LOCUS       NM_130767               2086 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens acyl-CoA thioesterase 12 (ACOT12), mRNA.
ACCESSION   NM_130767
VERSION     NM_130767.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2086)
  AUTHORS   Bao,Z., Zhang,N., Niu,W., Mu,M., Zhang,X., Hu,S. and Niu,C.
  TITLE     Exosomal miR-155-5p derived from glioma stem-like cells promotes
            mesenchymal transition via targeting ACOT12
  JOURNAL   Cell Death Dis 13 (8), 725 (2022)
   PUBMED   35986010
  REMARK    GeneRIF: Exosomal miR-155-5p derived from glioma stem-like cells
            promotes mesenchymal transition via targeting ACOT12.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2086)
  AUTHORS   Park,S., Song,J., Baek,I.J., Jang,K.Y., Han,C.Y., Jun,D.W.,
            Kim,P.K., Raught,B. and Jin,E.J.
  TITLE     Loss of Acot12 contributes to NAFLD independent of lipolysis of
            adipose tissue
  JOURNAL   Exp Mol Med 53 (7), 1159-1169 (2021)
   PUBMED   34285335
  REMARK    GeneRIF: Loss of Acot12 contributes to NAFLD independent of
            lipolysis of adipose tissue.
REFERENCE   3  (bases 1 to 2086)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2086)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2086)
  AUTHORS   Argos,M., Tong,L., Pierce,B.L., Rakibuz-Zaman,M., Ahmed,A.,
            Islam,T., Rahman,M., Paul-Brutus,R., Rahaman,R., Roy,S.,
            Jasmine,F., Kibriya,M.G. and Ahsan,H.
  TITLE     Genome-wide association study of smoking behaviours among
            Bangladeshi adults
  JOURNAL   J Med Genet 51 (5), 327-333 (2014)
   PUBMED   24665060
REFERENCE   6  (bases 1 to 2086)
  AUTHORS   Ludwig,K.U., Mangold,E., Herms,S., Nowak,S., Reutter,H., Paul,A.,
            Becker,J., Herberz,R., AlChawa,T., Nasser,E., Bohmer,A.C.,
            Mattheisen,M., Alblas,M.A., Barth,S., Kluck,N., Lauster,C.,
            Braumann,B., Reich,R.H., Hemprich,A., Potzsch,S., Blaumeiser,B.,
            Daratsianos,N., Kreusch,T., Murray,J.C., Marazita,M.L.,
            Ruczinski,I., Scott,A.F., Beaty,T.H., Kramer,F.J., Wienker,T.F.,
            Steegers-Theunissen,R.P., Rubini,M., Mossey,P.A., Hoffmann,P.,
            Lange,C., Cichon,S., Propping,P., Knapp,M. and Nothen,M.M.
  TITLE     Genome-wide meta-analyses of nonsyndromic cleft lip with or without
            cleft palate identify six new risk loci
  JOURNAL   Nat Genet 44 (9), 968-971 (2012)
   PUBMED   22863734
REFERENCE   7  (bases 1 to 2086)
  AUTHORS   Suematsu,N. and Isohashi,F.
  TITLE     Molecular cloning and functional expression of human cytosolic
            acetyl-CoA hydrolase
  JOURNAL   Acta Biochim Pol 53 (3), 553-561 (2006)
   PUBMED   16951743
  REMARK    GeneRIF: The human CACH cDNA encodes a 555-amino-acid sequence that
            is 81.4%/78.7% identical to those of the mouse/rat homologue,
            suggesting a conserved role for this enzyme in the human and rodent
            livers.
REFERENCE   8  (bases 1 to 2086)
  AUTHORS   Hunt,M.C., Yamada,J., Maltais,L.J., Wright,M.W., Podesta,E.J. and
            Alexson,S.E.
  TITLE     A revised nomenclature for mammalian acyl-CoA
            thioesterases/hydrolases
  JOURNAL   J Lipid Res 46 (9), 2029-2032 (2005)
   PUBMED   16103133
REFERENCE   9  (bases 1 to 2086)
  AUTHORS   Suematsu,N., Okamoto,K. and Isohashi,F.
