LOCUS       NM_203379               3253 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens acyl-CoA synthetase long chain family member 5
            (ACSL5), transcript variant 2, mRNA.
ACCESSION   NM_203379
VERSION     NM_203379.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3253)
  AUTHORS   Ye,W., Wang,J., Huang,J., He,X., Ma,Z., Li,X., Huang,X., Li,F.,
            Huang,S., Pan,J., Jin,J., Ling,Q., Wang,Y., Yu,Y., Sun,J. and
            Jin,J.
  TITLE     ACSL5, a prognostic factor in acute myeloid leukemia, modulates the
            activity of Wnt/beta-catenin signaling by palmitoylation
            modification
  JOURNAL   Front Med 17 (4), 685-698 (2023)
   PUBMED   37131085
  REMARK    GeneRIF: ACSL5, a prognostic factor in acute myeloid leukemia,
            modulates the activity of Wnt/beta-catenin signaling by
            palmitoylation modification.
REFERENCE   2  (bases 1 to 3253)
  AUTHORS   Zhang,Q., Xiong,L., Wei,T., Liu,Q., Yan,L., Chen,J., Dai,L.,
            Shi,L., Zhang,W., Yang,J., Roessler,S. and Liu,L.
  TITLE     Hypoxia-responsive PPARGC1A/BAMBI/ACSL5 axis promotes progression
            and resistance to lenvatinib in hepatocellular carcinoma
  JOURNAL   Oncogene 42 (19), 1509-1523 (2023)
   PUBMED   36932115
  REMARK    GeneRIF: Hypoxia-responsive PPARGC1A/BAMBI/ACSL5 axis promotes
            progression and resistance to lenvatinib in hepatocellular
            carcinoma.
REFERENCE   3  (bases 1 to 3253)
  AUTHORS   Li,S. and Yuan,Z.
  TITLE     More than just a histone deacetylase: cytoplasmic SIRT6 facilitates
            fatty acid oxidation through ACSL5 deacetylation
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (3), 525-527 (2023)
   PUBMED   36880305
  REMARK    GeneRIF: More than just a histone deacetylase: cytoplasmic SIRT6
            facilitates fatty acid oxidation through ACSL5 deacetylation.
REFERENCE   4  (bases 1 to 3253)
  AUTHORS   Zhang,L., Liu,X., Liu,Y., Yan,F., Zeng,Y., Song,Y., Fang,H.,
            Song,D. and Wang,X.
  TITLE     Lysophosphatidylcholine inhibits lung cancer cell proliferation by
            regulating fatty acid metabolism enzyme long-chain acyl-coenzyme A
            synthase 5
  JOURNAL   Clin Transl Med 13 (1), e1180 (2023)
   PUBMED   36639836
  REMARK    GeneRIF: Lysophosphatidylcholine inhibits lung cancer cell
            proliferation by regulating fatty acid metabolism enzyme long-chain
            acyl-coenzyme A synthase 5.
REFERENCE   5  (bases 1 to 3253)
  AUTHORS   de Luis,D., Izaola,O., Primo,D. and Pacheco,D.
  TITLE     The gene variant rs2419621 of ACYL-CoA synthetase long-chain 5 gene
            is associated with weight loss and metabolic changes in response to
            a robotic sleeve gastrectomy in morbid obese subjects
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (22), 7037-7043 (2021)
   PUBMED   34859867
  REMARK    GeneRIF: The gene variant rs2419621 of ACYL-CoA synthetase
            long-chain 5 gene is associated with weight loss and metabolic
            changes in response to a robotic sleeve gastrectomy in morbid obese
            subjects.
REFERENCE   6  (bases 1 to 3253)
  AUTHORS   Lewin,T.M., Van Horn,C.G., Krisans,S.K. and Coleman,R.A.
  TITLE     Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein
            located in two distinct subcellular organelles, peroxisomes, and
            mitochondrial-associated membrane
  JOURNAL   Arch Biochem Biophys 404 (2), 263-270 (2002)
   PUBMED   12147264
REFERENCE   7  (bases 1 to 3253)
  AUTHORS   Minekura,H., Kang,M.J., Inagaki,Y., Suzuki,H., Sato,H., Fujino,T.
            and Yamamoto,T.T.
