LOCUS       NM_001099               3174 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens acid phosphatase 3 (ACP3), transcript variant 1, mRNA.
ACCESSION   NM_001099
VERSION     NM_001099.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3174)
  AUTHORS   Liu,X., Yu,L., Xia,Z., Li,J., Meng,W., Min,L., Li,F. and Wang,X.
  TITLE     Purification, identification and Cryo-EM structure of prostatic
            acid phosphatase in human semen
  JOURNAL   Biochem Biophys Res Commun 702, 149652 (2024)
   PUBMED   38341922
  REMARK    GeneRIF: Purification, identification and Cryo-EM structure of
            prostatic acid phosphatase in human semen.
REFERENCE   2  (bases 1 to 3174)
  AUTHORS   Alpert,E., Akhavan,A., Gruzman,A., Hansen,W.J., Lehrer-Graiwer,J.,
            Hall,S.C., Johansen,E., McAllister,S., Gulati,M., Lin,M.F. and
            Lingappa,V.R.
  TITLE     Multifunctionality of prostatic acid phosphatase in prostate cancer
            pathogenesis
  JOURNAL   Biosci Rep 41 (10) (2021)
   PUBMED   34677582
  REMARK    GeneRIF: Multifunctionality of prostatic acid phosphatase in
            prostate cancer pathogenesis.
REFERENCE   3  (bases 1 to 3174)
  AUTHORS   Pan,X., Sang,S., Fei,G., Jin,L., Liu,H., Wang,Z., Wang,H. and
            Zhong,C.
  TITLE     Enhanced Activities of Blood Thiamine Diphosphatase and
            Monophosphatase in Alzheimer's Disease
  JOURNAL   PLoS One 12 (1), e0167273 (2017)
   PUBMED   28060825
  REMARK    GeneRIF: Enhanced TDPase and TMPase activities may contribute to
            the reduction of TDP level in AD patients. The results imply that
            an imbalance of phosphorylation-dephosphorylation related to
            thiamine and glucose metabolism may be a potential target for AD
            prevention and therapy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3174)
  AUTHORS   Srivastava,K.R., French,K.C., Tzul,F.O., Makhatadze,G.I. and
            Lapidus,L.J.
  TITLE     Intramolecular diffusion controls aggregation of the PAPf39 peptide
  JOURNAL   Biophys Chem 216, 37-43 (2016)
   PUBMED   27393931
  REMARK    GeneRIF: we have measured the intramolecular diffusion of the full
            length and 8-residue deletion peptides at two different pHs and
            found a correlation with fibrillization lag time. These results can
            be explained by a simple kinetic model of the early stages of
            aggregation in which oligomerization is controlled by the rate of
            peptide reconfiguration.
REFERENCE   5  (bases 1 to 3174)
  AUTHORS   Zylka,M.J., Sowa,N.A., Taylor-Blake,B., Twomey,M.A., Herrala,A.,
            Voikar,V. and Vihko,P.
  TITLE     Prostatic acid phosphatase is an ectonucleotidase and suppresses
            pain by generating adenosine
  JOURNAL   Neuron 60 (1), 111-122 (2008)
   PUBMED   18940592
  REMARK    GeneRIF: Suppresses pain by functioning as an ecto-5'-nucleotidase,
            activating A1-adenosine receptors in the dorsal spinal cord.
REFERENCE   6  (bases 1 to 3174)
  AUTHORS   Quintero,I.B., Araujo,C.L., Pulkka,A.E., Wirkkala,R.S.,
            Herrala,A.M., Eskelinen,E.L., Jokitalo,E., Hellstrom,P.A.,
            Tuominen,H.J., Hirvikoski,P.P. and Vihko,P.T.
  TITLE     Prostatic acid phosphatase is not a prostate specific target
  JOURNAL   Cancer Res 67 (14), 6549-6554 (2007)
   PUBMED   17638863
  REMARK    GeneRIF: Prostatic acid phosphatase is not a prostate specific
            target
REFERENCE   7  (bases 1 to 3174)
  AUTHORS   Sharief,F.S. and Li,S.S.
