LOCUS       NM_006821               1622 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens acyl-CoA thioesterase 2 (ACOT2), transcript variant 1,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_006821
VERSION     NM_006821.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1622)
  AUTHORS   Yin,X., Lyu,C., Li,Z., Wang,Q., Ding,Y., Wang,Y., Qiu,Y., Cui,S.,
            Guo,D. and Xu,R.
  TITLE     High Expression of ACOT2 Predicts Worse Overall Survival and
            Abnormal Lipid Metabolism: A Potential Target for Acute Myeloid
            Leukemia
  JOURNAL   J Healthc Eng 2022, 2669114 (2022)
   PUBMED   36193167
  REMARK    GeneRIF: High Expression of ACOT2 Predicts Worse Overall Survival
            and Abnormal Lipid Metabolism: A Potential Target for Acute Myeloid
            Leukemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1622)
  AUTHORS   St Clair,L.A., Mills,S.A., Lian,E., Soma,P.S., Nag,A.,
            Montgomery,C., Ramirez,G., Chotiwan,N., Gullberg,R.C. and Perera,R.
  TITLE     Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty
            Acids Modulates Dengue Virus Serotype 2 Replication
  JOURNAL   Viruses 14 (2), 240 (2022)
   PUBMED   35215835
  REMARK    GeneRIF: Acyl-Coa Thioesterases: A Rheostat That Controls Activated
            Fatty Acids Modulates Dengue Virus Serotype 2 Replication.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1622)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1622)
  AUTHORS   Shen,C., Huo,L.R., Zhao,X.L., Wang,P.R. and Zhong,N.
  TITLE     Novel interactive partners of neuroligin 3: new aspects for
            pathogenesis of autism
  JOURNAL   J Mol Neurosci 56 (1), 89-101 (2015)
   PUBMED   25464930
REFERENCE   5  (bases 1 to 1622)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1622)
  AUTHORS   Hunt,M.C., Rautanen,A., Westin,M.A., Svensson,L.T. and Alexson,S.E.
  TITLE     Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene
            clusters shows that convergent, functional evolution results in a
            reduced number of human peroxisomal ACOTs
  JOURNAL   FASEB J 20 (11), 1855-1864 (2006)
   PUBMED   16940157
REFERENCE   7  (bases 1 to 1622)
  AUTHORS   Hunt,M.C., Yamada,J., Maltais,L.J., Wright,M.W., Podesta,E.J. and
            Alexson,S.E.
  TITLE     A revised nomenclature for mammalian acyl-CoA
            thioesterases/hydrolases
  JOURNAL   J Lipid Res 46 (9), 2029-2032 (2005)
   PUBMED   16103133
REFERENCE   8  (bases 1 to 1622)
  AUTHORS   Westin,M.A., Alexson,S.E. and Hunt,M.C.
  TITLE     Molecular cloning and characterization of two mouse peroxisome
            proliferator-activated receptor alpha (PPARalpha)-regulated
            peroxisomal acyl-CoA thioesterases
  JOURNAL   J Biol Chem 279 (21), 21841-21848 (2004)
   PUBMED   15007068
REFERENCE   9  (bases 1 to 1622)
  AUTHORS   Jones,J.M. and Gould,S.J.
  TITLE     Identification of PTE2, a human peroxisomal long-chain acyl-CoA
            thioesterase
  JOURNAL   Biochem Biophys Res Commun 275 (1), 233-240 (2000)
   PUBMED   10944470
REFERENCE   10 (bases 1 to 1622)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005225.2.
            
            On Jul 8, 2020 this sequence version replaced NM_006821.5.
            
            Summary: This gene encodes a member of the acyl-CoA thioesterase
            protein family, and is one of four acyl-CoA hydrolase genes located
            in a cluster on chromosome 14. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006335.2, DQ082755.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 16940157; reported by
                                                  MitoCarta
            MANE Ensembl match                 :: ENST00000238651.10/
                                                  ENSP00000238651.5
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-671               AC005225.2         90484-91154         c
            672-874             AC005225.2         86777-86979         c
            875-1622            AC005225.2         84712-85459         c
FEATURES             Location/Qualifiers
     source          1..1622
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..1622
                     /gene="ACOT2"
                     /gene_synonym="CTE-IA; CTE1A; MTE1; PTE2; PTE2A; ZAP128"
                     /note="acyl-CoA thioesterase 2"
                     /db_xref="GeneID:10965"
                     /db_xref="HGNC:HGNC:18431"
                     /db_xref="MIM:609972"
     exon            1..671
