LOCUS       NM_001037171            4318 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens acyl-CoA thioesterase 9 (ACOT9), transcript variant 1,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001037171
VERSION     NM_001037171.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4318)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 4318)
  AUTHORS   Hunt,M.C., Yamada,J., Maltais,L.J., Wright,M.W., Podesta,E.J. and
            Alexson,S.E.
  TITLE     A revised nomenclature for mammalian acyl-CoA
            thioesterases/hydrolases
  JOURNAL   J Lipid Res 46 (9), 2029-2032 (2005)
   PUBMED   16103133
REFERENCE   3  (bases 1 to 4318)
  AUTHORS   Poupon,V., Begue,B., Gagnon,J., Dautry-Varsat,A., Cerf-Bensussan,N.
            and Benmerah,A.
  TITLE     Molecular cloning and characterization of MT-ACT48, a novel
            mitochondrial acyl-CoA thioesterase
  JOURNAL   J Biol Chem 274 (27), 19188-19194 (1999)
   PUBMED   10383425
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL548456.3, BX648512.1 and
            AC093011.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001037171.1.
            
            Summary: The protein encoded by this gene is a mitochondrial
            acyl-CoA thioesterase of unknown function. Two transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Mar 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.695133.1,
                                           SRR1660809.24253.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000379303.10/
                                                  ENSP00000368605.5
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL548456.3         15-17
            4-1713              BX648512.1         2-1711
            1714-4318           AC093011.3         6152-8756
FEATURES             Location/Qualifiers
     source          1..4318
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.11"
     gene            1..4318
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /note="acyl-CoA thioesterase 9"
                     /db_xref="GeneID:23597"
                     /db_xref="HGNC:HGNC:17152"
                     /db_xref="MIM:300862"
     exon            1..152
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1479
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; mitochondrial Acyl-CoA Thioesterase;
                     acyl-Coenzyme A thioesterase 2, mitochondrial; acyl-CoA
                     thioester hydrolase 9"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase 9, mitochondrial
                     isoform a precursor"
                     /protein_id="NP_001032248.1"
                     /db_xref="CCDS:CCDS43924.1"
                     /db_xref="GeneID:23597"
                     /db_xref="HGNC:HGNC:17152"
                     /db_xref="MIM:300862"
                     /translation="MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSI
                     HVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLP
                     LGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSPLSIVTALVDK
                     IDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQLHGDEFCPVLDATFVMVARDSE
                     NKGPAFVNPLIPESPEEEELFRQGELNKGRRIAFSSTSLLKMAPSAEERTTIHEMFLS
                     TLDPKTISFRSRVLPSNAVWMENSKLKSLEICHPQERNIFNRIFGGFLMRKAYELAWA
                     TACSFGGSRPFVVAVDDIMFQKPVEVGSLLFLSSQVCFTQNNYIQVRVHSEVASLQEK
                     QHTTTNVFHFTFMSEKEVPLVFPKTYGESMLYLDGQRHFNSMSGPATLRKDYLVEP"
     exon            153..250
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /inference="alignment:Splign:2.1.0"
