LOCUS       NM_024560               8391 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens acyl-CoA synthetase short chain family member 3
            (ACSS3), transcript variant 1, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_024560
VERSION     NM_024560.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8391)
  AUTHORS   Wang,L., Yuan,H., Li,W., Yan,P., Zhao,M., Li,Z., Zhao,H., Wang,S.,
            Wan,R., Li,Y., Yang,J., Pan,X., Rosas,I. and Yu,G.
  TITLE     ACSS3 regulates the metabolic homeostasis of epithelial cells and
            alleviates pulmonary fibrosis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (2), 166960 (2024)
   PUBMED   37979225
  REMARK    GeneRIF: ACSS3 regulates the metabolic homeostasis of epithelial
            cells and alleviates pulmonary fibrosis.
REFERENCE   2  (bases 1 to 8391)
  AUTHORS   Jo,J., Song,Y., Yoon,D., Lee,C.G. and Won,S.
  TITLE     Genome-wide assessment reveals a significant association between
            ACSS3 and physical activity
  JOURNAL   Genes Brain Behav 22 (1), e12834 (2023)
   PUBMED   36510703
  REMARK    GeneRIF: Genome-wide assessment reveals a significant association
            between ACSS3 and physical activity.
REFERENCE   3  (bases 1 to 8391)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 8391)
  AUTHORS   Zhou,L., Song,Z., Hu,J., Liu,L., Hou,Y., Zhang,X., Yang,X. and
            Chen,K.
  TITLE     ACSS3 represses prostate cancer progression through downregulating
            lipid droplet-associated protein PLIN3
  JOURNAL   Theranostics 11 (2), 841-860 (2021)
   PUBMED   33391508
  REMARK    GeneRIF: ACSS3 represses prostate cancer progression through
            downregulating lipid droplet-associated protein PLIN3.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8391)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 8391)
  AUTHORS   Yoshimura,Y., Araki,A., Maruta,H., Takahashi,Y. and Yamashita,H.
  TITLE     Molecular cloning of rat acss3 and characterization of mammalian
            propionyl-CoA synthetase in the liver mitochondrial matrix
  JOURNAL   J Biochem 161 (3), 279-289 (2017)
   PUBMED   28003429
REFERENCE   7  (bases 1 to 8391)
  AUTHORS   Chouraki,V., De Bruijn,R.F., Chapuis,J., Bis,J.C., Reitz,C.,
            Schraen,S., Ibrahim-Verbaas,C.A., Grenier-Boley,B., Delay,C.,
            Rogers,R., Demiautte,F., Mounier,A., Fitzpatrick,A.L., Berr,C.,
            Dartigues,J.F., Uitterlinden,A.G., Hofman,A., Breteler,M.,
            Becker,J.T., Lathrop,M., Schupf,N., Alperovitch,A., Mayeux,R., van
            Duijn,C.M., Buee,L., Amouyel,P., Lopez,O.L., Ikram,M.A., Tzourio,C.
            and Lambert,J.C.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     A genome-wide association meta-analysis of plasma Abeta peptides
            concentrations in the elderly
  JOURNAL   Mol Psychiatry 19 (12), 1326-1335 (2014)
   PUBMED   24535457
REFERENCE   8  (bases 1 to 8391)
  AUTHORS   Ritchie,M.D., Verma,S.S., Hall,M.A., Goodloe,R.J., Berg,R.L.,
            Carrell,D.S., Carlson,C.S., Chen,L., Crosslin,D.R., Denny,J.C.,
            Jarvik,G., Li,R., Linneman,J.G., Pathak,J., Peissig,P.,
            Rasmussen,L.V., Ramirez,A.H., Wang,X., Wilke,R.A., Wolf,W.A.,
            Torstenson,E.S., Turner,S.D. and McCarty,C.A.
  TITLE     Electronic medical records and genomics (eMERGE) network
            exploration in cataract: several new potential susceptibility loci
  JOURNAL   Mol Vis 20, 1281-1295 (2014)
   PUBMED   25352737
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 8391)
  AUTHORS   Hunter,A.M., Leuchter,A.F., Power,R.A., Muthen,B., McGrath,P.J.,
            Lewis,C.M., Cook,I.A., Garriock,H.A., McGuffin,P., Uher,R. and
            Hamilton,S.P.
