LOCUS       NM_002036               1146 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens atypical chemokine receptor 1 (Duffy blood group)
            (ACKR1), transcript variant 2, mRNA.
ACCESSION   NM_002036
VERSION     NM_002036.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1146)
  AUTHORS   Shaikh,R., Kanjaksha,G., Kashivishwanath,V., Kulkarni,S.,
            Jadhav,S., Maru,H. and Gorakshakar,A.
  TITLE     ACKR1 gene polymorphisms in Bombay blood group (Oh) individuals of
            Indian origin
  JOURNAL   Transfus Apher Sci 63 (5), 103975 (2024)
   PUBMED   39126827
  REMARK    GeneRIF: ACKR1 gene polymorphisms in Bombay blood group (Oh)
            individuals of Indian origin.
            Erratum:[Transfus Apher Sci. 2024 Oct;63(5):103992. doi:
            10.1016/j.transci.2024.103992.. PMID: 39180920]
REFERENCE   2  (bases 1 to 1146)
  AUTHORS   Palmblad,J., Sohlberg,E., Nilsson,C.C., Lindqvist,H., Deneberg,S.,
            Ratcliffe,P., Meinke,S., Mortberg,A., Klimkowska,M. and Hoglund,P.
  TITLE     Clinical and immunological features in ACKR1/DARC-associated
            neutropenia
  JOURNAL   Blood Adv 8 (3), 571-580 (2024)
   PUBMED   38039514
  REMARK    GeneRIF: Clinical and immunological features in
            ACKR1/DARC-associated neutropenia.
REFERENCE   3  (bases 1 to 1146)
  AUTHORS   Adda Neggaz,L., Deba,T., Bekada,A., Meroufel Sebaa,D.N., Mediene
            Benchekor,S. and Benhamamouch,S.
  TITLE     Allelic frequency variation of ACKR1 in three Algerian populations:
            Zenata, Reguibat, and Oran
  JOURNAL   Transfus Clin Biol 31 (1), 7-12 (2024)
   PUBMED   37865156
  REMARK    GeneRIF: Allelic frequency variation of ACKR1 in three Algerian
            populations: Zenata, Reguibat, and Oran.
REFERENCE   4  (bases 1 to 1146)
  AUTHORS   Wang,Z., Yan,N., Sheng,H., Xiao,Y., Sun,J. and Cao,C.
  TITLE     Single-cell Transcriptomic Analysis Reveals an Immunosuppressive
            Network Between POSTN CAFs and ACKR1 ECs in TKI-resistant Lung
            Cancer
  JOURNAL   Cancer Genomics Proteomics 21 (1), 65-78 (2024)
   PUBMED   38151287
  REMARK    GeneRIF: Single-cell Transcriptomic Analysis Reveals an
            Immunosuppressive Network Between POSTN CAFs and ACKR1 ECs in
            TKI-resistant Lung Cancer.
REFERENCE   5  (bases 1 to 1146)
  AUTHORS   Moskovitz,R., Pholcharee,T., DonVito,S.M., Guloglu,B., Lowe,E.,
            Mohring,F., Moon,R.W. and Higgins,M.K.
  TITLE     Structural basis for DARC binding in reticulocyte invasion by
            Plasmodium vivax
  JOURNAL   Nat Commun 14 (1), 3637 (2023)
   PUBMED   37336887
  REMARK    GeneRIF: Structural basis for DARC binding in reticulocyte invasion
            by Plasmodium vivax.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1146)
  AUTHORS   Lu,Z.H., Wang,Z.X., Horuk,R., Hesselgesser,J., Lou,Y.C.,
            Hadley,T.J. and Peiper,S.C.
  TITLE     The promiscuous chemokine binding profile of the Duffy
            antigen/receptor for chemokines is primarily localized to sequences
            in the amino-terminal domain
  JOURNAL   J Biol Chem 270 (44), 26239-26245 (1995)
   PUBMED   7592830
REFERENCE   7  (bases 1 to 1146)
  AUTHORS   Tournamille,C., Colin,Y., Cartron,J.P. and Le Van Kim,C.
  TITLE     Disruption of a GATA motif in the Duffy gene promoter abolishes
            erythroid gene expression in Duffy-negative individuals
  JOURNAL   Nat Genet 10 (2), 224-228 (1995)
   PUBMED   7663520
REFERENCE   8  (bases 1 to 1146)
  AUTHORS   Neote,K., Mak,J.Y., Kolakowski,L.F. Jr. and Schall,T.J.
  TITLE     Functional and biochemical analysis of the cloned Duffy antigen:
            identity with the red blood cell chemokine receptor
  JOURNAL   Blood 84 (1), 44-52 (1994)
   PUBMED   7517217
REFERENCE   9  (bases 1 to 1146)
  AUTHORS   Raeymaekers,P., Van Broeckhoven,C., Backhovens,H., Wehnert,A.,
            Muylle,L., De Jonghe,P., Gheuens,J. and Vandenberghe,A.
  TITLE     The Duffy blood group is linked to the alpha-spectrin locus in a
            large pedigree with autosomal dominant inheritance of
            Charcot-Marie-Tooth disease type 1
  JOURNAL   Hum Genet 78 (1), 76-78 (1988)
   PUBMED   2892777
REFERENCE   10 (bases 1 to 1146)
  AUTHORS   Iwatsuki,K., Hashimoto,Y. and Shima,T.
  TITLE     [AH8165, a new muscle relaxant]
  JOURNAL   Masui 26 (3), 342-344 (1977)
   PUBMED   16148
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291593.1 and BM671230.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 29, 2018 this sequence version replaced NM_002036.3.
