LOCUS       NM_015162               6215 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens acyl-CoA synthetase bubblegum family member 1
            (ACSBG1), transcript variant 1, mRNA.
ACCESSION   NM_015162
VERSION     NM_015162.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6215)
  AUTHORS   Yu,Z., Ueno,K., Funayama,R., Sakai,M., Nariai,N., Kojima,K.,
            Kikuchi,Y., Li,X., Ono,C., Kanatani,J., Ono,J., Iwamoto,K.,
            Hashimoto,K., Kinoshita,K., Nakayama,K., Nagasaki,M. and Tomita,H.
  TITLE     Sex-Specific Differences in the Transcriptome of the Human
            Dorsolateral Prefrontal Cortex in Schizophrenia
  JOURNAL   Mol Neurobiol 60 (2), 1083-1098 (2023)
   PUBMED   36414910
  REMARK    GeneRIF: Sex-Specific Differences in the Transcriptome of the Human
            Dorsolateral Prefrontal Cortex in Schizophrenia.
REFERENCE   2  (bases 1 to 6215)
  AUTHORS   Ohkuni,A., Ohno,Y. and Kihara,A.
  TITLE     Identification of acyl-CoA synthetases involved in the mammalian
            sphingosine 1-phosphate metabolic pathway
  JOURNAL   Biochem Biophys Res Commun 442 (3-4), 195-201 (2013)
   PUBMED   24269233
REFERENCE   3  (bases 1 to 6215)
  AUTHORS   Pei,Z., Jia,Z. and Watkins,P.A.
  TITLE     The second member of the human and murine bubblegum family is a
            testis- and brainstem-specific acyl-CoA synthetase
  JOURNAL   J Biol Chem 281 (10), 6632-6641 (2006)
   PUBMED   16371355
REFERENCE   4  (bases 1 to 6215)
  AUTHORS   Asheuer,M., Bieche,I., Laurendeau,I., Moser,A., Hainque,B.,
            Vidaud,M. and Aubourg,P.
  TITLE     Decreased expression of ABCD4 and BG1 genes early in the
            pathogenesis of X-linked adrenoleukodystrophy
  JOURNAL   Hum Mol Genet 14 (10), 1293-1303 (2005)
   PUBMED   15800013
  REMARK    GeneRIF: expression tends to be correlated with the severity of
            X-linked adrenoleukodystrophy
REFERENCE   5  (bases 1 to 6215)
  AUTHORS   Jia,Z., Pei,Z., Li,Y., Wei,L., Smith,K.D. and Watkins,P.A.
  TITLE     X-linked adrenoleukodystrophy: role of very long-chain acyl-CoA
            synthetases
  JOURNAL   Mol Genet Metab 83 (1-2), 117-127 (2004)
   PUBMED   15464426
REFERENCE   6  (bases 1 to 6215)
  AUTHORS   Fraisl,P., Forss-Petter,S., Zigman,M. and Berger,J.
  TITLE     Murine bubblegum orthologue is a microsomal very long-chain
            acyl-CoA synthetase
  JOURNAL   Biochem J 377 (Pt 1), 85-93 (2004)
   PUBMED   14516277
REFERENCE   7  (bases 1 to 6215)
  AUTHORS   Pei,Z., Oey,N.A., Zuidervaart,M.M., Jia,Z., Li,Y., Steinberg,S.J.,
            Smith,K.D. and Watkins,P.A.
  TITLE     The acyl-CoA synthetase 'bubblegum' (lipidosin): further
            characterization and role in neuronal fatty acid beta-oxidation
  JOURNAL   J Biol Chem 278 (47), 47070-47078 (2003)
   PUBMED   12975357
REFERENCE   8  (bases 1 to 6215)
  AUTHORS   Moriya-Sato,A., Hida,A., Inagawa-Ogashiwa,M., Wada,M.R.,
            Sugiyama,K., Shimizu,J., Yabuki,T., Seyama,Y. and Hashimoto,N.
