LOCUS       NM_003500               2297 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens acyl-CoA oxidase 2 (ACOX2), mRNA.
ACCESSION   NM_003500
VERSION     NM_003500.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2297)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2297)
  AUTHORS   Zhang,Q., Zhang,Y., Sun,S., Wang,K., Qian,J., Cui,Z., Tao,T. and
            Zhou,J.
  TITLE     ACOX2 is a prognostic marker and impedes the progression of
            hepatocellular carcinoma via PPARalpha pathway
  JOURNAL   Cell Death Dis 12 (1), 15 (2021)
   PUBMED   33414412
  REMARK    GeneRIF: ACOX2 is a prognostic marker and impedes the progression
            of hepatocellular carcinoma via PPARalpha pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2297)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2297)
  AUTHORS   Lisowska,M., Pietrucha,T. and Sakowicz,A.
  TITLE     Preeclampsia and Related Cardiovascular Risk: Common Genetic
            Background
  JOURNAL   Curr Hypertens Rep 20 (8), 71 (2018)
   PUBMED   29971632
  REMARK    GeneRIF: ACOX2, physiologically responsible for one of the stages
            in the degradation of branched-chain fatty acids and bile acid, may
            be a possible genetic risk factor linking Preeclampsia and Related
            Cardiovascular diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2297)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2297)
  AUTHORS   Moghrabi,N.N., Naylor,S.L., Van Veldhoven,P.P., Baumgart,E.,
            Dawson,D.B. and Bennett,M.J.
  TITLE     Assignment of the human peroxisomal branched-chain acyl-CoA oxidase
            gene to chromosome 3p21.1-p14.2 by rodent/human somatic cell
            hybridization
  JOURNAL   Biochem Biophys Res Commun 231 (3), 767-769 (1997)
   PUBMED   9070889
REFERENCE   7  (bases 1 to 2297)
  AUTHORS   Baumgart,E., Vanhooren,J.C., Fransen,M., Mannaerts,G.P. and Van
            Veldhoven,P.P.
  TITLE     Mammalian peroxisomal acyl-CoA oxidases. III. Molecular
            characterization of human branched chain fatty acyl-CoA oxidase
  JOURNAL   Ann N Y Acad Sci 804, 678-679 (1996)
   PUBMED   8993592
REFERENCE   8  (bases 1 to 2297)
  AUTHORS   Baumgart,E., Vanhooren,J.C., Fransen,M., Marynen,P., Puype,M.,
            Vandekerckhove,J., Leunissen,J.A., Fahimi,H.D., Mannaerts,G.P. and
            van Veldhoven,P.P.
  TITLE     Molecular characterization of the human peroxisomal branched-chain
            acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue
            distribution, and evidence for the absence of the protein in
            Zellweger syndrome
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 13748-13753 (1996)
   PUBMED   8943006
REFERENCE   9  (bases 1 to 2297)
  AUTHORS   Vanhove,G.F., Van Veldhoven,P.P., Fransen,M., Denis,S.,
            Eyssen,H.J., Wanders,R.J. and Mannaerts,G.P.
  TITLE     The CoA esters of 2-methyl-branched chain fatty acids and of the
            bile acid intermediates di- and trihydroxycoprostanic acids are
            oxidized by one single peroxisomal branched chain acyl-CoA oxidase
            in human liver and kidney
  JOURNAL   J Biol Chem 268 (14), 10335-10344 (1993)
   PUBMED   8387517
REFERENCE   10 (bases 1 to 2297)
  AUTHORS   Casteels,M., Schepers,L., Van Veldhoven,P.P., Eyssen,H.J. and
            Mannaerts,G.P.
  TITLE     Separate peroxisomal oxidases for fatty acyl-CoAs and
            trihydroxycoprostanoyl-CoA in human liver
  JOURNAL   J Lipid Res 31 (10), 1865-1872 (1990)
   PUBMED   2079609
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG698950.1, BC047700.1 and
            AC116036.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003500.3.
