LOCUS       NM_001318510            4891 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens acyl-CoA synthetase long chain family member 4
            (ACSL4), transcript variant 4, mRNA.
ACCESSION   NM_001318510 XM_005262110
VERSION     NM_001318510.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4891)
  AUTHORS   Wu,Y., Wu,Z., Yao,M., Liu,L., Song,Y., Ma,L. and Liu,C.
  TITLE     GABPA inhibits tumorigenesis in clear cell renal cell carcinoma by
            regulating ferroptosis through ACSL4
  JOURNAL   Sci Rep 14 (1), 26521 (2024)
   PUBMED   39489850
  REMARK    GeneRIF: GABPA inhibits tumorigenesis in clear cell renal cell
            carcinoma by regulating ferroptosis through ACSL4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4891)
  AUTHORS   Zhao,Y., Ding,W., Cai,Y., Li,Q., Zhang,W., Bai,Y., Zhang,Y., Xu,Q.
            and Feng,Z.
  TITLE     The m6A eraser FTO suppresses ferroptosis via mediating ACSL4 in
            LPS-induced macrophage inflammation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167354 (2024)
   PUBMED   39004378
  REMARK    GeneRIF: The m[6]A eraser FTO suppresses ferroptosis via mediating
            ACSL4 in LPS-induced macrophage inflammation.
REFERENCE   3  (bases 1 to 4891)
  AUTHORS   Rupa,D., Chuang,H.W., Hu,C.E., Su,W.M., Wu,S.R., Lee,H.S. and
            Yuan,T.C.
  TITLE     ACSL4 upregulates IFI44 and IFI44L expression and promotes the
            proliferation and invasiveness of head and neck squamous cell
            carcinoma cells
  JOURNAL   Cancer Sci 115 (9), 3026-3040 (2024)
   PUBMED   38989827
  REMARK    GeneRIF: ACSL4 upregulates IFI44 and IFI44L expression and promotes
            the proliferation and invasiveness of head and neck squamous cell
            carcinoma cells.
REFERENCE   4  (bases 1 to 4891)
  AUTHORS   Rao,Y., Li,J., Shi,L., Chen,X., Hu,Y., Mao,Y., Zhang,X. and Liu,X.
  TITLE     Silencing CK19 regulates ferroptosis by affecting the expression of
            GPX4 and ACSL4 in oral squamous cell carcinoma in vivo and in vitro
  JOURNAL   Sci Rep 14 (1), 15968 (2024)
   PUBMED   38987531
  REMARK    GeneRIF: Silencing CK19 regulates ferroptosis by affecting the
            expression of GPX4 and ACSL4 in oral squamous cell carcinoma in
            vivo and in vitro.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4891)
  AUTHORS   Meloni,I., Muscettola,M., Raynaud,M., Longo,I., Bruttini,M.,
            Moizard,M.P., Gomot,M., Chelly,J., des Portes,V., Fryns,J.P.,
            Ropers,H.H., Magi,B., Bellan,C., Volpi,N., Yntema,H.G., Lewis,S.E.,
            Schaffer,J.E. and Renieri,A.
  TITLE     FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific
            X-linked mental retardation
  JOURNAL   Nat Genet 30 (4), 436-440 (2002)
   PUBMED   11889465
  REMARK    GeneRIF: FACL4, encoding fatty acid-CoA ligase 4, is mutated in
            nonspecific X-linked mental retardation
REFERENCE   6  (bases 1 to 4891)
  AUTHORS   Cao,Y., Traer,E., Zimmerman,G.A., McIntyre,T.M. and Prescott,S.M.
  TITLE     Cloning, expression, and chromosomal localization of human
            long-chain fatty acid-CoA ligase 4 (FACL4)
  JOURNAL   Genomics 49 (2), 327-330 (1998)
   PUBMED   9598324
REFERENCE   7  (bases 1 to 4891)
  AUTHORS   Jonsson,J.J., Renieri,A., Gallagher,P.G., Kashtan,C.E.,
            Cherniske,E.M., Bruttini,M., Piccini,M., Vitelli,F., Ballabio,A.
            and Pober,B.R.
  TITLE     Alport syndrome, mental retardation, midface hypoplasia, and
            elliptocytosis: a new X linked contiguous gene deletion syndrome?
  JOURNAL   J Med Genet 35 (4), 273-278 (1998)
   PUBMED   9598718
REFERENCE   8  (bases 1 to 4891)
  AUTHORS   Piccini,M., Vitelli,F., Bruttini,M., Pober,B.R., Jonsson,J.J.,
            Villanova,M., Zollo,M., Borsani,G., Ballabio,A. and Renieri,A.
