LOCUS       NM_020311               2015 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens atypical chemokine receptor 3 (ACKR3), mRNA.
ACCESSION   NM_020311
VERSION     NM_020311.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2015)
  AUTHORS   Isci,D., Kuppens,A., Scalisi,J., Cokaiko,J., D'Uonnolo,G.,
            Wantz,M., Szpakowska,M., Chevigne,A., Rogister,B. and Neirinckx,V.
  TITLE     Heterogeneous expression of the atypical chemokine receptor ACKR3
            in glioblastoma patient-derived tissue samples and cell cultures
  JOURNAL   Sci Rep 14 (1), 21925 (2024)
   PUBMED   39300240
  REMARK    GeneRIF: Heterogeneous expression of the atypical chemokine
            receptor ACKR3 in glioblastoma patient-derived tissue samples and
            cell cultures.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2015)
  AUTHORS   Otun,O., Aljamous,C., Del Nero,E., Arimont-Segura,M., Bosma,R.,
            Zarzycka,B., Girbau,T., Leyrat,C., de Graaf,C., Leurs,R.,
            Durroux,T., Granier,S., Cong,X. and Bechara,C.
  TITLE     Conformational dynamics underlying atypical chemokine receptor 3
            activation
  JOURNAL   Proc Natl Acad Sci U S A 121 (30), e2404000121 (2024)
   PUBMED   39008676
  REMARK    GeneRIF: Conformational dynamics underlying atypical chemokine
            receptor 3 activation.
REFERENCE   3  (bases 1 to 2015)
  AUTHORS   Klaver,D., Gander,H., Frena,B., Amato,M. and Thurnher,M.
  TITLE     Crosstalk between purinergic receptor P2Y11 and chemokine receptor
            CXCR7 is regulated by CXCR4 in human macrophages
  JOURNAL   Cell Mol Life Sci 81 (1), 132 (2024)
   PUBMED   38472446
  REMARK    GeneRIF: Crosstalk between purinergic receptor P2Y11 and chemokine
            receptor CXCR7 is regulated by CXCR4 in human macrophages.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2015)
  AUTHORS   Wang,T., Wang,D., Sun,Y., Zhuang,T., Li,X., Yang,H., Zang,Y.,
            Liu,Z., Yang,P., Zhang,C., Cui,J., Fu,M., Zhang,S., Su,P., Li,Z.,
            Zhu,J. and Ding,Y.
  TITLE     Regulation of the Hippo/YAP axis by CXCR7 in the tumorigenesis of
            gastric cancer
  JOURNAL   J Exp Clin Cancer Res 42 (1), 297 (2023)
   PUBMED   37950281
  REMARK    GeneRIF: Regulation of the Hippo/YAP axis by CXCR7 in the
            tumorigenesis of gastric cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2015)
  AUTHORS   Yang,Y., Li,J., Lei,W., Wang,H., Ni,Y., Liu,Y., Yan,H., Tian,Y.,
            Wang,Z., Yang,Z., Yang,S., Yang,Y. and Wang,Q.
  TITLE     CXCL12-CXCR4/CXCR7 Axis in Cancer: from Mechanisms to Clinical
            Applications
  JOURNAL   Int J Biol Sci 19 (11), 3341-3359 (2023)
   PUBMED   37497001
  REMARK    GeneRIF: CXCL12-CXCR4/CXCR7 Axis in Cancer: from Mechanisms to
            Clinical Applications.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2015)
  AUTHORS   Nagata,S., Ishihara,T., Robberecht,P., Libert,F., Parmentier,M.,
            Christophe,J. and Vassart,G.
  TITLE     RDC1 may not be VIP receptor
  JOURNAL   Trends Pharmacol Sci 13 (3), 102-103 (1992)
   PUBMED   1315461
REFERENCE   7  (bases 1 to 2015)
  AUTHORS   Libert,F., Passage,E., Parmentier,M., Simons,M.J., Vassart,G. and
            Mattei,M.G.
