LOCUS       NM_001004318            2903 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens acid phosphatase 7, tartrate resistant (putative)
            (ACP7), transcript variant 1, mRNA.
ACCESSION   NM_001004318 XM_372727
VERSION     NM_001004318.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2903)
  AUTHORS   Ma,N., Zhang,X., Yu,F., Gao,P., Fan,Q., Liu,L. and Liu,D.
  TITLE     Role of IFN-ks, IFN-ks related genes and the DEPDC5 gene in
            Hepatitis B virus-related liver disease
  JOURNAL   J Viral Hepat 21 (7), e29-e38 (2014)
   PUBMED   25032264
  REMARK    GeneRIF: PAPL, IL10RB and DEPDC5 polymorphisms have an impact on
            progression of hepatitis B virus-related liver disease.
REFERENCE   2  (bases 1 to 2903)
  AUTHORS   Sim,X., Ong,R.T., Suo,C., Tay,W.T., Liu,J., Ng,D.P., Boehnke,M.,
            Chia,K.S., Wong,T.Y., Seielstad,M., Teo,Y.Y. and Tai,E.S.
  TITLE     Transferability of type 2 diabetes implicated loci in multi-ethnic
            cohorts from Southeast Asia
  JOURNAL   PLoS Genet 7 (4), e1001363 (2011)
   PUBMED   21490949
REFERENCE   3  (bases 1 to 2903)
  AUTHORS   Flanagan,J.U., Cassady,A.I., Schenk,G., Guddat,L.W. and Hume,D.A.
  TITLE     Identification and molecular modeling of a novel, plant-like, human
            purple acid phosphatase
  JOURNAL   Gene 377, 12-20 (2006)
   PUBMED   16793224
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131245.1, AC011443.6 and BC142613.1.
            
            On May 17, 2019 this sequence version replaced NM_001004318.2.
            
            Summary: Purple acid phosphatases (PAPs), including PAPL, are a
            family of binuclear metallohydrolases that have been identified in
            plants, animals, and fungi (Flanagan et al., 2006 [PubMed
            16793224]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.257723.1,
                                           SRR1803613.221760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331256.10/ ENSP00000327557.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1284              AK131245.1         64-1347
            1285-1285           AC011443.6         39370-39370
            1286-1433           AK131245.1         1349-1496
            1434-1434           AC011443.6         44928-44928
            1435-2248           AK131245.1         1498-2311
            2249-2899           BC142613.1         2233-2883
            2900-2903           AC011443.6         49362-49365
FEATURES             Location/Qualifiers
     source          1..2903
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2903
                     /gene="ACP7"
                     /gene_synonym="PAPL; PAPL1"
                     /note="acid phosphatase 7, tartrate resistant (putative)"
                     /db_xref="GeneID:390928"
                     /db_xref="HGNC:HGNC:33781"
                     /db_xref="MIM:610490"
     exon            1..33
                     /gene="ACP7"
                     /gene_synonym="PAPL; PAPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            34..332
                     /gene="ACP7"
                     /gene_synonym="PAPL; PAPL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1528
                     /gene="ACP7"
                     /gene_synonym="PAPL; PAPL1"
                     /EC_number="3.1.3.2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; iron/zinc purple acid phosphatase-like protein;
                     acid phosphatase type 7; purple acid phosphatase long form
                     1"
                     /codon_start=1
                     /product="acid phosphatase type 7 isoform 1 precursor"
                     /protein_id="NP_001004318.2"
                     /db_xref="CCDS:CCDS33018.1"
                     /db_xref="GeneID:390928"
                     /db_xref="HGNC:HGNC:33781"
                     /db_xref="MIM:610490"
                     /translation="MHPLPGYWSCYCLLLLFSLGVQGSLGAPSAAPEQVHLSYPGEPG
                     SMTVTWTTWVPTRSEVQFGLQPSGPLPLRAQGTFVPFVDGGILRRKLYIHRVTLRKLL
                     PGVQYVYRCGSAQGWSRRFRFRALKNGAHWSPRLAVFGDLGADNPKAVPRLRRDTQQG
                     MYDAVLHVGDFAYNLDQDNARVGDRFMRLIEPVAASLPYMTCPGNHEERYNFSNYKAR
                     FSMPGDNEGLWYSWDLGPAHIISFSTEVYFFLHYGRHLVQRQFRWLESDLQKANKNRA
                     ARPWIITMGHRPMYCSNADLDDCTRHESKVRKGLQGKLYGLEDLFYKYGVDLQLWAHE
                     HSYERLWPIYNYQVFNGSREMPYTNPRGPVHIITGSAGCEERLTPFAVFPRPWSAVRV
                     KEYGYTRLHILNGTHIHIQQVSDDQDGKIVDDVWVVRPLFGRRMYL"
     exon            333..533
                     /gene="ACP7"
                     /gene_synonym="PAPL; PAPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..716
                     /gene="ACP7"
                     /gene_synonym="PAPL; PAPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..840
                     /gene="ACP7"
                     /gene_synonym="PAPL; PAPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..903
                     /gene="ACP7"