            
            Summary: The protein encoded by this gene is a glycosylated
            membrane protein and a non-specific receptor for several
            chemokines. The encoded protein is the receptor for the human
            malarial parasites Plasmodium vivax and Plasmodium knowlesi.
            Polymorphisms in this gene are the basis of the Duffy blood group
            system. Two transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (b)
            has a shorter and distinct N-terminus compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.1047.1, BC017817.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368122.4/ ENSP00000357104.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1144              AK291593.1         863-2006
            1145-1146           BM671230.1         17-18               c
FEATURES             Location/Qualifiers
     source          1..1146
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.2"
     gene            1..1146
                     /gene="ACKR1"
                     /gene_synonym="CCBP1; CD234; DARC; DARC/ACKR1; Dfy; FY;
                     GPD; GpFy; WBCQ1"
                     /note="atypical chemokine receptor 1 (Duffy blood group)"
                     /db_xref="GeneID:2532"
                     /db_xref="HGNC:HGNC:4035"
                     /db_xref="MIM:613665"
     exon            1..106
                     /gene="ACKR1"
                     /gene_synonym="CCBP1; CD234; DARC; DARC/ACKR1; Dfy; FY;
                     GPD; GpFy; WBCQ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1096
                     /gene="ACKR1"
                     /gene_synonym="CCBP1; CD234; DARC; DARC/ACKR1; Dfy; FY;
                     GPD; GpFy; WBCQ1"
                     /note="isoform b is encoded by transcript variant 2;
                     glycoprotein D; Fy glycoprotein; Duffy blood group,
                     chemokine receptor; Duffy blood group antigen; plasmodium
                     vivax receptor; Duffy antigen chemokine receptor; Duffy
                     blood group system protein; solute carrier family 29
                     member 1 (augustine blood group); bloodgroup FY protein"
                     /codon_start=1
                     /product="atypical chemokine receptor 1 isoform b"
                     /protein_id="NP_002027.2"
                     /db_xref="CCDS:CCDS1183.1"
                     /db_xref="GeneID:2532"
                     /db_xref="HGNC:HGNC:4035"
                     /db_xref="MIM:613665"
                     /translation="MGNCLHRAELSPSTENSSQLDFEDVWNSSYGVNDSFPDGDYGAN
                     LEAAAPCHSCNLLDDSALPFFILTSVLGILASSTVLFMLFRPLFRWQLCPGWPVLAQL
                     AVGSALFSIVVPVLAPGLGSTRSSALCSLGYCVWYGSAFAQALLLGCHASLGHRLGAG
                     QVPGLTLGLTVGIWGVAALLTLPVTLASGASGGLCTLIYSTELKALQATHTVACLAIF
                     VLLPLGLFGAKGLKKALGMGPGPWMNILWAWFIFWWPHGVVLGLDFLVRSKLLLLSTC
                     LAQQALDLLLNLAEALAILHCVATPLLLALFCHQATRTLLPSLPLPEGWSSHLDTLGS
                     KS"
     exon            107..1146
                     /gene="ACKR1"
                     /gene_synonym="CCBP1; CD234; DARC; DARC/ACKR1; Dfy; FY;
                     GPD; GpFy; WBCQ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1121..1126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACKR1"
                     /gene_synonym="CCBP1; CD234; DARC; DARC/ACKR1; Dfy; FY;
                     GPD; GpFy; WBCQ1"
                     /note="hexamer: ATTAAA"
     polyA_site      1146
                     /gene="ACKR1"
                     /gene_synonym="CCBP1; CD234; DARC; DARC/ACKR1; Dfy; FY;
                     GPD; GpFy; WBCQ1"
                     /note="major polyA site"
ORIGIN      
        1 attagtcctt ggctcttatc ttggaagcac aggcgctgac agccgtccca gcccttctgt
       61 ctgcgggcct gaaccaaacg gtgccatggg gaactgtctg cacagggcgg agctctcccc
      121 ctcaactgag aactcaagtc agctggactt cgaagatgta tggaattctt cctatggtgt
      181 gaatgattcc ttcccagatg gagactatgg tgccaacctg gaagcagctg ccccctgcca
      241 ctcctgtaac ctgctggatg actctgcact gcccttcttc atcctcacca gtgtcctggg
      301 tatcctagct agcagcactg tcctcttcat gcttttcaga cctctcttcc gctggcagct
      361 ctgccctggc tggcctgtcc tggcacagct ggctgtgggc agtgccctct tcagcattgt
      421 ggtgcccgtc ttggccccag ggctaggtag cactcgcagc tctgccctgt gtagcctggg
      481 ctactgtgtc tggtatggct cagcctttgc ccaggctttg ctgctagggt gccatgcctc
      541 cctgggccac agactgggtg caggccaggt cccaggcctc accctggggc tcactgtggg
      601 aatttgggga gtggctgccc tactgacact gcctgtcacc ctggccagtg gtgcttctgg
      661 tggactctgc accctgatat acagcacgga gctgaaggct ttgcaggcca cacacactgt
      721 agcctgtctt gccatctttg tcttgttgcc attgggtttg tttggagcca aggggctgaa
      781 gaaggcattg ggtatggggc caggcccctg gatgaatatc ctgtgggcct ggtttatttt
      841 ctggtggcct catggggtgg ttctaggact ggatttcctg gtgaggtcca agctgttgct
      901 gttgtcaaca tgtctggccc agcaggctct ggacctgctg ctgaacctgg cagaagccct
      961 ggcaattttg cactgtgtgg ctacgcccct gctcctcgcc ctattctgcc accaggccac
     1021 ccgcaccctc ttgccctctc tgcccctccc tgaaggatgg tcttctcatc tggacaccct
     1081 tggaagcaaa tcctagttct cttcccacct gtcaacctga attaaagtct acactgcctt
     1141 tgtgaa
//
