LOCUS       NM_016361               6956 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens acid phosphatase 6, lysophosphatidic (ACP6),
            transcript variant 1, mRNA.
ACCESSION   NM_016361
VERSION     NM_016361.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6956)
  AUTHORS   Gao,L., Xiong,D.D., Yang,X., Li,J.D., He,R.Q., Huang,Z.G.,
            Lai,Z.F., Liu,L.M., Luo,J.Y., Du,X.F., Zeng,J.H., Li,M.F., Li,S.H.,
            Dang,Y.W. and Chen,G.
  TITLE     The expression characteristics and clinical significance of ACP6, a
            potential target of nitidine chloride, in hepatocellular carcinoma
  JOURNAL   BMC Cancer 22 (1), 1244 (2022)
   PUBMED   36456931
  REMARK    GeneRIF: The expression characteristics and clinical significance
            of ACP6, a potential target of nitidine chloride, in hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6956)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 6956)
  AUTHORS   Chryplewicz,A., Tienda,S.M., Nahotko,D.A., Peters,P.N., Lengyel,E.
            and Eckert,M.A.
  TITLE     Mutant p53 regulates LPA signaling through lysophosphatidic acid
            phosphatase type 6
  JOURNAL   Sci Rep 9 (1), 5195 (2019)
   PUBMED   30914657
  REMARK    GeneRIF: Mutant p53 regulates LPA signaling through
            lysophosphatidic acid phosphatase type 6.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6956)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6956)
  AUTHORS   Li,J., Dong,Y., Lu,X., Wang,L., Peng,W., Zhang,X.C. and Rao,Z.
  TITLE     Crystal structures and biochemical studies of human
            lysophosphatidic acid phosphatase type 6
  JOURNAL   Protein Cell 4 (7), 548-561 (2013)
   PUBMED   23807634
  REMARK    GeneRIF: structures and biochemical studies of human
            lysophosphatidic acid phosphatase type 6
REFERENCE   6  (bases 1 to 6956)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6956)
  AUTHORS   Tanaka,M., Kishi,Y., Takanezawa,Y., Kakehi,Y., Aoki,J. and Arai,H.
  TITLE     Prostatic acid phosphatase degrades lysophosphatidic acid in
            seminal plasma
  JOURNAL   FEBS Lett 571 (1-3), 197-204 (2004)
   PUBMED   15280042
  REMARK    GeneRIF: Human seminal plasma contains this enzyme which converts
            lysophospholipids to lysophosphatidic acid.
REFERENCE   8  (bases 1 to 6956)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 6956)
  AUTHORS   Hiroyama,M. and Takenawa,T.
  TITLE     Isolation of a cDNA encoding human lysophosphatidic acid
            phosphatase that is involved in the regulation of mitochondrial
            lipid biosynthesis
  JOURNAL   J Biol Chem 274 (41), 29172-29180 (1999)
   PUBMED   10506173
REFERENCE   10 (bases 1 to 6956)
  AUTHORS   Hiroyama,M. and Takenawa,T.
  TITLE     Purification and characterization of a lysophosphatidic
            acid-specific phosphatase
  JOURNAL   Biochem J 336 (Pt 2) (Pt 2), 483-489 (1998)
   PUBMED   9820827
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC241644.1, AL520992.3,
            BC009965.1, AB031478.1 and AB209248.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_016361.4.
            
            Summary: This gene encodes a member of the histidine acid
            phosphatase protein family. The encoded protein hydrolyzes
            lysophosphatidic acid, which is involved in G protein-coupled
            receptor signaling, lipid raft modulation, and in balancing lipid
            composition within the cell. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, May 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009965.1, AB031478.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000583509.7/ ENSP00000463574.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC241644.1         145804-145815
            13-32               AL520992.3         1-20
            33-350              BC009965.1         1-318
            351-457             AB031478.1         251-357
            458-1298            BC009965.1         426-1266
