LOCUS       NM_001017992            2794 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens actin beta like 2 (ACTBL2), mRNA.
ACCESSION   NM_001017992 XM_293924
VERSION     NM_001017992.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2794)
  AUTHORS   Topalov,N.E., Mayr,D., Kuhn,C., Leutbecher,A., Scherer,C.,
            Kraus,F.B.T., Tauber,C.V., Beyer,S., Meister,S., Hester,A.,
            Kolben,T., Burges,A., Mahner,S., Trillsch,F., Kessler,M.,
            Jeschke,U. and Czogalla,B.
  TITLE     Characterization and prognostic impact of ACTBL2-positive
            tumor-infiltrating leukocytes in epithelial ovarian cancer
  JOURNAL   Sci Rep 13 (1), 22620 (2023)
   PUBMED   38114558
  REMARK    GeneRIF: Characterization and prognostic impact of ACTBL2-positive
            tumor-infiltrating leukocytes in epithelial ovarian cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2794)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2794)
  AUTHORS   Malek,N., Michrowska,A., Mazurkiewicz,E., Mrowczynska,E.,
            Mackiewicz,P. and Mazur,A.J.
  TITLE     The origin of the expressed retrotransposed gene ACTBL2 and its
            influence on human melanoma cells' motility and focal adhesion
            formation
  JOURNAL   Sci Rep 11 (1), 3329 (2021)
   PUBMED   33558623
  REMARK    GeneRIF: The origin of the expressed retrotransposed gene ACTBL2
            and its influence on human melanoma cells' motility and focal
            adhesion formation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2794)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2794)
  AUTHORS   Ghazanfar,S., Fatima,I., Aslam,M., Musharraf,S.G., Sherman,N.E.,
            Moskaluk,C., Fox,J.W., Akhtar,M.W. and Sadaf,S.
  TITLE     Identification of actin beta-like 2 (ACTBL2) as novel, upregulated
            protein in colorectal cancer
  JOURNAL   J Proteomics 152, 33-40 (2017)
   PUBMED   27989943
  REMARK    GeneRIF: identified a novel protein, ACTBL2, which was demonstrated
            to be upregulated in colorectal cancer
REFERENCE   6  (bases 1 to 2794)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   7  (bases 1 to 2794)
  AUTHORS   Joseph,R., Srivastava,O.P. and Pfister,R.R.
  TITLE     Downregulation of beta-actin gene and human antigen R in human
            keratoconus
  JOURNAL   Invest Ophthalmol Vis Sci 53 (7), 4032-4041 (2012)
   PUBMED   22562506
  REMARK    GeneRIF: -actin is downregulated in the corneal stroma of patients
            with KC, which may be related to reduced levels of a stabilizing
            factor (HuR) for beta-actin mRNA.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2794)
  AUTHORS   Tao,S., Wang,Z., Feng,J., Hsu,F.C., Jin,G., Kim,S.T., Zhang,Z.,
            Gronberg,H., Zheng,L.S., Isaacs,W.B., Xu,J. and Sun,J.
  TITLE     A genome-wide search for loci interacting with known prostate
            cancer risk-associated genetic variants
  JOURNAL   Carcinogenesis 33 (3), 598-603 (2012)
   PUBMED   22219177
REFERENCE   9  (bases 1 to 2794)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   10 (bases 1 to 2794)
  AUTHORS   Chang,K.W., Yang,P.Y., Lai,H.Y., Yeh,T.S., Chen,T.C. and Yeh,C.T.
  TITLE     Identification of a novel actin isoform in hepatocellular carcinoma
  JOURNAL   Hepatol Res 36 (1), 33-39 (2006)
   PUBMED   16824795
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025470.5 and BX648504.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001017992.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BX648504.1, BC137470.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000423391.3/ ENSP00000416706.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC025470.5         15868-15869
            3-2794              BX648504.1         2-2793
FEATURES             Location/Qualifiers
     source          1..2794
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..2794
                     /gene="ACTBL2"
                     /gene_synonym="ACT"
                     /note="actin beta like 2"
                     /db_xref="GeneID:345651"
                     /db_xref="HGNC:HGNC:17780"
                     /db_xref="MIM:614835"
     exon            1..2794
                     /gene="ACTBL2"
                     /gene_synonym="ACT"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1235
                     /gene="ACTBL2"
                     /gene_synonym="ACT"
                     /note="actin-like protein; kappa-actin"
                     /codon_start=1
                     /product="beta-actin-like protein 2"
                     /protein_id="NP_001017992.1"
                     /db_xref="CCDS:CCDS34163.1"
                     /db_xref="GeneID:345651"
                     /db_xref="HGNC:HGNC:17780"
                     /db_xref="MIM:614835"