  TITLE     Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues
  JOURNAL   Biochem Biophys Res Commun 279 (1), 62-68 (2000)
   PUBMED   11112418
REFERENCE   9  (bases 1 to 6215)
  AUTHORS   Steinberg,S.J., Morgenthaler,J., Heinzer,A.K., Smith,K.D. and
            Watkins,P.A.
  TITLE     Very long-chain acyl-CoA synthetases. Human 'bubblegum' represents
            a new family of proteins capable of activating very long-chain
            fatty acids
  JOURNAL   J Biol Chem 275 (45), 35162-35169 (2000)
   PUBMED   10954726
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC401742.1, AK054882.1,
            BC009289.2 and AC090260.13.
            
            On Nov 22, 2018 this sequence version replaced NM_015162.4.
            
            Summary: The protein encoded by this gene possesses long-chain
            acyl-CoA synthetase activity. It is thought to play a central role
            in brain very long-chain fatty acids metabolism and myelinogenesis.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.83676.1,
                                           SRR1803616.152834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258873.9/ ENSP00000258873.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 DC401742.1         143-150
            9-1421              AK054882.1         1-1413
            1422-1422           BC009289.2         1363-1363
            1423-2792           AK054882.1         1415-2784
            2793-2838           BC009289.2         2734-2779
            2839-6215           AC090260.13        29244-32620
FEATURES             Location/Qualifiers
     source          1..6215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.1"
     gene            1..6215
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /note="acyl-CoA synthetase bubblegum family member 1"
                     /db_xref="GeneID:23205"
                     /db_xref="HGNC:HGNC:29567"
                     /db_xref="MIM:614362"
     exon            1..195
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..2239
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /EC_number="6.2.1.3"
                     /note="isoform 1 is encoded by transcript variant 1; very
                     long-chain acyl-CoA synthetase; long-chain-fatty-acid--CoA
                     ligase ACSBG1; bubblegum; lipidosin"
                     /codon_start=1
                     /product="long-chain-fatty-acid--CoA ligase ACSBG1 isoform
                     1"
                     /protein_id="NP_055977.3"
                     /db_xref="CCDS:CCDS10298.1"
                     /db_xref="GeneID:23205"
                     /db_xref="HGNC:HGNC:29567"
                     /db_xref="MIM:614362"
                     /translation="MPRNSGAGYGCPHGDPSMLDSRETPQESRQDMIVRTTQEKLKTS
                     SLTDRQPLSKESLNHALELSVPEKVNNAQWDAPEEALWTTRADGRVRLRIDPSCPQLP
                     YTVHRMFYEALDKYGDLIALGFKRQDKWEHISYSQYYLLARRAAKGFLKLGLKQAHSV
                     AILGFNSPEWFFSAVGTVFAGGIVTGIYTTSSPEACQYIAYDCCANVIMVDTQKQLEK
                     ILKIWKQLPHLKAVVIYKEPPPNKMANVYTMEEFMELGNEVPEEALDAIIDTQQPNQC
                     CVLVYTSGTTGNPKGVMLSQDNITWTARYGSQAGDIRPAEVQQEVVVSYLPLSHIAAQ
                     IYDLWTGIQWGAQVCFAEPDALKGSLVNTLREVEPTSHMGVPRVWEKIMERIQEVAAQ
