LOCUS       NM_005622               2533 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens acyl-CoA synthetase medium chain family member 3
            (ACSM3), transcript variant 1, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_005622
VERSION     NM_005622.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2533)
  AUTHORS   Zhu,W., Wei,X. and Fang,M.
  TITLE     Acyl-CoA Medium-Chain Synthetase-3 (ACSM3) Is Regulated by Insulin
            Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) and Inhibits
            Proliferation, Motility and Stem Cell Properties of Breast Invasive
            Carcinoma
  JOURNAL   Ann Clin Lab Sci 53 (4), 539-547 (2023)
   PUBMED   37625834
  REMARK    GeneRIF: Acyl-CoA Medium-Chain Synthetase-3 (ACSM3) Is Regulated by
            Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) and
            Inhibits Proliferation, Motility and Stem Cell Properties of Breast
            Invasive Carcinoma.
REFERENCE   2  (bases 1 to 2533)
  AUTHORS   Yang,X., Wu,G., Zhang,Q., Chen,X., Li,J., Han,Q., Yang,L., Wang,C.,
            Huang,M., Li,Y., Chen,J., LiLi, Wang,H. and Liu,K.
  TITLE     ACSM3 suppresses the pathogenesis of high-grade serous ovarian
            carcinoma via promoting AMPK activity
  JOURNAL   Cell Oncol (Dordr) 45 (1), 151-161 (2022)
   PUBMED   35124784
  REMARK    GeneRIF: ACSM3 suppresses the pathogenesis of high-grade serous
            ovarian carcinoma via promoting AMPK activity.
REFERENCE   3  (bases 1 to 2533)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 2533)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2533)
  AUTHORS   Gopal,R., Selvarasu,K., Pandian,P.P. and Ganesan,K.
  TITLE     Integrative transcriptome analysis of liver cancer profiles
            identifies upstream regulators and clinical significance of ACSM3
            gene expression
  JOURNAL   Cell Oncol (Dordr) 40 (3), 219-233 (2017)
   PUBMED   28390038
  REMARK    GeneRIF: Our data provide evidence for a differential expression
            and regulation of the ACSM3 gene in hepatocellular carcinoma
REFERENCE   6  (bases 1 to 2533)
  AUTHORS   Gumprecht,J., Zychma,M.J., Grzeszczak,W. and
            Zukowska-Szczechowska,E.
  CONSRTM   End-stage Renal Disease Study Group
  TITLE     Human SA gene Pst1 polymorphism and chronic renal failure: results
            of the family-based study
  JOURNAL   Nephrol Dial Transplant 16 (2), 387-390 (2001)
   PUBMED   11158418
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2533)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
REFERENCE   8  (bases 1 to 2533)
  AUTHORS   Nabika,T., Bonnardeaux,A., James,M., Julier,C., Jeunemaitre,X.,
            Corvol,P., Lathrop,M. and Soubrier,F.
  TITLE     Evaluation of the SA locus in human hypertension
  JOURNAL   Hypertension 25 (1), 6-13 (1995)
   PUBMED   7843754
REFERENCE   9  (bases 1 to 2533)
  AUTHORS   Samani,N.J., Whitmore,S.A., Kaiser,M.A., Harris,J., See,C.G.,
            Callen,D.F. and Lodwick,D.
  TITLE     Chromosomal assignment of the human SA gene to 16p13.11 and
            demonstration of its expression in the kidney
  JOURNAL   Biochem Biophys Res Commun 199 (2), 862-868 (1994)
   PUBMED   8135833
REFERENCE   10 (bases 1 to 2533)
  AUTHORS   Iwai,N., Ohmichi,N., Hanai,K., Nakamura,Y. and Kinoshita,M.
