LOCUS       NM_001365788            1370 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens acyl-CoA thioesterase 6 (ACOT6), transcript variant 1,
            mRNA.
ACCESSION   NM_001365788 XM_011537076
VERSION     NM_001365788.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1370)
  AUTHORS   Xu,B., Roos,J.L., Dexheimer,P., Boone,B., Plummer,B., Levy,S.,
            Gogos,J.A. and Karayiorgou,M.
  TITLE     Exome sequencing supports a de novo mutational paradigm for
            schizophrenia
  JOURNAL   Nat Genet 43 (9), 864-868 (2011)
   PUBMED   21822266
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1370)
  AUTHORS   Hunt,M.C., Rautanen,A., Westin,M.A., Svensson,L.T. and Alexson,S.E.
  TITLE     Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene
            clusters shows that convergent, functional evolution results in a
            reduced number of human peroxisomal ACOTs
  JOURNAL   FASEB J 20 (11), 1855-1864 (2006)
   PUBMED   16940157
REFERENCE   3  (bases 1 to 1370)
  AUTHORS   Hunt,M.C., Yamada,J., Maltais,L.J., Wright,M.W., Podesta,E.J. and
            Alexson,S.E.
  TITLE     A revised nomenclature for mammalian acyl-CoA
            thioesterases/hydrolases
  JOURNAL   J Lipid Res 46 (9), 2029-2032 (2005)
   PUBMED   16103133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005225.2.
            
            On Sep 12, 2018 this sequence version replaced XM_011537076.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000645972.2/ ENSP00000496277.1
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-516               AC005225.2         47335-47850         c
            517-715             AC005225.2         43175-43373         c
            716-1370            AC005225.2         40479-41133         c
FEATURES             Location/Qualifiers
     source          1..1370
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..1370
                     /gene="ACOT6"
                     /gene_synonym="C14orf42; c14_5530"
                     /note="acyl-CoA thioesterase 6"
                     /db_xref="GeneID:641372"
                     /db_xref="HGNC:HGNC:33159"
                     /db_xref="MIM:614267"
     exon            1..516
                     /gene="ACOT6"
                     /gene_synonym="C14orf42; c14_5530"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1321
                     /gene="ACOT6"
                     /gene_synonym="C14orf42; c14_5530"
                     /EC_number="3.1.2.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative acyl-coenzyme A thioesterase 6; putative acyl-CoA
                     thioesterase 6"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase 6 isoform 1"
                     /protein_id="NP_001352717.1"
                     /db_xref="CCDS:CCDS91900.1"
                     /db_xref="GeneID:641372"
                     /db_xref="HGNC:HGNC:33159"
                     /db_xref="MIM:614267"
                     /translation="MAATLILEPAGRCCWDEPLRIAVRGLAPEQPVTLRTSLRDEEGA
                     LFRAHARYRADARDELDLERAPALGGSFAGLQPMGLLWALEPEKALVRLVKRDVRTPF
                     AVELEVLDGHDTEPGRLLCLAQNKRDFLRPGVRREPVRAGPVRAALFLPPDEGPFPGI
                     IDLFGSSRGLCEYRASLLAGHGFAVLALAYFRFEDLPEDLNDVHLEYFEEAVDFMLQH
                     PKVKGPSIALLGFSKGGDLCLSMASFLKGITATVLINACVANTVAPLHYKDMIIPKLV
                     DDLGKVKITKSGFLTFMDTWSNPLEEHNHQSLVPLEKAQVPFLFIVGMDDQSWKSEFY
                     AQIASERLQAHGKERPQIICYPETGHCIDPPYFPPSRASVHAVLGEAIFYGGEPKAHS
                     KAQVDAWQQIQTFFHKHLNGKKSVKHSKI"
     exon            517..715
                     /gene="ACOT6"
                     /gene_synonym="C14orf42; c14_5530"
                     /inference="alignment:Splign:2.1.0"
     exon            716..1370
                     /gene="ACOT6"
                     /gene_synonym="C14orf42; c14_5530"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1349..1354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACOT6"
                     /gene_synonym="C14orf42; c14_5530"
                     /note="hexamer: AATAAA"
     polyA_site      1370
                     /gene="ACOT6"
                     /gene_synonym="C14orf42; c14_5530"
                     /note="major polyA site"
ORIGIN      
        1 aggcccgccc actgactccg cggagctggg tcgcccctgt tctacccaga ttgggatggc
       61 agcgacgctg atcctggagc ccgcgggccg ctgctgctgg gacgagccgc tgcgcatcgc
      121 agtgcgcggc ctggccccgg agcagccagt cacgctgcgc acgtccctgc gcgacgaaga
      181 gggcgcgctc ttccgggccc acgcgcgcta ccgtgccgac gcccgcgacg agctggacct
      241 ggagcgcgcg cccgcgctgg gaggcagctt cgcggggctc cagcccatgg ggctgctgtg
      301 ggcgttggag cccgagaaag ccttggtgcg gctggtgaag cgcgacgtgc ggacgccctt
      361 cgccgtggag ctggaagtgc tggacggcca cgacaccgag cccgggcggc tgctgtgcct
      421 ggcgcagaac aagcgcgact ttctccggcc gggggtgcgg cgcgagccgg tgcgcgcggg
      481 cccggtgcgc gccgcgctct tcctgccgcc ggatgagggg ccctttcctg ggatcattga
      541 tctgtttggg agcagcaggg gcctttgtga atacagggcc agcctcctgg ccggacatgg
      601 ttttgctgtg cttgccctgg cttatttcag atttgaagac ctccccgaag atctgaatga
      661 tgtacatctg gagtactttg aagaagccgt ggactttatg ctgcagcatc caaaggtgaa
      721 aggtcctagt attgcgcttc ttggattttc caaaggaggt gacctgtgtc tctcaatggc
      781 ttctttcttg aagggcatca cagccactgt acttatcaat gcctgtgtag ccaacacagt
      841 agctcctcta cattacaagg atatgattat tcctaaactt gtcgatgatc taggaaaagt
      901 aaaaatcact aagtcaggat ttctcacttt tatggacact tggagcaatc cactggagga
      961 acacaatcac caaagtcttg ttccattgga aaaggcgcag gtgcccttct tgtttattgt
     1021 tggcatggat gatcaaagct ggaagagtga attctatgct cagatagcct ctgaaaggct
     1081 acaagctcat gggaaagaaa gaccccagat aatctgttac ccagaaactg gtcactgtat
     1141 tgacccacct tattttcctc cttctagagc ttctgtgcac gctgttttgg gtgaggcaat
     1201 attctatgga ggtgagccaa aggctcactc aaaggcacag gtagatgcct ggcagcaaat
     1261 tcaaactttc ttccataaac atctcaatgg taaaaaatct gtcaagcaca gcaaaatata
     1321 acattgtagc cacagaccag ataccattaa taaaaatcct attcatacaa
//
