LOCUS       NM_001080454            2349 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens acyl-CoA synthetase medium chain family member 4
            (ACSM4), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001080454 XM_292035
VERSION     NM_001080454.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2349)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2349)
  AUTHORS   Guzman-Fulgencio,M., Jimenez,J.L., Jimenez-Sousa,M.A., Bellon,J.M.,
            Garcia-Alvarez,M., Soriano,V., Gijon-Vidaurreta,P.,
            Bernal-Morell,E., Viciana,P., Munoz-Fernandez,M.A. and Resino,S.
  TITLE     ACSM4 polymorphisms are associated with rapid AIDS progression in
            HIV-infected patients
  JOURNAL   J Acquir Immune Defic Syndr 65 (1), 27-32 (2014)
   PUBMED   23982661
  REMARK    GeneRIF: SNPs associated with rapid AIDS progression
REFERENCE   3  (bases 1 to 2349)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2349)
  AUTHORS   Watkins,P.A., Maiguel,D., Jia,Z. and Pevsner,J.
  TITLE     Evidence for 26 distinct acyl-coenzyme A synthetase genes in the
            human genome
  JOURNAL   J Lipid Res 48 (12), 2736-2750 (2007)
   PUBMED   17762044
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131205.3.
            
            On Jan 27, 2021 this sequence version replaced NM_001080454.1.
            
            Sequence Note:.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399422.5/ ENSP00000382349.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-461               AC131205.3         69109-69569         c
            462-672             AC131205.3         66898-67108         c
            673-880             AC131205.3         62895-63102         c
            881-1024            AC131205.3         56361-56504         c
            1025-1181           AC131205.3         55459-55615         c
            1182-1261           AC131205.3         52837-52916         c
            1262-1385           AC131205.3         51100-51223         c
            1386-1466           AC131205.3         50327-50407         c
            1467-1568           AC131205.3         50081-50182         c
            1569-1696           AC131205.3         49241-49368         c
            1697-1796           AC131205.3         49043-49142         c
            1797-1916           AC131205.3         46546-46665         c
            1917-2349           AC131205.3         44922-45354         c
FEATURES             Location/Qualifiers
     source          1..2349
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..2349
                     /gene="ACSM4"
                     /note="acyl-CoA synthetase medium chain family member 4"
                     /db_xref="GeneID:341392"
                     /db_xref="HGNC:HGNC:32016"
                     /db_xref="MIM:614360"
     exon            1..461
                     /gene="ACSM4"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..2003
                     /gene="ACSM4"
                     /EC_number="6.2.1.2"
                     /note="acyl-coenzyme A synthetase ACSM4, mitochondrial"
                     /codon_start=1
                     /product="acyl-coenzyme A synthetase ACSM4, mitochondrial
                     precursor"
                     /protein_id="NP_001073923.1"
                     /db_xref="CCDS:CCDS44825.1"
                     /db_xref="GeneID:341392"
                     /db_xref="HGNC:HGNC:32016"
                     /db_xref="MIM:614360"
                     /translation="MKIFFRYQTFRFIWLTKPPGRRLHKDHQLWTPLTLADFEAINRC
                     NRPLPKNFNFAADVLDQWSQKEKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAA
                     NVLTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRAS
                     KAKCIVASEEVAPAVESIVLECPDLKTKLLVSPQSWNGWLSFQELFQFASEEHSCVET
                     GSQEPMTIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVK
                     AAIGSVFSSWLCGACVFVHRMAQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQKDLKR
                     YKFKSLRHCLTGGEPLNPEVLEQWRVQTGLELYEGYGQTEVGMICANQKGQEIKPGSM
                     GKGMLPYDVQIIDENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRGDF
                     YVTGDRGVMDSDGYFWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQ
                     IRGEVVKAFVVLAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGK
                     IKRNVLRDQEWRGR"
     exon            462..672
                     /gene="ACSM4"
                     /inference="alignment:Splign:2.1.0"
     exon            673..880
                     /gene="ACSM4"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1024
                     /gene="ACSM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1181
                     /gene="ACSM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1261
                     /gene="ACSM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1385
                     /gene="ACSM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1466
                     /gene="ACSM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1568
                     /gene="ACSM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1696
                     /gene="ACSM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1796
                     /gene="ACSM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1916
                     /gene="ACSM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2349
                     /gene="ACSM4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttttagac tcatctggtc acagacagaa tgaagaggaa gggtccagtg gcagggagac
       61 cagtcagtgg ctaaggcagc agctctgagg aaggatgagg tgtttttcag gtgttcccca
      121 acttgccagg gacacacagc cacaaatcca cctcccagtc tcaccacaga gcatcaagaa
      181 actgatactc tctatccatc tctccctaca ggctgtagta cttctgtgtc catagcagta
      241 gacaaagtcc tttgggaacc atgaagattt ttttccgcta ccagacattt agattcatct
      301 ggctcaccaa gccacctggc cggcgcttac acaaagatca ccagctttgg acgcctctga
      361 ctcttgctga ctttgaagcc ataaatcgct gtaacaggcc attgcctaaa aactttaact
      421 ttgctgcaga tgtgctggac cagtggtccc aaaaggagaa gacaggggag agaccagcta
      481 acccagccct gtggtgggtg aatggcaaag gggatgaggt aaaatggagc ttcagagaac
      541 tgggctcctt gtcccgaaaa gctgccaacg tgctcaccaa gccctgtggc ctgcagagag
      601 gagaccgttt ggccgtgatt ctgcccagaa tccctgagtg gtggctggtc aatgtagctt
      661 gcatacgaac agggatcatc ttcatgccgg gaacaatcca gctgacagca aaagacatcc
      721 tctaccggct gcgagcatcc aaggccaagt gcattgtggc cagtgaggag gtggccccag
      781 cggtggagtc cattgtattg gagtgtcctg accttaagac aaaactcctg gtgtctccac
      841 aaagctggaa tgggtggctc agcttccagg agttatttca attcgcctct gaagagcaca
      901 gctgtgtgga aacaggaagt caagaaccaa tgaccattta tttcaccagt gggaccacag
      961 gctttcctaa aatggcccag cactctcaga gcagcctcgg cattgggttc accctctgcg
     1021 gaaggtattg gctggacttg aagtcctcag atatcatatg gaatatgtct gacacgggct
     1081 gggtcaaggc cgccattggc agtgtgtttt cttcctggct gtgtggagcc tgtgtttttg
     1141 tgcatcgaat ggcacagttt gacactgaca ccttcctaga cacacttact acttatccca
     1201 tcacgaccct gtgcagtcct cccactgtgt accggatgct cgtgcaaaaa gaccttaaga
     1261 gatataaatt caagagtctg cggcactgct tgaccggagg ggagccactc aacccagaag
     1321 tgctggagca gtggagggtg caaactgggc tggagctata tgagggctat ggacagacgg
     1381 aagtgggaat gatttgtgcc aatcagaaag gccaagaaat taaaccaggt tcaatgggga
     1441 aaggaatgct gccctatgat gtccagatta tagatgaaaa tggcaatgtt ctaccacctg
     1501 gcaaagaagg ggaaattgcc ctcagactca aacctacacg gcccttctgt ttcttctcta
     1561 aatatgtgga caatccacag aaaactgctg ccacgataag aggagatttt tatgtcactg
     1621 gagacagagg agtgatggac agtgatgggt atttctggtt tgtcggcaga gctgatgatg
     1681 tcattatatc ctctgggtac cgtattgggc catttgaagt ggagagtgca ctcattgagc
     1741 atccagcagt tgttgaatcg gctgttgtca gtagtccaga tcaaatccgc ggagaggtgg
     1801 tgaaagcttt tgttgtctta gctgcaccct ttaagtccta caacccagag aaattaactc
     1861 ttgaacttca ggatcatgtg aaaaaatcaa ctgcacctta caaatatcca agaaaggtgg
     1921 aatttgttca agaactccca aagacaatca ctgggaaaat caaacgcaac gttttaagag
     1981 accaagaatg gagaggaaga tagtttgata acaaagctga agggttaagc agtaatatgg
     2041 ttgctttctt ttagtatttg ttccgataat tcagcgacta ctctcttaaa atgtttaaga
     2101 tctttcctgc ttgaaaactc aactgttgat tttttggttt ttacttagct aaaaagttta
     2161 aaagtaaata aaagcctcaa aaacgtatgg atgaaaattg ttataatgac caaactgaca
     2221 aaggtaatga tgatgatttg tagtgtttaa aatagcagga ataaaatgat tgcttagaac
     2281 aagaaagtgc acattgaatc tgtatttcat ttaccttgtg cctgattgat tcaaaataaa
     2341 catatatcc
//