  TITLE     Simple and unique purification by size-exclusion chromatography for
            an oligomeric enzyme, rat liver cytosolic acetyl-coenzyme A
            hydrolase
  JOURNAL   J Chromatogr B Analyt Technol Biomed Life Sci 790 (1-2), 239-244
            (2003)
   PUBMED   12767336
REFERENCE   10 (bases 1 to 2086)
  AUTHORS   Suematsu,N., Okamoto,K., Shibata,K., Nakanishi,Y. and Isohashi,F.
  TITLE     Molecular cloning and functional expression of rat liver cytosolic
            acetyl-CoA hydrolase
  JOURNAL   Eur J Biochem 268 (9), 2700-2709 (2001)
   PUBMED   11322891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089437.1, AB078619.1, AK122960.1 and AC008411.5.
            
            On Nov 22, 2018 this sequence version replaced NM_130767.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122960.1, BC075011.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307624.8/ ENSP00000303246.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-516               BC089437.1         46-561
            517-1795            AB078619.1         520-1798
            1796-1954           AK122960.1         1796-1954
            1955-2086           AC008411.5         60961-61092         c
FEATURES             Location/Qualifiers
     source          1..2086
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.1"
     gene            1..2086
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /note="acyl-CoA thioesterase 12"
                     /db_xref="GeneID:134526"
                     /db_xref="HGNC:HGNC:24436"
                     /db_xref="MIM:614315"
     exon            1..147
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1688
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /EC_number="3.1.2.1"
                     /note="StAR-related lipid transfer (START) domain
                     containing 15; acyl-coenzyme A thioesterase 12; cytosolic
                     acetyl-CoA hydrolase; hCACH-1; acyl-CoA thioester
                     hydrolase 12; START domain-containing protein 15;
                     cytoplasmic acetyl-CoA hydrolase 1"
                     /codon_start=1
                     /product="acetyl-coenzyme A thioesterase"
                     /protein_id="NP_570123.1"
                     /db_xref="CCDS:CCDS4055.1"
                     /db_xref="GeneID:134526"
                     /db_xref="HGNC:HGNC:24436"
                     /db_xref="MIM:614315"
                     /translation="MERPAPGEVVMSQAIQPAHATARGELSAGQLLKWIDTTACLAAE
                     KHAGVSCVTASVDDIQFEETARVGQVITIKAKVTRAFSTSMEISIKVMVQDMLTGIEK
                     LVSVAFSTFVAKPVGKEKIHLKPVTLLTEQDHVEHNLAAERRKVRLQHEDTFNNLMKE
                     SSKFDDLIFDEEEGAVSTRGTSVQSIELVLPPHANHHGNTFGGQIMAWMETVATISAS
                     RLCWAHPFLKSVDMFKFRGPSTVGDRLVFTAIVNNTFQTCVEVGVRVEAFDCQEWAEG
                     RGRHINSAFLIYNAADDKENLITFPRIQPISKDDFRRYRGAIARKRIRLGRKYVISHK
                     EEVPLCIHWDISKQASLSDSNVEALKKLAAKRGWEVTSTVEKIKIYTLEEHDVLSVWV
                     EKHVGSPAHLAYRLLSDFTKRPLWDPHFVSCEVIDWVSEDDQLYHITCPILNDDKPKD
                     LVVLVSRRKPLKDGNTYTVAVKSVILPSVPPSPQYIRSEIICAGFLIHAIDSNSCIVS
                     YFNHMSASILPYFAGNLGGWSKSIEETAASCIQFLENPPDDGFVSTF"
     exon            148..217
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /inference="alignment:Splign:2.1.0"
     exon            218..278
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /inference="alignment:Splign:2.1.0"
     exon            279..380
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /inference="alignment:Splign:2.1.0"
     exon            381..516
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /inference="alignment:Splign:2.1.0"
