LOCUS       NM_030924               2734 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens acyl-CoA synthetase bubblegum family member 2
            (ACSBG2), transcript variant 2, mRNA.
ACCESSION   NM_030924
VERSION     NM_030924.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2734)
  AUTHORS   Fraisl,P., Tanaka,H., Forss-Petter,S., Lassmann,H., Nishimune,Y.
            and Berger,J.
  TITLE     A novel mammalian bubblegum-related acyl-CoA synthetase restricted
            to testes and possibly involved in spermatogenesis
  JOURNAL   Arch Biochem Biophys 451 (1), 23-33 (2006)
   PUBMED   16762313
REFERENCE   2  (bases 1 to 2734)
  AUTHORS   Pei,Z., Jia,Z. and Watkins,P.A.
  TITLE     The second member of the human and murine bubblegum family is a
            testis- and brainstem-specific acyl-CoA synthetase
  JOURNAL   J Biol Chem 281 (10), 6632-6641 (2006)
   PUBMED   16371355
  REMARK    GeneRIF: The limited tissue expression pattern and limited
            substrate specificity rule out a likely role for this enzyme in
            X-linked adrenoleukodystrophy pathology.
REFERENCE   3  (bases 1 to 2734)
  AUTHORS   Zheng,Y., Zhou,Z.M., Min,X., Li,J.M. and Sha,J.H.
  TITLE     Identification and characterization of the BGR-like gene with a
            potential role in human testicular development/spermatogenesis
  JOURNAL   Asian J Androl 7 (1), 21-32 (2005)
   PUBMED   15685348
  REMARK    GeneRIF: A new gene exhibiting 50-fold difference in expression
            level between adult and fetal human testes was cloned and named the
            BGR-like gene. It was exclusively expressed in testes and was a
            testes-specific isoform of the BGR gene.
REFERENCE   4  (bases 1 to 2734)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY011431.1, BC090046.1 and AK093433.1.
            
            On Jun 2, 2019 this sequence version replaced NM_030924.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, and 3 encode the same isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005321.1, BC090046.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000588485.6/ ENSP00000466336.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                HY011431.1         22-71
            51-701              BC090046.1         1-651
            702-702             AK093433.1         704-704
            703-2734            BC090046.1         653-2684
FEATURES             Location/Qualifiers
     source          1..2734
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2734
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /note="acyl-CoA synthetase bubblegum family member 2"
                     /db_xref="GeneID:81616"
                     /db_xref="HGNC:HGNC:24174"
                     /db_xref="MIM:614363"
     exon            1..243
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /inference="alignment:Splign:2.1.0"
     exon            244..341
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..2275
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /note="isoform a is encoded by transcript variant 2;
                     long-chain-fatty-acid--CoA ligase ACSBG2;
                     bubblegum-related protein; testicular tissue protein Li 8;
                     arachidonate--CoA ligase ACSBG2"
                     /codon_start=1
                     /product="long-chain-fatty-acid--CoA ligase ACSBG2 isoform
                     a"
                     /protein_id="NP_112186.3"
                     /db_xref="CCDS:CCDS12159.1"
                     /db_xref="GeneID:81616"
                     /db_xref="HGNC:HGNC:24174"
                     /db_xref="MIM:614363"
                     /translation="MTGTPKTQEGAKDLEVDMNKTEVTPRLWTTCRDGEVLLRLSKHG
                     PGHETPMTIPEFFRESVNRFGTYPALASKNGKKWEILNFNQYYEACRKAAKSLIKLGL
                     ERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVEN
                     DQQLQKILSIPQSSLEPLKAIIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIES
                     QKANQCAVLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHI
                     AAQMMDIWVPIKIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKN
                     SAKSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCH
                     SFISGTAPLNQETAEFFLSLDIPIGELYGLSESSGPHTISNQNNYRLLSCGKILTGCK
                     NMLFQQNKDGIGEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLYV
                     TGHIKEILITAGGENVPPIPVETLVKKKIPIISNAMLVGDKLKFLSMLLTLKCEMNQM
                     SGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQDPLVYKAIQQGINAVNQEAMNNAQR
                     IEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMYH"
