LOCUS       NM_147161               3084 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens acyl-CoA thioesterase 11 (ACOT11), transcript variant
            2, mRNA.
ACCESSION   NM_147161
VERSION     NM_147161.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3084)
  AUTHORS   Tillman,M.C., Imai,N., Li,Y., Khadka,M., Okafor,C.D., Juneja,P.,
            Adhiyaman,A., Hagen,S.J., Cohen,D.E. and Ortlund,E.A.
  TITLE     Allosteric regulation of thioesterase superfamily member 1 by lipid
            sensor domain binding fatty acids and lysophosphatidylcholine
  JOURNAL   Proc Natl Acad Sci U S A 117 (36), 22080-22089 (2020)
   PUBMED   32820071
  REMARK    GeneRIF: Allosteric regulation of thioesterase superfamily member 1
            by lipid sensor domain binding fatty acids and
            lysophosphatidylcholine.
REFERENCE   2  (bases 1 to 3084)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3084)
  AUTHORS   Okada,K., LeClair,K.B., Zhang,Y., Li,Y., Ozdemir,C., Krisko,T.I.,
            Hagen,S.J., Betensky,R.A., Banks,A.S. and Cohen,D.E.
  TITLE     Thioesterase superfamily member 1 suppresses cold thermogenesis by
            limiting the oxidation of lipid droplet-derived fatty acids in
            brown adipose tissue
  JOURNAL   Mol Metab 5 (5), 340-351 (2016)
   PUBMED   27110486
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3084)
  AUTHORS   Chen,D., Latham,J., Zhao,H., Bisoffi,M., Farelli,J. and
            Dunaway-Mariano,D.
  TITLE     Human brown fat inducible thioesterase variant 2 cellular
            localization and catalytic function
  JOURNAL   Biochemistry 51 (35), 6990-6999 (2012)
   PUBMED   22897136
  REMARK    GeneRIF: The N-terminal region of human fat inducible thioesterase
            variant 2 constitutes a mitochondrial location signal sequence,
            which undergoes mitochondrion-dependent posttranslational cleavage.
REFERENCE   5  (bases 1 to 3084)
  AUTHORS   Kirkby,B., Roman,N., Kobe,B., Kellie,S. and Forwood,J.K.
  TITLE     Functional and structural properties of mammalian acyl-coenzyme A
            thioesterases
  JOURNAL   Prog Lipid Res 49 (4), 366-377 (2010)
   PUBMED   20470824
  REMARK    Review article
REFERENCE   6  (bases 1 to 3084)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 3084)
  AUTHORS   Hunt,M.C., Yamada,J., Maltais,L.J., Wright,M.W., Podesta,E.J. and
            Alexson,S.E.
  TITLE     A revised nomenclature for mammalian acyl-CoA
            thioesterases/hydrolases
  JOURNAL   J Lipid Res 46 (9), 2029-2032 (2005)
   PUBMED   16103133
REFERENCE   8  (bases 1 to 3084)
  AUTHORS   Adams,S.H., Chui,C., Schilbach,S.L., Yu,X.X., Goddard,A.D.,
            Grimaldi,J.C., Lee,J., Dowd,P., Colman,S. and Lewin,D.A.
  TITLE     BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown
            adipose tissue: cloning, organization of the human gene and
            assessment of a potential link to obesity
  JOURNAL   Biochem J 360 (Pt 1), 135-142 (2001)
   PUBMED   11696000
  REMARK    GeneRIF: BFIT supports the transition of thermogenic brown adipose
            tissue towards increased metabolic activity, probably through
            alteration of intracellular fatty acyl-CoA concentration.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK023937.1 and AL590093.10.
            
            On Jun 2, 2019 this sequence version replaced NM_147161.3.
            
            Summary: This gene encodes a member of the acyl-CoA thioesterase
            family which catalyse the conversion of activated fatty acids to
            the corresponding non-esterified fatty acid and coenzyme A.