                     /gene="ACOT2"
                     /gene_synonym="CTE-IA; CTE1A; MTE1; PTE2; PTE2A; ZAP128"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1480
                     /gene="ACOT2"
                     /gene_synonym="CTE-IA; CTE1A; MTE1; PTE2; PTE2A; ZAP128"
                     /EC_number="3.1.2.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitochondrial acyl-CoA thioesterase 1; acyl-coenzyme A
                     thioester hydrolase 2a; peroxisomal long-chain acyl-coA
                     thioesterase 2; acyl-coenzyme A thioesterase 2,
                     mitochondrial; long-chain acyl-CoA thioesterase 2"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase 2, mitochondrial
                     isoform 1"
                     /protein_id="NP_006812.3"
                     /db_xref="CCDS:CCDS9816.1"
                     /db_xref="GeneID:10965"
                     /db_xref="HGNC:HGNC:18431"
                     /db_xref="MIM:609972"
                     /translation="MSNKLLSPHPHSVVLRSEFKMASSPAVLRASRLYQWSLKSSAQF
                     LGSPQLRQVGQIIRVPARMAATLILEPAGRCCWDEPVRIAVRGLAPEQPVTLRASLRD
                     EKGALFQAHARYRADTLGELDLERAPALGGSFAGLEPMGLLWALEPEKPLVRLVKRDV
                     RTPLAVELEVLDGHDPDPGRLLCQTRHERYFLPPGVRREPVRVGRVRGTLFLPPEPGP
                     FPGIVDMFGTGGGLLEYRASLLAGKGFAVMALAYYNYEDLPKTMETLHLEYFEEAMNY
                     LLSHPEVKGPGVGLLGISKGGELCLSMASFLKGITAAVVINGSVANVGGTLHYKGETL
                     PPVGVNRNRIKVTKDGYADIVDVLNSPLEGPDQKSFIPVERAESTFLFLVGQDDHNWK
                     SEFYANEACKRLQAHGRRKPQIICYPETGHYIEPPYFPLCRASLHALVGSPIIWGGEP
                     RAHAMAQVDAWKQLQTFFHKHLGGHEGTIPSKV"
     exon            672..874
                     /gene="ACOT2"
                     /gene_synonym="CTE-IA; CTE1A; MTE1; PTE2; PTE2A; ZAP128"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1622
                     /gene="ACOT2"
                     /gene_synonym="CTE-IA; CTE1A; MTE1; PTE2; PTE2A; ZAP128"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1606..1611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACOT2"
                     /gene_synonym="CTE-IA; CTE1A; MTE1; PTE2; PTE2A; ZAP128"
                     /note="hexamer: AATGAA"
     polyA_site      1622
                     /gene="ACOT2"
                     /gene_synonym="CTE-IA; CTE1A; MTE1; PTE2; PTE2A; ZAP128"
                     /note="major polyA site"
ORIGIN      
        1 gcttagcctg cgacggcagc ccgagaggat gtctaacaag cttctttctc cccaccccca
       61 ttcagttgtt ctcaggtctg aattcaaaat ggcctcatct cctgctgtcc ttcgagcgtc
      121 ccggctgtac caatggagcc tgaagagttc ggcgcagttc ctggggtctc cacagctgag
      181 gcaggttggt cagatcatta gggttcctgc tcggatggcg gcgacgctga tcctggagcc
      241 tgcgggccgc tgctgctggg acgaaccggt gcgaatcgcc gtgcgcggcc tagccccgga
      301 gcagccggtc acgctgcgcg cgtccctgcg cgacgagaag ggcgcgcttt tccaggccca
      361 cgcgcgctac cgcgccgaca ctcttggcga gctggacctg gagcgcgcgc ccgcgctggg
      421 cggcagcttc gcggggcttg agcccatggg gctgctctgg gccttggagc ccgagaaacc
      481 tttggtgcgg ctggtgaagc gcgacgtgcg aacgcccttg gccgtggagc tggaggtgct
      541 ggatggccac gaccccgacc ccgggcggct gctgtgccag acgcggcacg agcgctactt
      601 cctcccgccc ggggtgcggc gcgagccggt gcgcgtgggc cgggtgcgag gcacgctctt
      661 cctgccgcca gaacctgggc cctttcctgg gattgtggac atgttcggaa ctggaggtgg
      721 cctgctggag tatcgggcta gtctgctggc tgggaagggt tttgctgtga tggctctggc
      781 ttattataac tatgaagacc tccccaagac catggagacg ctccatctgg agtactttga
      841 agaagccatg aactacttgc tcagtcatcc cgaggtaaaa ggtccaggag ttgggctgct
      901 tggaatttcc aaagggggtg agctctgcct ttccatggcc tctttcctga agggcatcac
      961 ggctgctgtc gtcatcaacg gctctgtggc caatgttggg ggaaccttac actacaaggg
     1021 cgagaccctg ccccctgtgg gcgtcaacag aaatcgcatc aaggtgacca aagatggcta
     1081 tgcagacatt gtggatgtcc tgaacagccc tttggaagga cctgaccaga agagcttcat
     1141 tcctgtggaa agggcagaga gcaccttcct gttcctggta ggtcaggatg accacaactg
     1201 gaagagtgag ttctatgcta atgaggcctg taaacgcttg caggcccatg ggaggagaaa
     1261 gccccagatc atctgttacc cagagacagg gcactatatt gagcctcctt acttccccct
     1321 gtgtcgggct tccctgcatg ccttggtggg cagtcctatt atctggggag gggagcccag
     1381 ggctcatgcc atggctcagg tggatgcttg gaaacaactc cagactttct tccacaaaca
     1441 cttgggtggc cacgagggga caatcccatc aaaagtgtaa attttatttg atcatgtggc
     1501 ctctctgttg ctaatctctc ctggaaacat ctgccacatt tagtgtgtgt atgtgtattc
     1561 attcttttgt ttttaataac taaagttttt tcccctcatt attaaaatga atttaccagt
     1621 aa
//