                     SGFIRRKMLLWAMSVTLEQNLTCPGSDLKPFTTRLADYLVLAKVRQALGFAKCQKNFY
                     GAAPMMAETQHFFLGLNIRLYAGYGLSETSGPHFMSSPYNYRLYSSGKLVPGCRVKLV
                     NQDAEGIGEICLWGRTIFMGYLNMEDKTCEAIDEEGWLHTGDAGRLDADGFLYITGRL
                     KELIITAGGENVPPVPIEEAVKMELPIISNAMLIGDQRKFLSMLLTLKCTLDPDTSDQ
                     TDNLTEQAMEFCQRVGSRATTVSEIIEKKDEAVYQAIEEGIRRVNMNAAARPYHIQKW
                     AILERDFSISGGELGPTMKLKRLTVLEKYKGIIDSFYQEQKM"
     exon            196..296
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /inference="alignment:Splign:2.1.0"
     exon            297..517
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /inference="alignment:Splign:2.1.0"
     exon            518..606
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /inference="alignment:Splign:2.1.0"
     exon            607..727
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /inference="alignment:Splign:2.1.0"
     exon            728..808
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /inference="alignment:Splign:2.1.0"
     exon            809..958
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1135
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1317
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1548
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1766
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1906
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2153
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..6215
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2813..2818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /note="hexamer: ATTAAA"
     polyA_site      2838
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /note="major polyA site"
     regulatory      4048..4053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /note="hexamer: AACAAA"
     polyA_site      4074
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
     polyA_site      6215
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
ORIGIN      
        1 gctcactcaa ggctagcctc tctcagtggg tgactgagct gtcttcagtg gaagcccgag
       61 gcagatgcca cgcaattctg gagctggata cggctgccca cacggggacc ccagcatgct
      121 ggacagcaga gagaccccac aggagagccg gcaggacatg attgtgagga ccacccaaga
      181 aaaattgaaa accagctcac tgactgacag gcagccactc tccaaagagt ccctgaacca
      241 tgctctcgag ctctcagtgc cagagaaggt gaataatgcc cagtgggatg ctccagagga
      301 ggcgctgtgg acgactcggg ccgatgggcg ggtgcgcctg cgcatagacc ccagctgccc
      361 acagcttccc tacactgtgc atcggatgtt ctacgaggcc ctggataagt atggggacct
      421 catcgctttg ggcttcaagc gccaggacaa gtgggaacac atctcctact cccaatacta
      481 cctgctcgcc cgcagagccg ccaagggctt cctgaagctc ggcctgaagc aggcccacag
      541 tgtggccatc ctcggcttca actccccgga gtggttcttc tcggcagtgg gcacagtatt
      601 tgcaggtggc atcgtcactg gcatctacac caccagctcc ccagaggcct gccagtacat
      661 cgcttatgac tgctgcgcca atgtcatcat ggtcgacacg cagaagcagc tggaaaagat
      721 cctgaagatc tggaaacagt tgccacatct aaaggcagtc gtgatatata aagaacctcc
      781 tccaaacaag atggccaatg tgtacacgat ggaggaattc atggagctgg ggaatgaagt
      841 gcctgaggaa gccctggacg ccatcattga cacccagcag cccaaccagt gctgtgtgct
      901 agtctacact tccggcacca ctgggaaccc caagggcgtg atgctgagtc aagacaatat
      961 cacgtggacg gcacggtacg gcagccaggc cggtgacatc cggccggcag aagtccagca
