LOCUS       NM_018367               7333 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens alkaline ceramidase 3 (ACER3), transcript variant 1,
            mRNA.
ACCESSION   NM_018367
VERSION     NM_018367.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7333)
  AUTHORS   Yi,J.K., Xu,R., Obeid,L.M., Hannun,Y.A., Airola,M.V. and Mao,C.
  TITLE     Alkaline ceramidase catalyzes the hydrolysis of ceramides via a
            catalytic mechanism shared by Zn2+-dependent amidases
  JOURNAL   PLoS One 17 (9), e0271540 (2022)
   PUBMED   36048828
  REMARK    GeneRIF: Alkaline ceramidase catalyzes the hydrolysis of ceramides
            via a catalytic mechanism shared by Zn2+-dependent amidases.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7333)
  AUTHORS   Bai,K., Ma,Y. and Li,J.
  TITLE     Circular RNA circ_0001955 promotes hepatocellular carcinoma
            tumorigenesis by up-regulating alkaline ceramidase 3 expression
            through microRNA-655-3p
  JOURNAL   Bioengineered 13 (2), 2099-2113 (2022)
   PUBMED   35034572
  REMARK    GeneRIF: Circular RNA circ_0001955 promotes hepatocellular
            carcinoma tumorigenesis by up-regulating alkaline ceramidase 3
            expression through microRNA-655-3p.
REFERENCE   3  (bases 1 to 7333)
  AUTHORS   Chen,W., Wang,F., Zhang,J., Li,C. and Hong,L.
  TITLE     LINC01087 indicates a poor prognosis of glioma patients with
            preoperative MRI
  JOURNAL   Funct Integr Genomics 22 (1), 55-64 (2022)
   PUBMED   34817752
  REMARK    GeneRIF: LINC01087 indicates a poor prognosis of glioma patients
            with preoperative MRI.
REFERENCE   4  (bases 1 to 7333)
  AUTHORS   Dehnavi,A.Z., Heidari,E., Rasulinezhad,M., Heidari,M.,
            Ashrafi,M.R., Hosseini,M.M., Sadeghzadeh,F., Fallah,M.S.,
            Rostampour,N., Bahraini,A., Garshasbi,M. and Tavasoli,A.R.
  TITLE     ACER3-related leukoencephalopathy: expanding the clinical and
            imaging findings spectrum due to novel variants
  JOURNAL   Hum Genomics 15 (1), 45 (2021)
   PUBMED   34281620
  REMARK    GeneRIF: ACER3-related leukoencephalopathy: expanding the clinical
            and imaging findings spectrum due to novel variants.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7333)
  AUTHORS   Vasiliauskaite-Brooks,I., Healey,R.D., Rochaix,P., Saint-Paul,J.,
            Sounier,R., Grison,C., Waltrich-Augusto,T., Fortier,M., Hoh,F.,
            Saied,E.M., Arenz,C., Basu,S., Leyrat,C. and Granier,S.
  TITLE     Structure of a human intramembrane ceramidase explains enzymatic
            dysfunction found in leukodystrophy
  JOURNAL   Nat Commun 9 (1), 5437 (2018)
   PUBMED   30575723
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7333)
  AUTHORS   Hu,W., Xu,R., Sun,W., Szulc,Z.M., Bielawski,J., Obeid,L.M. and
            Mao,C.
  TITLE     Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain
            ceramides, and its down-regulation inhibits both cell proliferation
            and apoptosis
  JOURNAL   J Biol Chem 285 (11), 7964-7976 (2010)
   PUBMED   20068046
  REMARK    GeneRIF: ACER3 catalyzes the hydrolysis of unsaturated long chain
            ceramides and dihydroceramides and coordinates with ACER2 to
            regulate cell proliferation and survival
REFERENCE   7  (bases 1 to 7333)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 7333)
  AUTHORS   Wheeler,H.E., Metter,E.J., Tanaka,T., Absher,D., Higgins,J.,
            Zahn,J.M., Wilhelmy,J., Davis,R.W., Singleton,A., Myers,R.M.,
            Ferrucci,L. and Kim,S.K.
  TITLE     Sequential use of transcriptional profiling, expression
            quantitative trait mapping, and gene association implicates MMP20
            in human kidney aging
  JOURNAL   PLoS Genet 5 (10), e1000685 (2009)
   PUBMED   19834535
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 7333)
  AUTHORS   Mao,C. and Obeid,L.M.
  TITLE     Ceramidases: regulators of cellular responses mediated by ceramide,
            sphingosine, and sphingosine-1-phosphate
  JOURNAL   Biochim Biophys Acta 1781 (9), 424-434 (2008)
   PUBMED   18619555
  REMARK    Review article
REFERENCE   10 (bases 1 to 7333)
  AUTHORS   Mao,C., Xu,R., Szulc,Z.M., Bielawska,A., Galadari,S.H. and
            Obeid,L.M.