     exon            251..277
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /inference="alignment:Splign:2.1.0"
     exon            278..323
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /inference="alignment:Splign:2.1.0"
     exon            324..494
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /inference="alignment:Splign:2.1.0"
     exon            495..532
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /inference="alignment:Splign:2.1.0"
     exon            533..616
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /inference="alignment:Splign:2.1.0"
     exon            617..720
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /inference="alignment:Splign:2.1.0"
     exon            721..794
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /inference="alignment:Splign:2.1.0"
     exon            795..862
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /inference="alignment:Splign:2.1.0"
     exon            863..974
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1065
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1151
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1239
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1390
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..4318
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1677..1682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /note="hexamer: AATAAA"
     polyA_site      1696
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /note="major polyA site"
     regulatory      4294..4299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
                     /note="hexamer: AGTAAA"
     polyA_site      4318
                     /gene="ACOT9"
                     /gene_synonym="ACATE2; CGI-16; MT-ACT48; MTACT48"
ORIGIN      
        1 gctgtccggc tcccgggctg tcctcagcaa gggcgcggtc tggtactcgt gcgtctttta
       61 tcgcctcagt ttccctccgc cgactagcgc gcggggcccg gttctccatc gcgcgcacgg
      121 cagcctagcg caatgaggcg ggcagcactg cggctttgtg ccttgggcaa agggcagctt
      181 actcctggaa gaggactgac tcaaggaccc cagaacccca agaaacaggg aatcttccac
      241 attcatgaag catgttcatc tatacatgtg aatcatgttc gagataagtt gcgggagata
      301 gtaggagcat ccacaaactg gagagaccat gtgaaggcaa tggaagaaag gaaattactt
      361 catagtttct tggctaaatc acaggatgga ctgcctccta ggagaatgaa ggacagttat
      421 attgaagttc tcttgccttt gggcagtgag cctgaattac gagagaaata tttgactgtt
      481 caaaacaccg taagatttgg caggattctt gaggatcttg acagcttggg agttcttatt
      541 tgttacatgc acaacaaaat ccactccgcc aagatgtctc ctttatcgat agttacagcc
      601 ctggtggata agattgatat gtgtaagaag agcttgagcc cagaacagga cattaagttc
      661 agtggccatg ttagctgggt cgggaagaca tccatggaag tgaagatgca aatgttccag
      721 ttacatggtg atgaattttg tcctgttttg gatgcaacat ttgtaatggt ggctcgtgat
      781 tctgaaaata aagggccggc atttgtaaat ccactcatcc ctgaaagccc agaggaagag
      841 gagctcttta gacaagggga attgaacaag gggagaagaa ttgccttcag ctccacgtcg
      901 ttactgaaaa tggcccccag cgctgaggag aggaccacca tacatgagat gtttctcagc
      961 acactggatc caaagactat aagttttcgg agtcgagttt taccctctaa tgcagtgtgg
     1021 atggagaatt caaaactgaa gagtttggaa atttgccacc ctcaggagcg gaacattttc
     1081 aatcggatct ttggtggttt ccttatgagg aaggcatatg aacttgcgtg ggctactgct
     1141 tgtagctttg gtggttctcg accgtttgtg gtagcagtag atgacatcat gtttcagaaa
     1201 cctgttgagg ttggctcatt gctctttctt tcttcacagg tatgctttac tcagaataat
     1261 tatattcaag tcagagtaca cagtgaagtg gcctccctgc aggagaagca gcatacaacc
     1321 accaatgtct ttcatttcac gttcatgtcg gaaaaagaag tgccattggt tttcccaaaa
     1381 acatatggag agtccatgtt gtacttagat gggcagcggc atttcaactc catgagtggc
