LOCUS       NM_016557               2310 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens atypical chemokine receptor 4 (ACKR4), transcript
            variant 2, mRNA.
ACCESSION   NM_016557
VERSION     NM_016557.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2310)
  AUTHORS   Naser,I.H., Hamza,A.A., Alhili,A., Faisal,A.N., Ali,M.S.,
            Kadhim,N.A., Suliman,M., Alshahrani,M.Y. and Alawadi,A.
  TITLE     Atypical chemokine receptor 4 (ACKR4/CCX-CKR): A comprehensive
            exploration across physiological and pathological landscapes in
            contemporary research
  JOURNAL   Cell Biochem Funct 42 (3), e4009 (2024)
   PUBMED   38597217
  REMARK    GeneRIF: Atypical chemokine receptor 4 (ACKR4/CCX-CKR): A
            comprehensive exploration across physiological and pathological
            landscapes in contemporary research.
            Review article
REFERENCE   2  (bases 1 to 2310)
  AUTHORS   Jiang,C.Y., Wu,L.W., Liu,Y.W., Feng,B., Ye,L.C., Huang,X., He,Y.Y.,
            Shen,Y., Zhu,Y.F., Zhou,X.L., Jiang,D.J., Qi,H.K., Zhang,H. and
            Yan,Y.
  TITLE     Identification of ACKR4 as an immune checkpoint in pulmonary
            arterial hypertension
  JOURNAL   Front Immunol 14, 1153573 (2023)
   PUBMED   37449198
  REMARK    GeneRIF: Identification of ACKR4 as an immune checkpoint in
            pulmonary arterial hypertension.
            Erratum:[Front Immunol. 2024 Feb 20;15:1382832. doi:
            10.3389/fimmu.2024.1382832.. PMID: 38444849]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2310)
  AUTHORS   Friess,M.C., Kritikos,I., Schineis,P., Medina-Sanchez,J.D.,
            Gkountidi,A.O., Vallone,A., Sigmund,E.C., Schwitter,C., Vranova,M.,
            Matti,C., Arasa,J., Saygili Demir,C., Bovay,E., Proulx,S.T.,
            Tomura,M., Rot,A., Legler,D.F., Petrova,T.V. and Halin,C.
  TITLE     Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T
            cell de-adhesion and passive transport by flow in inflamed afferent
            lymphatics
  JOURNAL   Cell Rep 38 (5), 110334 (2022)
   PUBMED   35108538
  REMARK    GeneRIF: Mechanosensitive ACKR4 scavenges CCR7 chemokines to
            facilitate T cell de-adhesion and passive transport by flow in
            inflamed afferent lymphatics.
REFERENCE   4  (bases 1 to 2310)
  AUTHORS   Mohammed,M.M., Shaker,O., Ramzy,M.M., Gaber,S.S., Kamel,H.S. and
            Abed El Baky,M.F.
  TITLE     The relation between ACKR4 and CCR7 genes expression and breast
            cancer metastasis
  JOURNAL   Life Sci 279, 119691 (2021)
   PUBMED   34102193
  REMARK    GeneRIF: The relation between ACKR4 and CCR7 genes expression and
            breast cancer metastasis.
REFERENCE   5  (bases 1 to 2310)
  AUTHORS   Lewandowska,P., Wierzbicki,J., Zawadzki,M., Agrawal,A. and
            Krzystek-Korpacka,M.
  TITLE     Biphasic Expression of Atypical Chemokine Receptor (ACKR) 2 and
            ACKR4 in Colorectal Neoplasms in Association with Histopathological
            Findings
  JOURNAL   Biomolecules 11 (1), 8 (2020)
   PUBMED   33374792
  REMARK    GeneRIF: Biphasic Expression of Atypical Chemokine Receptor (ACKR)
            2 and ACKR4 in Colorectal Neoplasms in Association with
            Histopathological Findings.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2310)
  AUTHORS   Khoja,H., Wang,G., Ng,C.T., Tucker,J., Brown,T. and Shyamala,V.
  TITLE     Cloning of CCRL1, an orphan seven transmembrane receptor related to
            chemokine receptors, expressed abundantly in the heart
  JOURNAL   Gene 246 (1-2), 229-238 (2000)
   PUBMED   10767544
REFERENCE   7  (bases 1 to 2310)
  AUTHORS   Schweickart,V.L., Epp,A., Raport,C.J. and Gray,P.W.
  TITLE     CCR11 is a functional receptor for the monocyte chemoattractant
            protein family of chemokines
  JOURNAL   J Biol Chem 275 (13), 9550-9556 (2000)
   PUBMED   10734104
REFERENCE   8  (bases 1 to 2310)
  AUTHORS   Gosling,J., Dairaghi,D.J., Wang,Y., Hanley,M., Talbot,D., Miao,Z.
            and Schall,T.J.
  TITLE     Cutting edge: identification of a novel chemokine receptor that
            binds dendritic cell- and T cell-active chemokines including ELC,
            SLC, and TECK
  JOURNAL   J Immunol 164 (6), 2851-2856 (2000)
   PUBMED   10706668
REFERENCE   9  (bases 1 to 2310)
  AUTHORS   Bacon,K.B., Schall,T.J. and Dairaghi,D.J.