            
            Summary: The product of this gene belongs to the acyl-CoA oxidase
            family. It encodes the branched-chain acyl-CoA oxidase which is
            involved in the degradation of long branched fatty acids and bile
            acid intermediates in peroxisomes. Deficiency of this enzyme
            results in the accumulation of branched fatty acids and bile acid
            intermediates, and may lead to Zellweger syndrome, severe cognitive
            disability, and death in children. [provided by RefSeq, Mar 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.462859.1,
                                           SRR5189667.126401.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302819.10/ ENSP00000307697.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BG698950.1         123-131
            10-137              BC047700.1         1-128
            138-138             AC116036.3         147998-147998       c
            139-2297            BC047700.1         130-2288
FEATURES             Location/Qualifiers
     source          1..2297
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.3"
     gene            1..2297
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /note="acyl-CoA oxidase 2"
                     /db_xref="GeneID:8309"
                     /db_xref="HGNC:HGNC:120"
                     /db_xref="MIM:601641"
     exon            1..72
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            73..323
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..2209
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /EC_number="1.17.99.3"
                     /note="acyl-Coenzyme A oxidase 2, branched chain; THCA-CoA
                     oxidase; trihydroxycoprostanoyl-CoA oxidase; peroxisomal
                     branched chain acyl-CoA oxidase;
                     3-alpha,7-alpha,
                     12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase;
                     3-alpha,7-alpha,
                     12-alpha-trihydroxy-5-beta-cholestanoyl-CoA
                     24-hydroxylase; acyl-CoA oxidase 2, branched chain"
                     /codon_start=1
                     /product="peroxisomal acyl-coenzyme A oxidase 2"
                     /protein_id="NP_003491.1"
                     /db_xref="CCDS:CCDS33775.1"
                     /db_xref="GeneID:8309"
                     /db_xref="HGNC:HGNC:120"
                     /db_xref="MIM:601641"
                     /translation="MGSPVHRVSLGDTWSRQMHPDIESERYMQSFDVERLTNILDGGA
                     QNTALRRKVESIIHSYPEFSCKDNYFMTQNERYKAAMRRAFHIRLIARRLGWLEDGRE
                     LGYAYRALSGDVALNIHRVFVRALRSLGSEEQIAKWDPLCKNIQIIATYAQTELGHGT
                     YLQGLETEATYDAATQEFVIHSPTLTATKWWPGDLGRSATHALVQAQLICSGARRGMH
                     AFIVPIRSLQDHTPLPGIIIGDIGPKMDFDQTDNGFLQLNHVRVPRENMLSRFAQVLP
                     DGTYVKLGTAQSNYLPMVVVRVELLSGEILPILQKACVIAMRYSVIRRQSRLRPSDPE
                     AKVLDYQTQQQKLFPQLAISYAFHFLAVSLLEFFQHSYTAILNQDFSFLPELHALSTG
                     MKAMMSEFCTQGAEMCRRACGGHGYSKLSGLPSLVTKLSASCTYEGENTVLYLQVARF
                     LVKSYLQTQMSPGSTPQRSLSPSVAYLTAPDLARCPAQRAADFLCPELYTTAWAHVAV
                     RLIKDSVQHLQTLTQSGADQHEAWNQTTVIHLQAAKVHCYYVTVKGFTEALEKLENEP
                     AIQQVLKRLCDLHAIHGILTNSGDFLHDAFLSGAQVDMARTAYLDLLRLIRKDAILLT
                     DAFDFTDQCLNSALGCYDGNVYERLFQWAQKSPTNTQENPAYEEYIRPLLQSWRSKL"
     exon            324..486
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            487..638
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            639..746
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            747..866
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            867..982
