LOCUS       NM_004300               1474 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens acid phosphatase 1 (ACP1), transcript variant 3, mRNA.
ACCESSION   NM_004300
VERSION     NM_004300.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1474)
  AUTHORS   Faria,A.V.S., Yu,B., Mommersteeg,M., de Souza-Oliveira,P.F.,
            Andrade,S.S., Spaander,M.C.W., de Maat,M.P.M., Peppelenbosch,M.P.,
            Ferreira-Halder,C.V. and Fuhler,G.M.
  TITLE     Platelet-dependent signaling and Low Molecular Weight Protein
            Tyrosine Phosphatase expression promote aggressive phenotypic
            changes in gastrointestinal cancer cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1868 (1), 166280 (2022)
   PUBMED   34610471
  REMARK    GeneRIF: Platelet-dependent signaling and Low Molecular Weight
            Protein Tyrosine Phosphatase expression promote aggressive
            phenotypic changes in gastrointestinal cancer cells.
REFERENCE   2  (bases 1 to 1474)
  AUTHORS   Faria,A.V.S., Fonseca,E.M.B., Cordeiro,H.G., Clerici,S.P. and
            Ferreira-Halder,C.V.
  TITLE     Low molecular weight protein tyrosine phosphatase as signaling hub
            of cancer hallmarks
  JOURNAL   Cell Mol Life Sci 78 (4), 1263-1273 (2021)
   PUBMED   33052434
  REMARK    GeneRIF: Low molecular weight protein tyrosine phosphatase as
            signaling hub of cancer hallmarks.
            Review article
REFERENCE   3  (bases 1 to 1474)
  AUTHORS   Cordeiro,H.G., de Sousa Faria,A.V. and Ferreira-Halder,C.V.
  TITLE     Vemurafenib downmodulates aggressiveness mediators of colorectal
            cancer (CRC): Low Molecular Weight Protein Tyrosine Phosphatase
            (LMWPTP), Protein Tyrosine Phosphatase 1B (PTP1B) and Transforming
            Growth Factor beta (TGFbeta)
  JOURNAL   Biol Chem 401 (9), 1063-1069 (2020)
   PUBMED   32229687
  REMARK    GeneRIF: Vemurafenib downmodulates aggressiveness mediators of
            colorectal cancer (CRC): Low Molecular Weight Protein Tyrosine
            Phosphatase (LMWPTP), Protein Tyrosine Phosphatase 1B (PTP1B) and
            Transforming Growth Factor beta (TGFbeta).
REFERENCE   4  (bases 1 to 1474)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1474)
  AUTHORS   Faria,A.V.S., Clerici,S.P., de Souza Oliveira,P.F., Queiroz,K.C.S.,
            Peppelenbosch,M.P. and Ferreira-Halder,C.V.
  TITLE     LMWPTP modulates the antioxidant response and autophagy process in
            human chronic myeloid leukemia cells
  JOURNAL   Mol Cell Biochem 466 (1-2), 83-89 (2020)
   PUBMED   32016696
  REMARK    GeneRIF: LMWPTP modulates the antioxidant response and autophagy
            process in human chronic myeloid leukemia cells.
REFERENCE   6  (bases 1 to 1474)
  AUTHORS   Dissing,J. and Johnsen,A.H.
  TITLE     Human red cell acid phosphatase (ACP1): the primary structure of
            the two pairs of isozymes encoded by the ACP1*A and ACP1*C alleles
  JOURNAL   Biochim Biophys Acta 1121 (3), 261-268 (1992)
   PUBMED   1627603
REFERENCE   7  (bases 1 to 1474)
  AUTHORS   Shekels,L.L., Smith,A.J., Van Etten,R.L. and Bernlohr,D.A.
  TITLE     Identification of the adipocyte acid phosphatase as a PAO-sensitive
            tyrosyl phosphatase
  JOURNAL   Protein Sci 1 (6), 710-721 (1992)
   PUBMED   1304913
REFERENCE   8  (bases 1 to 1474)
  AUTHORS   Wo,Y.Y., McCormack,A.L., Shabanowitz,J., Hunt,D.F., Davis,J.P.,
            Mitchell,G.L. and Van Etten,R.L.
