LOCUS       NP_057445                428 aa            linear   PRI 09-FEB-2025
DEFINITION  lysophosphatidic acid phosphatase type 6 isoform 1 [Homo sapiens].
ACCESSION   NP_057445
VERSION     NP_057445.4
DBSOURCE    REFSEQ: accession NM_016361.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 428)
  AUTHORS   Gao,L., Xiong,D.D., Yang,X., Li,J.D., He,R.Q., Huang,Z.G.,
            Lai,Z.F., Liu,L.M., Luo,J.Y., Du,X.F., Zeng,J.H., Li,M.F., Li,S.H.,
            Dang,Y.W. and Chen,G.
  TITLE     The expression characteristics and clinical significance of ACP6, a
            potential target of nitidine chloride, in hepatocellular carcinoma
  JOURNAL   BMC Cancer 22 (1), 1244 (2022)
   PUBMED   36456931
  REMARK    GeneRIF: The expression characteristics and clinical significance
            of ACP6, a potential target of nitidine chloride, in hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 428)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (residues 1 to 428)
  AUTHORS   Chryplewicz,A., Tienda,S.M., Nahotko,D.A., Peters,P.N., Lengyel,E.
            and Eckert,M.A.
  TITLE     Mutant p53 regulates LPA signaling through lysophosphatidic acid
            phosphatase type 6
  JOURNAL   Sci Rep 9 (1), 5195 (2019)
   PUBMED   30914657
  REMARK    GeneRIF: Mutant p53 regulates LPA signaling through
            lysophosphatidic acid phosphatase type 6.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 428)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 428)
  AUTHORS   Li,J., Dong,Y., Lu,X., Wang,L., Peng,W., Zhang,X.C. and Rao,Z.
  TITLE     Crystal structures and biochemical studies of human
            lysophosphatidic acid phosphatase type 6
  JOURNAL   Protein Cell 4 (7), 548-561 (2013)
   PUBMED   23807634
  REMARK    GeneRIF: structures and biochemical studies of human
            lysophosphatidic acid phosphatase type 6
REFERENCE   6  (residues 1 to 428)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 428)
  AUTHORS   Tanaka,M., Kishi,Y., Takanezawa,Y., Kakehi,Y., Aoki,J. and Arai,H.
  TITLE     Prostatic acid phosphatase degrades lysophosphatidic acid in
            seminal plasma
  JOURNAL   FEBS Lett 571 (1-3), 197-204 (2004)
   PUBMED   15280042
  REMARK    GeneRIF: Human seminal plasma contains this enzyme which converts
            lysophospholipids to lysophosphatidic acid.
REFERENCE   8  (residues 1 to 428)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (residues 1 to 428)
  AUTHORS   Hiroyama,M. and Takenawa,T.
  TITLE     Isolation of a cDNA encoding human lysophosphatidic acid
            phosphatase that is involved in the regulation of mitochondrial
            lipid biosynthesis
  JOURNAL   J Biol Chem 274 (41), 29172-29180 (1999)
   PUBMED   10506173
REFERENCE   10 (residues 1 to 428)
  AUTHORS   Hiroyama,M. and Takenawa,T.
  TITLE     Purification and characterization of a lysophosphatidic
            acid-specific phosphatase
  JOURNAL   Biochem J 336 (Pt 2) (Pt 2), 483-489 (1998)
   PUBMED   9820827
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC241644.1, AL520992.3,
            BC009965.1, AB031478.1 and AB209248.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 12, 2013 this sequence version replaced NP_057445.3.
            
            Summary: This gene encodes a member of the histidine acid
            phosphatase protein family. The encoded protein hydrolyzes
            lysophosphatidic acid, which is involved in G protein-coupled
            receptor signaling, lipid raft modulation, and in balancing lipid
            composition within the cell. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, May 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009965.1, AB031478.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000583509.7/ ENSP00000463574.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     Protein         1..428
                     /product="lysophosphatidic acid phosphatase type 6 isoform
                     1"
                     /EC_number="3.1.3.2"
                     /note="acid phosphatase-like protein 1"
                     /calculated_mol_wt=45313
     transit_peptide 1..32
                     /note="Mitochondrion.
                     /evidence=ECO:0000269|PubMed:15340161; propagated from
                     UniProtKB/Swiss-Prot (Q9NPH0.3)"
                     /calculated_mol_wt=3591
     mat_peptide     33..428
                     /product="Lysophosphatidic acid phosphatase type 6.
                     /id=PRO_0000023965"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NPH0.3)"
                     /calculated_mol_wt=45313
     Region          49..379
                     /region_name="HP_HAP_like"
                     /note="Histidine phosphatase domain found in histidine
                     acid phosphatases and phytases; contains a His residue
                     which is phosphorylated during the reaction; cd07061"
                     /db_xref="CDD:132717"
     Site            order(58..59,62,168,334..335)
                     /site_type="active"
                     /note="catalytic core [active]"
                     /db_xref="CDD:132717"
     Region          58..168
                     /region_name="Substrate binding. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NPH0.3)"
     CDS             1..428
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /coded_by="NM_016361.5:477..1763"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS928.1"
                     /db_xref="GeneID:51205"
                     /db_xref="HGNC:HGNC:29609"
                     /db_xref="MIM:611471"
ORIGIN      
        1 mitgvfsmrl wtpvgvltsl ayclhqrrva laelqeadgq cpvdrsllkl kmvqvvfrhg
       61 arsplkplpl eeqvewnpql levppqtqfd ytvtnlaggp kpyspydsqy hettlkggmf
      121 agqltkvgmq qmfalgerlr knyvedipfl sptfnpqevf irstnifrnl estrcllagl
      181 fqcqkegpii ihtdeadsev lypnyqscws lrqrtrgrrq taslqpgise dlkkvkdrmg
      241 idssdkvdff illdnvaaeq ahnlpscpml krfarmieqr avdtslyilp kedreslqma
      301 vgpflhiles nllkamdsat apdkirklyl yaahdvtfip llmtlgifdh kwppfavdlt
      361 melyqhlesk ewfvqlyyhg keqvprgcpd glcpldmfln amsvytlspe kyhalcsqtq
      421 vmevgnee
//