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1155
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1318
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1509
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1689
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1795
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..2013
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2146
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2297
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2279..2284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /note="hexamer: ATTAAA"
     polyA_site      2297
                     /gene="ACOX2"
                     /gene_synonym="BCOX; BRCACOX; BRCOX; CBAS6; THCCox"
                     /note="major polyA site"
ORIGIN      
        1 agaggctgcg gcctacagcc ggggagaggc cagcccggcc tacagtgcgg acacaggaca
       61 gaggggagcc aggttctttg cactgaccaa tgctgagagc agaccctcgg agcagccggg
      121 ttggaagtgt ctctccatag tcaccagaca gatccaggat aggatgggca gcccagtgca
      181 ccgagtgtca ttgggggata cctggagcag gcaaatgcac cccgacatag agagcgagag
      241 gtatatgcag tcctttgacg tggaacggct caccaacatc cttgatggag gtgcccagaa
      301 cactgcactc cgcaggaaag ttgagagcat catccacagt tacccggagt ttagctgtaa
      361 ggacaattat ttcatgaccc agaatgagcg ttataaggct gccatgcgga gggcattcca
      421 catccggttg atagctcggc gcctgggttg gttagaagat ggtcgtgaat taggctacgc
      481 ttacagagcc ctttctggag acgtggcctt aaatatacac agagtcttcg tgagagccct
      541 caggagcctg ggctcagagg agcagattgc caaatgggac ccactctgca aaaacatcca
      601 gatcatcgca acgtatgcac agacagagtt gggacatggg acatatcttc agggcctgga
      661 gactgaagcc acctatgacg cagccaccca ggagtttgtg atacacagcc ccacgctgac
      721 tgccaccaaa tggtggcctg gagacttggg acggtcagcc acccatgccc tggtccaggc
      781 ccagctgatc tgctcaggag ccaggcgggg catgcacgct tttattgtgc caatccggag
      841 tcttcaggac cacaccccac tgccaggaat catcattggg gacatcggac ccaagatgga
      901 ctttgatcaa acagacaatg gcttcctgca gctgaaccat gtgcgggtcc ccagggagaa
      961 catgctgagt cgctttgcac aggtcttgcc agatggcacc tacgtcaaac tcggtacagc
     1021 acagagcaac taccttccca tggtggtggt gcgggtggag ctgctgtcag gggagatcct
     1081 ccctatactg cagaaggcct gtgtcatcgc catgcgctac tcggtcatcc gccgccaatc
     1141 ccggctccgg cccagtgacc cagaggcaaa ggtcctggac taccagacac aacagcagaa
     1201 actctttcct cagctggcca tcagttatgc cttccatttc ctggcagtca gcctcttgga
     1261 gttcttccag cactcctaca ctgccattct gaaccaagac ttcagcttcc tgcctgagct
     1321 ccacgcactg agcacgggca tgaaggccat gatgtcagaa ttctgcaccc agggagctga
     1381 gatgtgccgc agggcctgtg gcggacatgg ctactcaaag ctgagtggcc tgccatcact
     1441 ggtcaccaaa ttgtcggcct cctgtaccta cgagggtgag aacacagtgc tctacctgca
     1501 ggtggccagg ttcctggtga agagctacct gcagactcag atgtcccctg gctccacgcc
     1561 acagagatct ctctctccat ctgtcgcata tctcaccgca cctgacctgg ccaggtgtcc
     1621 agcccagagg gcagccgact tcctctgccc ggagctctac accacggcct gggcacatgt
     1681 ggcagtaagg ctcataaagg actcagtgca gcatttacag accctgacgc aatccggagc
     1741 tgaccagcac gaggcttgga accagaccac tgtcatacac ctccaggctg ctaaggtgca
     1801 ctgctactat gtcactgtga agggttttac agaagctctg gagaaactag aaaatgaacc
     1861 agcgattcag caggtgctca agcgcctctg tgacctccat gccatacatg gaatcttgac
     1921 taactcgggt gactttctcc atgacgcctt cctgtctggt gcccaagtgg acatggcaag
     1981 aacagcctac ctggacctgc tccgcctgat ccggaaggat gccatcctgt taactgatgc
     2041 ttttgacttc accgatcagt gtttaaattc agcacttggc tgttatgatg gaaacgtcta
     2101 cgaacgcctg ttccagtggg ctcagaagtc accaaccaat actcaggaga accctgccta
     2161 tgaggaatat ataagaccac ttttacaaag ttggagatcc aagctatgaa ataaccaaca
     2221 gtattcaaga agcaaccagc accatcatgt gataatggta ctatggcata tatgcaacat
     2281 taaaatttta aattaga
//