                     /translation="MTDNELSALVVDNGSGMCKAGFGGDDAPRAVFPSMIGRPRHQGV
                     MVGMGQKDCYVGDEAQSKRGVLTLKYPIEHGVVTNWDDMEKIWYHTFYNELRVAPDEH
                     PILLTEAPLNPKINREKMTQIMFEAFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGV
                     THIVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYNFTTTAEREIVRDVKEKLC
                     YVALDFEQEMVRAAASSSPERSYELPDGQVITIGNERFRCPEAIFQPSFLGIESSGIH
                     ETTFNSIMKCDVDIRKDLYANTVLSGGSTMYPGIADRMQKEIITLAPSTMKIKIIAPP
                     ERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPPIVHRKCF"
     regulatory      1755..1760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTBL2"
                     /gene_synonym="ACT"
                     /note="hexamer: AATAAA"
     polyA_site      1775
                     /gene="ACTBL2"
                     /gene_synonym="ACT"
     regulatory      2772..2777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACTBL2"
                     /gene_synonym="ACT"
                     /note="hexamer: ATTAAA"
     polyA_site      2794
                     /gene="ACTBL2"
                     /gene_synonym="ACT"
                     /note="major polyA site"
ORIGIN      
        1 gtgtctgaaa gcatttctgg agtgttttag gcctgttcac tttctcttac tcactgtcta
       61 ttcacttgtc ctgttcactc gtctggaaga tctcagccag caccatgact gacaatgagc
      121 tgtctgcctt ggtagtggat aatgggtcag ggatgtgcaa ggcaggcttt ggtggtgacg
      181 atgccccccg ggctgtgttc ccctccatga tagggcgtcc tcgacaccag ggcgttatgg
      241 taggcatggg ccagaaggac tgctacgtgg gagatgaggc tcagagcaag agaggcgtcc
      301 tgaccctgaa gtatcctatc gagcatggag tggtcaccaa ctgggacgat atggaaaaga
      361 tctggtacca cacattctac aatgagctcc gtgtggcacc agatgagcat cccatcctcc
      421 tcaccgaggc acccctgaac cccaagatca accgggaaaa gatgactcag atcatgttcg
      481 aggctttcaa cacaccagcc atgtatgtcg ccatccaggc tgtgctgtcc ctctatgcct
      541 caggacggac cacaggcatc gtgatggatt ctggggatgg ggtcactcac atcgtgccca
      601 tctatgaagg ttatgccctg cctcatgcca ttctacgcct ggatctggca gggagagacc
      661 tgactgatta cctcatgaag atcctgacag agcgaggcta taacttcacc accactgctg
      721 agcgggagat tgtgcgagat gtcaaagaga agctgtgcta cgtagccctg gactttgagc
      781 aggagatggt cagggcagcc gcatcctcct caccggaacg gagctatgaa cttcctgatg
      841 ggcaggtgat caccattggg aatgaacgct tccgatgccc tgaagccatt ttccagcctt
      901 cctttctggg cattgagtcc agtgggatcc atgagacaac cttcaactct atcatgaagt
      961 gcgatgtgga tattcgcaag gatctctatg ccaacaccgt gttatctgga gggagcacca
     1021 tgtacccagg cattgctgac aggatgcaga aagaaatcat aaccctggca cccagcacca
     1081 tgaaaatcaa gatcatagct cccccagagc ggaagtattc tgtttggatt gggggctcca
     1141 tccttgccag cctgtccaca ttccagcaga tgtggatcag taagcaggaa tatgatgagg
     1201 ctggtcctcc tatcgttcac agaaaatgtt tctgaatggg cttccatatt agtgggctta
     1261 cattttccct tttcctaggt cacagtgatg gtactgcttt tatccgcttt cagtagaatc
     1321 gaggtaaata cgtcactctt cctagtgtaa accagcaaac ccatctctcc atccaagtaa
     1381 cctgggctct tacccagata accacatccg gttctccatc aagtgaaggt gaattctaat
     1441 accatattcc tttttctttg cctatactgt tcaaagatag gtaggccagc ttaaatacat
     1501 ataagtgaca aggagtaaaa tcacgagaaa tgtcatttca gaatggataa ctataattat
     1561 caagctttaa aacttagttc tcgctaaaat atttaacaag aacaggctgt ataaacttgt
     1621 ttaaaaaaaa aaggtgcgta tgcatttagc agccgtgtct tactagttaa gtatctttgt
     1681 tttgtttact tctttgtatg gagataatga attataaagt tcaataatat ccatatatac
     1741 ataagcacca gggaaataaa atatattgtg aaatatgctg atgtatctag ctatctgaac
     1801 agctaatgtg aatttcttta ctcccaaaag tcatcgttgt actaggtaca tattttaatt
     1861 gtttccctta ctaaataagc ataatgagac agccaccatt ccattaatgt ttataaatca
     1921 tctaaatttt cagctcatag tggagttctg ctggtcaaat tatattttaa tatctttctt
     1981 actgaacctt ctcataccaa aactacagac aatgtctaat tcttaagaga gatagatatt
     2041 ataatatcaa attaatgtca ttatggtaca atttgacaga ggtaatttta tttctatttc
     2101 ttagtgtaat agcacatctt aaataatttc tgtagaccag gattacagat acttctcttg
     2161 tgcaaggatt tcactgtggg aaaatatagc tgcagcatct ttattaatta tacattttac
     2221 taccagtata ctaacacagt tttatccttg gaaagctttt agaataattc tactttatta
     2281 tgtccagtaa ctagcaatac ttatttatgc aaagtgtctc tgagatacta acatctttga
     2341 aaatatcaat gtatgttcct ataatgtcta aaatatttta gttactccag tgatgattta
     2401 ttaaccaatt ttaagtacca gtatgtttat tccaatctat gcagtgattt ctgaatattt
     2461 ggatatcagc attatttgta tttttcaggg taatttctga aaatttaaaa tatttatttg
     2521 gattgcttat tcaggcatta taaggtactc tggaggaagg aatcacttct ctttttttct
     2581 tagttgggaa acttgtactt atgttataaa tctttaaaat ggaatcagta agaatttttt
     2641 gtttaaggta atacttttca aataatttga ttattcctta ttggctttat ctgacaacat
     2701 aatctttaaa atgcatgtaa ccaaaattaa tctccaaaaa cactttattt tatataactt
     2761 gctttcagta cattaaaatt gcttcatact tgta
//