  TITLE     Genomic organization and transcription units of the human acyl-CoA
            synthetase 3 gene
  JOURNAL   Gene 278 (1-2), 185-192 (2001)
   PUBMED   11707336
REFERENCE   8  (bases 1 to 3253)
  AUTHORS   Lewin,T.M., Kim,J.H., Granger,D.A., Vance,J.E. and Coleman,R.A.
  TITLE     Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different
            subcellular membranes in rat liver and can be inhibited
            independently
  JOURNAL   J Biol Chem 276 (27), 24674-24679 (2001)
   PUBMED   11319232
REFERENCE   9  (bases 1 to 3253)
  AUTHORS   Yamashita,Y., Kumabe,T., Cho,Y.Y., Watanabe,M., Kawagishi,J.,
            Yoshimoto,T., Fujino,T., Kang,M.J. and Yamamoto,T.T.
  TITLE     Fatty acid induced glioma cell growth is mediated by the acyl-CoA
            synthetase 5 gene located on chromosome 10q25.1-q25.2, a region
            frequently deleted in malignant gliomas
  JOURNAL   Oncogene 19 (51), 5919-5925 (2000)
   PUBMED   11127823
REFERENCE   10 (bases 1 to 3253)
  AUTHORS   Lehner,R. and Kuksis,A.
  TITLE     Biosynthesis of triacylglycerols
  JOURNAL   Prog Lipid Res 35 (2), 169-201 (1996)
   PUBMED   8944226
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL157786.13, AK000339.1,
            CF595490.1, AY358520.1 and AK024932.1.
            
            On Jun 2, 2019 this sequence version replaced NM_203379.1.
            
            Summary: The protein encoded by this gene is an isozyme of the
            long-chain fatty-acid-coenzyme A ligase family. Although differing
            in substrate specificity, subcellular localization, and tissue
            distribution, all isozymes of this family convert free long-chain
            fatty acids into fatty acyl-CoA esters, and thereby play a key role
            in lipid biosynthesis and fatty acid degradation. This isozyme is
            highly expressed in uterus and spleen, and in trace amounts in
            normal brain, but has markedly increased levels in malignant
            gliomas. This gene functions in mediating fatty acid-induced glioma
            cell growth. Three transcript variants encoding two different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding region compared to variant 1. This results in translation
            initiation from a downstream ATG and an isoform (b) that has a
            shorter N-terminus compared to isoform a. Both variants 2 and 3
            encode isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000339.1, SRR1660803.91901.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354655.9/ ENSP00000346680.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AL157786.13        67208-67249
            43-102              AK000339.1         150-209
            103-680             CF595490.1         64-641
            681-2905            AY358520.1         739-2963
            2906-3253           AK024932.1         3004-3351
FEATURES             Location/Qualifiers
     source          1..3253
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.2"
     gene            1..3253
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /note="acyl-CoA synthetase long chain family member 5"
                     /db_xref="GeneID:51703"
                     /db_xref="HGNC:HGNC:16526"
                     /db_xref="MIM:605677"
     exon            1..154
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            155..339
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2235
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /note="isoform b is encoded by transcript variant 2;
                     long-chain acyl-CoA synthetase 5; fatty-acid-Coenzyme A
                     ligase, long-chain 5; FACL5 for fatty acid coenzyme A
