LOCUS       NM_001323625            2497 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens acid phosphatase 6, lysophosphatidic (ACP6),
            transcript variant 2, mRNA.
ACCESSION   NM_001323625
VERSION     NM_001323625.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2497)
  AUTHORS   Gao,L., Xiong,D.D., Yang,X., Li,J.D., He,R.Q., Huang,Z.G.,
            Lai,Z.F., Liu,L.M., Luo,J.Y., Du,X.F., Zeng,J.H., Li,M.F., Li,S.H.,
            Dang,Y.W. and Chen,G.
  TITLE     The expression characteristics and clinical significance of ACP6, a
            potential target of nitidine chloride, in hepatocellular carcinoma
  JOURNAL   BMC Cancer 22 (1), 1244 (2022)
   PUBMED   36456931
  REMARK    GeneRIF: The expression characteristics and clinical significance
            of ACP6, a potential target of nitidine chloride, in hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2497)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2497)
  AUTHORS   Chryplewicz,A., Tienda,S.M., Nahotko,D.A., Peters,P.N., Lengyel,E.
            and Eckert,M.A.
  TITLE     Mutant p53 regulates LPA signaling through lysophosphatidic acid
            phosphatase type 6
  JOURNAL   Sci Rep 9 (1), 5195 (2019)
   PUBMED   30914657
  REMARK    GeneRIF: Mutant p53 regulates LPA signaling through
            lysophosphatidic acid phosphatase type 6.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2497)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2497)
  AUTHORS   Li,J., Dong,Y., Lu,X., Wang,L., Peng,W., Zhang,X.C. and Rao,Z.
  TITLE     Crystal structures and biochemical studies of human
            lysophosphatidic acid phosphatase type 6
  JOURNAL   Protein Cell 4 (7), 548-561 (2013)
   PUBMED   23807634
  REMARK    GeneRIF: structures and biochemical studies of human
            lysophosphatidic acid phosphatase type 6
REFERENCE   6  (bases 1 to 2497)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2497)
  AUTHORS   Tanaka,M., Kishi,Y., Takanezawa,Y., Kakehi,Y., Aoki,J. and Arai,H.
  TITLE     Prostatic acid phosphatase degrades lysophosphatidic acid in
            seminal plasma
  JOURNAL   FEBS Lett 571 (1-3), 197-204 (2004)
   PUBMED   15280042
  REMARK    GeneRIF: Human seminal plasma contains this enzyme which converts
            lysophospholipids to lysophosphatidic acid.
REFERENCE   8  (bases 1 to 2497)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 2497)
  AUTHORS   Hiroyama,M. and Takenawa,T.
  TITLE     Isolation of a cDNA encoding human lysophosphatidic acid
            phosphatase that is involved in the regulation of mitochondrial
            lipid biosynthesis
  JOURNAL   J Biol Chem 274 (41), 29172-29180 (1999)
   PUBMED   10506173
REFERENCE   10 (bases 1 to 2497)
  AUTHORS   Hiroyama,M. and Takenawa,T.
  TITLE     Purification and characterization of a lysophosphatidic
            acid-specific phosphatase
  JOURNAL   Biochem J 336 (Pt 2) (Pt 2), 483-489 (1998)
   PUBMED   9820827
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC241644.1.
            
            On May 31, 2019 this sequence version replaced NM_001323625.1.
            
            Summary: This gene encodes a member of the histidine acid
            phosphatase protein family. The encoded protein hydrolyzes
            lysophosphatidic acid, which is involved in G protein-coupled
            receptor signaling, lipid raft modulation, and in balancing lipid
            composition within the cell. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, May 2016].
            