  TITLE     A genome-wide association study of a sustained pattern of
            antidepressant response
  JOURNAL   J Psychiatr Res 47 (9), 1157-1165 (2013)
   PUBMED   23726668
REFERENCE   10 (bases 1 to 8391)
  AUTHORS   Watkins,P.A., Maiguel,D., Jia,Z. and Pevsner,J.
  TITLE     Evidence for 26 distinct acyl-coenzyme A synthetase genes in the
            human genome
  JOURNAL   J Lipid Res 48 (12), 2736-2750 (2007)
   PUBMED   17762044
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK025616.1, AK074938.1, AK074267.1, AC078920.17 and AI022900.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024560.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025616.1, SRR1803612.162160.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000548058.6/ ENSP00000449535.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2264              AK025616.1         1-2264
            2265-2984           AK074938.1         1495-2214
            2985-3278           AK074267.1         1458-1751
            3279-3279           AC078920.17        89361-89361         c
            3280-3935           AK074267.1         1753-2408
            3936-3940           AI022900.1         21-25               c
            3941-8391           AC078920.17        84249-88699         c
FEATURES             Location/Qualifiers
     source          1..8391
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.31"
     gene            1..8391
                     /gene="ACSS3"
                     /note="acyl-CoA synthetase short chain family member 3"
                     /db_xref="GeneID:79611"
                     /db_xref="HGNC:HGNC:24723"
                     /db_xref="MIM:614356"
     exon            1..353
                     /gene="ACSS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2103
                     /gene="ACSS3"
                     /EC_number="6.2.1.1"
                     /EC_number="6.2.1.17"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; acyl-CoA synthetase short-chain family member
                     3, mitochondrial; AMP-binding enzyme, 33217; acetate--CoA
                     ligase 3; propionate--CoA ligase"
                     /codon_start=1
                     /product="acyl-CoA synthetase short-chain family member 3,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_078836.1"
                     /db_xref="CCDS:CCDS9022.1"
                     /db_xref="GeneID:79611"
                     /db_xref="HGNC:HGNC:24723"
                     /db_xref="MIM:614356"
                     /translation="MKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAALRALVVPGPRG
                     GLGGRGCRALSSGSGSEYKTHFAASVTDPERFWGKAAEQISWYKPWTKTLENKHSPST
                     RWFVEGMLNICYNAVDRHIENGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVL
                     VKHGIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKV
                     VVTASFGIEPGRRVEYVPLVEEALKIGQHKPDKILIYNRPNMEAVPLAPGRDLDWDEE
                     MAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGE
                     VWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFT
                     APTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKNVFRVPVLDHWWQ
                     TETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKARCLGNIVVKLPL
