LOCUS       NM_001037161            1686 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens acyl-CoA thioesterase 1 (ACOT1), mRNA.
ACCESSION   NM_001037161 XM_929560
VERSION     NM_001037161.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1686)
  AUTHORS   Yu,Y., Zhang,Z., Dong,X., Yang,R., Duan,Z., Xiang,Z., Li,J., Li,G.,
            Yan,F., Xue,H., Jiao,D., Lu,J., Lu,H., Zhang,W., Wei,Y., Fan,S.,
            Li,J., Jia,J., Zhang,J., Ji,J., Liu,P., Lu,H., Zhao,H., Chen,S.,
            Wei,C., Chen,H. and Zhu,Z.
  TITLE     Pangenomic analysis of Chinese gastric cancer
  JOURNAL   Nat Commun 13 (1), 5412 (2022)
   PUBMED   36109518
  REMARK    GeneRIF: Genes ACOT1, GSTM1, SIGLEC14 and UGT2B17 are identified as
            highly absent genes in gastric cancer population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1686)
  AUTHORS   St Clair,L.A., Mills,S.A., Lian,E., Soma,P.S., Nag,A.,
            Montgomery,C., Ramirez,G., Chotiwan,N., Gullberg,R.C. and Perera,R.
  TITLE     Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty
            Acids Modulates Dengue Virus Serotype 2 Replication
  JOURNAL   Viruses 14 (2), 240 (2022)
   PUBMED   35215835
  REMARK    GeneRIF: Acyl-Coa Thioesterases: A Rheostat That Controls Activated
            Fatty Acids Modulates Dengue Virus Serotype 2 Replication.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1686)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1686)
  AUTHORS   Cavalli,M., Diamanti,K., Dang,Y., Xing,P., Pan,G., Chen,X. and
            Wadelius,C.
  TITLE     The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2
            Diabetes Detected in a Multi-Omics Study of Human Liver
  JOURNAL   OMICS 25 (10), 652-659 (2021)
   PUBMED   34520261
  REMARK    GeneRIF: The Thioesterase ACOT1 as a Regulator of Lipid Metabolism
            in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver.
REFERENCE   5  (bases 1 to 1686)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1686)
  AUTHORS   Wang,F., Wu,J., Qiu,Z., Ge,X., Liu,X., Zhang,C., Xu,W., Wang,F.,
            Hua,D., Qi,X. and Mao,Y.
  TITLE     ACOT1 expression is associated with poor prognosis in gastric
            adenocarcinoma
  JOURNAL   Hum Pathol 77, 35-44 (2018)
   PUBMED   29555575
  REMARK    GeneRIF: that increased expression of ACOT1 is correlated with
            pivotal clinicopathological parameters and poor prognosis in
            gastric adenocarcinoma through increased expression of the
            potential tumor-promoting protein GLI3
REFERENCE   7  (bases 1 to 1686)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   8  (bases 1 to 1686)
  AUTHORS   Li,J., Liu,F., Wang,H., Liu,X., Liu,J., Li,N., Wan,F., Wang,W.,
            Zhang,C., Jin,S., Liu,J., Zhu,P. and Liu,Y.
  TITLE     Systematic mapping and functional analysis of a family of human
            epididymal secretory sperm-located proteins
  JOURNAL   Mol Cell Proteomics 9 (11), 2517-2528 (2010)
   PUBMED   20736409
REFERENCE   9  (bases 1 to 1686)
  AUTHORS   Hunt,M.C., Rautanen,A., Westin,M.A., Svensson,L.T. and Alexson,S.E.
  TITLE     Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene
            clusters shows that convergent, functional evolution results in a
            reduced number of human peroxisomal ACOTs
  JOURNAL   FASEB J 20 (11), 1855-1864 (2006)
   PUBMED   16940157
REFERENCE   10 (bases 1 to 1686)
  AUTHORS   Hunt,M.C., Yamada,J., Maltais,L.J., Wright,M.W., Podesta,E.J. and
            Alexson,S.E.