  TITLE     Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor,
            and a new subtype of serotonin receptor
  JOURNAL   Genomics 11 (1), 225-227 (1991)
   PUBMED   1662665
  REMARK    Erratum:[Genomics 1994 Sep 1;23(1):305]
REFERENCE   8  (bases 1 to 2015)
  AUTHORS   Sreedharan,S.P., Robichon,A., Peterson,K.E. and Goetzl,E.J.
  TITLE     Cloning and expression of the human vasoactive intestinal peptide
            receptor
  JOURNAL   Proc Natl Acad Sci U S A 88 (11), 4986-4990 (1991)
   PUBMED   1675791
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1993 Oct 1;90(19):9233]
REFERENCE   9  (bases 1 to 2015)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
REFERENCE   10 (bases 1 to 2015)
  AUTHORS   Iwatsuki,K., Hashimoto,Y. and Shima,T.
  TITLE     [AH8165, a new muscle relaxant]
  JOURNAL   Masui 26 (3), 342-344 (1977)
   PUBMED   16148
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP426139.1, DQ822477.1 and
            BC036661.2.
            
            On Nov 24, 2018 this sequence version replaced NM_020311.2.
            
            Summary: This gene encodes a member of the G-protein coupled
            receptor family. Although this protein was earlier thought to be a
            receptor for vasoactive intestinal peptide (VIP), it is now
            considered to be an orphan receptor, in that its endogenous ligand
            has not been identified. The protein is also a coreceptor for human
            immunodeficiency viruses (HIV). Translocations involving this gene
            and HMGA2 on chromosome 12 have been observed in lipomas. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.239549.1,
                                           SRR1163658.217408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272928.4/ ENSP00000272928.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               BP426139.1         89-291
            204-1215            DQ822477.1         78-1089
            1216-2015           BC036661.2         1501-2300
FEATURES             Location/Qualifiers
     source          1..2015
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..2015
                     /gene="ACKR3"
                     /gene_synonym="CMKOR1; CXC-R7; CXCR-7; CXCR7; GPR159;
                     RDC-1; RDC1"
                     /note="atypical chemokine receptor 3"
                     /db_xref="GeneID:57007"
                     /db_xref="HGNC:HGNC:23692"
                     /db_xref="MIM:610376"
     exon            1..100
                     /gene="ACKR3"
                     /gene_synonym="CMKOR1; CXC-R7; CXCR-7; CXCR7; GPR159;
                     RDC-1; RDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            101..2015
                     /gene="ACKR3"
                     /gene_synonym="CMKOR1; CXC-R7; CXCR-7; CXCR7; GPR159;
                     RDC-1; RDC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1215
                     /gene="ACKR3"
                     /gene_synonym="CMKOR1; CXC-R7; CXCR-7; CXCR7; GPR159;
                     RDC-1; RDC1"
                     /note="chemokine orphan receptor 1; G protein-coupled
                     receptor; C-X-C chemokine receptor type 7; G-protein
                     coupled receptor 159; G-protein coupled receptor RDC1
                     homolog; chemokine (C-X-C motif) receptor 7"
                     /codon_start=1
                     /product="atypical chemokine receptor 3"
                     /protein_id="NP_064707.1"
                     /db_xref="CCDS:CCDS2516.1"
                     /db_xref="GeneID:57007"
                     /db_xref="HGNC:HGNC:23692"