                     ligase 5; long-chain fatty acid coenzyme A ligase 5;
                     long-chain-fatty-acid--CoA ligase 5; LACS 5;
                     arachidonate--CoA ligase"
                     /codon_start=1
                     /product="long-chain-fatty-acid--CoA ligase 5 isoform b"
                     /protein_id="NP_976313.1"
                     /db_xref="CCDS:CCDS7573.1"
                     /db_xref="GeneID:51703"
                     /db_xref="HGNC:HGNC:16526"
                     /db_xref="MIM:605677"
                     /translation="MLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDL
                     NNQSVGIEGGARKGVSQKNNDLTSCCFSDAKTMYEVFQRGLAVSDNGPCLGYRKPNQP
                     YRWLSYKQVSDRAEYLGSCLLHKGYKSSPDQFVGIFAQNRPEWIISELACYTYSMVAV
                     PLYDTLGPEAIVHIVNKADIAMVICDTPQKALVLIGNVEKGFTPSLKVIILMDPFDDD
                     LKQRGEKSGIEILSLYDAENLGKEHFRKPVPPSPEDLSVICFTSGTTGDPKGAMITHQ
                     NIVSNAAAFLKCVEHAYEPTPDDVAISYLPLAHMFERIVQAVVYSCGARVGFFQGDIR
                     LLADDMKTLKPTLFPAVPRLLNRIYDKVQNEAKTPLKKFLLKLAVSSKFKELQKGIIR
                     HDSFWDKLIFAKIQDSLGGRVRVIVTGAAPMSTSVMTFFRAAMGCQVYEAYGQTECTG
                     GCTFTLPGDWTSGHVGVPLACNYVKLEDVADMNYFTVNNEGEVCIKGTNVFKGYLKDP
                     EKTQEALDSDGWLHTGDIGRWLPNGTLKIIDRKKNIFKLAQGEYIAPEKIENIYNRSQ
                     PVLQIFVHGESLRSSLVGVVVPDTDVLPSFAAKLGVKGSFEELCQNQVVREAILEDLQ
                     KIGKESGLKTFEQVKAIFLHPEPFSIENGLLTPTLKAKRGELSKYFRTQIDSLYEHIQ
                     D"
     exon            340..448
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            449..513
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            514..615
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            616..715
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            716..894
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            895..927
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            928..979
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1053
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1131
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1266
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1401
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1497
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1570
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1659
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1776
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1920
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2022
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2094
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..3253
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2409..2414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /note="hexamer: AATAAA"
     polyA_site      2432
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /note="major polyA site"
     regulatory      3236..3241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /note="hexamer: AATAAA"
     polyA_site      3253
                     /gene="ACSL5"
                     /gene_synonym="ACS2; ACS5; DIAR13; FACL5"
                     /note="major polyA site"
ORIGIN      
        1 actctcagga cagtacacag tagcttcggg tgtgtcccag tcagtcctag gagctgtgga
       61 aagagtagaa gtgcctgaat gtggtgctga atcaatacag ccagctgtga ggggagcact
      121 tcctggaccc aggaagggag agtcttcttc caaggtctga atttcctgct gctgttcaca
      181 aagatgcttt ttatctttaa ctttttgttt tccccacttc cgaccccggc gttgatctgc
      241 atcctgacat ttggagctgc catcttcttg tggctgatca ccagacctca acccgtctta
      301 cctcttcttg acctgaacaa tcagtctgtg ggaattgagg gaggagcacg gaagggggtt