  TITLE     Cloning and characterization of a novel human alkaline ceramidase.
            A mammalian enzyme that hydrolyzes phytoceramide
  JOURNAL   J Biol Chem 276 (28), 26577-26588 (2001)
   PUBMED   11356846
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK315000.1, DB461413.1, AP002498.3, AP000752.4 and AI885537.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018367.6.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279847.3098.1, SRR1803612.56196.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000532485.6/ ENSP00000434480.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               AK315000.1         12-223
            213-242             DB461413.1         249-278
            243-484             AK315000.1         254-495
            485-485             AP002498.3         115096-115096
            486-863             AK315000.1         497-874
            864-7204            AP000752.4         21965-28305
            7205-7333           AI885537.1         13-141              c
FEATURES             Location/Qualifiers
     source          1..7333
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.5"
     gene            1..7333
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /note="alkaline ceramidase 3"
                     /db_xref="GeneID:55331"
                     /db_xref="HGNC:HGNC:16066"
                     /db_xref="MIM:617036"
     exon            1..162
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..863
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /EC_number="3.5.1.23"
                     /note="isoform a is encoded by transcript variant 1;
                     phytoceramidase, alkaline; alkaline phytoceramidase;
                     alkCDase 3; alkaline CDase 3; alkaline dihydroceramidase
                     SB89"
                     /codon_start=1
                     /product="alkaline ceramidase 3 isoform a"
                     /protein_id="NP_060837.3"
                     /db_xref="CCDS:CCDS8247.1"
                     /db_xref="GeneID:55331"
                     /db_xref="HGNC:HGNC:16066"
                     /db_xref="MIM:617036"
                     /translation="MAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMI
                     IPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCI
                     FVYCMFECFKIKNSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRS
                     IYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHA
                     WWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPVILFEPLRKH"
     exon            163..273
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /inference="alignment:Splign:2.1.0"
     exon            274..326
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /inference="alignment:Splign:2.1.0"
     exon            327..379
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /inference="alignment:Splign:2.1.0"
     exon            380..461
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /inference="alignment:Splign:2.1.0"
     exon            462..497
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /inference="alignment:Splign:2.1.0"
     exon            498..556
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /inference="alignment:Splign:2.1.0"
     exon            557..658
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /inference="alignment:Splign:2.1.0"
     exon            659..763
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /inference="alignment:Splign:2.1.0"
     exon            764..809
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /inference="alignment:Splign:2.1.0"
     exon            810..7333
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4184
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /note="major polyA site"
     regulatory      7312..7317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /note="hexamer: AATAAT"
     polyA_site      7333
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /note="major polyA site"
ORIGIN      
        1 gtcgccagcc taacccggca cagtgagcgg agcgcctggg cggcggcggc ggcggcgtga
       61 tggctccggc cgcggaccga gagggctact ggggccccac gacctccacg ctggactggt
      121 gcgaggagaa ctactccgtg acctggtaca tcgccgagtt ctggaataca gtgagtaacc
      181 tgatcatgat tatacctcca atgttcggtg cagttcagag tgttagagac ggtctggaaa
      241 agcggtacat tgcttcttat ttagcactca cagtggtagg aatgggatcc tggtgcttcc
      301 acatgactct gaaatatgaa atgcagctat tggatgaact cccaatgata tacagctgtt