            1299-1299           AB209248.1         1158-1158
            1300-1714           BC009965.1         1268-1682
            1715-1715           AB209248.1         4464-4464
            1716-1820           BC009965.1         1684-1788
            1821-6956           AC241644.1         168963-174098
FEATURES             Location/Qualifiers
     source          1..6956
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..6956
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /note="acid phosphatase 6, lysophosphatidic"
                     /db_xref="GeneID:51205"
                     /db_xref="HGNC:HGNC:29609"
                     /db_xref="MIM:611471"
     exon            1..695
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             477..1763
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /EC_number="3.1.3.2"
                     /note="isoform 1 is encoded by transcript variant 1; acid
                     phosphatase-like protein 1"
                     /codon_start=1
                     /product="lysophosphatidic acid phosphatase type 6 isoform
                     1"
                     /protein_id="NP_057445.4"
                     /db_xref="CCDS:CCDS928.1"
                     /db_xref="GeneID:51205"
                     /db_xref="HGNC:HGNC:29609"
                     /db_xref="MIM:611471"
                     /translation="MITGVFSMRLWTPVGVLTSLAYCLHQRRVALAELQEADGQCPVD
                     RSLLKLKMVQVVFRHGARSPLKPLPLEEQVEWNPQLLEVPPQTQFDYTVTNLAGGPKP
                     YSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVF
                     IRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTDEADSEVLYPNYQSCWSLRQRTRGR
                     RQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARM
                     IEQRAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAMDSATAPDKIRKLYLYAAH
                     DVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLESKEWFVQLYYHGKEQVPRGCPDGL
                     CPLDMFLNAMSVYTLSPEKYHALCSQTQVMEVGNEE"
     exon            696..824
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..955
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1035
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1123
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1256
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1357
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1453
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1619
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..6956
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1797..1802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /note="hexamer: AATAAA"
     polyA_site      1818
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /note="major polyA site"
     regulatory      6259..6264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /note="hexamer: AATAAA"
     polyA_site      6282
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
     regulatory      6929..6934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /note="hexamer: AATAAA"
     polyA_site      6956
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
ORIGIN      
        1 cacttgggac gggtccctga gtaggtgagg aggtgggtag gagcttgctt atagaaaagt
       61 ggaatcgagt agtccttgct ggtggagccg ctgccgccag ggaactcagg gccggctcct
      121 gttccttcaa gagtgctgga ggccaaactt gaaatacaag tttaatgttc ctcgtcgggc
      181 aaaagataag gatccgatct cccccggccc ggtgtgcagc aggagcgacc aaccccgacc
      241 cgggttaaaa ctcccaggga ctcttcgctg ctgccacctc ttgttctctc ccccgttccc
      301 actcggggtc tccctcaggg ccgggaggca cagcggtccc tgcttgctga agggctggat
      361 gtacgcatcc gcaggttccc gcggacttgg gggcgcccgc tgagccccgg cgcccgcaga
      421 agacttgtgt ttgcctcctg cagcctcaac ccggagggca gcgagggcct accaccatga
      481 tcactggtgt gttcagcatg cgcttgtgga ccccagtggg cgtcctgacc tcgctggcgt
      541 actgcctgca ccagcggcgg gtggccctgg ccgagctgca ggaggccgat ggccagtgtc
      601 cggtcgaccg cagcctgctg aagttgaaaa tggtgcaggt cgtgtttcga cacggggctc
