LOCUS       NM_001386863            4460 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens apoptotic chromatin condensation inducer 1 (ACIN1),
            transcript variant 6, mRNA.
ACCESSION   NM_001386863
VERSION     NM_001386863.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4460)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 4460)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4460)
  AUTHORS   Chen,Y.S., Liu,C.W., Lin,Y.C., Tsai,C.Y., Yang,C.H. and Lin,J.C.
  TITLE     The SRSF3-MBNL1-Acin1 circuit constitutes an emerging axis to
            lessen DNA fragmentation in colorectal cancer via an alternative
            splicing mechanism
  JOURNAL   Neoplasia 22 (12), 702-713 (2020)
   PUBMED   33142236
  REMARK    GeneRIF: The SRSF3-MBNL1-Acin1 circuit constitutes an emerging axis
            to lessen DNA fragmentation in colorectal cancer via an alternative
            splicing mechanism.
REFERENCE   4  (bases 1 to 4460)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   5  (bases 1 to 4460)
  AUTHORS   Xue,L., Xie,L., Song,X. and Song,X.
  TITLE     [Expression and Significance of ACIN1 mRNA in Platelets of Lung
            Cancer]
  JOURNAL   Zhongguo Fei Ai Za Zhi 21 (9), 677-681 (2018)
   PUBMED   30201066
  REMARK    GeneRIF: ACIN1 mRNA was highly expressed in platelets of lung
            cancer patients
REFERENCE   6  (bases 1 to 4460)
  AUTHORS   Hu,Y., Yao,J., Liu,Z., Liu,X., Fu,H. and Ye,K.
  TITLE     Akt phosphorylates acinus and inhibits its proteolytic cleavage,
            preventing chromatin condensation
  JOURNAL   EMBO J 24 (20), 3543-3554 (2005)
   PUBMED   16177823
  REMARK    GeneRIF: Akt phosphorylation of acinus on serine 422 and 573
            results in its resistance to caspase cleavage in the nucleus and
            the inhibition of acinus-dependent chromatin condensation.
REFERENCE   7  (bases 1 to 4460)
  AUTHORS   Schwerk,C., Prasad,J., Degenhardt,K., Erdjument-Bromage,H.,
            White,E., Tempst,P., Kidd,V.J., Manley,J.L., Lahti,J.M. and
            Reinberg,D.
  TITLE     ASAP, a novel protein complex involved in RNA processing and
            apoptosis
  JOURNAL   Mol Cell Biol 23 (8), 2981-2990 (2003)
   PUBMED   12665594
REFERENCE   8  (bases 1 to 4460)
  AUTHORS   Sordet,O., Rebe,C., Plenchette,S., Zermati,Y., Hermine,O.,
            Vainchenker,W., Garrido,C., Solary,E. and Dubrez-Daloz,L.
  TITLE     Specific involvement of caspases in the differentiation of
            monocytes into macrophages
  JOURNAL   Blood 100 (13), 4446-4453 (2002)
   PUBMED   12393560
REFERENCE   9  (bases 1 to 4460)
  AUTHORS   Zermati,Y., Garrido,C., Amsellem,S., Fishelson,S., Bouscary,D.,
            Valensi,F., Varet,B., Solary,E. and Hermine,O.
  TITLE     Caspase activation is required for terminal erythroid
            differentiation
  JOURNAL   J Exp Med 193 (2), 247-254 (2001)
   PUBMED   11208865
REFERENCE   10 (bases 1 to 4460)
  AUTHORS   Sahara,S., Aoto,M., Eguchi,Y., Imamoto,N., Yoneda,Y. and
            Tsujimoto,Y.
