LOCUS       NM_007274               1806 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens acyl-CoA thioesterase 7 (ACOT7), transcript variant
            hBACHa, mRNA.
ACCESSION   NM_007274
VERSION     NM_007274.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1806)
  AUTHORS   Tao,R., Liu,Z., Zhang,Z. and Zhang,Z.
  TITLE     USP3 promotes cisplatin resistance in non-small cell lung cancer
            cells by suppressing ACOT7-regulated ferroptosis
  JOURNAL   Anticancer Drugs 35 (6), 483-491 (2024)
   PUBMED   38502867
  REMARK    GeneRIF: USP3 promotes cisplatin resistance in non-small cell lung
            cancer cells by suppressing ACOT7-regulated ferroptosis.
REFERENCE   2  (bases 1 to 1806)
  AUTHORS   St Clair,L.A., Mills,S.A., Lian,E., Soma,P.S., Nag,A.,
            Montgomery,C., Ramirez,G., Chotiwan,N., Gullberg,R.C. and Perera,R.
  TITLE     Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty
            Acids Modulates Dengue Virus Serotype 2 Replication
  JOURNAL   Viruses 14 (2), 240 (2022)
   PUBMED   35215835
  REMARK    GeneRIF: Acyl-Coa Thioesterases: A Rheostat That Controls Activated
            Fatty Acids Modulates Dengue Virus Serotype 2 Replication.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1806)
  AUTHORS   Feng,H. and Liu,X.
  TITLE     Interaction between ACOT7 and LncRNA NMRAL2P via Methylation
            Regulates Gastric Cancer Progression
  JOURNAL   Yonsei Med J 61 (6), 471-481 (2020)
   PUBMED   32469171
  REMARK    GeneRIF: NMRAL2P activation suppresses ACOT7 expression in gastric
            cancer.
REFERENCE   4  (bases 1 to 1806)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1806)
  AUTHORS   Zhang,X., Liu,B., Zhang,J., Yang,X., Zhang,G., Yang,S., Wang,J.,
            Shi,J., Hu,K., Wang,J., Jing,H., Ke,X. and Fu,L.
  TITLE     Expression level of ACOT7 influences the prognosis in acute myeloid
            leukemia patients
  JOURNAL   Cancer Biomark 26 (4), 441-449 (2019)
   PUBMED   31640082
  REMARK    GeneRIF: Patients in high ACOT7 group had a significant lower EFS
            and OS, while patients in high versus low expression levels of
            other types of ACOT showed no significant difference on the outcome
REFERENCE   6  (bases 1 to 1806)
  AUTHORS   Hunt,M.C., Yamada,J., Maltais,L.J., Wright,M.W., Podesta,E.J. and
            Alexson,S.E.
  TITLE     A revised nomenclature for mammalian acyl-CoA
            thioesterases/hydrolases
  JOURNAL   J Lipid Res 46 (9), 2029-2032 (2005)
   PUBMED   16103133
REFERENCE   7  (bases 1 to 1806)
  AUTHORS   Yamada,J.
  TITLE     Long-chain acyl-CoA hydrolase in the brain
  JOURNAL   Amino Acids 28 (3), 273-278 (2005)
   PUBMED   15731883
  REMARK    Review article
REFERENCE   8  (bases 1 to 1806)
  AUTHORS   Yang,J.W., Czech,T., Yamada,J., Csaszar,E., Baumgartner,C.,
            Slavc,I. and Lubec,G.
  TITLE     Aberrant cytosolic acyl-CoA thioester hydrolase in hippocampus of
            patients with mesial temporal lobe epilepsy
  JOURNAL   Amino Acids 27 (3-4), 269-275 (2004)
   PUBMED   15592755
  REMARK    GeneRIF: BACH was deranged in hippocampus of mesial temporal lobe
            epilepsy patients.
REFERENCE   9  (bases 1 to 1806)
  AUTHORS   Yamada,J., Kuramochi,Y., Takagi,M., Watanabe,T. and Suga,T.
  TITLE     Human brain acyl-CoA hydrolase isoforms encoded by a single gene
  JOURNAL   Biochem Biophys Res Commun 299 (1), 49-56 (2002)
   PUBMED   12435388
  REMARK    GeneRIF: the human BACH gene can express long-chain acyl-CoA
            hydrolase activity in multiple intracellular compartments by
            generating BACH isoforms with differential localization signals to
            affect various cellular functions that involve acyl-CoAs
REFERENCE   10 (bases 1 to 1806)
  AUTHORS   Yamada,J., Kurata,A., Hirata,M., Taniguchi,T., Takama,H.,
            Furihata,T., Shiratori,K., Iida,N., Takagi-Sakuma,M., Watanabe,T.,
            Kurosaki,K., Endo,T. and Suga,T.
