LOCUS       NM_001096               4293 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ATP citrate lyase (ACLY), transcript variant 1, mRNA.
ACCESSION   NM_001096
VERSION     NM_001096.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4293)
  AUTHORS   Sun,X., Zhao,X., Wang,S., Liu,Q., Wei,W., Xu,J., Wang,H. and
            Yang,W.
  TITLE     The pathological significance and potential mechanism of ACLY in
            cholangiocarcinoma
  JOURNAL   Front Immunol 15, 1477267 (2024)
   PUBMED   39399493
  REMARK    GeneRIF: The pathological significance and potential mechanism of
            ACLY in cholangiocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4293)
  AUTHORS   Wang,J., Du,J., Wang,Y., Song,Y., Wu,J., Wang,T., Yu,Z. and Song,B.
  TITLE     CILP2 promotes hypertrophic scar through Snail acetylation by
            interaction with ACLY
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167202 (2024)
   PUBMED   38670440
  REMARK    GeneRIF: CILP2 promotes hypertrophic scar through Snail acetylation
            by interaction with ACLY.
REFERENCE   3  (bases 1 to 4293)
  AUTHORS   Liu,P., Wang,Y., Li,X., Liu,Z., Sun,Y., Liu,H., Shao,Z., Jiang,E.,
            Zhou,X. and Shang,Z.
  TITLE     Enhanced lipid biosynthesis in oral squamous cell carcinoma
            cancer-associated fibroblasts contributes to tumor progression:
            Role of IL8/AKT/p-ACLY axis
  JOURNAL   Cancer Sci 115 (5), 1433-1445 (2024)
   PUBMED   38494608
  REMARK    GeneRIF: Enhanced lipid biosynthesis in oral squamous cell
            carcinoma cancer-associated fibroblasts contributes to tumor
            progression: Role of IL8/AKT/p-ACLY axis.
REFERENCE   4  (bases 1 to 4293)
  AUTHORS   Schulz-Kuhnt,A., Ruhle,K., Javidmehr,A., Dobronti,M., Biwank,J.,
            Knittel,S., Neidlinger,P., Leupold,J., Liu,L.J., Dedden,M.,
            Taudte,R.V., Gessner,A., Fromm,M.F., Mielenz,D., Kreiss,L.,
            Waldner,M.J., Schurmann,S., Friedrich,O., Dietel,B.,
            Lopez-Posadas,R., Plattner,C., Zundler,S., Becker,C., Atreya,R.,
            Neurath,M.F. and Atreya,I.
  CONSRTM   TRR241 IBDome Consortium
  TITLE     ATP citrate lyase (ACLY)-dependent immunometabolism in mucosal T
            cells drives experimental colitis in vivo
  JOURNAL   Gut 73 (4), 601-612 (2024)
   PUBMED   38176897
  REMARK    GeneRIF: ATP citrate lyase (ACLY)-dependent immunometabolism in
            mucosal T cells drives experimental colitis in vivo.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4293)
  AUTHORS   Nickenig,M., Mangan,M.S.J., Lee,H.E., Symeonidis,K., Henne,A.,
            Kaiser,R., Geissmar,E., Garritsen,H., Abdullah,Z., Hiller,K.,
            Latz,E. and Lauterbach,M.A.
  TITLE     Cutting Edge: STING Induces ACLY Activation and Metabolic
            Adaptations in Human Macrophages through TBK1
  JOURNAL   J Immunol 212 (1), 7-11 (2024)
   PUBMED   38038390
  REMARK    GeneRIF: Cutting Edge: STING Induces ACLY Activation and Metabolic
            Adaptations in Human Macrophages through TBK1.
REFERENCE   6  (bases 1 to 4293)
  AUTHORS   Elshourbagy,N.A., Near,J.C., Kmetz,P.J., Wells,T.N., Groot,P.H.,
            Saxty,B.A., Hughes,S.A., Franklin,M. and Gloger,I.S.
  TITLE     Cloning and expression of a human ATP-citrate lyase cDNA
  JOURNAL   Eur J Biochem 204 (2), 491-499 (1992)
   PUBMED   1371749
REFERENCE   7  (bases 1 to 4293)
  AUTHORS   Ramakrishna,S., D'Angelo,G. and Benjamin,W.B.