  TITLE     Acinus is a caspase-3-activated protein required for apoptotic
            chromatin condensation
  JOURNAL   Nature 401 (6749), 168-173 (1999)
   PUBMED   10490026
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL117258.4 and AL132780.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Apoptosis is defined by several morphologic nuclear
            changes, including chromatin condensation and nuclear
            fragmentation. This gene encodes a nuclear protein that induces
            apoptotic chromatin condensation after activation by caspase-3,
            without inducing DNA fragmentation. This protein has also been
            shown to be a component of a splicing-dependent multiprotein exon
            junction complex (EJC) that is deposited at splice junctions on
            mRNAs, as a consequence of pre-mRNA splicing. It may thus be
            involved in mRNA metabolism associated with splicing. Alternatively
            spliced transcript variants encoding different isoforms have been
            described for this gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (6) uses a downstream
            transcription start site and a downstream in-frame translation
            start site, compared to variant 1. The encoded isoform (6) has a
            shorter N-terminus, compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB014570.2, AF124726.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000605057.6/ ENSP00000474349.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AL117258.4         149945-150106
            163-228             AL117258.4         151537-151602
            229-340             AL117258.4         154448-154559
            341-460             AL117258.4         154980-155099
            461-549             AL132780.5         185545-185633       c
            550-1812            AL132780.5         183344-184606       c
            1813-2031           AL132780.5         182617-182835       c
            2032-2147           AL132780.5         181948-182063       c
            2148-2289           AL132780.5         173273-173414       c
            2290-2332           AL132780.5         169763-169805       c
            2333-2466           AL132780.5         168152-168285       c
            2467-2619           AL132780.5         167902-168054       c
            2620-2761           AL132780.5         167233-167374       c
            2762-2907           AL132780.5         166726-166871       c
            2908-3015           AL132780.5         166213-166320       c
            3016-3123           AL132780.5         165965-166072       c
            3124-3448           AL132780.5         165095-165419       c
            3449-3549           AL132780.5         164881-164981       c
            3550-4460           AL132780.5         162361-163271       c
FEATURES             Location/Qualifiers
     source          1..4460
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..4460
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /note="apoptotic chromatin condensation inducer 1"
                     /db_xref="GeneID:22985"
                     /db_xref="HGNC:HGNC:17066"
                     /db_xref="MIM:604562"
     exon            1..162
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..3876
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /note="isoform 6 is encoded by transcript variant 6;
                     apoptotic chromatin condensation inducer in the nucleus;
                     functional spliceosome-associated protein 152"
                     /codon_start=1
                     /product="apoptotic chromatin condensation inducer in the
                     nucleus isoform 6"
                     /protein_id="NP_001373792.1"
                     /db_xref="CCDS:CCDS91850.1"
                     /db_xref="GeneID:22985"
                     /db_xref="HGNC:HGNC:17066"
                     /db_xref="MIM:604562"
                     /translation="MAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRL
                     KGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAA
                     ELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDD
                     EKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEE
                     EEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVL
                     ERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRL
                     TEDRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPAVLI
                     QLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQKST
                     LADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLP
                     SHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPR
                     GRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVAT
                     PPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEP
                     PAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPIADQVSN
                     DDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPGRKRRWGASTA
                     TTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISEDETERNGDDGTHDKG
                     LKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQVSVEVALPPPAEHEVKKVT
                     LGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQLKE
                     LLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAE
                     QDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQW
                     AEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQE
                     EPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKE
                     REKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRD
                     TKRHSRSRSRSTPVRDRGGRR"
     exon            163..228
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     exon            229..340
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     exon            341..460
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     exon            461..549
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     exon            550..1812
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..2031
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2147
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2289
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2332
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2466
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2619
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2761
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2907
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3015
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3123
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3448
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     exon            3449..3549
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..4460
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4436..4441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /note="hexamer: AATAAA"
     polyA_site      4460
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /note="major polyA site"
ORIGIN      
        1 acggacccga gtacctcacg caagatggcg gagctggagg aggtgactct ggacgggaag
       61 cctcttcagg cgctgcgggt gaccgacctg aaggccgcac tggagcagcg aggcctagcc
      121 aagagcgggc agaagagtgc cctggtcaag cggctcaaag gggctctaat gctagaaaat
      181 ttacagaaac actcaacacc ccatgctgca ttccagccaa attcccagat tggtgaggaa
      241 atgagccaga acagtttcat aaaacagtat ctggaaaagc agcaggagct acttaggcag
      301 cgtctggaac gtgaagctcg agaagctgca gaacttgaag aagcttcagc tgagtcggag
      361 gacgagatga tccatcctga gggagtggct tccctgctgc ctcctgactt tcagagcagc
      421 ctggagagac cagagctgga gctcagcaga cattcgccca gaaaaagctc ctcaatttct
      481 gaagagaaag gtgactctga tgatgagaaa ccaaggaaag gagaaagacg atcatctagg
      541 gtcagacagg caagagcagc taaactgtct gagggcagcc aacctgctga ggaggaagag
      601 gatcaagaaa caccttccag aaacctaagg gtcagagcag atcgaaattt gaaaacagag
      661 gaggaagaag aggaggagga ggaggaggaa gaagatgatg aagaagagga aggtgatgat
      721 gagggacaaa aatctaggga ggcaccaatc ctgaaagagt ttaaggaaga aggggaagag
      781 atacctagag taaaaccaga ggagatgatg gatgagagac ccaaaacaag atcccaggaa
      841 caggaggtgt tagagagagg agggagattt acaagatccc aggaagaggc tagaaaaagt
      901 catctggcca gacagcagca ggagaaggaa atgaaaacaa catctcccct tgaggaggaa
      961 gaaagagaaa taaaatcttc acaaggctta aaggaaaaat cgaagtctcc ttcccctcct
     1021 cgactgactg aagatcgaaa gaaggcctca cttgtagcgc tgccagagca aactgccagc