     exon            342..571
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /inference="alignment:Splign:2.1.0"
     exon            572..660
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /inference="alignment:Splign:2.1.0"
     exon            661..781
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /inference="alignment:Splign:2.1.0"
     exon            782..862
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1012
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1180
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1362
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1596
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1814
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1954
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2201
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2310
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2734
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2716..2721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /note="hexamer: AATAAA"
     polyA_site      2734
                     /gene="ACSBG2"
                     /gene_synonym="BGR; BRGL; PRTD-NY3; PRTDNY3"
                     /note="major polyA site"
ORIGIN      
        1 gaatggggta gaaggcctgt tgtggaggga aaccacccat cctcctgcct cccaccacca
       61 ccatcatcct ggctggacgg agagggtgac gggggctggg aaggggcagc tcatgttcag
      121 gtttccagga ggggctacct gttgactgtc tttgcaggaa gaagaaaaca cctgagtgac
      181 cagatgtccc agctccaggt gccttgccag atggccagaa ccacacctct tgaagagtga
      241 cagtgctgtg gagcatggtt tctgcacacc tggaatgact ggaaccccaa agactcaaga
      301 aggagctaaa gatcttgaag tagacatgaa taaaacagaa gttactccca ggctgtggac
      361 cacctgtcga gatggagaag tccttctgag gctatccaaa cacggaccag gccatgagac
      421 cccgatgacc atccctgaat tttttcgaga gtcagtcaac cgatttggaa cttatccagc
      481 cctcgcatcc aagaatggca aaaagtggga aattctgaat ttcaaccagt actatgaggc
      541 ttgtcggaag gctgcaaaat ccttgatcaa gctgggtttg gagcgtttcc acggagttgg
      601 tatcctgggg tttaactctg cagagtggtt tatcactgct gttggtgcca tcctagccgg
      661 gggtctttgt gttggtattt atgccaccaa ctctgccgag gtttgtcaat atgtcatcac
      721 tcatgccaaa gtgaacatct tgctggttga gaatgatcaa cagttacaga aaatcctttc
      781 gattccacag agcagcctag agcccctaaa agcgatcatc cagtacagac tgccaatgaa
      841 gaagaacaac aacttgtact cttgggatga tttcatggaa cttggcagaa gtatccctga
      901 cacccaactg gagcaggtca tcgagagcca gaaggcgaat caatgcgcag tgctcatcta
      961 cacttcaggg accacaggca tacccaaggg agtgatgctc agtcatgaca acatcacgtg
     1021 gattgcagga gcagtgacaa aggactttaa actgacagac aagcatgaga cggtggttag
     1081 ctacctccca ctcagccata ttgcagcaca gatgatggac atctgggtac ccataaagat
     1141 tggggcgctc acatactttg ctcaagcaga tgctctcaag ggcaccttgg taagtactct
     1201 aaaggaggta aaacctactg tcttcattgg agtgcctcaa atttgggaga agatacatga
     1261 gatggtgaag aaaaatagtg ccaagtccat gggcttgaag aagaaggcat tcgtgtgggc
     1321 aagaaacatt ggcttcaagg tcaactcaaa aaagatgttg gggaaatata atactcccgt
     1381 gagctaccgc atggctaaga ctctcgtgtt cagcaaagtc aagacatccc ttggcttgga
     1441 tcactgtcac tcttttatca gtgggactgc gcccctcaac caagagactg ccgagttctt
     1501 tctaagcttg gacataccta taggcgagtt gtatgggttg agtgagagct cgggacccca
     1561 cacgatatcc aaccagaata actacaggct tctaagctgt ggcaagatct tgactgggtg
     1621 taagaatatg ctgttccagc agaacaagga tggcattggg gagatctgcc tctggggtag
     1681 gcacatcttc atgggctatc tggaaagtga gactgaaact acagaggcca tcgatgatga
     1741 aggctggcta cactctgggg atctgggcca gctggacggt ctgggtttcc tctatgtcac
     1801 cggccacatc aaagaaatcc ttatcactgc tggtggtgaa aatgtgcccc ccattcctgt
     1861 tgagaccttg gttaagaaga agatccccat catcagtaac gccatgttag taggagataa
     1921 actgaagttt ctgagcatgt tgctgacgct gaagtgtgag atgaatcaga tgagcggaga
     1981 acctctggac aagctgaact tcgaggccat caacttctgt cggggtctgg gcagccaggc
     2041 atccaccgtg actgagattg tgaagcagca agaccccctg gtctacaagg ccatccagca
     2101 aggcatcaat gctgtgaacc aggaagccat gaacaatgca cagaggattg aaaagtgggt
     2161 catcttggag aaggactttt ccatctatgg tggagagcta ggtccaatga tgaaacttaa
     2221 gagacatttt gtagcccaga aatacaaaaa acaaattgat cacatgtacc actgactgct
     2281 ttgatggagc tgctctcagc tgttctgatg ccttcagcag gaagacctca ttgcaataag
     2341 tgaaatgctg ctctaggtag aagctctccc tgctgttttt aagaagccac attcctcatt
     2401 ggtcagtttc ttgattgttc gtctgttgga gaggtgctcc ctagaagaac ctgccatacg
     2461 tttcaaagca ataaaatcac tgtatatctt tctaaggacc ttcaagtcat gactccaggg
     2521 aagcctattg ggaagtctac taaaaactgc ctgatttaca agaaagacct gaacttgtgg
     2581 gctcccattt gatttttttc tcctcagggg actcagacat tagaaagaaa aagcctcaca
     2641 gatttgaaga actggacccc caaatcaact cacctgcctg gaagcaactg ggaaaccctt
     2701 ccaataagtc ctgataataa agcacttcag ggtc
//