                     /db_xref="MIM:610376"
                     /translation="MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLL
                     YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVV
                     SLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMV
                     RRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVV
                     LGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDI
                     FSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKY
                     SAKTGLTKLIDASRVSETEYSALEQSTK"
     regulatory      1991..1996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACKR3"
                     /gene_synonym="CMKOR1; CXC-R7; CXCR-7; CXCR7; GPR159;
                     RDC-1; RDC1"
                     /note="hexamer: AATAAA"
     polyA_site      2015
                     /gene="ACKR3"
                     /gene_synonym="CMKOR1; CXC-R7; CXCR-7; CXCR7; GPR159;
                     RDC-1; RDC1"
                     /note="major polyA site"
ORIGIN      
        1 acagttgttg caaagtgctc agcactaagg gagccagcgc acagcacagc caggaaggcg
       61 agcgagccca gccagcccag ccagcccagc cagcccggag gtcatttgat tgcccgcctc
      121 agaacgatgg atctgcatct cttcgactac tcagagccag ggaacttctc ggacatcagc
      181 tggccatgca acagcagcga ctgcatcgtg gtggacacgg tgatgtgtcc caacatgccc
      241 aacaaaagcg tcctgctcta cacgctctcc ttcatttaca ttttcatctt cgtcatcggc
      301 atgattgcca actccgtggt ggtctgggtg aatatccagg ccaagaccac aggctatgac
      361 acgcactgct acatcttgaa cctggccatt gccgacctgt gggttgtcct caccatccca
      421 gtctgggtgg tcagtctcgt gcagcacaac cagtggccca tgggcgagct cacgtgcaaa
      481 gtcacacacc tcatcttctc catcaacctc ttcggcagca ttttcttcct cacgtgcatg
      541 agcgtggacc gctacctctc catcacctac ttcaccaaca cccccagcag caggaagaag
      601 atggtacgcc gtgtcgtctg catcctggtg tggctgctgg ccttctgcgt gtctctgcct
      661 gacacctact acctgaagac cgtcacgtct gcgtccaaca atgagaccta ctgccggtcc
      721 ttctaccccg agcacagcat caaggagtgg ctgatcggca tggagctggt ctccgttgtc
      781 ttgggctttg ccgttccctt ctccattatc gctgtcttct acttcctgct ggccagagcc
      841 atctcggcgt ccagtgacca ggagaagcac agcagccgga agatcatctt ctcctacgtg
      901 gtggtcttcc ttgtctgctg gctgccctac cacgtggcgg tgctgctgga catcttctcc
      961 atcctgcact acatcccttt cacctgccgg ctggagcacg ccctcttcac ggccctgcat
     1021 gtcacacagt gcctgtcgct ggtgcactgc tgcgtcaacc ctgtcctcta cagcttcatc
     1081 aatcgcaact acaggtacga gctgatgaag gccttcatct tcaagtactc ggccaaaaca
     1141 gggctcacca agctcatcga tgcctccaga gtctcagaga cggagtactc tgccttggag
     1201 cagagcacca aatgatctgc cctggagagg ctctgggacg ggtttacttg tttttgaaca
     1261 gggtgatggg ccctatggtt ttctagagca aagcaaagta gcttcgggtc ttgatgcttg
     1321 agtagagtga agaggggagc acgtgccccc tgcatccatt ctctctttct cttgatgacg
     1381 cagctgtcat ttggctgtgc gtgctgacag ttttgcaaca ggcagagctg tgtcgcacag
     1441 cagtgctgtg cgtcagagcc agctgaggac aggcttgcct ggacttctgt aagataggat
     1501 tttctgtgtt tcctgaattt tttatatggt gatttgtatt taaattttaa gactttattt
     1561 tctcactatt ggtgtacctt ataaatgtat ttgaaagtta aatatatttt aaatattgtt
     1621 tgggaggcat agtgctgaca tatattcaga gtgttgtagt tttaaggtta gcgtgacttc
     1681 agttttgact aaggatgaca ctaattgtta gctgttttga aattatatat atataaatat
     1741 atataaatat ataaatatat gccagtcttg gctgaaatgt tttatttacc atagttttat
     1801 atctgtgtgg tgttttgtac cggcacggga tatggaacga aaactgcttt gtaatgcagt
     1861 ttgtgacatt aatagtattg taaagttaca ttttaaaata aacaaaaaac tgttctggac
     1921 tgcaaatctg cacacacaac gaacagttgc atttcagaga gttctctcaa tttgtaagtt
     1981 attttttttt aataaagatt tttgtttcct aaaaa
//