     1081 gaggaggaga ctcctccacc tttactaaca aaggaagcat cttctccacc acctcatcca
     1141 cagctccata gcgaagaaga aatagagccc atggaaggcc cagcccccgc tgtcctcatt
     1201 cagttatctc ctcctaatac agatgctgac accagggagc tattagtatc tcagcatact
     1261 gtccagttgg taggaggcct gtctcctttg tcaagtcctt cagacaccaa agcagaatct
     1321 ccagcagaga aagtgccaga ggagagtgtc ctgcctctgg ttcagaaaag cacactggct
     1381 gactactcag cccagaagga tcttgaacct gagtcagaca gatctgctca gcccctccct
     1441 ctaaaaattg aggaattagc actggccaaa ggaatcactg aagaatgtct gaaacagcca
     1501 tctttggaac agaaggaagg cagaagagct tctcataccc ttctcccaag ccacagattg
     1561 aaacagtcag ctgattcatc ctctagccgg tcctcctcat cttcctcctc cagttctaga
     1621 tcaagatctc gctctcctga cagttcaggt tctcggtctc attcaccgct cagatccaag
     1681 cagagagatg tagcccaggc acgtactcat gccaaccctc gtggtagacc caagatgggc
     1741 tccagatcaa catcagagtc cagatcaagg tcacgttcac gttctcgttc agcatcaagc
     1801 aacagcagaa aatctctgag ccctggagtc tccagggaca gcagcaccag ctatactgaa
     1861 accaaagatc cctcttctgg tcaggaggtt gcaactccac cagtgccaca actgcaggtc
     1921 tgtgagccaa aggagaggac ttccacctcc tcatcctctg tccaagcaag gcgtctgagt
     1981 cagcctgaat cagctgaaaa gcatgtgacc cagaggttac agcctgagcg ggggagccca
     2041 aagaagtgtg aagctgaaga ggcagagcca ccagctgcca cacagcccca aacctcagag
     2101 actcagacct ctcatctgcc agaatcagaa agaattcatc acactgttga ggagaaggag
     2161 gaagtgacca tggacacaag tgaaaacaga cctgaaaatg atgttccaga acctcccatg
     2221 cctattgcag accaagtcag caatgatgac cgcccggagg gcagtgttga agatgaggag
     2281 aagaaagaga gctcgctgcc caaatcattc aagaggaaga tctccgttgt ctcagctacc
     2341 aagggggtgc cagctggaaa cagtgacaca gaggggggcc agcctggtcg gaaacgacgc
     2401 tggggagcca gcacagccac cacacagaag aaaccttcca tcagtatcac cactgaatca
     2461 ctaaagagcc tcatccccga catcaaaccc ctggcggggc aggaggctgt tgtggatctt
     2521 catgctgatg actctcgcat ctctgaggat gagacagagc gtaatggcga tgatgggacc
     2581 catgacaagg ggctgaaaat atgccggaca gtcactcagg tagtacctgc agagggccag
     2641 gagaatgggc agagggaaga agaggaagaa gagaaggaac ctgaagcaga acctcctgta
     2701 cctccccagg tgtcagtaga ggtggccttg cccccacctg cagagcatga agtaaagaaa
     2761 gtgactttag gagatacctt aactcgacgt tccattagcc agcagaagtc cggagtttcc
     2821 attaccattg atgacccagt ccgaactgcc caggtgccct ccccaccccg gggcaagatt
     2881 agcaacattg tccatatctc caatttggtc cgtcctttca ctttaggcca gctaaaggag
     2941 ttgttggggc gcacaggaac cttggtggaa gaggccttct ggattgacaa gatcaaatct
     3001 cattgctttg taacgtactc aacagtagag gaagctgttg ccacccgcac agctctgcac
     3061 ggggtcaaat ggccccagtc caatcccaaa ttcctttgtg ctgactatgc cgagcaagat
     3121 gagctggatt atcaccgagg cctcttggtg gaccgtccct ctgaaactaa gacagaggag
     3181 cagggaatac cacggcccct gcacccccca cccccacccc cggtccagcc accacagcac
     3241 ccccgggcag agcagcggga gcaggaacgg gcagtgcggg aacagtgggc agaacgggaa
     3301 cgggaaatgg agcggcggga gcggactcga tcagagcgtg aatgggatcg ggacaaagtt
     3361 cgagaagggc cccgttcccg atcaaggtcc cgtgaccgcc gccgcaagga acgtgcgaag
     3421 tctaaagaaa agaagagtga gaagaaagag aaagcccagg aggaaccacc tgccaagctg
     3481 ctggatgacc ttttccgaaa gaccaaggca gctccctgca tctattggct cccactgact
     3541 gacagccaga tcgttcagaa agaggcagag cgggccgaac gggccaagga gcgggagaag
     3601 cggcgaaagg agcaagaaga agaagagcaa aaggagcggg agaaggaagc cgagcgggaa
     3661 cggaaccgac agctggagcg agagaaacgt cgggagcaca gtcgggagag ggacagggag
     3721 agagagagag aaagggagcg ggacaggggg gaccgagatc gggataggga aagggaccga
     3781 gaacgaggca gggaaaggga tcgcagggac accaagcgcc acagcagaag ccggagtcgg
     3841 agcacacctg tgcgggaccg gggtgggcgc cgctagctgg gaaaacacta gagctgcagg
     3901 taccagccac tcggccccag ggggttatgg ccacagaggg ataggcacag tctccaccac
     3961 cctggagcca agggtctttc acatcaccta tccctacata cataccaaat ggaaaagtgg
     4021 ccatcctttt ccccccaaac acaccccctt aacctatctc ttgggactta gcccgaccct
     4081 ccctctcatt tcccattaag tctgagaggc aagagctagg ttaggcaagg aggtggttgg
     4141 ccagagatgg ggaacagcca ggtgccccag tcctctgatt tttcctccat cctgcttacc
     4201 acctccctgg gtacttacag ccttctcttg ggaacagccg gggccaggac tgggtcacct
     4261 atgagctgaa tcagcatctc ctcctgagtc ccagggcccc tgcagttccc agtctcttct
     4321 gtcctgcagc ccttgcctct ttcccacagg ttccacttta tatccacctt ttccttttgt
     4381 tcaattttta tttttatttt ttttattatt aaatgatgtg gtctatggaa aaaaaaataa
     4441 aaatctgact tagttttaaa
//