  TITLE     Purification, molecular cloning, and genomic organization of human
            brain long-chain acyl-CoA hydrolase
  JOURNAL   J Biochem 126 (6), 1013-1019 (1999)
   PUBMED   10578051
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031848.11 and AL031847.17.
            
            On May 17, 2020 this sequence version replaced NM_007274.3.
            
            Summary: This gene encodes a member of the acyl coenzyme family.
            The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA
            and other long-chain fatty acids. Decreased expression of this gene
            may be associated with mesial temporal lobe epilepsy. Alternatively
            spliced transcript variants encoding distinct isoforms with
            different subcellular locations have been characterized. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (hBACHa) differs in the 5' UTR and
            5' coding region, compared to variant hBACHb. It encodes isoform
            hBACHa that has a shorter and distinct N-terminus lacking a
            mitochondrial targetting sequence, compared to isoform hBACHb.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017365.2, U91316.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361521.9/ ENSP00000354615.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-511               AL031848.11        59061-59571
            512-629             AL031848.11        102962-103079
            630-786             AL031848.11        113239-113395
            787-878             AL031848.11        119260-119351
            879-993             AL031848.11        125415-125529
            994-1080            AL031848.11        134250-134336
            1081-1197           AL031847.17        14883-14999
            1198-1382           AL031847.17        28577-28761
            1383-1806           AL031847.17        45168-45591
FEATURES             Location/Qualifiers
     source          1..1806
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31"
     gene            1..1806
                     /gene="ACOT7"
                     /gene_synonym="ACH1; ACT; BACH; CTE-II; hBACH; LACH;
                     LACH1"
                     /note="acyl-CoA thioesterase 7"
                     /db_xref="GeneID:11332"
                     /db_xref="HGNC:HGNC:24157"
                     /db_xref="MIM:602587"
     exon            1..511
                     /gene="ACOT7"
                     /gene_synonym="ACH1; ACT; BACH; CTE-II; hBACH; LACH;
                     LACH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..1481
                     /gene="ACOT7"
                     /gene_synonym="ACH1; ACT; BACH; CTE-II; hBACH; LACH;
                     LACH1"
                     /EC_number="3.1.2.2"
                     /note="isoform hBACHa is encoded by transcript variant
                     hBACHa; cytosolic acyl coenzyme A thioester hydrolase;
                     brain acyl-CoA hydrolase; long chain acyl-CoA thioester
                     hydrolase; acyl-CoA thioesterase, long chain; acyl-CoA
                     thioesterase 2; CTE-IIa"
                     /codon_start=1
                     /product="cytosolic acyl coenzyme A thioester hydrolase
                     isoform hBACHa"
                     /protein_id="NP_009205.3"
                     /db_xref="CCDS:CCDS30573.1"
                     /db_xref="GeneID:11332"
                     /db_xref="HGNC:HGNC:24157"
                     /db_xref="MIM:602587"
                     /translation="MARPGLIHSAPGLPDTCALLQPPAASAAAAPSMSGPDVETPSAI
                     QICRIMRPDDANVAGNVHGGTILKMIEEAGAIISTRHCNSQNGERCVAALARVERTDF
                     LSPMCIGEVAHVSAEITYTSKHSVEVQVNVMSENILTGAKKLTNKATLWYVPLSLKNV
                     DKVLEVPPVVYSRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPVLNPEPNTVSYSQS
                     SLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKIRK
                     GCVITISGRMTFTSNKSMEIEVLVDADPVVDSSQKRYRAASAFFTYVSLSQEGRSLPV
                     PQLVPETEDEKKRFEEGKGRYLQMKAKRQGHAEPQP"
     exon            512..629
                     /gene="ACOT7"
                     /gene_synonym="ACH1; ACT; BACH; CTE-II; hBACH; LACH;