  TITLE     Human SA gene locus as a candidate locus for essential hypertension
  JOURNAL   Hypertension 23 (3), 375-380 (1994)
   PUBMED   7907320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI770558.1, X80062.1, D16350.1, BU170035.1, BM828310.1 and
            AC004381.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005622.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.169679.1,
                                           SRR5189661.67996.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289416.10/ ENSP00000289416.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BI770558.1         25-58
            35-1387             X80062.1           8-1360
            1388-1550           D16350.1           1252-1414
            1551-1791           BU170035.1         427-667
            1792-1867           D16350.1           1656-1731
            1868-2109           BM828310.1         287-528
            2110-2533           AC004381.1         153513-153936
FEATURES             Location/Qualifiers
     source          1..2533
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..2533
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /note="acyl-CoA synthetase medium chain family member 3"
                     /db_xref="GeneID:6296"
                     /db_xref="HGNC:HGNC:10522"
                     /db_xref="MIM:145505"
     exon            1..112
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /inference="alignment:Splign:2.1.0"
     exon            113..382
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1924
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /EC_number="6.2.1.2"
                     /EC_number="6.2.1.17"
                     /note="isoform 1 is encoded by transcript variant 1; SA
                     (rat hypertension-associated) homolog; acyl-coenzyme A
                     synthetase ACSM3, mitochondrial; SA
                     hypertension-associated homolog; protein SA homolog;
                     butyrate--CoA ligase 3; butyryl-coenzyme A synthetase 3;
                     middle-chain acyl-CoA synthetase 3; propionate--CoA
                     ligase"
                     /codon_start=1
                     /product="acyl-coenzyme A synthetase ACSM3, mitochondrial
                     isoform 1"
                     /protein_id="NP_005613.2"
                     /db_xref="CCDS:CCDS10589.1"
                     /db_xref="GeneID:6296"
                     /db_xref="HGNC:HGNC:10522"
                     /db_xref="MIM:145505"
                     /translation="MLARVTRKMLRHAKCFQRLAIFGSVRALHKDNRTATPQNFSNYE
                     SMKQDFKLGIPEYFNFAKDVLDQWTDKEKAGKKPSNPAFWWINRNGEEMRWSFEELGS
                     LSRKFANILSEACSLQRGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQLTQKDIL
                     YRLQSSKANCIITNDVLAPAVDAVASKCENLHSKLIVSENSREGWGNLKELMKHASDS
                     HTCVKTKHNEIMAIFFTSGTSGYPKMTAHTHSSFGLGLSVNGRFWLDLTPSDVMWNTS
                     DTGWAKSAWSSVFSPWIQGACVFTHHLPRFEPTSILQTLSKYPITVFCSAPTVYRMLV
                     QNDITSYKFKSLKHCVSAGEPITPDVTEKWRNKTGLDIYEGYGQTETVLICGNFKGMK
                     IKPGSMGKPSPAFDVKIVDVNGNVLPPGQEGDIGIQVLPNRPFGLFTHYVDNPSKTAS
                     TLRGNFYITGDRGYMDKDGYFWFVARADDVILSSGYRIGPFEVENALNEHPSVAESAV
                     VSSPDPIRGEVVKAFVVLNPDYKSHDQEQLIKEIQEHVKKTTAPYKYPRKVEFIQELP
                     KTISGKTKRNELRKKEWKTI"
     exon            383..593
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /inference="alignment:Splign:2.1.0"
     exon            594..801
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /inference="alignment:Splign:2.1.0"
     exon            802..945
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1102
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1182
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1306
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1387
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1489
