LOCUS       NM_001258406            2147 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens aconitate decarboxylase 1 (ACOD1), mRNA.
ACCESSION   NM_001258406 XM_001133269 XM_003403661
VERSION     NM_001258406.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2147)
  AUTHORS   Schofield,J.H., Longo,J., Sheldon,R.D., Albano,E., Ellis,A.E.,
            Hawk,M.A., Murphy,S., Duong,L., Rahmy,S., Lu,X., Jones,R.G. and
            Schafer,Z.T.
  TITLE     Acod1 expression in cancer cells promotes immune evasion through
            the generation of inhibitory peptides
  JOURNAL   Cell Rep 43 (4), 113984 (2024)
   PUBMED   38520689
  REMARK    GeneRIF: Acod1 expression in cancer cells promotes immune evasion
            through the generation of inhibitory peptides.
REFERENCE   2  (bases 1 to 2147)
  AUTHORS   Chen,F., Yalcin,I., Zhao,M., Chen,C., Blankenfeldt,W., Pessler,F.
            and Bussow,K.
  TITLE     Amino acid positions near the active site determine the reduced
            activity of human ACOD1 compared to murine ACOD1
  JOURNAL   Sci Rep 13 (1), 10360 (2023)
   PUBMED   37365251
  REMARK    GeneRIF: Amino acid positions near the active site determine the
            reduced activity of human ACOD1 compared to murine ACOD1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2147)
  AUTHORS   Zhou,L., Fang,F., Deng,J., Liu,S.J., Chen,C.H., Li,H., Ren,C.H. and
            Wu,Y.
  TITLE     [Clinical features of 6 children with uridine-responsive
            developmental epileptic encephalopathy 50 caused by CAD gene
            variants]
  JOURNAL   Zhonghua Er Ke Za Zhi 61 (5), 453-458 (2023)
   PUBMED   37096266
  REMARK    GeneRIF: [Clinical features of 6 children with uridine-responsive
            developmental epileptic encephalopathy 50 caused by CAD gene
            variants].
REFERENCE   4  (bases 1 to 2147)
  AUTHORS   Chen,Y.J., Li,G.N., Li,X.J., Wei,L.X., Fu,M.J., Cheng,Z.L.,
            Yang,Z., Zhu,G.Q., Wang,X.D., Zhang,C., Zhang,J.Y., Sun,Y.P.,
            Saiyin,H., Zhang,J., Liu,W.R., Zhu,W.W., Guan,K.L., Xiong,Y.,
            Yang,Y., Ye,D. and Chen,L.L.
  TITLE     Targeting IRG1 reverses the immunosuppressive function of
            tumor-associated macrophages and enhances cancer immunotherapy
  JOURNAL   Sci Adv 9 (17), eadg0654 (2023)
   PUBMED   37115931
  REMARK    GeneRIF: Targeting IRG1 reverses the immunosuppressive function of
            tumor-associated macrophages and enhances cancer immunotherapy.
REFERENCE   5  (bases 1 to 2147)
  AUTHORS   Kohl,L., Siddique,M.N.A.A., Bodendorfer,B., Berger,R.,
            Preikschat,A., Daniel,C., Olke,M., Liebler-Tenorio,E.,
            Schulze-Luehrmann,J., Mauermeir,M., Yang,K.T., Hayek,I.,
            Szperlinski,M., Andrack,J., Schleicher,U., Bozec,A., Kronke,G.,
            Murray,P.J., Wirtz,S., Yamamoto,M., Schatz,V., Jantsch,J.,
            Oefner,P., Degrandi,D., Pfeffer,K., Mertens-Scholz,K., Rauber,S.,
            Bogdan,C., Dettmer,K., Luhrmann,A. and Lang,R.
  TITLE     Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate
            pathway for containment of Q fever
  JOURNAL   EMBO Mol Med 15 (2), e15931 (2023)
   PUBMED   36479617
  REMARK    GeneRIF: Macrophages inhibit Coxiella burnetii by the
            ACOD1-itaconate pathway for containment of Q fever.
REFERENCE   6  (bases 1 to 2147)
  AUTHORS   Wolber,L.E., Girotto,G., Buniello,A., Vuckovic,D., Pirastu,N.,
            Lorente-Canovas,B., Rudan,I., Hayward,C., Polasek,O., Ciullo,M.,
            Mangino,M., Steves,C., Concas,M.P., Cocca,M., Spector,T.D.,
            Gasparini,P., Steel,K.P. and Williams,F.M.
  TITLE     Salt-inducible kinase 3, SIK3, is a new gene associated with
            hearing
  JOURNAL   Hum Mol Genet 23 (23), 6407-6418 (2014)
   PUBMED   25060954
REFERENCE   7  (bases 1 to 2147)
  AUTHORS   Li,Y., Zhang,P., Wang,C., Han,C., Meng,J., Liu,X., Xu,S., Li,N.,
            Wang,Q., Shi,X. and Cao,X.
