LOCUS       NM_032489               1905 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens acrosin binding protein (ACRBP), mRNA.
ACCESSION   NM_032489
VERSION     NM_032489.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1905)
  AUTHORS   Ning,W., Huang,M., Wu,S., Wang,H., Yao,J., Ge,Y., Tang,Y., Sun,K.,
            Xie,X. and Hu,Q.
  TITLE     CT23 knockdown attenuating malignant behaviors of hepatocellular
            carcinoma cell is associated with upregulation of metallothionein 1
  JOURNAL   Cell Biol Int 45 (6), 1231-1245 (2021)
   PUBMED   33559934
  REMARK    GeneRIF: CT23 knockdown attenuating malignant behaviors of
            hepatocellular carcinoma cell is associated with upregulation of
            metallothionein 1.
REFERENCE   2  (bases 1 to 1905)
  AUTHORS   Luo,B., Yun,X., Li,J., Fan,R., Guo,W.W., Liu,C., Lin,Y.D., Ge,Y.Y.,
            Zeng,X., Bi,S.Q., Nong,W.X., Zhang,Q.M. and Xie,X.X.
  TITLE     Cancer-testis Antigen OY-TES-1 Expression and Immunogenicity in
            Hepatocellular Carcinoma
  JOURNAL   Curr Med Sci 40 (4), 719-728 (2020)
   PUBMED   32862383
  REMARK    GeneRIF: Cancer-testis Antigen OY-TES-1 Expression and
            Immunogenicity in Hepatocellular Carcinoma.
REFERENCE   3  (bases 1 to 1905)
  AUTHORS   Fu,J., Luo,B., Guo,W.W., Zhang,Q.M., Shi,L., Hu,Q.P., Chen,F.,
            Xiao,S.W. and Xie,X.X.
  TITLE     Down-regulation of cancer/testis antigen OY-TES-1 attenuates
            malignant behaviors of hepatocellular carcinoma cells in vitro
  JOURNAL   Int J Clin Exp Pathol 8 (7), 7786-7797 (2015)
   PUBMED   26339343
  REMARK    GeneRIF: Down regulation of OY-TES-1 increased expression of
            apoptosis-regulated protein caspase-3, and decreased expression of
            cell cycle-regulated protein cyclin E, migration/invasion-regulated
            proteins MMP2 and MMP9.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1905)
  AUTHORS   Hu,Q., Fu,J., Luo,B., Huang,M., Guo,W., Lin,Y., Xie,X. and Xiao,S.
  TITLE     OY-TES-1 may regulate the malignant behavior of liver cancer via
            NANOG, CD9, CCND2 and CDCA3: a bioinformatic analysis combine with
            RNAi and oligonucleotide microarray
  JOURNAL   Oncol Rep 33 (4), 1965-1975 (2015)
   PUBMED   25673160
  REMARK    GeneRIF: OY-TES-1 downregulation in liver cancer cells caused 2
            opposite effects on cell proliferation: promotion by upregulating
            CCND2 and CDCA3, and inhibition by CD9 upregulation and NANOG
            downregulation. OY-TES-1 may play multiple roles in liver cancer.
REFERENCE   5  (bases 1 to 1905)
  AUTHORS   Fan,R., Huang,W., Luo,B., Zhang,Q.M., Xiao,S.W. and Xie,X.X.
  TITLE     Cancer testis antigen OY-TES-1: analysis of protein expression in
            ovarian cancer with tissue microarrays
  JOURNAL   Eur J Gynaecol Oncol 36 (3), 298-303 (2015)
   PUBMED   26189257
  REMARK    GeneRIF: OY-TES-1 was expressed in ovarian cancer (OC) tissues with
            a high proportion, and some of OC tissues presented OY-TES-1
            expression in high level vs OC adjacent tissues.
REFERENCE   6  (bases 1 to 1905)
  AUTHORS   Cen,Y.H., Guo,W.W., Luo,B., Lin,Y.D., Zhang,Q.M., Zhou,S.F.,
            Luo,G.R., Xiao,S.W. and Xie,X.X.
  TITLE     Knockdown of OY-TES-1 by RNAi causes cell cycle arrest and
            migration decrease in bone marrow-derived mesenchymal stem cells
  JOURNAL   Cell Biol Int 36 (10), 917-922 (2012)
   PUBMED   22651134
  REMARK    GeneRIF: The down-regulation of OY-TES-1 expression in bone
            marrow-derived mesenchymal stem cells caused cell growth
            inhibition, cell cycle arrest, apoptosis induction and migration
            ability attenuation.
REFERENCE   7  (bases 1 to 1905)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   8  (bases 1 to 1905)
  AUTHORS   Whitehurst,A.W., Xie,Y., Purinton,S.C., Cappell,K.M., Swanik,J.T.,
            Larson,B., Girard,L., Schorge,J.O. and White,M.A.
  TITLE     Tumor antigen acrosin binding protein normalizes mitotic spindle
            function to promote cancer cell proliferation
  JOURNAL   Cancer Res 70 (19), 7652-7661 (2010)
   PUBMED   20876808
  REMARK    GeneRIF: High ACRBP expression correlated with reduced survival
            time and faster relapse among ovarian cancer patients.
