LOCUS       NM_001296               2990 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens atypical chemokine receptor 2 (ACKR2), mRNA.
ACCESSION   NM_001296
VERSION     NM_001296.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2990)
  AUTHORS   Dong,H., Zhou,S., Chen,X., Deng,X. and Fang,A.
  TITLE     Pan-cancer analysis of the prognostic significance of ACKR2
            expression and the related genetic/epigenetic dysregulations
  JOURNAL   Expert Rev Clin Immunol 20 (2), 225-236 (2024)
   PUBMED   37882761
  REMARK    GeneRIF: Pan-cancer analysis of the prognostic significance of
            ACKR2 expression and the related genetic/epigenetic dysregulations.
REFERENCE   2  (bases 1 to 2990)
  AUTHORS   Gowhari Shabgah,A., Jadidi-Niaragh,F., Mohammadi,H.,
            Ebrahimzadeh,F., Oveisee,M., Jahanara,A. and Gholizadeh
            Navashenaq,J.
  TITLE     The Role of Atypical Chemokine Receptor D6 (ACKR2) in Physiological
            and Pathological Conditions; Friend, Foe, or Both?
  JOURNAL   Front Immunol 13, 861931 (2022)
   PUBMED   35677043
  REMARK    GeneRIF: The Role of Atypical Chemokine Receptor D6 (ACKR2) in
            Physiological and Pathological Conditions; Friend, Foe, or Both?
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2990)
  AUTHORS   Lewandowska,P., Wierzbicki,J., Zawadzki,M., Agrawal,A. and
            Krzystek-Korpacka,M.
  TITLE     Biphasic Expression of Atypical Chemokine Receptor (ACKR) 2 and
            ACKR4 in Colorectal Neoplasms in Association with Histopathological
            Findings
  JOURNAL   Biomolecules 11 (1), 8 (2020)
   PUBMED   33374792
  REMARK    GeneRIF: Biphasic Expression of Atypical Chemokine Receptor (ACKR)
            2 and ACKR4 in Colorectal Neoplasms in Association with
            Histopathological Findings.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2990)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2990)
  AUTHORS   Yan,S., Cui,S., Zhang,L., Yang,B., Yuan,Y., Lv,X., Fu,H., Li,Y.,
            Huang,C. and Wang,P.
  TITLE     Expression of ACKR2 in placentas from different types of
            preeclampsia
  JOURNAL   Placenta 90, 121-127 (2020)
   PUBMED   32056543
  REMARK    GeneRIF: Expression of ACKR2 in placentas from different types of
            preeclampsia.
REFERENCE   6  (bases 1 to 2990)
  AUTHORS   Nibbs,R.J., Yang,J., Landau,N.R., Mao,J.H. and Graham,G.J.
  TITLE     LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha),
            has enhanced receptor interactions and potent HIV suppressive
            activity
  JOURNAL   J Biol Chem 274 (25), 17478-17483 (1999)
   PUBMED   10364178
REFERENCE   7  (bases 1 to 2990)
  AUTHORS   Nibbs,R.J., Wylie,S.M., Yang,J., Landau,N.R. and Graham,G.J.
  TITLE     Cloning and characterization of a novel promiscuous human
            beta-chemokine receptor D6
  JOURNAL   J Biol Chem 272 (51), 32078-32083 (1997)
   PUBMED   9405404
REFERENCE   8  (bases 1 to 2990)
  AUTHORS   Bonini,J.A., Martin,S.K., Dralyuk,F., Roe,M.W., Philipson,L.H. and
            Steiner,D.F.
  TITLE     Cloning, expression, and chromosomal mapping of a novel human
            CC-chemokine receptor (CCR10) that displays high-affinity binding
            for MCP-1 and MCP-3
  JOURNAL   DNA Cell Biol 16 (10), 1249-1256 (1997)
   PUBMED   9364936
REFERENCE   9  (bases 1 to 2990)
  AUTHORS   Nibbs,R.J., Wylie,S.M., Pragnell,I.B. and Graham,G.J.
  TITLE     Cloning and characterization of a novel murine beta chemokine
            receptor, D6. Comparison to three other related macrophage
            inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5
  JOURNAL   J Biol Chem 272 (19), 12495-12504 (1997)
   PUBMED   9139699
REFERENCE   10 (bases 1 to 2990)
  AUTHORS   Iwatsuki,K., Hashimoto,Y. and Shima,T.
  TITLE     [AH8165, a new muscle relaxant]
  JOURNAL   Masui 26 (3), 342-344 (1977)
   PUBMED   16148
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099329.2, DA853159.1 and
            BC008816.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001296.4.