                     PPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRI
                     SAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKDINATEEQVLEEIVKHVR
                     QNIGPVAAFRNAVFVKQLPKTRSGKIPRSALSAIVNGKPYKITSTIEDPSIFGHVEEM
                     LKQA"
     exon            354..498
                     /gene="ACSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            499..687
                     /gene="ACSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            688..822
                     /gene="ACSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..963
                     /gene="ACSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1044
                     /gene="ACSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1140
                     /gene="ACSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1292
                     /gene="ACSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1396
                     /gene="ACSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1492
                     /gene="ACSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1556
                     /gene="ACSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1638
                     /gene="ACSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1761
                     /gene="ACSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1861
                     /gene="ACSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2037
                     /gene="ACSS3"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..8391
                     /gene="ACSS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3918..3923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACSS3"
                     /note="hexamer: AATAAA"
     polyA_site      3940
                     /gene="ACSS3"
                     /note="major polyA site"
     regulatory      4030..4035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACSS3"
                     /note="hexamer: ATTAAA"
     polyA_site      4058
                     /gene="ACSS3"
     regulatory      4955..4960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACSS3"
                     /note="hexamer: ATTAAA"
     polyA_site      4976
                     /gene="ACSS3"
     regulatory      8366..8371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACSS3"
                     /note="hexamer: AATAAA"
     polyA_site      8391
                     /gene="ACSS3"
ORIGIN      
        1 accatttgtc gcacactcgg ggaccgcggg tggccggagg agatgaaacc gtcttggctg
       61 cagtgtcgta aagtcaccag cgccgggggg ctcggagggc ccttgcctgg gtcctctccg
      121 gcccggggag ccggtgcggc cctcagggct ttagtggtcc cgggcccgcg gggcggtctc
      181 gggggccggg gatgcagggc actgtcctcc ggcagtggca gcgagtacaa gacccacttc
      241 gcagcctcgg tgaccgaccc cgagaggttc tggggcaaag ctgccgagca gatcagctgg
      301 tacaagccct ggaccaaaac gctggagaac aaacactcgc cctctaccag gtggtttgtg
      361 gaaggaatgc ttaacatttg ttacaatgcc gttgatcgtc atattgaaaa tggtaaaggg
      421 gataagattg ctatcatcta tgacagtcct gttacaaaca ctaaagcaac ctttacctat
      481 aaagaagttc tggagcaggt ctccaagctg gctggtgtct tggtcaagca tggcatcaag
      541 aaaggtgaca ctgtggttat ctacatgcct atgatcccac aggcgatgta taccatgttg