     1021 ggaggtggta gtcagctacc tgcccctcag ccatattgcc gcccagatct acgacctgtg
     1081 gacaggcatc cagtgggggg cccaggtttg ctttgccgaa cccgacgccc tgaaggggag
     1141 cctggtgaac acgctgcggg aggtggagcc cacatcacac atgggggtgc cccgggtatg
     1201 ggagaagatc atggagcgca tccaggaggt ggcggctcag tctggcttca tccggcgaaa
     1261 gatgctgctg tgggccatgt cggtgacctt ggagcagaac ctcacctgcc ccggcagcga
     1321 cctgaagccc ttcacaacca gactggcaga ttacctggtg ctagccaagg ttcgccaggc
     1381 actgggattt gccaagtgtc aaaagaactt ctatggagcg gcccccatga tggcagagac
     1441 acagcacttc ttcctgggtc tcaacatccg cttgtatgcg ggctacggcc tcagtgagac
     1501 ctcaggcccc cacttcatgt ccagtcccta caactaccgg ctgtacagct caggcaagtt
     1561 ggtgcccggc tgtcgggtga agctggtgaa ccaggacgca gagggcattg gcgagatctg
     1621 cctgtggggc cgcaccatat tcatgggcta cctgaacatg gaggacaaga cttgtgaggc
     1681 catcgacgag gaaggctggc tgcacacggg tgatgctggc cgcctggacg ccgatggctt
     1741 cctctacatc actgggcgcc tcaaagaatt aatcatcaca gctggtgggg agaatgtgcc
     1801 ccctgtgccc atcgaggagg ccgtgaagat ggagctgccc atcatcagca acgccatgct
     1861 cattggggac cagaggaagt tcctgtccat gctgctcacc ttgaagtgca ctctggaccc
     1921 agacacctct gaccagactg ataatctgac tgaacaagct atggagttct gccagagggt
     1981 gggcagcaga gccaccacag tgtccgagat catagagaag aaggatgagg ccgtgtacca
     2041 ggccatcgaa gaggggatcc ggagggtcaa catgaacgcg gcggcccggc cctaccacat
     2101 ccagaagtgg gccattctcg agagagactt ctccatttcg ggtggagagt tgggtcccac
     2161 gatgaaactg aaacggctca cagttttgga gaagtacaaa ggtatcattg actcctttta
     2221 ccaagagcaa aaaatgtaat cagggcctat gcctgcagtt tctatagaat agagggcagg
     2281 cgttccgagc ctcttcctga gccccaggtc tcttcagtct gggcacaggc atttctgcca
     2341 agtctgttag atctccaggt cagggcacag cactggctct acatttacca ggtcttacgc
     2401 caacaatagc tgacaattcc aagaagcttc acgtgtgggt agttttaatt cagtttaagt
     2461 attgcttttt gttcaggtga caaatgagat cagctctcct tccagaacga aagggctgat
     2521 aatttttggc cttagttcca ggtagattaa aaagctgcta gctcacatac aggacagcca
     2581 gcagtaggct gtggagcggg taggagagag atggctgata ctgctcacgt gcgctgcagg
     2641 aaaagcaatc agtcacaact cacctagcga cctgacttac tctggaatct tggcgggcat
     2701 cgccgaccct attattccat taccaggcac tccgccaccc acatgccaac tgacttgatg
     2761 cttaataaaa ctgctgctgc ctgtttgatt ctatttaatg tataatttga atattaaacc
     2821 ttttaacaga actgtcaaca aggacctgat tttttttgtc aattgagcag gtgggaccag
     2881 tgcagagagt agtgggcatt taactcacag gactgtgcac agcgggcatg cgagtgacca
     2941 ttagtgccct ggaataaaca aaggtgcagg atggggtcaa gtggcgcatt ctcataaaag
     3001 cagccagctc tacgttagcc tgtcgccacc agaccacccc acttccattc tgaatacggg
     3061 aagcagccat tctcagtagc aagctgagcc aaaatgaccg aaggcatctg aacaggaaac
     3121 aggtagagaa agcaaacatc tcagttttgg aattctttat tactttgaac ccaagagcca
     3181 ctgataactg gcacaatcca atgaaacaga ggaagcagca gcttaaacaa aggaaaatac
     3241 atttaagatt ataagtctgg gggggcggtt acaagcttaa aaagtgaccc agacagggat
     3301 atcattgcta aaaaaaaaaa aatccccttg tgacctgggt acattttgca aagccacagg
     3361 tttgcaatgt tacacaaggg ccaaaggagg ccatgagttg tctttggttg tggggacaga
     3421 gggtaactgt tcatgaaaat agtgagtgtc tgaagattaa gaaaatcatg ctgcagcaga
     3481 ggagaaggga gaggaagaca ggaagggaaa ggagatgcct gagggtcaaa agctgagccc
     3541 aagcctaagc ccaagctcaa gctcaagccc cagcatggca taattttgtg aattaactca