  TITLE     A revised nomenclature for mammalian acyl-CoA
            thioesterases/hydrolases
  JOURNAL   J Lipid Res 46 (9), 2029-2032 (2005)
   PUBMED   16103133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005225.2 and DQ082754.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001037161.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX161396.1, DQ082754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311148.9/ ENSP00000311224.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC005225.2         123144-123224       c
            82-1684             DQ082754.1         1-1603
            1685-1686           AC005225.2         116571-116572       c
FEATURES             Location/Qualifiers
     source          1..1686
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..1686
                     /gene="ACOT1"
                     /gene_synonym="ACH2; CTE-1; LACH2"
                     /note="acyl-CoA thioesterase 1"
                     /db_xref="GeneID:641371"
                     /db_xref="HGNC:HGNC:33128"
                     /db_xref="MIM:614313"
     exon            1..736
                     /gene="ACOT1"
                     /gene_synonym="ACH2; CTE-1; LACH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..1545
                     /gene="ACOT1"
                     /gene_synonym="ACH2; CTE-1; LACH2"
                     /EC_number="3.1.2.2"
                     /note="CTE-I; CTE-Ib; long chain acyl-CoA hydrolase;
                     palmitoyl-coenzyme A thioesterase; long chain acyl-CoA
                     thioester hydrolase; inducible cytosolic acyl-coenzyme A
                     thioester hydrolase"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase 1"
                     /protein_id="NP_001032238.1"
                     /db_xref="CCDS:CCDS32117.1"
                     /db_xref="GeneID:641371"
                     /db_xref="HGNC:HGNC:33128"
                     /db_xref="MIM:614313"
                     /translation="MAATLILEPAGRCCWDEPVRIAVRGLAPEQPVTLRASLRDEKGA
                     LFQAHARYRADTLGELDLERAPALGGSFAGLEPMGLLWALEPEKPLVRLVKRDVRTPL
                     AVELEVLDGHDPDPGRLLCRVRHERYFLPPGVRREPVRAGRVRGTLFLPPEPGPFPGI
                     VDMFGTGGGLLEYRASLLAGKGFAVMALAYYNYEDLPKTMETLHLEYFEEAVNYLLSH
                     PEVKGPGVGLLGISKGGELCLSMASFLKGITAAVVINGSVANVGGTLRYKGETLPPVG
                     VNRNRIKVTKDGYADIVDVLNSPLEGPDQKSFIPVERAESTFLFLVGQDDHNWKSEFY
                     ANEACKRLQAHGRRKPQIICYPETGHYIEPPYFPLCRASLHALVGSPIIWGGEPRAHA
                     MAQVDAWKQLQTFFHKHLGGHEGTIPSKV"
     exon            737..939
                     /gene="ACOT1"
                     /gene_synonym="ACH2; CTE-1; LACH2"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1686
                     /gene="ACOT1"
                     /gene_synonym="ACH2; CTE-1; LACH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1670..1675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACOT1"
                     /gene_synonym="ACH2; CTE-1; LACH2"
                     /note="hexamer: AATGAA"
     polyA_site      1686
                     /gene="ACOT1"
                     /gene_synonym="ACH2; CTE-1; LACH2"
                     /note="major polyA site"
ORIGIN      
        1 attccgcgag ccagcaagct tctgaaaagc aaacctagga agttgctttc caacataaag
       61 tggaggtttc aacacaggag actttaagca agttccagtg tgtctatatt tggtctggct
      121 gatcggctgg actctggcct tccccgctca cattagcaga cagctctgcc ctagtgggcg
      181 tttagcctgc gacggcagcc cgagaggaag agttgggcag agttgcaggg gtctccacag
      241 ctgaggcagt ttggccggat tatttgggtt cctgctcgga tggcggcgac gctgatcctg
      301 gagcccgcgg gccgctgctg ctgggacgaa ccggtgcgaa tcgccgtgcg cggcctagcc
      361 ccggagcagc cggtcacgct gcgcgcgtcc ctgcgcgacg agaagggcgc gcttttccag
      421 gcccacgcgc gctaccgcgc cgacaccctt ggcgagctgg acctggagcg cgcgcccgcg
      481 ctgggcggca gcttcgcggg gcttgagccc atggggctgc tctgggcctt ggagcccgag
      541 aaacccttgg tgcggctggt gaagcgcgac gtgcgaacgc ccttggccgt ggagctggag
      601 gtgctggatg gccacgaccc cgaccccggg cggctgctgt gccgggtgcg gcacgagcgc
      661 tacttcctcc cgcccggggt gcggcgcgag ccggtgcgcg cgggccgggt gcgaggcacg
      721 ctcttcctgc cgccagaacc tgggcccttt cctggcattg tggacatgtt cggaactgga
      781 ggtggcctgc tggagtatcg ggctagtctg ctggctggga agggttttgc tgtgatggct
      841 ctggcttact ataactatga agacctcccc aagaccatgg agacgctcca tctggagtac
      901 tttgaagaag ctgtgaacta cttgctcagt catcctgagg taaaaggtcc aggagttggg
      961 ctgcttggaa tttccaaagg gggtgagctc tgcctttcca tggcctcttt cctgaagggc
     1021 atcacggctg ctgtcgtcat caacggctct gtggccaatg ttgggggaac cttacgctac
     1081 aagggcgaga ccctgccccc tgtgggcgtc aacagaaatc gcatcaaggt gaccaaagat
     1141 ggctatgcag acattgtgga tgtcctgaac agccctttgg aaggacctga ccagaagagc
     1201 ttcattcctg tggaaagggc agagagcacc ttcctgttcc tggtaggtca ggatgaccac
     1261 aactggaaga gtgagttcta tgctaatgag gcctgtaaac gcttgcaggc ccatgggagg
     1321 agaaagcccc agatcatctg ttacccagag acagggcact atattgagcc tccttacttc
     1381 cccctgtgtc gggcttccct gcatgccttg gtgggcagtc ctattatctg gggaggggag
     1441 cccagggctc atgccatggc tcaggtggat gcttggaaac aactccagac tttcttccac
     1501 aaacacttgg gtggccacga ggggacaatc ccatcaaaag tgtaaatttt atttgatcat
     1561 gtggcctctc tgttgctaat ctctcctgga aacatctgcc acatttagtg tgtgtatgtg
     1621 tattcattct ttctcataac ttcttaaagt ttcttcccct cattattaaa atgaatttac
     1681 cagtaa
//