  TITLE     Sequence of sites on ATP-citrate lyase and phosphatase inhibitor 2
            phosphorylated by multifunctional protein kinase (a glycogen
            synthase kinase 3 like kinase)
  JOURNAL   Biochemistry 29 (33), 7617-7624 (1990)
   PUBMED   2176822
REFERENCE   8  (bases 1 to 4293)
  AUTHORS   Stralfors,P.
  TITLE     Isoproterenol and insulin control the cellular localization of ATP
            citrate-lyase through its phosphorylation in adipocytes
  JOURNAL   J Biol Chem 262 (24), 11486-11489 (1987)
   PUBMED   3305493
REFERENCE   9  (bases 1 to 4293)
  AUTHORS   Suzuki,M. and Okuda,H.
  TITLE     ATP citrate lyase in human adipose tissue
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 27 (6), 595-598 (1981)
   PUBMED   6801225
REFERENCE   10 (bases 1 to 4293)
  AUTHORS   Szutowicz,A. and Lysiak,W.
  TITLE     Regional and subcellular distribution of ATP-citrate lyase and
            other enzymes of acetyl-CoA metabolism in rat brain
  JOURNAL   J Neurochem 35 (4), 775-785 (1980)
   PUBMED   6109001
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG037168.1, BC006195.2 and
            AC125257.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001096.2.
            
            Summary: ATP citrate lyase is the primary enzyme responsible for
            the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme
            is a tetramer (relative molecular weight approximately 440,000) of
            apparently identical subunits. It catalyzes the formation of
            acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant
            hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA,
            serves several important biosynthetic pathways, including
            lipogenesis and cholesterogenesis. In nervous tissue, ATP
            citrate-lyase may be involved in the biosynthesis of acetylcholine.
            Multiple transcript variants encoding distinct isoforms have been
            identified for this gene. [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) has an alternate splice site,
            which results in translation initiation at a downstream AUG start
            codon, compared to variant 3. The resulting isoform (1) is shorter
            at the N-terminus, compared to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.185732.1,
                                           SRR1803616.87216.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352035.7/ ENSP00000253792.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-440               BG037168.1         89-528
            441-4285            BC006195.2         477-4321
            4286-4293           AC125257.4         31607-31614         c
FEATURES             Location/Qualifiers
     source          1..4293
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..4293
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /note="ATP citrate lyase"
                     /db_xref="GeneID:47"
                     /db_xref="HGNC:HGNC:115"
                     /db_xref="MIM:108728"
     exon            1..72
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            73..254
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..3401
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /EC_number="2.3.3.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATP-citrate synthase; citrate cleavage enzyme; ATP-citrate
                     (pro-S-)-lyase"
                     /codon_start=1
                     /product="ATP-citrate synthase isoform 1"
                     /protein_id="NP_001087.2"
                     /db_xref="CCDS:CCDS11412.1"
                     /db_xref="GeneID:47"
                     /db_xref="HGNC:HGNC:115"
                     /db_xref="MIM:108728"
                     /translation="MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLL
                     QDHPWLLSQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFL
                     KNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKL
                     NPEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLA
                     AKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIW
                     TMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPD
                     GKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMG
                     EVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAP
                     SRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRA
                     VQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEV
                     DVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPA
                     TVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVY
                     EGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPI
                     VCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQ
                     SVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAG
                     MPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICA
                     RAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMG
                     IGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIG
                     VAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPW
                     DDISYVLPEHMSM"
     exon            255..377
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            378..440
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            441..631
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            632..711
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            712..842
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            843..961
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1098
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1160
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1278
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1433
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1524
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1554
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1696
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1865
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1970
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2167
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2249
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2360
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2488
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2582
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2737
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2888
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..3032
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            3033..3146
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3229
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3306
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..4293
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4266..4271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /note="hexamer: AATAAA"
     polyA_site      4293
                     /gene="ACLY"
                     /gene_synonym="ACL; ATPCL; CLATP"
                     /note="major polyA site"
ORIGIN      
        1 gctggggtgc tccggatttt gcggggttcg tcgggcctgt ggaagaagcg ccgcgcacgg
       61 acttcggcag aggtagagca ggtctctctg cagccatgtc ggccaaggca atttcagagc
      121 agacgggcaa agaactcctt tacaagttca tctgtaccac ctcagccatc cagaatcggt
      181 tcaagtatgc tcgggtcact cctgacacag actgggcccg cttgctgcag gaccacccct
      241 ggctgctcag ccagaacttg gtagtcaagc cagaccagct gatcaaacgt cgtggaaaac
      301 ttggtctcgt tggggtcaac ctcactctgg atggggtcaa gtcctggctg aagccacggc
      361 tgggacagga agccacagtt ggcaaggcca caggcttcct caagaacttt ctgatcgagc
      421 ccttcgtccc ccacagtcag gctgaggagt tctatgtctg catctatgcc acccgagaag
      481 gggactacgt cctgttccac cacgaggggg gtgtggacgt gggtgatgtg gacgccaagg
      541 cccagaagct gcttgttggc gtggatgaga aactgaatcc tgaggacatc aaaaaacacc
      601 tgttggtcca cgcccctgaa gacaagaaag aaattctggc cagttttatc tccggcctct
      661 tcaatttcta cgaggacttg tacttcacct acctcgagat caatcccctt gtagtgacca
      721 aagatggagt ctatgtcctt gacttggcgg ccaaggtgga cgccactgcc gactacatct
      781 gcaaagtgaa gtggggtgac atcgagttcc ctcccccctt cgggcgggag gcatatccag
      841 aggaagccta cattgcagac ctcgatgcca aaagtggggc aagcctgaag ctgaccttgc
      901 tgaaccccaa agggaggatc tggaccatgg tggccggggg tggcgcctct gtcgtgtaca