REFERENCE   9  (bases 1 to 1905)
  AUTHORS   Okumura,H., Noguchi,Y., Uenaka,A., Aji,T., Ono,T., Nakagawa,K.,
            Aoe,M., Shimizu,N. and Nakayama,E.
  TITLE     Identification of an HLA-A24-restricted OY-TES-1 epitope recognized
            by cytotoxic T-cells
  JOURNAL   Microbiol Immunol 49 (11), 1009-1016 (2005)
   PUBMED   16301813
  REMARK    GeneRIF: We showed identification of HLA-A24-binding OY-TES-1
            peptide, TES(401-409) (KTPFVSPLL) recognized by CD8 T-cells.
REFERENCE   10 (bases 1 to 1905)
  AUTHORS   Ono,T., Kurashige,T., Harada,N., Noguchi,Y., Saika,T., Niikawa,N.,
            Aoe,M., Nakamura,S., Higashi,T., Hiraki,A., Wada,H., Kumon,H.,
            Old,L.J. and Nakayama,E.
  TITLE     Identification of proacrosin binding protein sp32 precursor as a
            human cancer/testis antigen
  JOURNAL   Proc Natl Acad Sci U S A 98 (6), 3282-3287 (2001)
   PUBMED   11248070
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC135892.1.
            
            On Nov 25, 2018 this sequence version replaced NM_032489.2.
            
            Summary: The protein encoded by this gene is similar to proacrosin
            binding protein sp32 precursor found in mouse, guinea pig, and pig.
            This protein is located in the sperm acrosome and is thought to
            function as a binding protein to proacrosin for packaging and
            condensation of the acrosin zymogen in the acrosomal matrix. This
            protein is a member of the cancer/testis family of antigens and it
            is found to be immunogenic. In normal tissues, this mRNA is
            expressed only in testis, whereas it is detected in a range of
            different tumor types such as bladder, breast, lung, liver, and
            colon. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.225875.1,
                                           SRR5189667.186649.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229243.7/ ENSP00000229243.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AC135892.1         47407-47515         c
            110-328             AC135892.1         46877-47095         c
            329-423             AC135892.1         46566-46660         c
            424-541             AC135892.1         45303-45420         c
            542-1010            AC135892.1         44220-44688         c
            1011-1143           AC135892.1         43622-43754         c
            1144-1323           AC135892.1         40426-40605         c
            1324-1491           AC135892.1         40143-40310         c
            1492-1575           AC135892.1         39037-39120         c
            1576-1905           AC135892.1         38158-38487         c
FEATURES             Location/Qualifiers
     source          1..1905
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1905
                     /gene="ACRBP"
                     /gene_synonym="CT23; OY-TES-1; SP32"
                     /note="acrosin binding protein"
                     /db_xref="GeneID:84519"
                     /db_xref="HGNC:HGNC:17195"
                     /db_xref="MIM:608352"
     exon            1..109
                     /gene="ACRBP"
                     /gene_synonym="CT23; OY-TES-1; SP32"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1698
                     /gene="ACRBP"
                     /gene_synonym="CT23; OY-TES-1; SP32"
                     /note="proacrosin binding protein sp32; cancer/testis
                     antigen 23; cancer/testis antigen OY-TES-1; testicular
                     tissue protein Li 10; acrosin-binding protein, 60 kDa
                     form"
                     /codon_start=1
                     /product="acrosin-binding protein precursor"
                     /protein_id="NP_115878.2"
                     /db_xref="CCDS:CCDS8554.1"
                     /db_xref="GeneID:84519"
                     /db_xref="HGNC:HGNC:17195"
                     /db_xref="MIM:608352"
                     /translation="MRKPAAGFLPSLLKVLLLPLAPAAAQDSTQASTPGSPLSPTEYE
                     RFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSNLPYASWFES
                     FCQFTHYRCSNHVYYAKRVLCSQPVSILSPNTLKEIEASAEVSPTTMTSPISPHFTVT
                     ERQTFQPWPERLSNNVEELLQSSLSLGGQEQAPEHKQEQGVEHRQEPTQEHKQEEGQK
                     QEEQEEEQEEEGKQEEGQGTKEGREAVSQLQTDSEPKFHSESLSSNPSSFAPRVREVE
                     STPMIMENIQELIRSAQEIDEMNEIYDENSYWRNQNPGSLLQLPHTEALLVLCYSIVE