            Expression of a mouse homolog in brown adipose tissue is induced by
            low temperatures and repressed by warm temperatures. Higher levels
            of expression of the mouse homolog has been found in
            obesity-resistant mice compared with obesity-prone mice, suggesting
            a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing
            results in transcript variants. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (2) uses alternate exons in the 3'
            coding region and UTR, compared to variant 1. The encoded isoform
            (BFIT2) has a distinct C-terminus compared to isoform BFIT1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023937.1, AK223570.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343744.7/ ENSP00000340260.2
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1560              AK023937.1         1-1560
            1561-1561           AL590093.10        11596-11596
            1562-2203           AK023937.1         1562-2203
            2204-3084           AL590093.10        13803-14683
FEATURES             Location/Qualifiers
     source          1..3084
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..3084
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /note="acyl-CoA thioesterase 11"
                     /db_xref="GeneID:26027"
                     /db_xref="HGNC:HGNC:18156"
                     /db_xref="MIM:606803"
     exon            1..115
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1867
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /EC_number="3.1.2.2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     thioesterase superfamily member 1; START domain containing
                     14; StAR-related lipid transfer (START) domain containing
                     14; thioesterase, adipose associated; acyl-coenzyme A
                     thioesterase 11; acyl-CoA thioester hydrolase 11;
                     adipose-associated thioesterase; brown fat-inducible
                     thioesterase; palmitoyl-coenzyme A thioesterase"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase 11 isoform 2"
                     /protein_id="NP_671517.1"
                     /db_xref="CCDS:CCDS593.1"
                     /db_xref="GeneID:26027"
                     /db_xref="HGNC:HGNC:18156"
                     /db_xref="MIM:606803"
                     /translation="MIQNVGNHLRRGLASVFSNRTSRKSALRAGNDSAMADGEGYRNP
                     TEVQMSQLVLPCHTNQRGELSVGQLLKWIDTTACLSAERHAGCPCVTASMDDIYFEHT
                     ISVGQVVNIKAKVNRAFNSSMEVGIQVASEDLCSEKQWNVCKALATFVARREITKVKL
                     KQITPRTEEEKMEHSVAAERRRMRLVYADTIKDLLANCAIQGDLESRDCSRMVPAEKT
                     RVESVELVLPPHANHQGNTFGGQIMAWMENVATIAASRLCRAHPTLKAIEMFHFRGPS
                     QVGDRLVLKAIVNNAFKHSMEVGVCVEAYRQEAETHRRHINSAFMTFVVLDADDQPQL
                     LPWIRPQPGDGERRYREASARKKIRLDRKYIVSCKQTEVPLSVPWDPSNQVYLSYNNV
                     SSLKMLVAKDNWVLSSEISQVRLYTLEDDKFLSFHMEMVVHVDAAQAFLLLSDLRQRP
                     EWDKHYRSVELVQQVDEDDAIYHVTSPALGGHTKPQDFVILASRRKPCDNGDPYVIAL
                     RSVTLPTHRETPEYRRGETLCSGFCLWREGDQLTKVSYYNQATPGVLNYVTTNVAGLS
                     SEFYTTFKACEQFLLDNRNDLAPSLQTL"
     exon            116..323
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..393
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..454
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..553
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            554..689
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..846
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..966
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1111
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1167
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1234
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1318
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1452
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1584
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1711
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..3084
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2857..2862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /note="hexamer: TATAAA"
     polyA_site      2882