      961 gcgataccat ctgtgatcta gggggtgtca acgagctggc aaactatggg gagtactcag
     1021 gcgcccccag cgagcagcag acctatgact atgccaagac tatcctctcc ctcatgaccc
     1081 gagagaagca cccagatggc aagatcctca tcattggagg cagcatcgca aacttcacca
     1141 acgtggctgc cacgttcaag ggcatcgtga gagcaattcg agattaccag ggccccctga
     1201 aggagcacga agtcacaatc tttgtccgaa gaggtggccc caactatcag gagggcttac
     1261 gggtgatggg agaagtcggg aagaccactg ggatccccat ccatgtcttt ggcacagaga
     1321 ctcacatgac ggccattgtg ggcatggccc tgggccaccg gcccatcccc aaccagccac
     1381 ccacagcggc ccacactgca aacttcctcc tcaacgccag cgggagcaca tcgacgccag
     1441 cccccagcag gacagcatct ttttctgagt ccagggccga tgaggtggcg cctgcaaaga
     1501 aggccaagcc tgccatgcca caagattcag tcccaagtcc aagatccctg caaggaaaga
     1561 gcaccaccct cttcagccgc cacaccaagg ccattgtgtg gggcatgcag acccgggccg
     1621 tgcaaggcat gctggacttt gactatgtct gctcccgaga cgagccctca gtggctgcca
     1681 tggtctaccc tttcactggg gaccacaagc agaagtttta ctgggggcac aaagagatcc
     1741 tgatccctgt cttcaagaac atggctgatg ccatgaggaa gcatccggag gtagatgtgc
     1801 tcatcaactt tgcctctctc cgctctgcct atgacagcac catggagacc atgaactatg
     1861 cccagatccg gaccatcgcc atcatagctg aaggcatccc tgaggccctc acgagaaagc
     1921 tgatcaagaa ggcggaccag aagggagtga ccatcatcgg acctgccact gttggaggca
     1981 tcaagcctgg gtgctttaag attggcaaca caggtgggat gctggacaac atcctggcct
     2041 ccaaactgta ccgcccaggc agcgtggcct atgtctcacg ttccggaggc atgtccaacg
     2101 agctcaacaa tatcatctct cggaccacgg atggcgtcta tgagggcgtg gccattggtg
     2161 gggacaggta cccgggctcc acattcatgg atcatgtgtt acgctatcag gacactccag
     2221 gagtcaaaat gattgtggtt cttggagaga ttgggggcac tgaggaatat aagatttgcc
     2281 ggggcatcaa ggagggccgc ctcactaagc ccatcgtctg ctggtgcatc gggacgtgtg
     2341 ccaccatgtt ctcctctgag gtccagtttg gccatgctgg agcttgtgcc aaccaggctt
     2401 ctgaaactgc agtagccaag aaccaggctt tgaaggaagc aggagtgttt gtgccccgga
     2461 gctttgatga gcttggagag atcatccagt ctgtatacga agatctcgtg gccaatggag
     2521 tcattgtacc tgcccaggag gtgccgcccc caaccgtgcc catggactac tcctgggcca
     2581 gggagcttgg tttgatccgc aaacctgcct cgttcatgac cagcatctgc gatgagcgag
     2641 gacaggagct catctacgcg ggcatgccca tcactgaggt cttcaaggaa gagatgggca
     2701 ttggcggggt cctcggcctc ctctggttcc agaaaaggtt gcctaagtac tcttgccagt
     2761 tcattgagat gtgtctgatg gtgacagctg atcacgggcc agccgtctct ggagcccaca
     2821 acaccatcat ttgtgcgcga gctgggaaag acctggtctc cagcctcacc tcggggctgc
     2881 tcaccatcgg ggatcggttt gggggtgcct tggatgcagc agccaagatg ttcagtaaag
     2941 cctttgacag tggcattatc cccatggagt ttgtgaacaa gatgaagaag gaagggaagc
     3001 tgatcatggg cattggtcac cgagtgaagt cgataaacaa cccagacatg cgagtgcaga
     3061 tcctcaaaga ttacgtcagg cagcacttcc ctgccactcc tctgctcgat tatgcactgg
     3121 aagtagagaa gattaccacc tcgaagaagc caaatcttat cctgaatgta gatggtctca
     3181 tcggagtcgc atttgtagac atgcttagaa actgtgggtc ctttactcgg gaggaagctg
     3241 atgaatatat tgacattgga gccctcaatg gcatctttgt gctgggaagg agtatggggt
     3301 tcattggaca ctatcttgat cagaagaggc tgaagcaggg gctgtatcgt catccgtggg
     3361 atgatatttc atatgttctt ccggaacaca tgagcatgta acagagccag gaaccctact
     3421 gcagtaaact gaagacaaga tctcttcccc caagaaaaag tgtacagaca gctggcagtg
     3481 gagcctgctt tatttagcag gggcctggaa tgtaaacagc cactggggta caggcaccga
     3541 agaccaacat ccacaggcta acaccccttc agtccacaca aagaagcttc atattttttt
     3601 tataagcata gaaataaaaa ccaagccaat atttgtgact ttgctctgct acctgctgta
     3661 tttattatat ggaagcatct aagtactgtc aggatggggt cttcctcatt gtagggcgtt
     3721 aggatgttgc tttctttttc cattagttaa acattttttt ctcctttgga ggaagggaat
     3781 gaaacattta tggcctcaag atactataca tttaaagcac cccaatgtct ctcttttttt
     3841 ttttttactt ccctttcttc ttccttatat aacatgaaga acattgtatt aatctgattt
     3901 ttaaagatct ttttgtatgt tacgtgttaa gggcttgttt ggtatcccac tgaaatgttc
     3961 tgtgttgcag accagagtct gtttatgtca gggggatggg gccattgcat ccttagccat
     4021 tgtcacaaaa tatgtggagt agtaacttaa tatgtaaagt tgtaacatac atacatttaa
     4081 aatggaaatg cagaaagctg tgaaatgtct tgtgtcttat gttctctgta tttatgcagc
     4141 tgatttgtct gtctgtaact gaagtgtggg tccaaggact cctaactact ttgcatctgt
     4201 aatccacaaa gattctgggc agctgccacc tcagtctctt ctctgtatta tcatagtctg
     4261 gtttaaataa actatatagt aacaatgaag gca
//