     exon            517..673
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /inference="alignment:Splign:2.1.0"
     exon            674..793
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /inference="alignment:Splign:2.1.0"
     exon            794..944
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1000
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1064
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1148
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1282
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1411
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1538
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..2086
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2062..2067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /note="hexamer: TATAAA"
     polyA_site      2086
                     /gene="ACOT12"
                     /gene_synonym="Cach; CACH-1; STARD15; THEAL"
                     /note="major polyA site"
ORIGIN      
        1 gtagcgctct cgccctggcc atggagcggc cggcgcccgg cgaggtggtc atgagccaag
       61 ccatccagcc ggcgcacgcc actgcgcgcg gcgagctgag cgcggggcag ctgctcaagt
      121 ggatcgacac caccgcctgc ctggcggctg agaaacatgc tggagtttcc tgcgttacag
      181 cctcagtgga tgacatacag tttgaggaga cagctagagt tggacaagtt ataaccatca
      241 aagcaaaagt tactagagca ttcagcacaa gcatggagat cagtatcaag gtcatggtac
      301 aggatatgct cactggcatt gagaagcttg ttagtgtggc tttctccaca tttgtagcca
      361 aaccagttgg aaaagaaaag attcatttaa aaccagtcac acttctaact gaacaagatc
      421 atgtggaaca taatctggct gctgagagaa ggaaagttcg attacaacat gaagatacct
      481 ttaacaattt aatgaaggaa agtagcaaat ttgatgatct catttttgat gaagaggaag
      541 gagcggtttc cacaaggggc acctccgttc agagcattga actggtcctc ccaccccatg
      601 caaaccatca cggaaataca tttggtggcc agattatggc gtggatggag acagtggcta
      661 ctatttctgc aagccgcctg tgttgggctc atccctttct gaagtccgta gatatgttta
      721 agttccgggg accatctaca gttggagatc gtcttgtctt cactgccatt gtcaacaata
      781 catttcagac ctgtgttgaa gttggagttc gcgtggaggc ctttgactgt caggaatggg
      841 ccgagggccg agggcgtcac atcaacagtg cttttctcat ttacaatgct gctgatgata
      901 aggaaaatct catcacgttt cccagaatcc aacccatttc aaaggatgat ttcagacgct
      961 atcggggagc tattgcacgc aagcgaattc gcctaggcag aaaatatgtt atttcccaca
     1021 aagaagaggt tccactttgc atacactggg atatcagcaa gcaggcatcc ctgagtgaca
     1081 gcaatgtgga ggccctcaaa aaactggcag ccaaaagggg ttgggaggtt accagcactg
     1141 tggaaaagat aaaaatatat actctggaag agcatgatgt tttatctgtt tgggttgaaa
     1201 agcacgtggg aagtccagca catttggctt atcgtctctt gtctgacttt acaaagcgac
     1261 ctttgtggga cccccatttt gtgtcctgtg aagtcataga ctgggtgagt gaagatgatc
     1321 agctgtatca catcacctgt cctatactga atgatgacaa acccaaagac ttggtagtac
     1381 tcgtatcacg aagaaaaccc ctcaaagatg gtaacactta cacagtggca gtgaagtcgg
     1441 tcattttgcc atcggtcccc ccgtctccac agtacatcag aagtgaaatc atatgtgccg
     1501 gatttctcat ccatgctatt gacagcaatt catgcatcgt atcttacttt aaccatatgt
     1561 ctgctagcat ccttccttac tttgctggaa atcttggtgg ctggtcaaaa tccattgaag
     1621 aaacagcagc ctcttgtata cagttcttag agaatcctcc tgatgatggg tttgtaagca
     1681 cattttaaag gtcaactttc aattactggt aatttaattt cccactttta attccaagca
     1741 cccttagccc tgacatctgt caagctttgg ggccacaaaa taatttaata taaccctaag
     1801 caaaatgcag tgacggagtt aaaaaacaaa atgcatctta agtcaaatac cagtgatttg
     1861 gattagcatt aaaagagctt tagaattctg ttgtaagtca tctgtggctc tgcctcttcc
     1921 aggggcacag atagtggaaa attgcctgta tgcagtacta tgtgttctat aaaatggcat
     1981 gaatttagtt taaattatcg taaacatttt taggttacag aggtgaaaca tgcattctgt
     2041 gtgaaattcc aaaaaaaaaa ttataaaatc taaaatgatt tgctaa
//