  TITLE     Structure of human prostatic acid phosphatase gene
  JOURNAL   Biochem Biophys Res Commun 184 (3), 1468-1476 (1992)
   PUBMED   1375464
REFERENCE   8  (bases 1 to 3174)
  AUTHORS   Nguyen,L., Chapdelaine,A. and Chevalier,S.
  TITLE     Prostatic acid phosphatase in serum of patients with prostatic
            cancer is a specific phosphotyrosine acid phosphatase
  JOURNAL   Clin Chem 36 (8 Pt 1), 1450-1455 (1990)
   PUBMED   1696855
REFERENCE   9  (bases 1 to 3174)
  AUTHORS   Cooper,J.F., Foti,A. and Herschman,H.
  TITLE     Combined serum and bone marrow radioimmunoassays for prostatic acid
            phosphatase
  JOURNAL   J Urol 122 (4), 498-502 (1979)
   PUBMED   480493
REFERENCE   10 (bases 1 to 3174)
  AUTHORS   Cooper,J.F., Foti,A.G. and Shank,P.W.
  TITLE     Radioimmunochemical measurement of bone marrow prostatic acid
            phosphatase
  JOURNAL   J Urol 119 (3), 392-395 (1978)
   PUBMED   76687
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC016344.1, BC008493.1,
            AC020633.3 and AA578274.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001099.4.
            
            Summary: This gene encodes an enzyme that catalyzes the conversion
            of orthophosphoric monoester to alcohol and orthophosphate. It is
            synthesized under androgen regulation and is secreted by the
            epithelial cells of the prostate gland. An alternatively spliced
            transcript variant encoding a longer isoform has been found for
            this gene. This isoform contains a transmembrane domain and is
            localized in the plasma membrane-endosomal-lysosomal pathway.
            [provided by RefSeq, Sep 2008].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the shorter, secreted isoform (PAP).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M24902.1, X52174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336375.10/ ENSP00000337471.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-898               BC016344.1         5-902
            899-1419            BC008493.1         896-1416
            1420-3168           AC020633.3         87008-88756         c
            3169-3174           AA578274.1         10-15               c
FEATURES             Location/Qualifiers
     source          1..3174
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..3174
                     /gene="ACP3"
                     /gene_synonym="5'-NT; ACP-3; ACPP; TM-PAP"
                     /note="acid phosphatase 3"
                     /db_xref="GeneID:55"
                     /db_xref="HGNC:HGNC:125"
                     /db_xref="MIM:171790"
     exon            1..170
                     /gene="ACP3"
                     /gene_synonym="5'-NT; ACP-3; ACPP; TM-PAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1211
                     /gene="ACP3"
                     /gene_synonym="5'-NT; ACP-3; ACPP; TM-PAP"
                     /EC_number="3.1.3.2"
                     /EC_number="3.1.3.48"
                     /EC_number="3.1.3.5"
                     /note="isoform PAP precursor is encoded by transcript
                     variant 1; prostatic acid phosphotase; TMPase;
                     ecto-5'-nucleotidase; thiamine monophosphatase; acid
                     phosphatase, prostate; protein tyrosine phosphatase ACP3"
                     /codon_start=1
                     /product="prostatic acid phosphatase isoform PAP
                     precursor"
                     /protein_id="NP_001090.2"