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /note="major polyA site"
     regulatory      3061..3066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
                     /note="hexamer: AATAAA"
     polyA_site      3084
                     /gene="ACOT11"
                     /gene_synonym="BFIT; STARD14; THEA; THEM1"
ORIGIN      
        1 atttggagtc aggcctggct gttgctcagg tgaccagctt gtgtctctgg gagggcgctg
       61 ctttccccgg ccacccggcg cgatgatcca gaatgtcgga aatcacctgc gacggggctt
      121 ggcctctgtg ttctccaacc gcacatcccg gaagtcagcc ttacgtgcgg ggaacgacag
      181 tgccatggca gacggcgagg gataccggaa ccccacggag gtgcagatga gccagctggt
      241 gctgccctgc cacaccaacc aacgtggtga gctgagcgtc gggcagctgc tcaagtggat
      301 tgacaccacg gcttgcctgt ccgcggagag gcacgctggc tgcccctgtg tcacagcttc
      361 catggatgac atctattttg agcacaccat tagtgttgga caagtggtga atatcaaggc
      421 caaggtgaac cgggccttca actccagcat ggaggtgggc atccaggtgg cctcggagga
      481 cctgtgctct gagaagcagt ggaatgtgtg caaggccttg gccaccttcg tggcccgccg
      541 agagatcacc aaggtgaagc tgaagcagat cacgccgcgg acagaagagg agaagatgga
      601 gcacagtgtg gcggctgagc gccggcgcat gcgccttgtc tatgcagaca ccatcaagga
      661 cctcctggcc aactgcgcca ttcagggcga tctggagagc agagactgta gccgcatggt
      721 gccggctgag aagacccgtg tggagagtgt ggagctggtc ctgcctcccc acgccaatca
      781 ccagggcaac acctttgggg gccagatcat ggcctggatg gagaatgtgg ccaccattgc
      841 agccagccgg ctctgccgtg cccaccctac gctgaaggcc attgaaatgt tccacttccg
      901 aggcccgtcc caggtcggcg accgtctggt gctcaaagcc atcgtgaaca atgccttcaa
      961 acatagcatg gaggtgggcg tgtgcgtgga ggcctatcgc caggaggctg agacccaccg
     1021 gcgccacatc aacagtgcct ttatgacctt tgtggtcctg gacgcagatg accagcccca
     1081 gttgctgccc tggattcggc cccagcccgg cgatggtgag cggcggtacc gagaggccag
     1141 tgccagaaag aagatccgcc tggacaggaa gtacatcgtg tcctgtaagc agacagaggt
     1201 gcccctctcc gtcccctggg accctagcaa ccaggtgtac ctgagctaca ataacgtctc
     1261 ctccttgaag atgcttgtgg ccaaggacaa ctgggtgctg tcctcggaga tcagtcaggt
     1321 ccgcctgtac actctggagg atgacaagtt cctctccttc cacatggaga tggtggtgca
     1381 tgtggatgca gcccaggcct tcctgctgct ctcggacctg cgtcagaggc cagagtggga
     1441 caagcactac cggagcgtgg agctagtgca gcaggtagac gaggacgacg ccatctacca
     1501 cgtcaccagc cctgccctcg gaggtcacac aaagccccag gacttcgtga tcctggcctc
     1561 gaggcggaag ccttgtgaca atggggaccc ctatgtcatc gcgctgaggt cggtcacgct
     1621 gcccacacac cgagagacgc cagagtacag acgcggagag accctctgct caggcttctg
     1681 cctctggcgc gagggggacc agctgaccaa ggtatcctac tacaaccagg ccaccccagg
     1741 tgttctcaac tatgtgacca ccaacgtggc cggcctctcc tctgagttct acaccacctt
     1801 caaggcttgt gagcagtttc tcttggacaa ccggaatgat ctggccccca gcctccagac
     1861 cctctagatg ccctcagtgg ccacatcatg cccactccca ctccatcctg tccccaagga
     1921 ctcacataca gtgcctggag aaagccaaag acctttattt cttcctgcct ccccgtggga
     1981 agcctccgcc ctgaggtccg ctggcccacc acccctgggt gctcagtttc taccaacatg
     2041 agccagcaag tccttgtggt agccctgggg tagcctgtag tagactcggg tcctgtccac
     2101 agccctagct gccagcaatg ctgtcctcac agaggcatag tcgcccccag ctgggttgtg
     2161 ctccactgtg acggtggccc ggggggagga tgccagcagc ctgcctatgg ctccagctgt
     2221 gctgtggccc agcagcatgg cctgcatctg gaaggacaca ggttgccaga gcccctggca
     2281 caactctagc atatctgtga gcagctgttc cctgtagcca ctgcccagca cctcctcagg
     2341 ccagcctggt gccacagtca cgtgggggaa gacctcagcc acagctgtaa gcagctctct
     2401 gccagccaca tggccgggga ccgaaaaact cccgtgggag attttggccc caacccacac
     2461 aggccaatgc aagaggccaa ggctggagag gcgtgccagc aaggccaggg atggccggag
     2521 ggctgcgggc tccgctattt gcaaatggat gccccagtgt ccgggatgtg tggccagctg
     2581 ctgcaggcag gactccagcg tcaggatgtt gccacttgga gtatgaacaa tgggcacggg
     2641 gttttcagcc acagttccct cgaggccagt gttcagcagg atcatgcctt ctgtgtctgg
     2701 aagaggcggc agaggcaaca gtgtttagga tttgggttat cataaggtgt taagagtccc
     2761 ttgttaaagg ggcagtggga gttatggggt catcaaggac cttgcctctc tggaatctgt
     2821 caacccagtt ttgggctcca ggtggatggg ttgctttata aatgtgcctg gtgcatgaga
     2881 aactcttgtt tcagctcttg gcctttaccc atgactcagc ctgggggctg gtgccggcct
     2941 tgcctgcagc aatgtagctg aggactggtc tgaaggccag gagccctgtg ctcttgacat
     3001 cactgtactc cctctccctc cccgcaaccc tgccccacct tgcatccagg gtatggtgta
     3061 aataaacctg tgttgccatg gcaa
//