      661 ggagtcctct caagccgctc ccgctggagg agcaggtaga gtggaacccc cagctattag
      721 aggtcccacc ccaaactcag tttgattaca cagtcaccaa tctagctggt ggtccgaaac
      781 catattctcc ttacgactct caataccatg agaccaccct gaaggggggc atgtttgctg
      841 ggcagctgac caaggtgggc atgcagcaaa tgtttgcctt gggagagaga ctgaggaaga
      901 actatgtgga agacattccc tttctttcac caaccttcaa cccacaggag gtctttattc
      961 gttccactaa catttttcgg aatctggagt ccacccgttg tttgctggct gggcttttcc
     1021 agtgtcagaa agaaggaccc atcatcatcc acactgatga agcagattca gaagtcttgt
     1081 atcccaacta ccaaagctgc tggagcctga ggcagagaac cagaggccgg aggcagactg
     1141 cctctttaca gccaggaatc tcagaggatt tgaaaaaggt gaaggacagg atgggcattg
     1201 acagtagtga taaagtggac ttcttcatcc tcctggacaa cgtggctgcc gagcaggcac
     1261 acaacctccc aagctgcccc atgctgaaga gatttgcaag gatgatcgaa cagagagctg
     1321 tggacacatc cttgtacata ctgcccaagg aagacaggga aagtcttcag atggcagtag
     1381 gcccattcct ccacatccta gagagcaacc tgctgaaagc catggactct gccactgccc
     1441 ccgacaagat cagaaagctg tatctctatg cggctcatga tgtgaccttc ataccgctct
     1501 taatgaccct ggggattttt gaccacaaat ggccaccgtt tgctgttgac ctgaccatgg
     1561 aactttacca gcacctggaa tctaaggagt ggtttgtgca gctctattac cacgggaagg
     1621 agcaggtgcc gagaggttgc cctgatgggc tctgcccgct ggacatgttc ttgaatgcca
     1681 tgtcagttta taccttaagc ccagaaaaat accacgcact ctgctctcaa actcaggtga
     1741 tggaagttgg aaatgaagag taactgattt ataaaagcag gatgtgttga ttttaaaata
     1801 aagtgccttt atacaatgcc tcctgctttg tgtgtttggg aagaggagag agcaaggggt
     1861 aatgtacttt aatataatgt aaggatattt cctttctgtg ggtttactaa gatttcttcc
     1921 tgaacggaaa aggggtataa tattgagacc aaaaggatat ttctctattt tgtgagttgg
     1981 tttctaaggt tagaagcatc tttgtgtgac acgggctggg gacatcatga ccctgtagaa
     2041 ttgtgtcggt tttggacttt agttcttttc tcctatatta atttcacatg tattgagcta
     2101 cctactaagt agtgatcatt ataaaggtga aaacactctg ccctcaagtt gttgcagtcc
     2161 agtgggagag gcagccgagt aaatcagtga tacagtgctg tatgttttat gctgtaatag
     2221 gtatttgagg ggctatttgg gtatagagaa gaaacttcct gctcacatgg caggggatgt
     2281 ggggaacagt caaggaaggc ttctgaaaaa gtcctggcct gatctgagta gagaaaggtg
     2341 ggtaggagtt aaccaggaaa gcaaggatga aagcgtgttg cgtttagata aaggataggc
     2401 ttcaaggtca gggaacgttg ctgggtggtg agatggaacc ctgatgtgga ggctcagcag
     2461 gaagaagcag gaaggacact gggcccctgg tggttttagt tccagaaaca aatgtgggcc
     2521 ccagggctct gcaatggtaa ggctggaact actcaacata agagctccac ctttaactgt
     2581 gccccctaag agtacctgat gatcccccta tctccttgtc aatgttgctg ttcttctcca
     2641 gaatctattt caacccttct ctgatttcaa accaccagtc cctttacctc tcagagaaaa
     2701 cagcaaccac aaaagcctct ccacttccta ctatcttaat attgacaact tccagatcag
     2761 ggagctgaga tatctcaagc tcaggtttct cttctgagct tcagacactt ttatccactt
     2821 ggatttcact ggcacaaaac tttccatgtt agaatcaaac ccccctcctc ccagacctgc
     2881 ttctcccaca cacttcccta tctgaatgaa agacacctcc actctccacc cagttgccaa
     2941 atcagaaatc tgtctttgtt ttctttgtct cacattttcc tatgtctaat cagttaagtt
     3001 ttatcaatac tacctgttta tttctttaat ctattcacat atctttatcc tcaatcttca
     3061 gcatcccctt cccatcctca gtctgctggt tactgtattt cctattttac taagaatcta
     3121 aaagagatca gaagaaaact tccacatccc ccaacaccca accaccaaat ctgctaaccc
     3181 agttgcattg gtgcttttat agccttcctt cctccctctt actaagaatg aaccaacact
     3241 attcctatca aagcccaacc ctctagcttt acattgactc ctagtgtctt ttttctggat
     3301 tgtcaatttt tttcctgacc aattattcta ttagcaatac aaatatgctg taaaatctct
     3361 taaacttttt tctctgcatc tttgaactgc tgttctcttt tccttctccc cttcatagca
     3421 gaactcctca aaagagttgc tacctctaat tcttcccttc cagttctctc atgaaccagc
     3481 tacaattaag tattcacccc caccactcca tggaaactgc tcttgtcaaa atcatcaata
     3541 gcctttgtgt ggtgaatcca atagccagtt ttcattcttc ttactaagct tctcatcagt
     3601 attcctagac tatttccttc actggcttcg acaaatgctt tcttggtttt cctccaattt
     3661 ctcgactttg ttcctgctga atctaccttt ttctaatccg taagtgttgg ggtgtcccag
     3721 ggcttactcc ttggaccttt tttccacctt ttcccctaca ctcacccact aggtgatctc