  TITLE     FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is
            deleted in a family with Alport syndrome, elliptocytosis, and
            mental retardation
  JOURNAL   Genomics 47 (3), 350-358 (1998)
   PUBMED   9480748
REFERENCE   9  (bases 1 to 4891)
  AUTHORS   Lehner,R. and Kuksis,A.
  TITLE     Biosynthesis of triacylglycerols
  JOURNAL   Prog Lipid Res 35 (2), 169-201 (1996)
   PUBMED   8944226
  REMARK    Review article
REFERENCE   10 (bases 1 to 4891)
  AUTHORS   Knights,K.M. and Jones,M.E.
  TITLE     Inhibition kinetics of hepatic microsomal long chain fatty acid-CoA
            ligase by 2-arylpropionic acid non-steroidal anti-inflammatory
            drugs
  JOURNAL   Biochem Pharmacol 43 (7), 1465-1471 (1992)
   PUBMED   1567471
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292070.1, BC034959.2 and
            AF030555.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 14, 2019 this sequence version replaced NM_001318510.1.
            
            Summary: The protein encoded by this gene is an isozyme of the
            long-chain fatty-acid-coenzyme A ligase family. Although differing
            in substrate specificity, subcellular localization, and tissue
            distribution, all isozymes of this family convert free long-chain
            fatty acids into fatty acyl-CoA esters, and thereby play a key role
            in lipid biosynthesis and fatty acid degradation. This isozyme
            preferentially utilizes arachidonate as substrate. The absence of
            this enzyme may contribute to the cognitive disability or Alport
            syndrome. Alternative splicing of this gene generates multiple
            transcript variants. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variant 1 and 4 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB061713.1, SRR14038193.4114284.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000672401.1/ ENSP00000500273.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2136              AK292070.1         29-2164
            2137-3868           BC034959.2         2132-3863
            3869-3951           AF030555.1         4003-4085
            3952-3993           BC034959.2         3947-3988
            3994-4891           AF030555.1         4129-5026
FEATURES             Location/Qualifiers
     source          1..4891
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..4891
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /note="acyl-CoA synthetase long chain family member 4"
                     /db_xref="GeneID:2182"
                     /db_xref="HGNC:HGNC:3571"
                     /db_xref="MIM:300157"
     exon            1..119
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /inference="alignment:Splign:2.1.0"
     exon            120..172
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /inference="alignment:Splign:2.1.0"
     exon            173..412
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..2197
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /note="isoform 1 is encoded by transcript variant 4;
                     fatty-acid-Coenzyme A ligase, long-chain 4;
                     lignoceroyl-CoA synthase; long-chain-fatty-acid--CoA
                     ligase 4; acyl-CoA synthetase 4; long-chain acyl-CoA
                     synthetase 4; long-chain fatty-acid-Coenzyme A ligase 4;
                     arachidonate--CoA ligase"
                     /codon_start=1
                     /product="long-chain-fatty-acid--CoA ligase 4 isoform 1"
                     /protein_id="NP_001305439.1"
                     /db_xref="CCDS:CCDS14549.1"
                     /db_xref="GeneID:2182"
                     /db_xref="HGNC:HGNC:3571"
                     /db_xref="MIM:300157"
                     /translation="MAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDH
                     AVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNNFGSGLT
                     ALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYL
                     ITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPEGFEIHSMQSVEELGSNPEN
                     LGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIG
                     YLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVP
                     EIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLLLFKKVKALLG
                     GNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAP
                     LICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQR
                     WFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKS
                     DQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANAMKLERF
                     EIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMYGGK"
     exon            413..590
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /inference="alignment:Splign:2.1.0"
     exon            591..700
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /inference="alignment:Splign:2.1.0"
     exon            701..839
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /inference="alignment:Splign:2.1.0"
     exon            840..990
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1114
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1186
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1326
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1499
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1574
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1766
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1881
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2039
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..4891
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4869..4874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /note="hexamer: AATAAA"
     polyA_site      4891
                     /gene="ACSL4"
                     /gene_synonym="ACS4; FACL4; LACS4; MRX63; MRX68; XLID63"
                     /note="major polyA site"
ORIGIN      
        1 ctggcctccg ccgcgcgctc ctcctcgtcc cagcgctagc gggcacgcgg ttcctttttg
       61 cgagctttcc gagtgccagg cgccggccgg ctgcgaagac gcggtgggcc gcccctccga
      121 ttgaaatcac agaagatatt cgtgttcttc ttaagagaaa aagaggacat ttaagaaaaa
      181 cgctatggca aagagaataa aagctaagcc cacttcagac aaacctggaa gtccatatcg
      241 ctctgtcaca cacttcgact cactagctgt aatagacatc cctggagcag atactctgga
      301 taaattattt gaccatgctg tatccaagtt tgggaagaag gacagccttg ggaccaggga
      361 aatcctaagt gaagaaaatg aaatgcagcc aaatggaaaa gtttttaaga agttaattct
      421 tgggaattat aaatggatga actatcttga agtgaatcgc agagtgaata actttggtag
      481 tggactcact gcactgggac taaaaccaaa gaacaccatt gccatcttct gtgagaccag
      541 ggccgaatgg atgattgcag cacagacctg ctttaagtac aactttcctc ttgtgacttt
      601 atatgccaca cttggcaaag aagcagtagt tcatgggcta aatgaatctg aggcttccta
      661 tctgattacc agtgttgaac ttctggaaag taaacttaag actgcattgt tagatatcag
      721 ttgtgttaaa catatcattt atgtggacaa taaggctatc aataaagcag agtaccctga
      781 aggatttgag attcacagca tgcaatcagt agaagagttg ggatctaacc cagaaaactt
      841 gggcattcct ccaagtagac caacgccttc agacatggcc attgttatgt atactagtgg
      901 ttctactggc cgacctaagg gagtgatgat gcatcatagc aatttgatag ctggaatgac
      961 aggccagtgt gaaagaatac ctggactggg accgaaggac acatatattg gctacttgcc
     1021 tttggctcat gtgctagaac tgacagcaga gatatcttgc tttacctatg gctgcaggat
     1081 tggatattct tctccgctta cactctctga ccagtccagc aaaattaaaa aaggaagcaa
     1141 aggagactgt actgtactga agcccacact tatggctgct gttccggaaa tcatggatag
     1201 aatttataag aatgttatga gcaaagtcca agagatgaat tatattcaga aaactctgtt
     1261 caagataggg tatgattaca aattggaaca gatcaaaaag ggatatgatg cacctctttg
     1321 caatctgtta ctgtttaaaa aggtcaaggc cctgctggga gggaatgtcc gcatgatgct
     1381 gtctggaggg gccccgctat ctcctcagac acaccgattc atgaatgtct gcttctgctg
     1441 cccaattggc cagggttatg gactgacaga atcatgtggt gctgggacag ttactgaagt
     1501 aactgactat actactggca gagttggagc acctcttatt tgctgtgaaa ttaagctaaa
     1561 agactggcaa gaaggcggtt atacaattaa tgacaagcca aaccccagag gtgaaatcgt
     1621 aattggtgga cagaacatct ccatgggata ttttaaaaat gaagagaaaa cagcagaaga