  TITLE     Sequencing, cloning, and expression of human red cell-type acid
            phosphatase, a cytoplasmic phosphotyrosyl protein phosphatase
  JOURNAL   J Biol Chem 267 (15), 10856-10865 (1992)
   PUBMED   1587862
REFERENCE   9  (bases 1 to 1474)
  AUTHORS   Junien,C., Kaplan,J.C., Bernheim,A. and Berger,R.
  TITLE     Regional assignment of red cell acid phosphatase locus to band 2p25
  JOURNAL   Hum Genet 48 (1), 17-21 (1979)
   PUBMED   457131
REFERENCE   10 (bases 1 to 1474)
  AUTHORS   Sensabaugh,G.F. and Golden,V.L.
  TITLE     Phenotype dependence in the inhibition of red cell acid phosphatase
            (ACP) by folates
  JOURNAL   Am J Hum Genet 30 (5), 553-560 (1978)
   PUBMED   736044
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB209838.1, DB443811.1 and
            BX481618.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004300.3.
            
            Summary: The product of this gene belongs to the phosphotyrosine
            protein phosphatase family of proteins. It functions as an acid
            phosphatase and a protein tyrosine phosphatase by hydrolyzing
            protein tyrosine phosphate to protein tyrosine and orthophosphate.
            This enzyme also hydrolyzes orthophosphoric monoesters to alcohol
            and orthophosphate. This gene is genetically polymorphic, and three
            common alleles segregating at the corresponding locus give rise to
            six phenotypes. Each allele appears to encode at least two
            electrophoretically different isozymes, Bf and Bs, which are
            produced in allele-specific ratios. Multiple alternatively spliced
            transcript variants encoding distinct isoforms have been identified
            for this gene. [provided by RefSeq, Aug 2008].
            
            Transcript Variant: This variant (3) has multiple differences in
            the coding region, compared to variant 4. The resulting protein
            (isoform c, also known as Bf) has a distinct C-terminus and is
            longer than isoform d.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1092612.1,
                                           SRR3476690.449309.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272065.10/ ENSP00000272065.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               AB209838.1         4-337
            335-388             DB443811.1         392-445
            389-1458            AB209838.1         392-1461
            1459-1474           BX481618.1         17-32               c
FEATURES             Location/Qualifiers
     source          1..1474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.3"
     gene            1..1474
                     /gene="ACP1"
                     /gene_synonym="HAAP; LMW-PTP; LMWPTP"
                     /note="acid phosphatase 1"
                     /db_xref="GeneID:52"
                     /db_xref="HGNC:HGNC:122"
                     /db_xref="MIM:171500"
     exon            1..61
                     /gene="ACP1"
                     /gene_synonym="HAAP; LMW-PTP; LMWPTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..495
                     /gene="ACP1"
                     /gene_synonym="HAAP; LMW-PTP; LMWPTP"
                     /EC_number="3.1.3.2"
                     /EC_number="3.1.3.48"
                     /note="isoform c is encoded by transcript variant 3; acid
                     phosphatase of erythrocyte; red cell acid phosphatase 1;
                     acid phosphatase 1, soluble; low molecular weight
                     phosphotyrosine protein phosphatase; cytoplasmic
                     phosphotyrosyl protein phosphatase; protein tyrosine
                     phosphatase; adipocyte acid phosphatase; LMW-PTPase; low
                     molecular weight cytosolic acid phosphatase; testicular
                     secretory protein Li 37"
                     /codon_start=1
