGLSGNTMLGVSHVVTTSVG
                     MCDIDIRPGLYGSVIVAGGNTLIQSFTDRLNRELSQKTPPSMRLKLIANNTTVERRFS
                     SWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKCP"
     exon            193..269
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            270..444
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            445..545
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..643
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..738
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..845
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..935
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..997
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1112
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1193
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1289
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1376
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1854
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1827..1832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /note="hexamer: AATAAA"
     polyA_site      1854
                     /gene="ACTL6A"
                     /gene_synonym="ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
                     SMARCN1"
                     /note="major polyA site"
ORIGIN      
        1 aagtgtggct gagctccggg gtgtgtggac gccgctttgt tgcctgaggt gggtggcggt
       61 ggaagttaag ggagtcaggg gctatcgctc ctcgagactc gcagtcgcgg ccactgcagt
      121 cacttcgcca gttagccctt agggtaggag tcgcgccggc agcagccatg agcggcggcg
      181 tgtacggggg agatgaagtt ggagcccttg tttttgacat tggatcctat actgtgagag
      241 ctggttatgc tggtgaggac tgccccaagg tggattttcc tacagctatt ggtatggtgg
      301 tagaaagaga tgacggaagc acattaatgg aaatagatgg cgataaaggc aaacaaggcg
      361 gtcccaccta ctacatagat actaatgctc tgcgtgttcc gagggagaat atggaggcca
      421 tttcacctct aaaaaatggg atggttgaag actgggatag tttccaagct attttggatc
      481 atacctacaa aatgcatgtc aaatcagaag ccagtctcca tcctgttctc atgtcagagg
      541 caccgtggaa tactagagca aagagagaga aactgacaga gttaatgttt gaacactaca
      601 acatccctgc cttcttcctt tgcaaaactg cagttttgac agcatttgct aatggtcgtt
      661 ctactgggct gattttggac agtggagcca ctcataccac tgcaattcca gtccacgatg
      721 gctatgtcct tcaacaaggc attgtgaaat cccctcttgc tggagacttt attactatgc
      781 agtgcagaga actcttccaa gaaatgaata ttgaattggt tcctccatat atgattgcat
      841 caaaagaagc tgttcgtgaa ggatctccag caaactggaa aagaaaagag aagttgcctc
      901 aggttacgag gtcttggcac aattatatgt gtaattgtgt tatccaggat tttcaagctt
      961 cggtacttca agtgtcagat tcaacttatg atgaacaagt ggctgcacag atgccaactg
     1021 ttcattatga attccccaat ggctacaatt gtgattttgg tgcagagcgg ctaaagattc
     1081 cagaaggatt atttgaccct tccaatgtaa aggggttatc aggaaacaca atgttaggag
     1141 tcagtcatgt tgtcaccaca agtgttggga tgtgtgatat tgacatcaga ccaggtctct
     1201 atggcagtgt aatagtggca ggaggaaaca cactaataca gagttttact gacaggttga
     1261 atagagagct gtctcagaaa actcctccaa gtatgcggtt gaaattgatt gcaaataata
     1321 caacagtgga acggaggttt agctcatgga ttggcggctc cattctagcc tctttgggta
     1381 cctttcaaca gatgtggatt tccaagcaag aatatgaaga aggagggaag cagtgtgtag
     1441 aaagaaaatg cccttgagaa agagttccca agcttctacc ttccttttgt caccttacgt
     1501 ttcatagctt tagtatactc aggaaaagaa tgaccatctt ttgtagaatg tttatacatt
     1561 tttgcatatt tcaatttcca cttaaatttt ttaaagcttt aactggctct ataaattaag
     1621 tttgtgcttt ccttgaaatg cacttattct tattacaagc attttataat tttgtataaa
     1681 tgtctatttt ctctaaatat tttgctttca gtaaaatgct ttccaactct gtttagtgta
     1741 ttaattacca gtggattggt agaactgctt tttattgact agtaaaagtt actgcctatg
     1801 ctttttacct taggcttaca gaattaaata aaaattagcc attccagaaa tata
//