                     NTCIITPTAKAWKYMEEEILGFGKSVCDSLGRRHMSTCALCDFCSLKLEQCHSEASLQ
                     RQQCDTSHKTPFVSPLLASQSLSIGNQVGSPESGRFYGLDLYGGLHMDFWCARLATKG
                     CEDVRVSGWLQTEFLSFQDGDFPTKICDTDYIQYPNYCSFKSQQCLMRNRNRKVSRMR
                     CLQNETYSALSPGKSEDVVLRWSQEFSTLTLGQFG"
     exon            110..328
                     /gene="ACRBP"
                     /gene_synonym="CT23; OY-TES-1; SP32"
                     /inference="alignment:Splign:2.1.0"
     exon            329..423
                     /gene="ACRBP"
                     /gene_synonym="CT23; OY-TES-1; SP32"
                     /inference="alignment:Splign:2.1.0"
     exon            424..541
                     /gene="ACRBP"
                     /gene_synonym="CT23; OY-TES-1; SP32"
                     /inference="alignment:Splign:2.1.0"
     exon            542..1010
                     /gene="ACRBP"
                     /gene_synonym="CT23; OY-TES-1; SP32"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1143
                     /gene="ACRBP"
                     /gene_synonym="CT23; OY-TES-1; SP32"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1323
                     /gene="ACRBP"
                     /gene_synonym="CT23; OY-TES-1; SP32"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1491
                     /gene="ACRBP"
                     /gene_synonym="CT23; OY-TES-1; SP32"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1575
                     /gene="ACRBP"
                     /gene_synonym="CT23; OY-TES-1; SP32"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1905
                     /gene="ACRBP"
                     /gene_synonym="CT23; OY-TES-1; SP32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1887..1892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACRBP"
                     /gene_synonym="CT23; OY-TES-1; SP32"
                     /note="hexamer: CATAAA"
     polyA_site      1905
                     /gene="ACRBP"
                     /gene_synonym="CT23; OY-TES-1; SP32"
                     /note="major polyA site"
ORIGIN      
        1 ctctctgcgg cttggcccgt tagaggcggc ttgtgtccac gggacgcggg cggatcttct
       61 ccggccatga ggaagccagc cgctggcttc cttccctcac tcctgaaggt gctgctcctg
      121 cctctggcac ctgccgcagc ccaggattcg actcaggcct ccactccagg cagccctctc
      181 tctcctaccg aatacgaacg cttcttcgca ctgctgactc caacctggaa ggcagagact
      241 acctgccgtc tccgtgcaac ccacggctgc cggaatccca cactcgtcca gctggaccaa
      301 tatgaaaacc acggcttagt gcccgatggt gctgtctgct ccaacctccc ttatgcctcc
      361 tggtttgagt ctttctgcca gttcactcac taccgttgct ccaaccacgt ctactatgcc
      421 aagagagtcc tgtgttccca gccagtctct attctctcac ctaacactct caaggagata
      481 gaagcttcag ctgaagtctc acccaccacg atgacctccc ccatctcacc ccacttcaca
      541 gtgacagaac gccagacctt ccagccctgg cctgagaggc tcagcaacaa cgtggaagag
      601 ctcctacaat cctccttgtc cctgggaggc caggagcaag cgccagagca caagcaggag
      661 caaggagtgg agcacaggca ggagccgaca caagaacaca agcaggaaga ggggcagaaa
      721 caggaagagc aagaagagga acaggaagag gagggaaagc aggaagaagg acaggggact
      781 aaggagggac gggaggctgt gtctcagctg cagacagact cagagcccaa gtttcactct
      841 gaatctctat cttctaaccc ttcctctttt gctccccggg tacgagaagt agagtctact
      901 cctatgataa tggagaacat ccaggagctc attcgatcag cccaggaaat agatgaaatg
      961 aatgaaatat atgatgagaa ctcctactgg agaaaccaaa accctggcag cctcctgcag
     1021 ctgccccaca cagaggcctt gctggtgctg tgctattcga tcgtggagaa tacctgcatc
     1081 ataaccccca cagccaaggc ctggaagtac atggaggagg agatccttgg tttcgggaag
     1141 tcggtctgtg acagccttgg gcggcgacac atgtctacct gtgccctctg tgacttctgc
     1201 tccttgaagc tggagcagtg ccactcagag gccagcctgc agcggcaaca atgcgacacc
     1261 tcccacaaga ctccctttgt cagccccttg cttgcctccc agagcctgtc catcggcaac
     1321 caggtagggt ccccagaatc aggccgcttt tacgggctgg atttgtacgg tgggctccac
     1381 atggacttct ggtgtgcccg gcttgccacg aaaggctgtg aagatgtccg agtctctggg
     1441 tggctccaga ctgagttcct tagcttccag gatggggatt tccctaccaa gatttgtgac
     1501 acagactata tccagtaccc aaactactgt tccttcaaaa gccagcagtg tctgatgaga
     1561 aaccgcaatc ggaaggtgtc ccgcatgaga tgtctgcaga atgagactta cagtgcgctg
     1621 agccctggca aaagtgagga cgttgtgctt cgatggagcc aggagttcag caccttgact
     1681 ctaggccagt tcggatgagc tggcgtctat tctgcccaca ccccagccca acctgcccac
     1741 gttctctatt gttttgagac cccattgctt tcaggctgcc ccttctgggt ctgttactcg
     1801 gcccctactc acatttcctt gggttggagc aacagtccca gagagggcca cggtgggagc
     1861 tgcgccctcc ttaaaagatg actttacata aaatgttgat cttca
//
