LOCUS       NM_207321               1675 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens acyl-CoA synthetase medium chain family member 6
            (ACSM6), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_207321
VERSION     NM_207321.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1675)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1675)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   3  (bases 1 to 1675)
  AUTHORS   Langley,R.J., Tsalik,E.L., van Velkinburgh,J.C., Glickman,S.W.,
            Rice,B.J., Wang,C., Chen,B., Carin,L., Suarez,A., Mohney,R.P.,
            Freeman,D.H., Wang,M., You,J., Wulff,J., Thompson,J.W.,
            Moseley,M.A., Reisinger,S., Edmonds,B.T., Grinnell,B., Nelson,D.R.,
            Dinwiddie,D.L., Miller,N.A., Saunders,C.J., Soden,S.S.,
            Rogers,A.J., Gazourian,L., Fredenburgh,L.E., Massaro,A.F.,
            Baron,R.M., Choi,A.M., Corey,G.R., Ginsburg,G.S., Cairns,C.B.,
            Otero,R.M., Fowler,V.G. Jr., Rivers,E.P., Woods,C.W. and
            Kingsmore,S.F.
  TITLE     An integrated clinico-metabolomic model improves prediction of
            death in sepsis
  JOURNAL   Sci Transl Med 5 (195), 195ra95 (2013)
   PUBMED   23884467
REFERENCE   4  (bases 1 to 1675)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK126134.1, BC104211.2 and BC063654.1.
            
            On Aug 13, 2020 this sequence version replaced NM_207321.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1968968, SAMEA2142586
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394005.4/ ENSP00000377573.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AK126134.1         39-116
            79-1333             BC104211.2         1-1255
            1334-1675           BC063654.1         761-1102
FEATURES             Location/Qualifiers
     source          1..1675
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..1675
                     /gene="ACSM6"
                     /gene_synonym="bA310E22.3; C10orf129"
                     /note="acyl-CoA synthetase medium chain family member 6"
                     /db_xref="GeneID:142827"
                     /db_xref="HGNC:HGNC:31665"
     exon            1..66
                     /gene="ACSM6"
                     /gene_synonym="bA310E22.3; C10orf129"
                     /inference="alignment:Splign:2.1.0"
     exon            67..279
                     /gene="ACSM6"
                     /gene_synonym="bA310E22.3; C10orf129"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1530
                     /gene="ACSM6"
                     /gene_synonym="bA310E22.3; C10orf129"
                     /EC_number="6.2.1.2"
                     /note="AMP-binding enzyme; acyl-coenzyme A synthetase
                     ACSM6, mitochondrial"
                     /codon_start=1
                     /product="acyl-coenzyme A synthetase ACSM6, mitochondrial
                     precursor"
                     /protein_id="NP_997204.2"
                     /db_xref="CCDS:CCDS7440.2"
                     /db_xref="GeneID:142827"
                     /db_xref="HGNC:HGNC:31665"
                     /translation="MLGRFQPFSLVRSFRLGFEACCYPNQKCATQTIRPPDSRCLVQA
                     VSQNFNFAKDVLDQWSQLEKDGLRGPYPALWKVSAKGEEDKWSFERMTQLSKKAASIL
                     SDTCALSHGDRLMIILPPTPEAYWICLACVRLGITFVPGSPQLTAKKIRYQLRMSKAQ
                     CIVANEAMAPVVNSAVSDCPTLKTKLLVSDKSYDGWLDFKKLIQVAPPKQTYMRTKSQ
                     DPMAIFFTKGTTGAPKMVEYSQYGLGMGFSQASRRWMDLQPTDVLWSLGDAFGGSLSL
                     SAVLGTWFQGACVFLCHMPTFCPETVLNVLSRFPITTLSANPEMYQELLQHKCFTSYR
                     FKSLKQCVAAGGPISPGVIEDWKRITKLDIYEGYGQTETGLLCATSKTIKLKPSSLGK