     3781 aagaatttcc agtttgaggc cgggcgcggt ggctcacgcc tgtaatccca gcactttggg
     3841 aggccaaggc aggcagatca cctgaggcca ggagttcgag accagcctgg ccaacatggc
     3901 aaaaccctgt ctccactaaa cctgcctcta ctaaaaatac aaaaattatt atatttttat
     3961 aaaattatta taattttata aaattattat atttatggag tacaatgtga tgtaatccca
     4021 gctactcgga aggctgtatg tgtctattta tggagtacaa tgtgcctgta atcccagcta
     4081 cttgggaggc tgaggcagga gaatcacttc aacctaggag gcagaggttg tgctgagcca
     4141 agatcgtgcc attgcactcc agcctgggca acaagagaga aataacatct caaaaaaaaa
     4201 aaaagaattt ccagttttaa atatttacac aatgtctcct aaatttatac cttcaaccta
     4261 gacctttccc tgtgaatccc agtctcattt ccaacagtct aatcaatgtc tctatttgga
     4321 tgtttaagat atacaatagg tatcaaactt cccattgtcc acaataaact ctcaatttcc
     4381 gtgccttttc aaacttactc cttccacagg ctttcccatc taggtaaatg acaccaccat
     4441 tcaccctgtt gctttggcca agaactttag aactgccctt gactcccctc tttttctcat
     4501 atcctacctc tactacatca gtaactcctg ttgtatctct cttcaaacta tatccagaat
     4561 tgaccatgtc ccaatacttc cattgctact gtcttagtcc cagtgtcatc ttttacctgg
     4621 attattgtaa aggcctcgta actagtcttc ctgtttctgc ccttcccttc tctgcccatc
     4681 tattctcaac acagtgttgc ttttaaaaca aagtaagatc gtgccactct tctgctctaa
     4741 attccccatt ggtttctcat ctcaaactaa gggccagtca taatgccctc acggtcctat
     4801 gacatctcac tgcaccccag ccatactcgc catcttacca ttcttcttct tttttgtaat
     4861 aaaaactttt tactttcttt ttagttgaca gataataatt gcgtatattt atggagtaca
     4921 atgtgatgtt ttgatatatg tatgcatgag ggaatgatta aatcaagcta attaacatat
     4981 tcatcacttc atctactcat cactttcttg tggtgaaaat gtttcagata tactctttag
     5041 tagttttcag gtgtacagtc gctgtggttt gagtgctttt gtcttctcta aatttgatgt
     5101 tgacacttag tgcccagtac aatgttactg ggaggtggag cctaatgggg atgtttaatg
     5161 gattaatgcc attataaaaa gggcttgcag gaatgggttc cttctctttt gcttttctgc
     5221 catatgatga caaagtgttc ctcctctctg gaggatgcag caacaggcac catctttgaa
     5281 gcagagagac caggccctaa ccttctggtg ccttgatctt ggacttctca gcttccagaa
     5341 ctgtgagata ataaatttct gttcattaca aattacccca tctgtggtat tctgttatag
     5401 caacacaaaa tggactaaga caacagtata ctgttatgaa ctatggtcac catgctgtgc
     5461 actagatcac aaaaacttat ttctactgtt taactgaaac tttgtacatt ttgactaaca
     5521 tctccctttt tcccatcatc ccatcccatt cttactatcg ttgaagatgg agtatgccaa
     5581 gtagtcctga gccatgtcct cacctcgggg tgagcacctg ttgttcctgt gcctggaatg
     5641 ctctcctaga catttgcgtg gctagctccc tcttttcatt cagatctcag ctcattgtca
     5701 tctcagagag gccctccttg ccctccttct acctcctgcc ttaggtatac tctgccacct
     5761 tctgtcatgg gctgaattgt gtccccccta aatccatatg ttgacatctt aacccctagt
     5821 acagtaagtc ctcacttgat gctatcaata ggctcttgga aatgtcggct ttcagtgaaa
     5881 ggacatatag caggtccttg aataacattg tgttttgttc aacatcgttg ccttgtaaca
     5941 ctgatgagca aaacagttgg ttctctaata tgttgtttta cttaaagcta cagtttccaa
     6001 gaacctatca atgatgttga ggactgaatg tacctcaggt gtaatgtatt tggagatagg
     6061 gccttttaag aggtaaagta aatgaggtca tatgggtagg ctgtaatcca atatgactgg
     6121 aatccttata agaagaggaa atgaggacac agacacagag ggaagatgac tatctgcaag
     6181 tcaaggagag aggcctcaga agaaaccaat gctgctgaca ccacgatctt ggacttctag
     6241 cctctagcac tgtgaggaaa taaatttctg ttgtttaagc cacctagtct gtgatacttt
     6301 gctacggcag gccctagcaa atgaatacac ttgtcttgtc tttcccccgc cctgtgatat
     6361 ttatcagtgc cggatattac atatttgtgt atctatatgc ttatttccct gactaaaatg
     6421 gaagctccat gaaggcagat ttcctcttgt tcactgatgt gtccccagca cctggaatag
     6481 tgcctagtgc atgccagtgc tcagacactt ggacatttga atgacatatc ccctctgtca
     6541 cttctctccg gggcccaagg ccaccctcct aggttaccac agtggcttcc taatgggcca
     6601 taccctcact tgctttccat caccccctga gacctggccc ctgcatacct ctccagcttc
     6661 acccctcaca tatctcccta gccagaccta tagtatgttt aaaaaaaaag gaaatcgcac
     6721 tcctctggcc tctttacctt ggcacacatt tttccatcac ctgacccctg acccacactc
     6781 ccttttcctg tgtaatccaa ttatctctag gcctcccgtg tttctgtttg tccttcaata
     6841 gaaggttgtt tgtcttgtct tttattgtat ttctagaacc aagtgcagag actgtacaaa
     6901 gtggacctca gcaaagattt accgaatgaa taaatgagtt cagaacgctg acttaa
//