                     /db_xref="CCDS:CCDS3073.1"
                     /db_xref="GeneID:55"
                     /db_xref="HGNC:HGNC:125"
                     /db_xref="MIM:171790"
                     /translation="MRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRH
                     GDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELGEYIRKRYRKFLNESYKHEQV
                     YIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRN
                     CPRFQELESETLKSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESV
                     HNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGVLVNEILNHMKRATQ
                     IPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNE
                     TQHEPYPLMLPGCSPSCPLERFAELVGPVIPQDWSTECMTTNSHQGTEDSTD"
     exon            171..266
                     /gene="ACP3"
                     /gene_synonym="5'-NT; ACP-3; ACPP; TM-PAP"
                     /inference="alignment:Splign:2.1.0"
     exon            267..353
                     /gene="ACP3"
                     /gene_synonym="5'-NT; ACP-3; ACPP; TM-PAP"
                     /inference="alignment:Splign:2.1.0"
     exon            354..506
                     /gene="ACP3"
                     /gene_synonym="5'-NT; ACP-3; ACPP; TM-PAP"
                     /inference="alignment:Splign:2.1.0"
     exon            507..605
                     /gene="ACP3"
                     /gene_synonym="5'-NT; ACP-3; ACPP; TM-PAP"
                     /inference="alignment:Splign:2.1.0"
     exon            606..698
                     /gene="ACP3"
                     /gene_synonym="5'-NT; ACP-3; ACPP; TM-PAP"
                     /inference="alignment:Splign:2.1.0"
     exon            699..831
                     /gene="ACP3"
                     /gene_synonym="5'-NT; ACP-3; ACPP; TM-PAP"
                     /inference="alignment:Splign:2.1.0"
     exon            832..914
                     /gene="ACP3"
                     /gene_synonym="5'-NT; ACP-3; ACPP; TM-PAP"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1018
                     /gene="ACP3"
                     /gene_synonym="5'-NT; ACP-3; ACPP; TM-PAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..3174
                     /gene="ACP3"
                     /gene_synonym="5'-NT; ACP-3; ACPP; TM-PAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3066..3071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACP3"
                     /gene_synonym="5'-NT; ACP-3; ACPP; TM-PAP"
                     /note="hexamer: AATAAA"
     polyA_site      3093
                     /gene="ACP3"
                     /gene_synonym="5'-NT; ACP-3; ACPP; TM-PAP"
                     /note="major polyA site"
     regulatory      3146..3151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACP3"
                     /gene_synonym="5'-NT; ACP-3; ACPP; TM-PAP"
                     /note="hexamer: AATAAA"
     polyA_site      3174
                     /gene="ACP3"
                     /gene_synonym="5'-NT; ACP-3; ACPP; TM-PAP"
ORIGIN      
        1 gaagtggtag cagttcctcc taactcctgc cagaaacagc tctcctcaac atgagagctg
       61 cacccctcct cctggccagg gcagcaagcc ttagccttgg cttcttgttt ctgctttttt
      121 tctggctaga ccgaagtgta ctagccaagg agttgaagtt tgtgactttg gtgtttcggc
      181 atggagaccg aagtcccatt gacacctttc ccactgaccc cataaaggaa tcctcatggc
      241 cacaaggatt tggccaactc acccagctgg gcatggagca gcattatgaa cttggagagt
      301 atataagaaa gagatataga aaattcttga atgagtccta taaacatgaa caggtttata