                     /gene_synonym="PAPL; PAPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1018
                     /gene="ACP7"
                     /gene_synonym="PAPL; PAPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1126
                     /gene="ACP7"
                     /gene_synonym="PAPL; PAPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1184
                     /gene="ACP7"
                     /gene_synonym="PAPL; PAPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1252
                     /gene="ACP7"
                     /gene_synonym="PAPL; PAPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1324
                     /gene="ACP7"
                     /gene_synonym="PAPL; PAPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1462
                     /gene="ACP7"
                     /gene_synonym="PAPL; PAPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..2903
                     /gene="ACP7"
                     /gene_synonym="PAPL; PAPL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2865..2870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACP7"
                     /gene_synonym="PAPL; PAPL1"
                     /note="hexamer: AATAAA"
     polyA_site      2903
                     /gene="ACP7"
                     /gene_synonym="PAPL; PAPL1"
                     /note="major polyA site"
ORIGIN      
        1 agaggcgcgt gcgggcagcc ggcgcccccg aggcacctgg ataaccaccc atcttgaagg
       61 agacctccct gccctgcctc tgttgtcccc cagagcactg cctgatcatc ctctgttccc
      121 catcctccca gcccttcctg ctgtacctgt ggggagctga tctcctcagt ccccctgctt
      181 ttccccggtc tgccatcacc accccaccac catgcacccc cttcctggct actggtcctg
      241 ttactgtcta ctcctgctat tctccttggg agtccagggg tccctggggg ctcccagcgc
      301 tgccccagag caagtccatc tgtcttaccc aggtgagcca ggctccatga ctgtaacttg
      361 gaccacatgg gtcccaaccc gctctgaagt gcaattcggg ttgcagccgt cggggcccct
      421 gcccctccgc gcccagggca ccttcgtccc ctttgtggac gggggcattc tccggcggaa
      481 gctctacata caccgagtca cgcttcgcaa gctgctgcca ggggttcagt atgtttatcg
      541 ctgtggcagt gcgcagggct ggagccgtcg gttccgcttc agggccctca agaatggggc
      601 ccactggagt ccccgtctgg ctgtgtttgg agacctgggg gctgacaacc cgaaggccgt
      661 cccccggctg cgcagggaca cccagcaggg catgtatgac gccgttctcc atgtgggaga
      721 ctttgcctac aacctggatc aggacaacgc ccgtgttggg gataggttca tgcggctcat
      781 tgaacccgtg gctgccagcc tgccgtacat gacatgccct gggaatcatg aagaacgcta
      841 caacttctct aactacaagg ctcgcttcag catgccgggg gataatgagg gcctgtggta
      901 cagctgggat ctgggtcccg cccacatcat ctccttctcc accgaggtct atttctttct
      961 ccattatggc cgccacttgg tacagaggca gtttcgctgg ctggagagcg acctccagaa
     1021 agccaataag aaccgggcag cccggccgtg gatcatcact atggggcacc ggcccatgta
     1081 ctgctccaac gcagatctgg acgactgcac acgacatgaa agcaaggtcc gcaaaggcct
     1141 ccaaggcaag ctgtacgggt tggaggatct tttctacaaa tatggagtgg atctgcagct
     1201 gtgggctcat gagcactcgt atgaacgact gtggccaatt tacaactacc aggtatttaa
     1261 cggcagccga gagatgccct acaccaaccc gcgagggcct gtccacatca tcacaggatc
     1321 tgctggctgt gaggagcggc tgacgccctt tgctgtcttc ccgaggccct ggagtgccgt
     1381 gcgtgtgaag gagtacgggt atacgcggct gcacatcctc aacgggaccc acatccacat
     1441 ccagcaggtg tcggacgacc aggatgggaa gatcgtagat gatgtctggg tggtgagacc
     1501 cctgtttggc cggaggatgt acctctaggg atggcggcag ctctcctcca gaagcctagg
     1561 ttttgccgcc ttggctgctg tgaccagaaa ctgcccaggc ctgggtgggg agttgggtgg
     1621 gccctgactc ccctgccctc cagaggcccc atgtagggta catgcagccc tatggagctg
     1681 gggcagctgt tccctcctgg agaggtggga gtcctggctg gctgtggagg gagggcaggt
     1741 gtgcgggcac agagtgacac acggcaggtt tctgctggca gggccccacc ctcctgcata
     1801 gctctgatcg ggcgaggtgc ccacggggct tcaggaatga agaggcttaa gctctggctc
     1861 catggattct gcacatctgc gggggatgcc gctgggcttc ctcctctcct gcccacctgg
     1921 caagggcatc gccaggtggg cacaaccgtc atgacactac tcaccagcag gtggcgtcag
     1981 gggctttttc ttctgagccc ggcactgaga gttggtctga agcctggctc cttcttcact
     2041 gctccaggac tgctatgaag agtcccttca tgcctcagtt tcccagcctg gcaccatctt
     2101 attcgggaag aggagacgtg ttaacactct tgcctcctag ctaggacaga tgacaaaccg
     2161 caagagccac agacttgcca gttccttccc tctttccttc ctttctttcc cttcttttat
     2221 ttattgaatc ataatttatt gagcatctac catgtgccag gctctgttct cagtgctgga
     2281 gagacagctg tgaatgagac agagatctcg gccctcacag agctgacatc ctaaccagag
     2341 agttggacaa aaatcacgat aaatgagttg gttaaatagc gatttgtgag tagaaaacgc
     2401 agggacggtg agagagcagt ttcaattttc agggggatct cactgagagg gcaacatttg
     2461 atctgaagga ggtggggaag gagccaagtg ggcagacatc tgggggaaga gcattccagg
     2521 cagaggaaca gccagtgcaa aggccctgag acagaaatgt gcctggccgg ctgggtacag
     2581 taactcacat ctgtagtccc agcactttgg gaggccgagg cgggcagatc acttgagccc
     2641 aggagtttga gaccagcctg ggcaacacag cgaaaccctt tctctaccaa aaatatgaaa
     2701 tttagctggg catggtggtg tgtgcctgta gtcccagctg ctcaggaggc tgaggcggga
     2761 ggatggcttg agcccaggag gttgaggctg cagtgagcca tgattgcgcc actgcacccc
     2821 agcctgggca acagagcaag accctgtctc aaaaaatata tataaataaa aaagttttaa
     2881 aaagagaaaa ataaacaaag aaa
//