     1441 ccagcgacct tgagaaagga ctaccttgtg gagccctaag aacaccacat ttgttgaaaa
     1501 ctagcactct acccacagtg acgtggtatc tgatgaagac ctgatcgagt gtattgattt
     1561 tagtattgct tcgtgtcctc cacacaggag gaggatgtat tcagccttta ggatgatcag
     1621 aaaagcagaa agagagagtg gccggatggg gctgagggga gaaagaatta ttaaacaata
     1681 aatactttca agacaatttt aattgtgaac ctaccatgtt gcctcccatc ttctgaaaaa
     1741 acaaaaaaat tgagaggctg ggcgtggtgg ctcatgccta taatcccagc actttgggag
     1801 gctgaggcgg gcggatcatg aagtcaggag atcaagacca tcctggccaa catggtgaaa
     1861 ccctgtctct actaaaaata cagaaaatta gccgtggtgg catgtgcctg tagtcccagc
     1921 tacttgggag gctgaggcag gagaattgct tgaacccagg aggtggaggt tgcagtgagc
     1981 tgagattgca ccattgcact ccagcctggg cgacagagag agactgtctc aaaaattaat
     2041 taattaatta attaattgag gataccattg gatgcattct tttcttacac atattgcaac
     2101 tgtcagtata caaggtttcc tgccagggta tttggatgac gttctttaaa cctaaccact
     2161 tgctctgtgc tgtctaaatc ccatcagccg tacatgattc ctttgcttcc ctctatttcc
     2221 cagcttttgt tgtcagaggg tagatgaaaa gttggggcga agggatttaa caaaagttac
     2281 tgcatccgta aagatttgtg ggaagattta ggtctgaaac cataccatta gaaggtgttt
     2341 agagatgatc tagataagga aatacaggac catttggtca ttctttcatt caccagacag
     2401 ctatttagca cattctgcta gtggctccgc aggatatatc tgatttaaaa aataggaacc
     2461 acaataataa tagctgctta tgcttatgga gcattgccat gtgctagata ggcaccatcc
     2521 tcagcccttg gcaggtctga gctcctttat ttcttccaat caacactatg aggcaggttc
     2581 tgtaaccccc cttagggtta ggccactcgg gaaactgaag cacagagagt ttaagtaact
     2641 tcctggaggt ccgacgcgta acatgtggag gtgctgggat tcaaaaccag gcaatgtggg
     2701 tcccgggcac tcttgaccag tgcctgtact tcttccaagg aatagagcaa gggaggtcat
     2761 accgaatatc acagtgtcac ctaggaagcc caagggaggt attcccgtta atctgcagcc
     2821 aaggccgggc gcggtagctc atgcctgtaa tcccagcact ttgggaggcc aaggcggatg
     2881 gatcatgagg tcaggagttc aagaccagcc tggccgagat ggtgaaaccc cgtttctact
     2941 aaaaatacaa aaattagccg ggcgtggtgg cggacgcctg taatcccagc tactcgggag
     3001 gctgaggcag agaactgctt gaacctggga ggcagaggtt gcagtgagct gtgatcatgc
     3061 cactgcactc cagcctgggt gacagaacga gactccatct caaaaaaaaa aaaaaaaaaa
     3121 aatctgtagc caagaccgtt ccttttttga caggaaggta acttagaaga aaaaataatc
     3181 tctgaaaaaa gtcctcccaa gaaggaagca atatttattg tgggttctac attagtgttc
     3241 acaaacttgg ctctgcctca gaattaggtg gaaagtattt ttgtgtgtgt gtgtgtgtgt
     3301 gagacagagt ttcactctgt cgctccagct ggagtgcagt ggcatgatct tggctcactg
     3361 caacctctac ctcccgggtt caagcgattc tcctgcctca gcctcctgag tagctaggat
     3421 tacaggtgtc agcccccatg cctggctagt ttttgtattt ttagtagaaa ggcggtttca
     3481 ccatgttggc cagctggtct caaattcctg acctcaggtg atccacctac cttggcctcc
     3541 caaagtgctg ggattatagg catgagccac tgcacccggc cggtggaaag catttttaac
     3601 aaaaaatttt taggccaggc acagtggtgg ctcatgcctg taatcccagc actttgggag
     3661 actgagatgg gaggatcgct tgagaccagc ctgggaaaca tagtgagacc ctttctctac
     3721 aaaaagttaa aaaattatct gagcatggtg gtgtgcacct gtagtcccag ttaggaggct
     3781 gaggtgagtg gattgcttga gtccaggagt ttgagtctgc agtgagctat gatcatgcca
     3841 ctgcactcca gtctgggtga cagcaagacc ctgtctcaag caattttttt atattagttt
     3901 atgtaatgtt tattgaaatc acagtgtcaa caagcacctc tggcatgaaa tagtcacagg
     3961 agcgaacaca actatctctt ggaagcatgc agtttgactc atggaatcaa gcatgtgctg
     4021 tactataata acttgtctct ccatgccgta atgccatcct gactgagatt tacctggccc
     4081 ttcaatatag cattttgcat atctacctat gacatgatgg gaggtggcta atggggaggg
     4141 atgcgccctg gggagttttg tgaatgtgtt aagtggagtt aagagaccta ctgcatgcta
     4201 ttgtatagat tatacattat atatttaacc atttgttgct gtacagtgaa gctttttcta
     4261 gtatttcttt tttgctatta taaacaatgt tgcagtaaat atcctaaata ctctaaaa
//