      361 ttcgaagcac agacgttgac cggactttga tgagtgctat gacaaacctg gcagccctgt
      421 ttcccccaga aggtgtcagc atctggaatc ctatcctact ctggcagccc atcccggtgc
      481 acacagttcc tctttctgaa gatcagttgc tatacctgcc tttcaggaac tgccctcgtt
      541 ttcaagaact tgagagtgag actttgaaat cagaggaatt ccagaagagg ctgcaccctt
      601 ataaggattt tatagctacc ttgggaaaac tttcaggatt acatggccag gacctttttg
      661 gaatttggag taaagtctac gaccctttat attgtgagag tgttcacaat ttcactttac
      721 cctcctgggc cactgaggac accatgacta agttgagaga attgtcagaa ttgtccctcc
      781 tgtccctcta tggaattcac aagcagaaag agaaatctag gctccaaggg ggtgtcctgg
      841 tcaatgaaat cctcaatcac atgaagagag caactcagat accaagctac aaaaaactca
      901 tcatgtattc tgcgcatgac actactgtga gtggcctaca gatggcgcta gatgtttaca
      961 acggactcct tcctccctat gcttcttgcc acttgacgga attgtacttt gagaaggggg
     1021 agtactttgt ggagatgtac tatcggaatg agacgcagca cgagccgtat cccctcatgc
     1081 tacctggctg cagccccagc tgtcctctgg agaggtttgc tgagctggtt ggccctgtga
     1141 tccctcaaga ctggtccacg gagtgtatga ccacaaacag ccatcaaggt actgaagaca
     1201 gtacagatta gtgtgcacag agatctctgt agaaggagta gctgcccttt ctcagggcag
     1261 atgatgcttt gagaacatac tttggccatt acccccagct ttgaggaaaa tgggctttgg
     1321 atgattattt tatgttttag ggacccccaa cctcaggcaa ttcctacctc ttcacctgac
     1381 cctgccccca cttgccataa aacttagcta agttttgttt tgtttttcag cgttaatgta
     1441 aaggggcagc agtgccaaaa tataatcaga gataaagctt aggtcaaagt tcatagagtt
     1501 cccatgaact atatgactgg ccacacagga tcttttgtat ttaaggattc tgagattttg
     1561 cttgagcagg attagataag gctgttcttt aaatgtctga aatggaacag atttcaaaaa
     1621 aaaaccccac aatctaggat gggaacaagg aaggaaagat gtgaataggc tgatgggcaa
     1681 aaaaccaatt tacccatcag ttccagcctt ctctcaagga gaggcaaaga aaggagatac
     1741 agtggagaca tctggaaagt tttctccact ggaaaactgc tactatctgt ttttatattt
     1801 ctgttaaaat atatgaggct acagaactaa aaattaaaac ctctttgtgt cccttggtcc
     1861 tggaacattt atgttccttt taaagaaaca aaaatcaaac tttacagaaa gatttgatgt
     1921 atgtaataca tatagcagct cttgaagtat atatatcata gcaaataagt catctgatga
     1981 gaacaagcta tttgggcaca acacatcagg aaagagagca ccacgtgatg gagtttctct
     2041 agaagctcca gtgataagag atgttgactc taaagttgat ttaaggccag gcatggtggt
     2101 ttacgcctat aatcccagca ttttgggagt ccgaggtggg cagatcactt gagctcagga
     2161 ggtcaagatc agcctgggca acatggtgaa acctggtctc tacataaaat acaaaaactt
     2221 agatgggcat ggtggtgtgt gcctatagtc ccactacttg tggggctaag gcaggaggat
     2281 cacttgagcc ccggaggtcg aggctacagt gagccaagag tgcactactg tactccagcc
     2341 agggcaagag agcgagaccc tgtctcaata aataaataaa taaataaata aataaataaa
     2401 taaataaata aaaacaaagt tgattaagaa aggaagtata ggccaggcac agtggctcac
     2461 acctgtaatc cttgcatttt ggaaggctga ggcaggagga tcactttagg cctggtgtgt
     2521 tcaagaccag cctggtcaac atagtgagac actgtctcta ccaaaaaaag gaaggaaggg
     2581 acacatatca aactgaaaca aaattagaaa tgtaattatg ttctaagtgc ctccaagttc
     2641 aaaacttatt ggaatgttga gagtgtggtt acgaaatacg ttaggaggac aaaaggaatg
     2701 tgtaagtctt taatgccgat atcttcagaa aacctaagca aacttacagg tcctgctgaa
     2761 actgcccact ctgcaagaag aaatcatgat atagctttgc catgtggcag atctacatgt
     2821 ctagagaaca ctgtgctcta ttaccattat ggataaagat gagatggttt ctagagatgg
     2881 tttctactgg ctgccagaat ctagagcaaa gccatccccg ctcctggttg gtcacagaat
     2941 gactgacaaa gacatcgatt gatatgcttc tttgtgttat ttccctccca agtaaatgtt
     3001 tgtccttggg tccattttct atgcttgtaa ctgtcttcta gcagtgagcc aaatgtaaaa
     3061 tagtgaataa agtcattatt aggaagttca aaagcattgc ttttataatg aacttagaaa
     3121 aacgtatgtg tgtgtgttta attagaataa aattcctcta ggcagatttc agga
//