                     LACH1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..786
                     /gene="ACOT7"
                     /gene_synonym="ACH1; ACT; BACH; CTE-II; hBACH; LACH;
                     LACH1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..878
                     /gene="ACOT7"
                     /gene_synonym="ACH1; ACT; BACH; CTE-II; hBACH; LACH;
                     LACH1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..993
                     /gene="ACOT7"
                     /gene_synonym="ACH1; ACT; BACH; CTE-II; hBACH; LACH;
                     LACH1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1080
                     /gene="ACOT7"
                     /gene_synonym="ACH1; ACT; BACH; CTE-II; hBACH; LACH;
                     LACH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1197
                     /gene="ACOT7"
                     /gene_synonym="ACH1; ACT; BACH; CTE-II; hBACH; LACH;
                     LACH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1382
                     /gene="ACOT7"
                     /gene_synonym="ACH1; ACT; BACH; CTE-II; hBACH; LACH;
                     LACH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1806
                     /gene="ACOT7"
                     /gene_synonym="ACH1; ACT; BACH; CTE-II; hBACH; LACH;
                     LACH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1784..1789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACOT7"
                     /gene_synonym="ACH1; ACT; BACH; CTE-II; hBACH; LACH;
                     LACH1"
                     /note="hexamer: AATAAA"
     polyA_site      1806
                     /gene="ACOT7"
                     /gene_synonym="ACH1; ACT; BACH; CTE-II; hBACH; LACH;
                     LACH1"
                     /note="major polyA site"
ORIGIN      
        1 acaaatattt accgccgcgc ggagagtgag ggcccaagtc cgccctgctc cgccacttag
       61 gccgccccag acgcttccct cggggctgcc accgggtcgg gcgcggctgc cgcggctagc
      121 gggccttccc cgcaccggcg cggcccaacc gccaccgaac cttctggaag cggcggctgc
      181 ctgggccccc acgccgccag aatcgtacgc ccgcgcgagc tctctgcagc cttggcggcc
      241 tgggaggcgg ggctcggggt ggggccggcg cgggggcggg gtcggcgcgg ggaggccgcg
      301 ttcgattgcc cccggcgcgc aggccccgcc tcaccagccc catcgctcca cctctgccct
      361 ccccctttat ggcgcggccc gggctcattc attccgcgcc gggcctgcca gacacctgcg
      421 cccttctgca gccgcccgcc gcatccgccg ccgcagcccc cagcatgtcg ggcccagacg
      481 tcgagacgcc gtccgccatc cagatctgcc ggatcatgcg gccagatgat gccaacgtgg
      541 ccggcaatgt ccacgggggg accatcctga agatgatcga ggaggcaggc gccatcatca
      601 gcacccggca ttgcaacagc cagaacgggg agcgctgtgt ggccgccctg gctcgtgtcg
      661 agcgcaccga cttcctgtct cccatgtgca tcggtgaggt ggcgcatgtc agcgcggaga
      721 tcacctacac ctccaagcac tctgtggagg tgcaggtcaa cgtgatgtcc gaaaacatcc
      781 tcacaggtgc caaaaagctg accaataagg ccaccctgtg gtatgtgccc ctgtcgctga
      841 agaatgtgga caaggtcctc gaggtgcctc ctgttgtgta ttcccggcag gagcaggagg
      901 aggagggccg gaagcggtat gaagcccaga agctggagcg catggagacc aagtggagga
      961 acggggacat cgtccagcca gtcctcaacc cagagccgaa cactgtcagc tacagccagt
     1021 ccagcttgat ccacctggtg gggccttcag actgcaccct gcacggcttt gtgcacggag
     1081 gtgtgaccat gaagctcatg gatgaggtcg ccgggatcgt ggctgcacgc cactgcaaga
     1141 ccaacatcgt cacagcttcc gtggacgcca ttaattttca tgacaagatc agaaaaggct
     1201 gcgtcatcac catctcggga cgcatgacct tcacgagcaa taagtccatg gagatcgagg
     1261 tgttggtgga cgccgaccct gttgtggaca gctctcagaa gcgctaccgg gccgccagtg
     1321 ccttcttcac ctacgtgtcg ctgagccagg aaggcaggtc gctgcctgtg ccccagctgg
     1381 tgcccgagac cgaggacgag aagaagcgct ttgaggaagg caaagggcgg tacctgcaga
     1441 tgaaggcgaa gcgacagggc cacgcggagc ctcagcccta gactccctcc tcctgccact
     1501 ggtgcctcga gtagccatgg caacgggccc agtgtccagt cacttagaag ttcccccctt
     1561 ggccaaaaac ccaattcaca ttgagagctg gtgttgtctg aagttttcgt atcacagtgt
     1621 taacctgtac tctctcctgc aaacctacac accaaagctt tatttatatc attccagtat
     1681 caatgctaca cagtgttgtc ccgagcgccg ggaggcgttg ggcagaaacc ctcgggaatg
     1741 cttccgagca cgctgtaggg tatgggaaga acccagcacc actaataaag ctgctgcttg
     1801 gctgga
//