                     /product="low molecular weight phosphotyrosine protein
                     phosphatase isoform c"
                     /protein_id="NP_004291.1"
                     /db_xref="CCDS:CCDS1639.1"
                     /db_xref="GeneID:52"
                     /db_xref="HGNC:HGNC:122"
                     /db_xref="MIM:171500"
                     /translation="MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDS
                     AATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNR
                     KSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH"
     exon            62..135
                     /gene="ACP1"
                     /gene_synonym="HAAP; LMW-PTP; LMWPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            136..249
                     /gene="ACP1"
                     /gene_synonym="HAAP; LMW-PTP; LMWPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            250..311
                     /gene="ACP1"
                     /gene_synonym="HAAP; LMW-PTP; LMWPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            312..417
                     /gene="ACP1"
                     /gene_synonym="HAAP; LMW-PTP; LMWPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            418..1474
                     /gene="ACP1"
                     /gene_synonym="HAAP; LMW-PTP; LMWPTP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      677..682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACP1"
                     /gene_synonym="HAAP; LMW-PTP; LMWPTP"
                     /note="hexamer: AATAAA"
     polyA_site      699
                     /gene="ACP1"
                     /gene_synonym="HAAP; LMW-PTP; LMWPTP"
                     /note="major polyA site"
     regulatory      1455..1460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACP1"
                     /gene_synonym="HAAP; LMW-PTP; LMWPTP"
                     /note="hexamer: AATACA"
     polyA_site      1474
                     /gene="ACP1"
                     /gene_synonym="HAAP; LMW-PTP; LMWPTP"
                     /note="major polyA site"
ORIGIN      
        1 gcctctgcgc gcgggaagat ggcggaacag gctaccaagt ccgtgctgtt tgtgtgtctg
       61 ggtaacattt gtcgatcacc cattgcagaa gcagttttca ggaaacttgt aaccgatcaa
      121 aacatctcag agaattggag ggtagacagc gcggcaactt ccgggtatga gatagggaac
      181 ccccctgact accgagggca gagctgcatg aagaggcacg gcattcccat gagccacgtt
      241 gcccggcaga ttaccaaaga agattttgcc acatttgatt atatactatg tatggatgaa
      301 agcaatctga gagatttgaa tagaaaaagt aatcaagtta aaacctgcaa agctaaaatt
      361 gaactacttg ggagctatga tccacaaaaa caacttatta ttgaagatcc ctattatggg
      421 aatgactctg actttgagac ggtgtaccag cagtgtgtca ggtgctgcag agcgttcttg
      481 gagaaggccc actgaggcag gttcgtgccc tgctgcggcc agcctgacta gaccccaccc
      541 tgaggtcctg catttctcag tcggtgtgta atcacgttcc agggcccaaa gcccagctct
      601 ttgttcagtt gacttactgt ttcttacctt aaaaagtaat tgtagatgga aatcagttgt
      661 gtttggcagg agaatcaata aaaatctttg attcagacag cttatggggt attttaagca
      721 ttcttagact agttgaacat ctcactttgc cccagttaca aaaatagtag aacaagcaac
      781 ataaaacaat gaaggaaaac ctcacttgaa ggcccaggtc aacatctaag cctgttgaga
      841 cttagataat cgagtctacc tcttcagtag gtttgtgtgg atggcctgga gggcaggtgc
      901 cctctgctcc ccagtgctac ctctctcttc cctagggcct tttgtggatt gacagtagtc
      961 ccctccgtag gagctcacag tctagattag aagtgtttta atttctacac acccatagtg
     1021 cacacttgta tattgaaaag atagggaaga gagaaacatt tatggaatca gtcgttggca
     1081 ccttcaatac ttcatgattt ttgtcgagtt tacttcatga ggaggtcagc ccattggctc
     1141 ccatctgaac cactttgcct ctgaaactta attacatcca gaaagaagga cacttgtatg
     1201 ctagtctatg gtcagttgag gaatatgact gtttttatat gcacatgtaa cccaaatgtc
     1261 caatataaat tggcttattt tttaaaataa ttttaaaagt tgggaaaagt gttattattt
     1321 ggcatgctta aatattgaat aagtattctt catcagcatt taataaatgt ataggcagat
     1381 gtaaggtaat ttctgtgtat tttgagataa tgtcaaaatc atgaatattt caaaataaac
     1441 tggggagtta taaaaataca actagagata taaa
//