            
            Summary: This gene encodes a beta chemokine receptor, which is
            predicted to be a seven transmembrane protein similar to G
            protein-coupled receptors. Chemokines and their receptor-mediated
            signal transduction are critical for the recruitment of effector
            immune cells to the inflammation site. This gene is expressed in a
            range of tissues and hemopoietic cells. The expression of this
            receptor in lymphatic endothelial cells and overexpression in
            vascular tumors suggested its function in chemokine-driven
            recirculation of leukocytes and possible chemokine effects on the
            development and growth of vascular tumors. This receptor appears to
            bind the majority of beta-chemokine family members; however, its
            specific function remains unknown. This gene is mapped to
            chromosome 3p21.3, a region that includes a cluster of chemokine
            receptor genes. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008816.2, AK313561.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000422265.6/ ENSP00000416996.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC099329.2         85912-85938
            28-39               DA853159.1         28-39
            40-2987             BC008816.2         1-2948
            2988-2990           AC099329.2         143751-143753
FEATURES             Location/Qualifiers
     source          1..2990
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..2990
                     /gene="ACKR2"
                     /gene_synonym="CCBP2; CCR10; CCR9; CMKBR9; D6; hD6"
                     /note="atypical chemokine receptor 2"
                     /db_xref="GeneID:1238"
                     /db_xref="HGNC:HGNC:1565"
                     /db_xref="MIM:602648"
     exon            1..88
                     /gene="ACKR2"
                     /gene_synonym="CCBP2; CCR10; CCR9; CMKBR9; D6; hD6"
                     /inference="alignment:Splign:2.1.0"
     exon            89..169
                     /gene="ACKR2"
                     /gene_synonym="CCBP2; CCR10; CCR9; CMKBR9; D6; hD6"
                     /inference="alignment:Splign:2.1.0"
     exon            170..2990
                     /gene="ACKR2"
                     /gene_synonym="CCBP2; CCR10; CCR9; CMKBR9; D6; hD6"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1361
                     /gene="ACKR2"
                     /gene_synonym="CCBP2; CCR10; CCR9; CMKBR9; D6; hD6"
                     /note="CC-chemokine-binding receptor JAB61; chemokine (C-C
                     motif) receptor 9; chemokine (C-C) receptor 9;
                     chemokine-binding protein 2; chemokine receptor D6;
                     chemokine receptor CCR-9; C-C chemokine receptor D6;
                     chemokine receptor CCR-10; chemokine-binding protein D6"
                     /codon_start=1
                     /product="atypical chemokine receptor 2"
                     /protein_id="NP_001287.2"
                     /db_xref="CCDS:CCDS2706.1"
                     /db_xref="GeneID:1238"
                     /db_xref="HGNC:HGNC:1565"
                     /db_xref="MIM:602648"
                     /translation="MAATASPQPLATEDADSENSSFYYYDYLDEVAFMLCRKDAVVSF
                     GKVFLPVFYSLIFVLGLSGNLLLLMVLLRYVPRRRMVEIYLLNLAISNLLFLVTLPFW
                     GISVAWHWVFGSFLCKMVSTLYTINFYSGIFFISCMSLDKYLEIVHAQPYHRLRTRAK
                     SLLLATIVWAVSLAVSIPDMVFVQTHENPKGVWNCHADFGGHGTIWKLFLRFQQNLLG
                     FLLPLLAMIFFYSRIGCVLVRLRPAGQGRALKIAAALVVAFFVLWFPYNLTLFLHTLL
                     DLQVFGNCEVSQHLDYALQVTESIAFLHCCFSPILYAFSSHRFRQYLKAFLAAVLGWH
                     LAPGTAQASLSSCSESSILTAQEEMTGMNDLGERQSENYPNKEDVGNKSA"
     regulatory      2963..2968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACKR2"
                     /gene_synonym="CCBP2; CCR10; CCR9; CMKBR9; D6; hD6"
                     /note="hexamer: ATTAAA"