      601 gcatgtgcaa ggataggtgc catccacagt ctcatatttg gaggatttgc ttccaaagaa
      661 ctaagtagtc gcattgatca tgtaaagccc aaggtggttg ttacagcatc atttggcatt
      721 gaacctggaa ggagggtaga gtacgtacca cttgtagaag aagcgctaaa aataggacaa
      781 cacaaaccag acaaaattct catttataat cgtccaaata tggaggcggt tcctttggct
      841 cccggtcgtg accttgattg ggatgaagag atggcaaaag cccagtcaca tgactgtgtt
      901 cctgttcttt cagaacaccc actgtatatt ctttacacat ctggcacaac ggggttacct
      961 aagggtgtga ttaggcccac tgggggatac gctgtcatgc tacactggtc aatgtcttcc
     1021 atatacggac ttcaacccgg agaggtgtgg tgggcagctt ctgacttagg ctgggttgtt
     1081 ggacattcct atatctgcta tggacctctt cttcatggga acacaacagt tttatatgag
     1141 gggaagcctg tgggaacacc agatgctggc gcttatttcc gtgtgcttgc agagcatgga
     1201 gtagctgcct tgtttacagc accaactgca attagagcaa tccgtcaaca ggaccctggg
     1261 gcagctttgg ggaagcagta ctctctgaca aggttcaaaa cattatttgt ggctggagaa
     1321 cgatgtgatg tagagaccct ggaatggtcc aaaaatgtct tcagagtacc tgtcttagac
     1381 cattggtggc aaactgagac tggatctcca attactgcgt catgtgttgg attaggcaat
     1441 tctaaaacac ctccaccagg gcaagcagga aaaagcgtcc caggatacaa tgttatgatt
     1501 ttggatgaca acatgcaaaa actgaaggct cggtgtttag gaaatattgt ggtaaagtta
     1561 ccattgccac ctggggcttt ttcaggactc tggaagaatc aggaagcatt caagcattta
     1621 tactttgaaa aatttcctgg atattatgat accatggatg ctggttacat ggatgaagaa
     1681 ggctatttgt atgttatgtc tcgagtggat gatgtaataa atgttgcagg tcacagaatt
     1741 tctgcaggcg ccattgaaga gtcaatcctt tcccatggta ccgtggcaga ctgtgctgtt
     1801 gttggcaagg aagatccctt aaaaggtcat gtccccttag cactctgtgt attgagaaaa
     1861 gatataaatg caacagagga gcaagttttg gaagaaattg tgaaacacgt tagacagaac
     1921 attggccctg tggctgcttt tcgaaatgca gtgtttgtca aacagctacc caaaaccaga
     1981 tctggcaaga tcccccgatc agctttatct gccattgtca atggcaagcc atacaagata
     2041 acttctacaa ttgaagaccc cagcattttt ggccacgtag aagaaatgct gaagcaagca
     2101 taatgagttt gtcttattcc tattttgagt tgatttaatt tcttaattga aattaaatta
     2161 tttgagttgt ttctcagaaa taaatatttc agtagaaatt acttgcaaaa tgaaatgtga
     2221 attgtaaaac ttggcctaaa caaatctaat gaaaacatgt gaaagacctg tgcctttttt
     2281 ttggtttgac cctgttagca ttgttattag ttatctataa catggcttat tgaatgtcat
     2341 ctactgcttt aggaaaaacg tatctagtgt attattttta aaattgtacc tcccaagaag
     2401 aacactttaa ttgaaagcaa cactaatata gagccacttc ctgaaaccaa gaatctgtag
     2461 ttttgatcca aaatctaaaa cttaaagtca gaaaataatt aaaatttttc ttgtagaaat
     2521 tttagatatt ttctagtatt ctttagatgc tcacattgtt ttaaataaaa tagatgaaat
     2581 gggaagttta ggtaatcatc tagacagatg aaattattat ctaggtagga gggcttttct
     2641 atacattttc tgagggaaag cagaacaccg gggttatagc tataccttca ggtcttttgt
     2701 tacttaggca aggaaaacca catgtctgac ctggttcagc atgtaatccg agcactttgg
     2761 gaggctgagg caggcggatc acttgaggtc agcagtttga gacgagcctg gccaacatgg
     2821 tgaaaccctg tagctactga aaatacaaaa ataagccagg cgtggtggcg ggaggctgag
     2881 gcaaggagaa tcacttgaat acaagaggca gaggttgcag tgagccaagt tcccccactg
     2941 tactccagcc tgggtgacag agtaagactc catctcaaaa caacaaaaac aacaaaaaaa
     3001 ccacatgcct ggcggagaac aaagagatca tttagtccaa tctcttcatg gagatgaggg
     3061 ctcctgggag cccctcttca tgtctcaggt tcttagttga ctatgtttat ccaaatgatt
     3121 ccagattcct gtggaaacaa ggaatcgatg tacaaatggg gtagggtggc aaggaaaact