  TITLE     Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by
            increasing A20 expression in macrophages through reactive oxygen
            species
  JOURNAL   J Biol Chem 288 (23), 16225-16234 (2013)
   PUBMED   23609450
  REMARK    GeneRIF: inducible IRG1 promotes endotoxin tolerance by increasing
            A20 expression through ROS, indicating a new molecular mechanism
            regulating hypoinflammation of sepsis and endotoxin tolerance.
REFERENCE   8  (bases 1 to 2147)
  AUTHORS   Michelucci,A., Cordes,T., Ghelfi,J., Pailot,A., Reiling,N.,
            Goldmann,O., Binz,T., Wegner,A., Tallam,A., Rausell,A., Buttini,M.,
            Linster,C.L., Medina,E., Balling,R. and Hiller,K.
  TITLE     Immune-responsive gene 1 protein links metabolism to immunity by
            catalyzing itaconic acid production
  JOURNAL   Proc Natl Acad Sci U S A 110 (19), 7820-7825 (2013)
   PUBMED   23610393
  REMARK    GeneRIF: IRG1 links cellular metabolism with immune defense by
            catalyzing itaconic acid production
            GeneRIF: Irg1 gene encodes an enzyme synthesizing itaconic acid
            from the TCA cycle intermediate cisaconitate. Furthermore, our data
            also show that IRG1 mediated itaconic acid production contributes
            to the antimicrobial activity of macrophages.
REFERENCE   9  (bases 1 to 2147)
  AUTHORS   Xiao,W., Wang,L., Xiao,R., Wu,M., Tan,J. and He,Y.
  TITLE     Expression profile of human immune-responsive gene 1 and generation
            and characterization of polyclonal antiserum
  JOURNAL   Mol Cell Biochem 353 (1-2), 177-187 (2011)
   PUBMED   21424586
  REMARK    GeneRIF: Results indicated that the IRG1 gene is differentially
            expressed in human fetal PBMCs and LPS-stimulated adult PBMCs.
REFERENCE   10 (bases 1 to 2147)
  AUTHORS   Chen,B., Zhang,D. and Pollard,J.W.
  TITLE     Progesterone regulation of the mammalian ortholog of methylcitrate
            dehydratase (immune response gene 1) in the uterine epithelium
            during implantation through the protein kinase C pathway
  JOURNAL   Mol Endocrinol 17 (11), 2340-2354 (2003)
   PUBMED   12893884
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC000403.1, DN831390.1, BX105915.1 and AI652725.1.
            
            On May 17, 2019 this sequence version replaced NM_001258406.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on partial human transcript alignments
            and RNA-seq data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1966682
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000377462.6/ ENSP00000366682.1
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC000403.1         72238-72297
            61-181              AC000403.1         76216-76336
            182-509             DN831390.1         53-380              c
            510-512             AC000403.1         79243-79245
            513-561             DN831390.1         1-49                c
            562-1710            AC000403.1         80780-81928
            1711-2145           BX105915.1         1-435
            2146-2147           AI652725.1         13-14               c
FEATURES             Location/Qualifiers
     source          1..2147
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q22.3"
     gene            1..2147
                     /gene="ACOD1"
                     /gene_synonym="CAD; IRG1"
                     /note="aconitate decarboxylase 1"
                     /db_xref="GeneID:730249"
                     /db_xref="HGNC:HGNC:33904"
                     /db_xref="MIM:615275"
     exon            1..60
                     /gene="ACOD1"
                     /gene_synonym="CAD; IRG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1494
                     /gene="ACOD1"
                     /gene_synonym="CAD; IRG1"
                     /EC_number="4.1.1.6"
                     /note="immune-responsive gene 1 protein homolog;
                     cis-aconitic acid decarboxylase; immunoresponsive 1
                     homolog"
                     /codon_start=1
                     /product="cis-aconitate decarboxylase"
                     /protein_id="NP_001245335.1"