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1617
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1717
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1837
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..2533
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2084..2089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /note="hexamer: AATAAA"
     polyA_site      2109
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /note="major polyA site"
     regulatory      2512..2517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
                     /note="hexamer: AATAAA"
     polyA_site      2533
                     /gene="ACSM3"
                     /gene_synonym="SA; SAH"
ORIGIN      
        1 cttctttaga ctgccacgag gaaaaagcag atgtgagaac tcaaggttca gggctgctct
       61 tctaagaaac aagtctgcca taatctccat ctgtgttgga atctgttaac taatgaactg
      121 gtctctgtgc aaatcctgag tgctaaagct tccaacaaga ctgatgctag ctcgtgtcac
      181 caggaagatg ctacgtcatg ccaagtgttt tcagcgccta gcaatttttg gttctgtgag
      241 ggcactgcat aaagataata gaacagcaac ccctcagaat ttctccaact atgaatccat
      301 gaaacaggac ttcaaactgg ggattccaga gtatttcaac tttgctaaag atgtcctgga
      361 ccaatggact gataaggaaa aggctggaaa gaaaccttca aatccagcct tctggtggat
      421 caacagaaat ggagaagaga tgcgatggag ttttgaggaa ctgggatctc tgtccagaaa
      481 atttgccaat atactttcag aagcctgttc cctacaaaga ggagatcggg taattctgat
      541 tctgcccagg gtcccagagt ggtggcttgc aaatgtggcc tgtctgcgaa cagggacagt
      601 tttaattcca ggaaccactc agctgaccca gaaagacatt ctctacagac tacaatcttc
      661 aaaagcaaac tgcattatca ccaatgatgt tttagcccca gcagtagacg ctgttgcatc
      721 caaatgtgaa aatctgcact ccaagctgat tgtatcagag aactccagag aggggtgggg
      781 gaacctcaag gagttgatga aacatgccag tgacagccac acctgtgtga agacaaaaca
      841 caatgagatc atggccatat tctttaccag tggaacaagt ggatatccga aaatgactgc
      901 acacacccac agcagttttg gtttaggatt atctgtaaat ggaaggttct ggctagattt
      961 gacaccctca gatgtgatgt ggaatacctc agatacgggc tgggcaaagt ctgcatggag
     1021 tagtgttttt tctccgtgga tccagggagc atgtgtattc acacaccatt taccccgttt
     1081 tgagccgact tctatcttgc aaacactctc caagtacccc atcacagtct tctgttcagc
     1141 accaactgta taccgaatgc ttgtacagaa tgatataacc agctataagt ttaaaagctt
     1201 aaagcactgt gtgagtgctg gggaaccaat tacccctgac gtgactgaaa aatggagaaa
     1261 caagacgggc ctggatatct acgaaggata tggacagact gaaacggtgc taatctgtgg
     1321 aaattttaag ggaatgaaaa ttaaacctgg ctcaatggga aaaccttctc ctgctttcga
     1381 tgttaagatt gtagatgtaa atggcaatgt tctacctcct ggacaagaag gagatattgg
     1441 cattcaagtt ctacccaacc gaccatttgg cctttttact cattacgtag ataatccttc
     1501 aaaaacagct tcaactctac gaggcaattt ctatatcact ggggacagag gatatatgga
     1561 taaagatggg tatttctggt ttgttgcaag agcagatgat gtcatattat cctctggcta
     1621 tcgaattgga ccatttgagg tagaaaatgc cctgaatgaa cacccttcag ttgcagagtc
     1681 agctgttgtc agcagcccag accccatcag aggagaggta gtaaaggctt ttgtcgttct
     1741 aaatcctgat tacaagtcac atgatcaaga acaactaata aaggagattc aggagcatgt
     1801 taaaaaaact acagcacctt acaaatatcc cagaaaggta gaatttattc aagagctgcc
     1861 aaagactatc agtgggaaga caaaaagaaa tgaactgagg aagaaagaat ggaagacaat
     1921 ttaaagttgt ttcattaatt accatatcta taaaacaaac atagtatctg tcaatctcta
     1981 gaaaccacaa gatgatggag aggtcataaa aactgtggta gtatgcttag aaactgttga
     2041 tttaaaatat cttgtggtta tgatatcaga ggctaaattt tgaaataaaa tatttggcaa
     2101 attcctccac attagtgtca atgttcctat catttcttaa tataaaaata ataccatcaa
     2161 ttgctgatta atttttaaat gtatagtata gaagcagttt ctgaaccaga tctctgctac
     2221 ataggttttc aaactttagt tgactaattc ttctgatatg ttgatataca aatcagaacc
     2281 aatgttcaag cctgaaataa aactaaagaa cttataaaag tttttagaaa aatataaaat
     2341 atcagttaga agattatgat aatctcaaag tacaagaatc tacctgaaaa tagactaggg
     2401 atttttatta gtcacatttt ttgcaaataa tttaaaaata gtttagactt gtttcaaggt
     2461 ctaactataa aagaaggatc atatactatt gttgcttatt atatgtaatc taataaatac
     2521 tgtttacaaa aga
//