            Transcript Variant: This variant (2) differs in the 3' UTR and
            coding region, compared to variant 1. The encoded isoform (2) has a
            shorter and distinct C-terminus, compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.219872.1,
                                           SRR1803611.99038.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-695               AC241644.1         145804-146498
            696-824             AC241644.1         156553-156681
            825-955             AC241644.1         156802-156932
            956-1035            AC241644.1         157289-157368
            1036-1123           AC241644.1         161080-161167
            1124-1256           AC241644.1         162002-162134
            1257-1357           AC241644.1         163779-163879
            1358-1453           AC241644.1         166090-166185
            1454-2497           AC241644.1         167917-168960
FEATURES             Location/Qualifiers
     source          1..2497
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..2497
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /note="acid phosphatase 6, lysophosphatidic"
                     /db_xref="GeneID:51205"
                     /db_xref="HGNC:HGNC:29609"
                     /db_xref="MIM:611471"
     exon            1..695
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             477..1688
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /EC_number="3.1.3.2"
                     /note="isoform 2 is encoded by transcript variant 2; acid
                     phosphatase-like protein 1"
                     /codon_start=1
                     /product="lysophosphatidic acid phosphatase type 6 isoform
                     2"
                     /protein_id="NP_001310554.1"
                     /db_xref="GeneID:51205"
                     /db_xref="HGNC:HGNC:29609"
                     /db_xref="MIM:611471"
                     /translation="MITGVFSMRLWTPVGVLTSLAYCLHQRRVALAELQEADGQCPVD
                     RSLLKLKMVQVVFRHGARSPLKPLPLEEQVEWNPQLLEVPPQTQFDYTVTNLAGGPKP
                     YSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVF
                     IRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTDEADSEVLYPNYQSCWSLRQRTRGR
                     RQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARM
                     IEQRAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAMDSATAPDKIRKLYLYAAH
                     DVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLESKEWFVQLYYHGKVIPLRWGWVVV
                     RHPPAKPTYLS"
     exon            696..824
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..955
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1035
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1123
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1256
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1357
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1453
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..2497
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2476..2481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /note="hexamer: AATAAA"
     polyA_site      2497
                     /gene="ACP6"
                     /gene_synonym="ACPL1; LPAP; PACPL1"
                     /note="major polyA site"
ORIGIN      
        1 cacttgggac gggtccctga gtaggtgagg aggtgggtag gagcttgctt atagaaaagt
       61 ggaatcgagt agtccttgct ggtggagccg ctgccgccag ggaactcagg gccggctcct
      121 gttccttcaa gagtgctgga ggccaaactt gaaatacaag tttaatgttc ctcgtcgggc
      181 aaaagataag gatccgatct cccccggccc ggtgtgcagc aggagcgacc aaccccgacc
      241 cgggttaaaa ctcccaggga ctcttcgctg ctgccacctc ttgttctctc ccccgttccc
      301 actcggggtc tccctcaggg ccgggaggca cagcggtccc tgcttgctga agggctggat
      361 gtacgcatcc gcaggttccc gcggacttgg gggcgcccgc tgagccccgg cgcccgcaga
      421 agacttgtgt ttgcctcctg cagcctcaac ccggagggca gcgagggcct accaccatga
      481 tcactggtgt gttcagcatg cgcttgtgga ccccagtggg cgtcctgacc tcgctggcgt
      541 actgcctgca ccagcggcgg gtggccctgg ccgagctgca ggaggccgat ggccagtgtc
      601 cggtcgaccg cagcctgctg aagttgaaaa tggtgcaggt cgtgtttcga cacggggctc
      661 ggagtcctct caagccgctc ccgctggagg agcaggtaga gtggaacccc cagctattag
      721 aggtcccacc ccaaactcag tttgattaca cagtcaccaa tctagctggt ggtccgaaac
      781 catattctcc ttacgactct caataccatg agaccaccct gaaggggggc atgtttgctg
      841 ggcagctgac caaggtgggc atgcagcaaa tgtttgcctt gggagagaga ctgaggaaga
      901 actatgtgga agacattccc tttctttcac caaccttcaa cccacaggag gtctttattc
      961 gttccactaa catttttcgg aatctggagt ccacccgttg tttgctggct gggcttttcc
     1021 agtgtcagaa agaaggaccc atcatcatcc acactgatga agcagattca gaagtcttgt
     1081 atcccaacta ccaaagctgc tggagcctga ggcagagaac cagaggccgg aggcagactg
     1141 cctctttaca gccaggaatc tcagaggatt tgaaaaaggt gaaggacagg atgggcattg
     1201 acagtagtga taaagtggac ttcttcatcc tcctggacaa cgtggctgcc gagcaggcac
     1261 acaacctccc aagctgcccc atgctgaaga gatttgcaag gatgatcgaa cagagagctg
     1321 tggacacatc cttgtacata ctgcccaagg aagacaggga aagtcttcag atggcagtag
     1381 gcccattcct ccacatccta gagagcaacc tgctgaaagc catggactct gccactgccc
     1441 ccgacaagat cagaaagctg tatctctatg cggctcatga tgtgaccttc ataccgctct
     1501 taatgaccct ggggattttt gaccacaaat ggccaccgtt tgctgttgac ctgaccatgg
     1561 aactttacca gcacctggaa tctaaggagt ggtttgtgca gctctattac cacgggaagg
     1621 taatacccct gaggtggggt tgggtggtgg tgaggcaccc tcctgcaaaa cccacctacc
     1681 tgagttagca ccaagtctcc ctcctcaggc ccagtggagt ctctcttggc acagtcagct
     1741 ctctgaatcc tatagggcaa ctcctggcta tggcccaggg gtcaggcaga acttgacaga
     1801 tggtggcagg atggggcttg agccttatcc cagttctgtt acagactcct aggaacaggg
     1861 tccccctcct cttctcctga gcgtccctgt caggatgtcg cctcctggct gtgagacctg
     1921 ttttggagat tgttggtggt atctttggga ggtgatgtgt gctgctgtta gcacccgtgg
     1981 tgttggctgc ttcatcaggg ctggggtcca gggcagaggc cagagcacgc cccagggatg
     2041 agcctgttgg ttctcccagc tcggggatgt aactcgactc tttcttccca gtcaattcaa
     2101 cactttttga gtgactttta caagcagagc atagtgcttt tattctggaa gctcaccggg
     2161 tagtggggcc ttcctgtctg taatatgtat gcacatgtat accacatgga tcagagcctc
     2221 tcagatctct gggcttagct ggaaatagca gaaggacagg ttcctcggcg gacctgctga
     2281 gttatgtttc ttctgcagga gcaggtgccg agaggttgcc ctgatgggct ctgcccgctg
     2341 gacatgttct tgaatgccat gtcagtttat accttaagcc cagaaaaata ccacgcactc
     2401 tgctctcaaa ctcaggtgat ggaagttgga aatgaagagt aactgattta taaaagcagg
     2461 atgtgttgat tttaaaataa agtgccttta tacaatg
//