  TITLE     RANTES activation of phospholipase D in Jurkat T cells: requirement
            of GTP-binding proteins ARF and RhoA
  JOURNAL   J Immunol 160 (4), 1894-1900 (1998)
   PUBMED   9469451
REFERENCE   10 (bases 1 to 2310)
  AUTHORS   Iwatsuki,K., Hashimoto,Y. and Shima,T.
  TITLE     [AH8165, a new muscle relaxant]
  JOURNAL   Masui 26 (3), 342-344 (1977)
   PUBMED   16148
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC419249.1, AF110640.1,
            AK225927.1 and BQ015927.1.
            
            On May 17, 2019 this sequence version replaced NM_016557.3.
            
            Summary: The protein encoded by this gene is a member of the G
            protein-coupled receptor family, and is a receptor for C-C type
            chemokines. This receptor has been shown to bind dendritic cell-
            and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and
            CCL25/TECK. A pseudogene of this gene is found on chromosome 6.
            Alternatively spliced transcript variants encoding the same protein
            have been described. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, as
            compared to variant 1. Both variants encode the some protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313923.1, AF110640.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249887.3/ ENSP00000249887.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DC419249.1         34-56
            24-74               AF110640.1         1-51
            75-1111             AK225927.1         22-1058
            1112-1878           AF110640.1         1089-1855
            1879-2310           BQ015927.1         14-445              c
FEATURES             Location/Qualifiers
     source          1..2310
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..2310
                     /gene="ACKR4"
                     /gene_synonym="CC-CKR-11; CCBP2; CCR-11; CCR10; CCR11;
                     CCRL1; CCX CKR; CCX-CKR; CKR-11; PPR1; VSHK1"
                     /note="atypical chemokine receptor 4"
                     /db_xref="GeneID:51554"
                     /db_xref="HGNC:HGNC:1611"
                     /db_xref="MIM:606065"
     exon            1..54
                     /gene="ACKR4"
                     /gene_synonym="CC-CKR-11; CCBP2; CCR-11; CCR10; CCR11;
                     CCRL1; CCX CKR; CCX-CKR; CKR-11; PPR1; VSHK1"
                     /inference="alignment:Splign:2.1.0"
     exon            55..2310
                     /gene="ACKR4"
                     /gene_synonym="CC-CKR-11; CCBP2; CCR-11; CCR10; CCR11;
                     CCRL1; CCX CKR; CCX-CKR; CKR-11; PPR1; VSHK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1116
                     /gene="ACKR4"
                     /gene_synonym="CC-CKR-11; CCBP2; CCR-11; CCR10; CCR11;
                     CCRL1; CCX CKR; CCX-CKR; CKR-11; PPR1; VSHK1"
                     /note="orphan seven-transmembrane receptor, chemokine
                     related; chemokine, cc motif, receptor-like protein 1; C-C
                     chemokine receptor type 11; chemocentryx chemokine
                     receptor; C-C CKR-11; CC chemokine receptor-like 1;
                     chemokine (C-C motif) receptor-like 1"
                     /codon_start=1
                     /product="atypical chemokine receptor 4"
                     /protein_id="NP_057641.1"
                     /db_xref="CCDS:CCDS3075.1"
                     /db_xref="GeneID:51554"
                     /db_xref="HGNC:HGNC:1611"
                     /db_xref="MIM:606065"
                     /translation="MALEQNQSTDYYYEENEMNGTYDYSQYELICIKEDVREFAKVFL
                     PVFLTIVFVIGLAGNSMVVAIYAYYKKQRTKTDVYILNLAVADLLLLFTLPFWAVNAV
                     HGWVLGKIMCKITSALYTLNFVSGMQFLACISIDRYVAVTKVPSQSGVGKPCWIICFC
                     VWMAAILLSIPQLVFYTVNDNARCIPIFPRYLGTSMKALIQMLEICIGFVVPFLIMGV
                     CYFITARTLMKMPNIKISRPLKVLLTVVIVFIVTQLPYNIVKFCRAIDIIYSLITSCN
                     MSKRMDIAIQVTESIALFHSCLNPILYVFMGASFKNYVMKVAKKYGSWRRQRQSVEEF
                     PFDSEGPTEPTSTFSI"
     regulatory      1856..1861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACKR4"
                     /gene_synonym="CC-CKR-11; CCBP2; CCR-11; CCR10; CCR11;