     1681 ttattctgtg gatgaaaatg gacaaaggtg gttttgcact ggtgatattg gagaattcca
     1741 tcccgatgga tgtttacaga ttatagatcg taagaaagat ctagtgaagt tacaagcagg
     1801 agagtatgta tctcttggga aagtagaagc tgcactgaag aattgtccac ttattgacaa
     1861 catctgtgct tttgccaaaa gtgatcagtc ctatgtgatc agttttgtgg ttcctaacca
     1921 gaaaaggttg acacttttgg cacaacagaa aggggtagaa ggaacttggg ttgatatctg
     1981 caataatcct gctatggaag ctgaaatact gaaagaaatt cgagaagctg caaatgccat
     2041 gaaattggag cgatttgaaa ttccaatcaa ggttcgatta agcccagagc catggacccc
     2101 tgaaactggt ttggtaactg atgctttcaa actgaaaagg aaggagctga ggaaccatta
     2161 cctcaaagac attgaacgaa tgtatggggg caaataaaat gttgttgtct tattgacagt
     2221 tgtgcaggag gtagcctggt ggttttcaac ctctagaatt ttaagccttt gttgaactgt
     2281 tagaatgtaa ggtatatcat tctaaagata gagtaaaaag aaaacaaaac caaaagttat
     2341 taaaattgtt gtccggttta ctttaactta gttttgcata gttctagtgc agctgaaatt
     2401 gaaaagttat ttccctttag ctgtgttatt atagagcaga aattctgttt ttaaaaatta
     2461 gcctaagata tacttgtttt tgtaaagaaa aatatttaat gttgaacaaa ataaattgga
     2521 gttggagtag aatgtagttt gaggaaattt gcagcttcca atgcctcttg tcttcctatt
     2581 tcagaagttt aaatattaag catgacagaa aatatgtatt aacactactc aaagcaaaag
     2641 tgctgcaggg ctttaaaatt ctcttccaac catttatctt gaaggaaaaa ttcaatagta
     2701 atataataca caaaatcaaa taatacctta gaaggtatta agattataat tgttgcatag
     2761 gttagatata gagtcattgt aatgttgtga ataattacag tgcctaaaat aagaatagaa
     2821 caacatatac aacaccaaaa aatatctagt aatatattta aagggaaatt gagctgcttt
     2881 ttttgaaact ttgagatcta aaaataactg taattatttg aatgactaag aggaaagtac
     2941 attttttgaa atgctgaaaa ttgcctttct gtgtttattc aaactgaaaa gctgagacca
     3001 agagcaagga aggtaaaaag ttaacaggca aacattttct cttagaaaag gtgataaaat
     3061 cataagtatt tggaattaga acccttgcac agcactgaac ctgggaaaga gatttaaact
     3121 ctgaatttat ctttgataac agggattgat tttaaaatgt acatgtatta aattacattt
     3181 gtaatttaag gtctgtttgc tgttgctgat tttattcttg atcagtagtt tgcatttcag
     3241 aaagcctttc attttgcttt aattttagca aagcgggtta taatgaatga cttccccaat
     3301 atcttgcttg aacttacagg tgattaactt ggatgagttt tgggaagtta aagggaagaa
     3361 aacactgtta tcattttttc ctgtttggga agagcttaga aactggaaat actagatttg
     3421 ggagaagggc agagttactt gataagggac tgatgtttgt gcagtaactt gggagtgtgg
     3481 tttctttttg aatctttaat taaaacctgg gattatatat ccctgataaa tattcacact
     3541 tgaaccatag ttactgtaaa atgcaaaaaa tcttaatact gttattcttt gcactttttc
     3601 ttaatcattt tttatatata tgcatatata tatgtgtgtg tgtgtgttgc ttatgttgtt
     3661 ttgtacagat gtgggccacc attgcaacaa aatacattct ttttgctcta aaatatttat
     3721 gaagaaaata cttaaatgtt atgtatatgg tggtaataag ggaaaaatca agtattataa
     3781 acaagaatga aggtttttgt aaagatttct gttcagcgtt ttgcaaggta aaattttagg
     3841 caagttttcc ctgaagttat gtgtatgtga gtattctcat tcttcccaac ttgcctttga
     3901 agagtgaaat accattatta tcaagtagac tactgttcag cttttattcc tgccctgctg
     3961 tttatccctt aagaatgagt ttcttagact tttccaatat gtgatttttt ttcccattta
     4021 gaatggtgat tttaaatgtg tgagtgcatg tactatctta tctcagatat ttgcaccccc
     4081 aatctgcccc caactcccaa aagctagaac actgccaact gatctgttat aggtccttta
     4141 gaaacacata attaacactt aaggttgggt gctgctaatt ctttgcaaaa atccaaatat
     4201 tgttaaggga ccagggagat gccactaccc cttgattttc catctaaaaa tatacatgtt
     4261 tatgtaaaca aatctttcca tatccatagt gacttttcaa gtatttaagc ctaaagattt
     4321 tgatctcaca tttttatacc tgtttaaatt gctcacagtt attacataca catcagccat
     4381 caactaaagt tgtactttaa aaatttacta caatatgtac atttctaagt caaacacttg
     4441 tgacttttgc tttaattcca tgaatgttcc tgcctccttg atatttgtat ttattctttt
     4501 tttctctaga gtagaggtat aattgtgtga tatttcagaa atacagataa atgattcaaa
     4561 aagtcacagt taaggagaat catgtttctt tgatcatgaa taactgatta gtaagtcttg
     4621 cctatatttt cctgatagca tatgacaaat gtttctaagg taacaagatg agaacagata
     4681 aagattgtgt ggtgttttgg atttggagag aaatatttta atttttaaat gcagttacaa
     4741 attataatgt attcatattt gtactttctg ttaaaatgca tgattgcaga attgtttaga
     4801 ttttgtgttt attcttgatg aaaagctttg tttgttcttg tttttaagtt tgcactcaaa
     4861 tcttaagaaa taaatccacc catgttatca a
//