     3601 ggctgagttg cctccagtct ttggaatgtc atcttatact ggtactgctg aggcagaggg
     3661 cagtaattgg tgctttggga taggagaagg ggcagttgct gaaatacaaa attaatagca
     3721 tcccaagttc ctcaattgca gccaaaatac atgtgttcgg gcctttcggc agtatcgccc
     3781 ccagaactac ctgctgtagt gtggtccatt cccagacagc aacatgcaag aataagttta
     3841 caatacactc agcccttctg gcttcagatc aggggctcag aggctgtgac aactcatgat
     3901 gctgaaaatg tatccagtga aaatgaagta ctagctctct gcttcattaa aagctcttgg
     3961 aaagaatatt aaatctcaag acaacaaaat aattgaacac acaatacatt tgtgtctttg
     4021 tatccaatat attacctttg tcttattaac aaaaattata tctctcatta tatatttctt
     4081 ggatctgaag tttttattca cactcagtaa tttctgtaaa ggacaaatct gtctctattt
     4141 tccatatcat ttagaaatat accacattca ctctttttga tgtgaacttt cccaggaaaa
     4201 ttctcttgtg cccatttagt tttagaagag tgtcattttg tgctattatg tcaatatcct
     4261 gttttatttc cattatgttt ttcaaaaacc gaagaaaata aggtttttct taaaaagtta
     4321 gacattttct cttgttaatt ctgtatcctg ttatttacag ctgaagagaa actattttaa
     4381 cttaagtgta aaatggttta gaatagcaaa tgatacagtc cactcagagt ttacaaaaaa
     4441 aacatttacc aggtagacac ttaataaata aaacaagcac ttggaaaaag ttctttgaaa
     4501 acagacctag ggacatccac ctgcatcttt tgcacagatt ttgttaagaa aaggccagat
     4561 ctaaaaatgt actgtcaaga aacaagcaaa ccaatgcata catacgtagg tattctaaac
     4621 agaggttcat gtggtgtcca tttagagtga ctgatgtaaa tgccagttgt agaagtgtta
     4681 atctaaatct tttactcggc gacagatttc ctctgtgaag tctgagcatt ttgcattgcc
     4741 tcccaaatct tttgtcaagc tctgagaaaa ggaaaaagca aaaataaaag atgtatccgc
     4801 aaactaaact aaaccaagga gattttaaag ccctcagtga gatgccacct gggcaagtta
     4861 ctcggctgct ctttcattta gttcctcatt tcaaagtgag gaaccactcc accaccatct
     4921 acccagccca ggaggatcgg gatccaatct catagtgtat acaacagcac tctgcaaaga
     4981 ataaggtgct cttgatgcaa agggaggcag ggagctttac caaaattttc cctttgttca
     5041 cacaatagac cctaacccag attagttggt catggatatt taaataaaag cgaatctaaa
     5101 taagaagttt cataaaaatc cttgggaaat atgtctcagg aatagacctg agacatattt
     5161 tgatctattt ttgtttttat tattattttt tttttagatg gagtctcact ctgttgccca
     5221 ggctggagtg cagtggcacg atcccagctc accacaacct ctgcctcctg ggttcaagcg
     5281 attctcctgc ctcagcgtcc tgaatagctg gaattacaag tgcatgccac catacccaac
     5341 taatttttgt atctgatcta tttttggagg ctgggacaca aatacgaaag aaatatttaa
     5401 atcattaact cttttttttt tttttaagag acggggtctc actatgtggc ccaggctggt
     5461 cttgaactca gaggctaagg tgatcctcct gcctcagcct atagctgcaa ctacaggcat
     5521 gcaccaccac acctgcctaa atcattaact cttaaacctc cctctttagg aaagaaagcc
     5581 tcccatacaa ctgatctgtt ctaccagctt atcctttctt tcctgcatac agaccccaat
     5641 atatttaatt ctctttatct ttccatccta cacaataaaa gggcccacta tgtaattcag
     5701 gcacctctct actgggctgt agattataac ttcccaaata taactttaaa gaataagaaa
     5761 atcatatgac ctccaatgtg actatcaggc tgttaaaaac aagcctgaat ttcttgtatt
     5821 ttggccacac gatataattt caaattacag aattttttta aaagaaggga ccaactttga
     5881 agatattacg ctaagtgaaa taagccagac tcaaaggaca aatactgtat gattccactt
     5941 acatgaggta cctagagtag tcaaattcat agagacagga agcagaatgg caggtgtcag
     6001 aggatgggag ggggaaggga aagttactgt ttaacgggtg cagagtctca gtttgagaaa
     6061 atgaaactgg tctggagatg actgatggtg atggttacat tacaatgtga atgtacttaa
     6121 cattattgaa ctgtatacct aaatacggct aaaatggcaa attttatgtt atgcatattt
     6181 ttcacaattt ttgttaaaaa ggacctcaaa ttagg
//