                     CCRL1; CCX CKR; CCX-CKR; CKR-11; PPR1; VSHK1"
                     /note="hexamer: AATAAA"
     polyA_site      1878
                     /gene="ACKR4"
                     /gene_synonym="CC-CKR-11; CCBP2; CCR-11; CCR10; CCR11;
                     CCRL1; CCX CKR; CCX-CKR; CKR-11; PPR1; VSHK1"
                     /note="major polyA site"
     regulatory      2167..2172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACKR4"
                     /gene_synonym="CC-CKR-11; CCBP2; CCR-11; CCR10; CCR11;
                     CCRL1; CCX CKR; CCX-CKR; CKR-11; PPR1; VSHK1"
                     /note="hexamer: AATAAA"
     regulatory      2185..2190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACKR4"
                     /gene_synonym="CC-CKR-11; CCBP2; CCR-11; CCR10; CCR11;
                     CCRL1; CCX CKR; CCX-CKR; CKR-11; PPR1; VSHK1"
                     /note="hexamer: AATAAA"
     polyA_site      2186
                     /gene="ACKR4"
                     /gene_synonym="CC-CKR-11; CCBP2; CCR-11; CCR10; CCR11;
                     CCRL1; CCX CKR; CCX-CKR; CKR-11; PPR1; VSHK1"
     polyA_site      2206
                     /gene="ACKR4"
                     /gene_synonym="CC-CKR-11; CCBP2; CCR-11; CCR10; CCR11;
                     CCRL1; CCX CKR; CCX-CKR; CKR-11; PPR1; VSHK1"
ORIGIN      
        1 catttgattt tatactctgt actcaagact gctcctctct gccgactaca acagattgga
       61 gccatggctt tggaacagaa ccagtcaaca gattattatt atgaggaaaa tgaaatgaat
      121 ggcacttatg actacagtca atatgaactg atctgtatca aagaagatgt cagagaattt
      181 gcaaaagttt tcctccctgt attcctcaca atagttttcg tcattggact tgcaggcaat
      241 tccatggtag tggcaattta tgcctattac aagaaacaga gaaccaaaac agatgtgtac
      301 atcctgaatt tggctgtagc agatttactc cttctattca ctctgccttt ttgggctgtt
      361 aatgcagttc atgggtgggt tttagggaaa ataatgtgca aaataacttc agccttgtac
      421 acactaaact ttgtctctgg aatgcagttt ctggcttgta tcagcataga cagatatgtg
      481 gcagtaacta aagtccccag ccaatcagga gtgggaaaac catgctggat catctgtttc
      541 tgtgtctgga tggctgccat cttgctgagc ataccccagc tggtttttta tacagtaaat
      601 gacaatgcta ggtgcattcc cattttcccc cgctacctag gaacatcaat gaaagcattg
      661 attcaaatgc tagagatctg cattggattt gtagtaccct ttcttattat gggggtgtgc
      721 tactttatca cagcaaggac actcatgaag atgccaaaca ttaaaatatc tcgaccccta
      781 aaagttctgc tcacagtcgt tatagttttc attgtcactc aactgcctta taacattgtc
      841 aagttctgcc gagccataga catcatctac tccctgatca ccagctgcaa catgagcaaa
      901 cgcatggaca tcgccatcca agtcacagaa agcatcgcac tctttcacag ctgcctcaac
      961 ccaatccttt atgtttttat gggagcatct ttcaaaaact acgttatgaa agtggccaag
     1021 aaatatgggt cctggagaag acagagacaa agtgtggagg agtttccttt tgattctgag
     1081 ggtcctacag agccaaccag tacttttagc atttaaaggt aaaactgctc tgccttttgc
     1141 ttggatacat atgaatgatg ctttcccctc aaataaaaca tctgcattat tctgaaactc
     1201 aaatctcaga cgccgtggtt gcaacttata ataaagaatg ggttggggga agggggagaa
     1261 ataaaagcca agaagaggaa acaagataat aaatgtacaa aacatgaaaa ttaaaatgaa
     1321 caatatagga aaataattgt aacaggcata agtgaataac actctgctgt aacgaagaag
     1381 agctttgtgg tgataatttt gtatcttggt tgcagtggtg cttatacaaa tctacacaag
     1441 tgataaaatg acacagaact atatacacac attgtaccaa tttcaatttc ctggttttga
     1501 cattatagta taattatgta agatggaacc attggggaaa actgggtgaa gggtacccag
     1561 gaccactctg taccatcttt gtaacttcct gtgaatttat aataatttca aaataaaaca
     1621 agttaaaaaa aaacccacta tgctataagt taggccatct aaaacagatt attaaagagg
     1681 ttcatgttaa aaggcattta taattatttt taattatcta agttttaata caagaacgat
     1741 ttccctgcat aattttagta cttgaataag tatgcagcag aactccaact atcttttttc
     1801 ctgttttttt taaatttgta agtaatttta taaaatccac ctcctccaaa aaagcaataa
     1861 aaaaaaaaca aactataata agcttttctg attcttttca aaacattcct ggtaagttcc
     1921 taaagacata atttgcttct atgatgtcaa ctttcttact aataactggt tatcatgaca
     1981 aatgttaggt ttatcatata tagtctaggt gtaatcctca gactatcatt ttcatctggg
     2041 ttccaatttc ttaacttcct aaagaattca tctgtttata caagtctacc actgccgatt
     2101 gactaaaaaa tacattatcc catgcataaa atgtcctatt ttcatttaaa cactttattt
     2161 ttgagtaata aaaatatgta ccacaataaa ttattgttaa ttaacatgta cagcttatct
     2221 tttttaaaaa aatttgctgt aaattattat aatccatgta atatgctcct actaaaatta
     2281 aattttgcta gcaattacat tggtcaaaaa
//