     3181 cttaagagag aaacatcaag gttttcacat taggttaaag acaagaaggt ttctaggcag
     3241 gtagtgtaat gtctaggtga ttttgaagtg aacttaagcc actaggtttg agggacaaag
     3301 gacagtagaa aatggtgaag actgcagatc acctgctata cctcaaggag cagcggaccc
     3361 agcagaatat ggcccaaaaa ggaggcaggt ctcctgttgc aagagcctct gtttttttaa
     3421 agagaaaaca aagaatcctg gtttttatgt gaaatctcta attttaaaat aataactcat
     3481 taaaaatatt gtaatgtcca aaagtatctt tccatttaac ttctaaaaat ctcttaaatg
     3541 ttttttttaa ataattgtaa agtgagtttt tgttaagctt ataggaatgg gccagttaac
     3601 taaggtagac agatgtagga aattaaatat ttgatttact tagggatcta tatgacatca
     3661 gttatcaaag aatacatttt aacccaaaag tataccatgc tcattgtatc tttgatcgtt
     3721 cttcaagtat ttctcaatct tttaatctat caggaacatt actatcaaga gcagattgtt
     3781 gtaacataat actcaggata catgaaatgt atgtgagaga taaatagata atagaaagtt
     3841 tattgttata aaaatgacct acaacttata taaaaaaatt ctgaaaatgt tgactttttt
     3901 tggactgaag actgcaaaat aaatggcttc tcaaagtaaa ttcctattta cttaaattgc
     3961 cttcttgatt gttacacctg gaaaaatata ttcatctact ttttcctttt aattatgtta
     4021 gtagactgaa ttaaaccagc tacatagaca ctctctcatt tgaagctgtt gggatccttg
     4081 agttgcctct ttcattggta cgttttatcc attgtcacaa ctgtggtctt cattaataac
     4141 tcattttaat gtcttaggag tagaatgtgt ttccttattt tttttcaaat aagagtcagt
     4201 taatttgaaa tggcaaatta tttacctgaa tgtgtatcat tgttcatttg caaggtttaa
     4261 gctcaggcag atccaataat taggtaaagg ttgcatcttt ggtcctcttg cacatttttt
     4321 ctggtaatca aatctgaagc gacatctcag caagcagact tgggttattt tccactagga
     4381 tgggaatgga aaacagtgct ggagactggg gaagtggcta tttcctgtgt ctcactgggg
     4441 aattgcaaga tcaaagaatg ttgttacttt tatgtgatga aaaaataggg caagaaagat
     4501 atacctgaat catcagactg cttaaaattt gggaggaaaa aattctattt tactactaac
     4561 cataaatcac ttttgctaga tagtacttta aagattctga attaaatgta tctttaaaaa
     4621 caacaatata atattactaa aaaatgcaga catacttaaa cttgctagaa taaattctgt
     4681 gaggtcttcg tttggtattt tcataggatt tcttactgtt aagttattgg aaaatgaaaa
     4741 tataaagtgc tttcagaagt tatagtattt tccaattcat tgaattactt tgcttgtgaa
     4801 aatatattaa acatatttaa atgagaccta tcctacattt aaaaaccagt tttgtttata
     4861 taaaattgta tttgaaaggt cctgaacatt aaaaatgtga aaatttataa tgttgatgat
     4921 caaaagtaac gtgttgagac tctgagctta atccattaaa tggattttag aatctagtag
     4981 aagttatctt tcttataaat taaaacatat tttatgcttc ttttttgagg gaaatacctg
     5041 gatcttttgc atcactatat gttagtgtct attatagatg attaatcttt ctaacttgat
     5101 ctttaaaaga aagaaattga ttttagtgat tgagtgttat ataatagtag atacaaatct
     5161 agttatggca ttataatgtc gtagttccta tattctattt catttctatg aatcaagatg
     5221 cccatgttta gatgagctta gaaagctact tctcattgtt cctactcagg ccacattttt
     5281 agaaaaaaat tttaagatca ctcccataag caagtttaga tctccctctt gtggcagact
     5341 caattttgaa gctaaatatt tgggtcaccc aaagaacaca tttcctgata gtttaagtaa
     5401 attgtcgagc cttatgtgac tagaaaacaa agcttaaaca gagaactgga attattattt
     5461 tttttattga caatggaaag ggtttctgtt atcattacct tttgactgaa tctgttaaat
     5521 aaaaatagac atcaaaacaa atgtaatgta cgtgcaaaca tagcaaatta aaatacagaa
     5581 aagaaattac taatgacagg tcttgcgctt aataagatca agcagcagaa aatcagcagt
     5641 tagataaatg gtattattaa ataggcttta ctttgaatct cccatataaa caaagaataa
     5701 acaacagtaa caccaccaaa taaagccaca gggaagagat tactcttcta tacttttata
     5761 cactatatat gttaatcatt ctgtctttca tttatttcct ctgataaaac tgacttcagg