                     PLPPYIVQIVDENSNLLPPGEEGNIAIRIKLNQPASLYCPHMVSWEEYASARGHMLYL
                     TGDRGIMDEDGYFWWSGRVDDVANALGQRL"
     exon            280..490
                     /gene="ACSM6"
                     /gene_synonym="bA310E22.3; C10orf129"
                     /inference="alignment:Splign:2.1.0"
     exon            491..698
                     /gene="ACSM6"
                     /gene_synonym="bA310E22.3; C10orf129"
                     /inference="alignment:Splign:2.1.0"
     exon            699..842
                     /gene="ACSM6"
                     /gene_synonym="bA310E22.3; C10orf129"
                     /inference="alignment:Splign:2.1.0"
     exon            843..999
                     /gene="ACSM6"
                     /gene_synonym="bA310E22.3; C10orf129"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1082
                     /gene="ACSM6"
                     /gene_synonym="bA310E22.3; C10orf129"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1206
                     /gene="ACSM6"
                     /gene_synonym="bA310E22.3; C10orf129"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1287
                     /gene="ACSM6"
                     /gene_synonym="bA310E22.3; C10orf129"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1389
                     /gene="ACSM6"
                     /gene_synonym="bA310E22.3; C10orf129"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1675
                     /gene="ACSM6"
                     /gene_synonym="bA310E22.3; C10orf129"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaggcaac agctctacca tcctccaaac atctgaagcc ccccatagaa actcctcttg
       61 gaattggtgg ttccctgtct gacccaaatg ctaggccgat ttcaaccctt ctccttggtc
      121 cggagtttca gactgggatt tgaagcctgc tgctatccaa accaaaaatg tgctactcag
      181 accatcagac cccctgactc caggtgccta gtccaagcag tttctcagaa ctttaatttt
      241 gcaaaggatg tgttggatca gtggtcccag ctggaaaagg acggactcag agggccttac
      301 cccgccctct ggaaggttag tgccaaagga gaagaggaca aatggagctt tgaaaggatg
      361 actcaactct ccaagaaggc cgccagcatc ctctcagaca cctgtgccct tagccatgga
      421 gaccggctga tgataatctt gcccccaaca cctgaagcct actggatctg cctggcctgt
      481 gtgcgcttgg gaatcacctt tgtgcctggg agcccccagc tgactgccaa gaaaattcgc
      541 tatcaattac gcatgtctaa ggcccagtgc attgtggcta atgaagctat ggccccagtt
      601 gtaaactctg ccgtgtccga ctgccccacc ttgaaaacca agctcctggt gtcagataag
      661 agctatgatg ggtggttgga tttcaagaag ttgattcaag ttgcccctcc aaagcagacc
      721 tacatgagga ccaaaagcca agatccaatg gccatattct tcaccaaggg tacaacagga
      781 gctcccaaaa tggtcgagta ttcccagtat ggtttgggaa tgggattcag ccaggcttcc
      841 agacggtgga tggatctcca gccaacagat gtcttgtgga gtctgggtga tgcctttggt
      901 ggatctttat ccctgagcgc tgtcttggga acttggttcc aaggagcctg tgtgtttctg
      961 tgtcacatgc caaccttctg ccctgagact gttctaaatg tcctgtccag atttcccatc
     1021 accactctat ctgcaaatcc agagatgtac caggaactgc ttcagcacaa gtgtttcacc
     1081 agctacagat tcaagagtct gaagcagtgt gtggctgcag gaggacccat cagccctggg
     1141 gtgattgagg actggaaacg catcactaag ttggacatct atgaaggcta tgggcagacg
     1201 gaaactggtc tactctgtgc cacttccaaa acaataaaat tgaagccaag ctctctgggg
     1261 aagccattgc caccttatat tgtccagatt gtggatgaaa actcaaatct cctgcctcca
     1321 ggggaagaag gaaatattgc aatccgcata aaactaaacc aacctgcttc tctgtactgt
     1381 ccacacatgg tgagctggga ggaatatgct tcagcaagag gccacatgct ttacctcaca
     1441 ggtgacagag ggatcatgga tgaagacggc tacttctggt ggtctggtag agttgatgat
     1501 gttgccaatg cattgggtca gagattgtga atgctttggt tattgctatt gagcctgggg
     1561 ctgtgggagt ttgaagaaga ctctggactg cttccaatac gtaggaatta tatttctaaa
     1621 gtttagaaaa tgcaaacaac caaaaataaa aaaataaaac tcatccataa tctca
//