     polyA_site      2990
                     /gene="ACKR2"
                     /gene_synonym="CCBP2; CCR10; CCR9; CMKBR9; D6; hD6"
                     /note="major polyA site"
ORIGIN      
        1 ctttcgattg tagcatttct cctttcagga tacagtacgg gatcctttct ggaatggagg
       61 tcttatgagc tgctattgaa cacggcagag cctgttggtg acctgcacac aggagccctc
      121 cagtcagtac tgattgaatt actcaaggct gcctctctgc aaagttgagc actacaggac
      181 gtcgggactg ggcatttcct tccaacatgg ccgccactgc ctctccgcag ccactcgcca
      241 ctgaggatgc cgattctgag aatagcagct tctattacta tgactacctg gatgaagtgg
      301 ccttcatgct ctgcaggaag gatgcagtgg tgtcctttgg caaagtcttc ctcccagtct
      361 tctatagcct gatttttgtg ttgggcctca gcgggaacct ccttcttctc atggtcttgc
      421 tccgttacgt gcctcgcagg cggatggttg agatctatct gctgaatctg gccatctcca
      481 accttctgtt tctggtgaca ctgcccttct ggggcatctc cgtggcctgg cattgggtct
      541 tcgggagttt cttgtgcaag atggtgagca ctctttatac tattaacttt tacagtggca
      601 tctttttcat tagctgcatg agcctggaca agtacctgga gatcgttcat gctcagccct
      661 accacaggct gaggacccgg gccaagagcc tgctccttgc taccatagta tgggctgtgt
      721 ccctggccgt ctccatccct gatatggtct ttgtacagac acatgaaaat cccaagggtg
      781 tgtggaactg ccacgcagat ttcggcgggc atgggaccat ttggaagctc ttcctccgct
      841 tccagcagaa cctcctaggg tttctccttc cactccttgc catgatcttc ttctactccc
      901 gtattggttg tgtcttggtg aggctgaggc ccgcaggcca gggccgggct ttaaaaatag
      961 ctgcagcctt ggtggtggcc ttcttcgtgc tatggttccc atacaatctc accttgtttc
     1021 tgcatacgct gttggacctg caagtattcg ggaactgtga ggtcagccag catctagact
     1081 acgcactcca ggtaacagag agcatcgcct tccttcactg ctgcttttcc cccatcctgt
     1141 atgccttctc cagtcaccgc ttccgccagt acctgaaggc tttcctggct gccgtgcttg
     1201 gatggcacct ggcacctggc actgcccagg cctcattatc cagctgttct gagagcagca
     1261 tacttactgc ccaagaggaa atgactggca tgaatgacct tggagagagg cagtctgaga
     1321 actaccctaa caaggaggat gtggggaata aatcagcctg agtgaccaaa ttttggtctg
     1381 gtgggaacag atgggaacca gctcaattgg gtgtccactc aaagtgctct ctccaggggc
     1441 ctcagtgact gtgttgctaa acccagtggt cagttctcag ttctcagcca tcagcagcat
     1501 ttgctcgccc cgccttcttc ctccactttc ttcacttgct tccaggatac cacgctttct
     1561 tttctgaatt gctacaatct ttcttccttc cttccttgct tccttccttc cttccttccc
     1621 tctctccctc cctccctccc tcgcttcttc ccttcctcct ttcctccctt cctactttcc
     1681 ttccttcctt ctgacagggt cttgctctat tgctctgtca cccaggctgg aatgcagtgg
     1741 cgagatctcc gctcactgta gcctcctccc cctgggttga agcaattctc atgcctcagc
     1801 ctcccaagta gccaggacta taggcacctg ccaccatgcc tggctaattt ttgtattttt
     1861 tttctttctt tctttctttt cttttttttt tttttttgag acggagtctc actcttgttg
     1921 cccaggctgg acaacaatgg cgcgatctcg gctcactgca acctccacct cccggattca
     1981 agcgattctc ctgcctcagc ctcctgagta gctggaacta catgcgcgtg ccaccacgca
     2041 cagctaattt ttataatttt agtagagatg gggtttcact gcgttggcca ggatgatctc
     2101 gatctcttga ccttgggatc cacccgcctt ggcctcccaa agtgctggga ttacaggtgt
     2161 gagccaccat gcctggccct aatttttgtg tttttattag aaacagagtt tcaccatgtt
     2221 ggccaggctg gagaattgct gtaatagttt tccaactggc ccctgtcctt cctctctctt
     2281 gctctcctcc catctcatct gcacctagca gccagagtga tcctgatact ctcggccttt
     2341 acttccgcct ccctcagagc agcagcctgt caaaacacca gattacaaca aatttagttt
     2401 aaaggtctca attagcgtta ttggcaattc tagaatcagg caacagactc attgaatcag
     2461 gaacagattc actccataaa atacagagag tgctgcaatg agctgggtag aagaggttag
     2521 ttttatagac aggaaggggc tgtcaaaggc agaaagaaat gaagaacaaa aaaaaagatt
     2581 gatttttttt tttttgagac aggatctcac tctgtcatcc aggctgaagt ccaatcccac
     2641 aatcatggct cactgcagcc accacctcct gagctcaagt gatcctccca tctaagcccc
     2701 caagtagcta ggactacagg agcacaccac cacacctggc taatttttgt attttttgtg
     2761 gagacagggt ctcagtatgt tacccaggtt ggactggaaa cccttggctc aagcaatttg
     2821 cctgcctcag cctcccaaag tgctgggatt acaggcgtga gccactgcac agggccagat
     2881 tcatcatttc aaagttactt tctatatgcg gccggaacag ggtggttgac atcagttttc
     2941 ttcaggttac tttttaataa tgattaaaac ggggaacttc attatcatga
//