     5821 gaagtcgcaa caaggccatc tcggctaaaa gcttataaca ttagacatga gtctggctaa
     5881 tgccctgtta cattgacaaa agggaaaggt atcttgggtt tcgttttctc tagtggaaat
     5941 gagcctcaga ctctgcggtg gttgacattc actgtccagt actggctggc atttcaagat
     6001 atttgaatga acatgtggtt cttagtaaag aagttttttt atcttttttt ttttcttggt
     6061 ccacaggtaa caagagaaga ttatggtttt ttaatataaa tttttaaata attgcttttg
     6121 acccttgtaa acagcttggc tttgttttgt attgaaaagg agatcaagcc atcacagtgc
     6181 tatttctaaa gatataggac atccctgatt gcctttaaag ctctattttt ggctccggtt
     6241 ccaggttaaa tcattctttt ttacatgatc agaggcaggt tgttcagctt taagtattga
     6301 cagacttgaa ggagaaacac gttgaagcat gaaacatgct tcaaggaaac atattgattt
     6361 gactattaac aatccaaaaa ctgtaaaaat ggtggaatgg taaaatacaa acagtacttg
     6421 gaattgtcaa atgtttgcac tcgagactcc atgaaccata tattttattt tttaaaaaat
     6481 catatttata tccatttaca taagacttac acatttaaaa agaaatgcac ggtaatacat
     6541 aaatgcctag tatattacaa taaaacatga aaaacaactg gcttcatttc ataaaagcat
     6601 ctgttgtaca gagtttatga tgtagatgat gtttattatt caaatgactt aagcatttta
     6661 ttacaatttg tagtaaacta atcaaatgta atatctgact ccccccaaaa atcacatttt
     6721 tcagctttta ataagtcatg acgtcattat ttccttagaa ttcagttttc acaaaggttt
     6781 tcactgctcg tcttcttaga tggtagtgca ctttaggtag agtagactga aaagacgcca
     6841 tctaaaatat acaatggata gcattagttc actgaaaagt cccagactgg gaaatctcat
     6901 tctactcctc tgtggtgtac ctccacgcag cctgcttact cctgtcctag aagatcatga
     6961 gaaggaaatc atctaggatg tagccaacag ccgtatgtaa ttaacatttg cttttctcca
     7021 atttggtgca ggggagctta acaaataata gaatttgctc aactttgtgg aaagtatggc
     7081 agtaatgtaa acaaaggtag ttatgcaaaa tgttagcatg ccttctgaaa aatttacaac
     7141 ttgctaatta ataaattggg ttgaattgac ctatttcata atgtagattt atattctagt
     7201 tcatatattt tagagttctt aaaaaatacc tttatttgtt acaaaaacat aacgataata
     7261 agtcacctat tgtaaacgtt tgtgtcagta gtatggcatt gctgattgtt ttcagccata
     7321 atgtacttag aaaaagctca caattgctat tactgacaca aaagaaacag caagtagtat
     7381 gctctggatt attttaatat caaaagtgtt gttgtttcac ccaaacaaaa aatggttgtc
     7441 ctagattgaa ttattgtaaa tgaatactgt tatcccaatt aatggtaaaa actaggaaat
     7501 atgaactaga atgtcatgca caaaaaacag attgcaaata gagtaactct acccatcact
     7561 taagagctaa gaagcaagca ctattgaaca tattaaatag tcatttgtaa attagtgaag
     7621 tgttcatttc ctgaagaaat tataatgcta tgtgtagaat ctaatataaa cagtattttg
     7681 ggagacctct tatttagcca aattattata tactttaaat catgtctaat taggtgccaa
     7741 attatatacc ataattaaaa ttttaatgta agggttgtac attctgaaat taaatctctt
     7801 atcgggatgc ttttcatttt atcagcttca aatagtgatc caaataaggc agcatatctg
     7861 ctcccatcct aagcccaaaa gaccaacaat aaattgtgtg gcacttttag ttcaaggcaa
     7921 tgaaaacagc acaaggtgag ttgttcctct gtctataact gttttctctt aaccctgtgc
     7981 acacattttg ttctaaatat cgctcttaaa aagtattttt ctaaaatatt gattcatcga
     8041 aagtggttaa atattttggt aaagcatagt tttaggttga aaaaaaatta tgaacatttg
     8101 acatttataa atctaagaaa ccacagtttt actattaaga ctgtttttca ataaaacctc
     8161 atttttatat ggattttaaa gtagctttca ttaattggta tttccttaaa atcaaatgct
     8221 tggtatttat ggttacatag gaaggttttg tgctggtcct attctccatt cttaaagtaa
     8281 ttttattttg ttcctatatg tcttaaatac ttaaaattta tatttgtttt tagcaagtgt
     8341 aaatcagatt gataagaaac aatgtaataa aggtttgaat ttttcacagt t
//