                     /db_xref="CCDS:CCDS58299.1"
                     /db_xref="GeneID:730249"
                     /db_xref="HGNC:HGNC:33904"
                     /db_xref="MIM:615275"
                     /translation="MMLKSITESFATAIHGLKVGHLTDRVIQRSKRMILDTLGAGFLG
                     TTTEVFHIASQYSKIYSSNISSTVWGQPDIRLPPTYAAFVNGVAIHSMDFDDTWHPAT
                     HPSGAVLPVLTALAEALPRSPKFSGLDLLLAFNVGIEVQGRLLHFAKEANDMPKRFHP
                     PSVVGTLGSAAAASKFLGLSSTKCREALAIAVSHAGAPMANAATQTKPLHIGNAAKHG
                     IEAAFLAMLGLQGNKQVLDLEAGFGAFYANYSPKVLPSIASYSWLLDQQDVAFKRFPA
                     HLSTHWVADAAASVRKHLVAERALLPTDYIKRIVLRIPNVQYVNRPFPVSEHEARHSF
                     QYVACAMLLDGGITVPSFHECQINRPQVRELLSKVELEYPPDNLPSFNILYCEISVTL
                     KDGATFTDRSDTFYGHWRKPLSQEDLEEKFRANASKMLSWDTVESLIKIVKNLEDLED
                     CSVLTTLLKGPSPPEVASNSPACNNSITNLS"
     exon            61..222
                     /gene="ACOD1"
                     /gene_synonym="CAD; IRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            223..312
                     /gene="ACOD1"
                     /gene_synonym="CAD; IRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..518
                     /gene="ACOD1"
                     /gene_synonym="CAD; IRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            519..2147
                     /gene="ACOD1"
                     /gene_synonym="CAD; IRG1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcctctgg ttcactcctc ctgaactgaa cctcttcttt acaacgaaat gatgctcaag
       61 tctatcacag aaagctttgc cacagcaatc catggcttga aagtgggaca cctgacagat
      121 cgtgttattc agaggagcaa gaggatgatt ctagacactc tgggtgctgg gttcctggga
      181 accactacgg aagtgtttca catagccagc caatatagca agatctacag ttccaacata
      241 tccagcactg tttggggtca gccagacatc aggctcccgc ccacatatgc tgcttttgtg
      301 aacggtgtgg ctattcactc catggatttt gatgacacgt ggcaccctgc cacccaccct
      361 tctggggctg tccttcctgt cctcacagct ttagcagaag ccctgccaag gagtccaaag
      421 ttttctggcc ttgacctgct gctggctttc aatgttggta ttgaagtgca aggccgatta
      481 ctgcatttcg ccaaggaggc caatgacatg ccaaagagat tccatccccc ttccgtggta
      541 ggaacgttgg gtagtgctgc tgctgcatcc aagtttttag gacttagctc gacaaagtgc
      601 cgagaagctc tggccattgc tgtttcccat gctggggcac ccatggccaa tgctgccacc
      661 cagaccaagc ccctccacat tggcaatgct gccaagcatg ggatagaagc tgcatttttg
      721 gcaatgttgg gtctccaagg aaacaagcag gtcttggact tggaggcagg atttggggcc
      781 ttttatgcca actattcccc aaaagtcctt ccaagcatag cttcctacag ttggctgctg
      841 gaccagcagg acgtggcctt taagcgtttt cctgcacatt tatctaccca ctgggtggca
      901 gacgcagctg catctgtgag aaagcacctt gtagcagaga gagccctgct tccaactgac
      961 tacattaaga gaattgtgct caggatacca aatgtccagt atgtaaacag gccctttcca
     1021 gtttcggagc atgaagcccg tcattcattc cagtatgtgg cctgtgccat gctgcttgat
     1081 ggtggcatca ctgtcccctc attccatgaa tgccagatca acaggccaca ggtgagagag
     1141 ctgctcagta aggtggagct ggagtaccct ccggacaact tgccaagctt caacatactg
     1201 tactgtgaaa taagtgtcac cctcaaggat ggagccacct tcacagatcg ctctgatacc
     1261 ttctatgggc actggagaaa accactgagc caggaggacc tagaggaaaa gttcagagcc
     1321 aatgcctcca agatgctgtc ctgggacaca gtggaaagcc ttataaagat agtcaaaaat
     1381 ctagaagacc tagaagactg ttctgtgtta actacacttc tcaaaggacc ctctccacca
     1441 gaggtagctt caaactctcc agcatgtaat aattctatca caaatctctc ctgaggctta
     1501 ccaacatcta aatgactttg catttgggga gattcaatga tttggtttgt aaagcaaggg
     1561 tctgctgctt ggttttccca ggaaaaatga acaaagatgg agagagtcca gaaacagaac
     1621 tacatatatc tggaaggagc cttctcctga aaattttgca ggacagttcc acttacctaa
     1681 atcaagatga aacacacaca caaaaatgag tttgtaagca ttcacaaggg tgaaattcaa
     1741 ctcacctgtg atttacttat aaaattaatc tcttcatagg aattatgtgt ggacttcatg
     1801 agcctcaagg ttttagaggg atgtgaacct gcatgtatat tttctgacag tggagagggc
     1861 tctggtgcat tgtgtcacca acagatctcc tagaccatgg cttattacca agccctccac
     1921 agtgcaaggg gtgctactgg ggaatgggtg ggtttaaatc ctgcctctgc cattcactag
     1981 atgtagcctt gagcatgtta ccattagccc tctgcctcag tttccctatt tgtcaagccg
     2041 aagtaaaaag cagtctggaa aaatcgcatt ttggctctag aacccatggt cttaagcact
     2101 gcaatatatc acctttcagt ataaaaatat ttgaatcaga gttgcaa
//