      361 tcccagaaga acaatgacct aacaagttgc tgcttctcag atgccaagac tatgtatgag
      421 gttttccaaa gaggactcgc tgtgtctgac aatgggccct gcttgggata tagaaaacca
      481 aaccagccct acagatggct atcttacaaa caggtgtctg atagagcaga gtacctgggt
      541 tcctgtctct tgcataaagg ttataaatca tcaccagacc agtttgtcgg catctttgct
      601 cagaataggc cagagtggat catctccgaa ttggcttgtt acacgtactc tatggtagct
      661 gtacctctgt atgacacctt gggaccagaa gccatcgtac atattgtcaa caaggctgat
      721 atcgccatgg tgatctgtga cacaccccaa aaggcattgg tgctgatagg gaatgtagag
      781 aaaggcttca ccccgagcct gaaggtgatc atccttatgg acccctttga tgatgacctg
      841 aagcaaagag gggagaagag tggaattgag atcttatccc tatatgatgc tgagaaccta
      901 ggcaaagagc acttcagaaa acctgtgcct cctagcccag aagacctgag cgtcatctgc
      961 ttcaccagtg ggaccacagg tgaccccaaa ggagccatga taacccatca aaatattgtt
     1021 tcaaatgctg ctgcctttct caaatgtgtg gagcatgctt atgagcccac tcctgatgat
     1081 gtggccatat cctacctccc tctggctcat atgtttgaga ggattgtaca ggctgttgtg
     1141 tacagctgtg gagccagagt tggattcttc caaggggata ttcggttgct ggctgacgac
     1201 atgaagactt tgaagcccac attgtttccc gcggtgcctc gactccttaa caggatctac
     1261 gataaggtac aaaatgaggc caagacaccc ttgaagaagt tcttgttgaa gctggctgtt
     1321 tccagtaaat tcaaagagct tcaaaagggt atcatcaggc atgatagttt ctgggacaag
     1381 ctcatctttg caaagatcca ggacagcctg ggcggaaggg ttcgtgtaat tgtcactgga
     1441 gctgccccca tgtccacttc agtcatgaca ttcttccggg cagcaatggg atgtcaggtg
     1501 tatgaagctt atggtcaaac agaatgcaca ggtggctgta catttacatt acctggggac
     1561 tggacatcag gtcacgttgg ggtgcccctg gcttgcaatt acgtgaagct ggaagatgtg
     1621 gctgacatga actactttac agtgaataat gaaggagagg tctgcatcaa gggtacaaac
     1681 gtgttcaaag gatacctgaa ggaccctgag aagacacagg aagccctgga cagtgatggc
     1741 tggcttcaca caggagacat tggtcgctgg ctcccgaatg gaactctgaa gatcatcgac
     1801 cgtaaaaaga acattttcaa gctggcccaa ggagaataca ttgcaccaga gaagatagaa
     1861 aatatctaca acaggagtca accagtgtta caaatttttg tacacgggga gagcttacgg
     1921 tcatccttag taggagtggt ggttcctgac acagatgtac ttccctcatt tgcagccaag
     1981 cttggggtga agggctcctt tgaggaactg tgccaaaacc aagttgtaag ggaagccatt
     2041 ttagaagact tgcagaaaat tgggaaagaa agtggcctta aaacttttga acaggtcaaa
     2101 gccatttttc ttcatccaga gccattttcc attgaaaatg ggctcttgac accaacattg
     2161 aaagcaaagc gaggagagct ttccaaatac tttcggaccc aaattgacag cctgtatgag
     2221 cacatccagg attaggataa ggtacttaag tacctgccgg cccactgtgc actgcttgtg
     2281 agaaaatgga ttaaaaacta ttcttacatt tgttttgcct ttcctcctat ttttttttaa
     2341 cctgttaaac tctaaagcca tagcttttgt tttatattga gacatataat gtgtaaactt
     2401 agttcccaaa taaatcaatc ctgtctttcc catcttcgat gttgctaata ttaaggcttc
     2461 agggctactt ttatcaacat gcctgtcttc aagatcccag tttatgttct gtgtccttcc
     2521 tcatgatttc caaccttaat actattagta accacaagtt caagggtcaa agggaccctc
     2581 tgtgccttct tctttgtttt gtgataaaca taacttgcca acagtctcta tgcttattta
     2641 catcttctac tgttcaaact aagagatttt taaattctga aaaactgctt acaattcatg
     2701 ttttctagcc actccacaaa ccactaaaat tttagtttta gcctatcact catgtcaatc
     2761 atatctatga gacaaatgtc tccgatgctc ttctgcgtaa attaaattgt gtactgaagg
     2821 gaaaagtttg atcataccaa acatttccta aactctctag ttagatatct gacttgggag
     2881 tattaaaaat tgggtctatg acatattgtc caaaaggaat gctgttctta aagcattatt
     2941 tacagtagga actggggagt aaatctgttc cctacagttt gctgctgagc tggaagctgt
     3001 gggggaagga gttgacaggt gggcccagtg aacttttcca gtaaatgaag caagcactga
     3061 ataaaaacct cctgaactgg gaacaaagat ctacaggcaa gcaagatgcc cacacaacag
     3121 gcttattttc tgtgaaggaa ccaactgatc tcccccaccc ttggattaga gttcctgctc
     3181 taccttaccc acagataaca catgttgttt ctacttgtaa atgtaaagtc tttaaaataa
     3241 actattacag ata
//