      361 gcatatttgt gtactgcatg tttgaatgtt tcaagatcaa gaactcagta aactaccatc
      421 tgctttttac cttagttcta ttcagtttaa tagtaaccac agtttacctt aaggtaaaag
      481 agccgatatt ccatcaggtc atgtatggaa tgttggtctt tacattagta cttcgatcta
      541 tttatattgt tacatgggtt tatccatggc ttagaggact gggttataca tcattgggta
      601 tatttttatt gggattttta ttttggaata tagataacat attttgtgag tcactgagga
      661 actttcgaaa gaaggtacca cctatcatag gtattaccac acaatttcat gcatggtggc
      721 atattttaac tggccttggt tcctatcttc acatcctttt cagtttgtat acaagaacac
      781 tttacctgag atataggcca aaagtgaagt ttctctttgg aatctggcca gtgatcctgt
      841 ttgagcctct caggaagcat tgatgaatca ttccaccaag aaaacaaaca agcacctacc
      901 atagacctgg cagaataaat aaggaaatcc ttaaagatct acaagttcaa atatgtcatg
      961 accatcacag cagaggagtg actttctgac taatgctgcc acccacacag agaataagga
     1021 gtagggcctg ctgggtgttt agctcatggc tttatcttat ttgtccccct cctcctttca
     1081 cgctccagtt tataaagaaa cagagatgat gtgtgtgtat gcctcaaatg cagaaacagt
     1141 tgggcttttc ttaacaggtt aacagtttgt gctggttata agaaattaac cttcttttct
     1201 ttttgccaag ggttgcatgt gaattatacc tttcttaata tttgattaaa taatgcagtc
     1261 agctaagagc caacaaaacc ccatatccag atagttagct gtgagccagc actcagctgt
     1321 gtcagatttg attaatattg tattaatctc atggatggtt ctcaaaggta aaaaaagaga
     1381 gagaaagaga gagagctagc tgtgggattc tgtgtagttc ttcactatct gttccagggc
     1441 tagtcggagg atcataagca agctcagacc tgcccccagt tcagtacttg accacatccc
     1501 aggatttatg gtgtctgtct atggccacag ccaaccagaa tgagtgggtc atcttataac
     1561 ctttctgaag ctccatgagg acatgtatag aatgctgcac cttcagccag ctctgctctg
     1621 atctttgcag atctttaagt tgtcactgtt tctacggcta gacaaatatg actggtggtc
     1681 tagactaccc atagttcatc ctcctcacat aacttatttg aagttgtcag ggaatgtcat
     1741 tacactctga tttttaaaat tatgcagtat tttccagttc tcagagaggt catggttgtg
     1801 cccagggaag tgtgttgcat taactaaagc taaaattatc agaatcctat ttacataaag
     1861 catattaaaa tatctgctcc ttaattttct gaaggaaata gatgtaagtt tctgctactt
     1921 gaaacctaca gaaccgacaa aaattagggt gctaaaaaaa tgacagtgaa atctcatcgt
     1981 aaggcagcta gttctaattt gcatttgaat gtataacaaa ttgcatcact tttcacaaac
     2041 ttaacacctg cctggagtaa aaatctgatt tgacccctct gctcatgttt catcatattt
     2101 gtagctctgc atcatttagc atttttatga ctttttttgc tttatataaa ttattgtaaa
     2161 atccagattg tttttaccac atgatgacgt gactcaggat taaatcctga gctacagttt
     2221 caaaaggaaa atcatttttt tcttatgcaa agatggtaaa acactgttgt cattttttcc
     2281 agtattcaat aagtagcctt tgtacaaatt taaaaccaaa aactattctg ttgtttttct
     2341 tcacctacta gccttagttt ttaaccaagt atccaaggat gtcaacttga catccttccc
     2401 ttagcatgcc aacaagccat tagactgatt cttccaccta tttttatgaa cctccaggaa
     2461 gaaaaacact tgccaaaaca ttaagagaac tttgattctg ccttaagagg gtataaaact
     2521 aaaccatttg aaggcacagc ccataagact atacttgatt ttgccccaag attctgactt
     2581 ctggctacat ttcacctgca gttacctggg ctatcggccg tgatacattt tttaattcat
     2641 ttgttttcca ccattatatt tttatacttt tcagttagat atacttctgc ataaagagta
     2701 tatatacagt gtaggataaa ggcatatcgt acatggcaat gctgttaaac atggtaagac
     2761 tgaggttctg caggattaaa gtcagattaa gggtacagaa agcacacctt gatactgagg
     2821 ccatttagag caatttgttt aatgagtggt tcagccatca ccaccagtgg ccacctgttc
     2881 aataaaattg cctagcacca cagtggagag tcatctacac cccaaggtga gctgtaagac
     2941 tggccaattc tttgaagacc tttttttctg ttgggagaat ggaaagcaga aagggaagcc
     3001 aggctcttta atgttccaag tcagctgtgc ctcacacaag gctctctttt tagctactaa
     3061 gtaacatact caagactttg tatctgtgca gcattttatg gaaatcactg gtgacctata
     3121 ggatattact aaattatttc aatagcttta tttttttcct acttggattc taggtggaca
     3181 ttacagagtt gaattcctca ctaccccctc ccgctgtcat ttgttttatt ggaaaacttc
     3241 atgttaacta gagtgtacaa aaagtctgtt tcctgctgag ccaatagtga tttgtttgca
     3301 tatcacctaa tgtgaaaagt gctcatctgt gaactctaca gcaaattata ttttagaaaa
     3361 tactttgtga ggccgggcat ggtggcagag cgagactccg tctcaaaaaa aaaaaaaaaa
     3421 aaaaaaaaga aaagaaaaga aaatataagg atgtaaaaga agcaatttgc ttgcacatct
     3481 gaatatcctt cttgtgcctc cattttcact cttgaaaact gaaagcaatt tgacttttat
     3541 ttttgttttt ctaaagaaca gctaggtgaa aggaggttaa gctgattgtc actctgcctg
     3601 cccactacct actccccacc atggtgtttc atgaaacatc cccaccacct gaagtgatct
     3661 ttttaatcct tgtgatagta aatgcattga taattaacag gaaaaacatg tttttaaata
     3721 atctacaaat gagaacccaa atagtagtgt tttgtttgac agaagtaaat caaatattat
     3781 ggtttaaata taatgcaaaa tttcaggaca gttaatttgg acttccctta ccctaagagg
     3841 gtttttctta taataaggag aagaggtgtg gttcaaagaa aattaagaga caaaaccttc
     3901 aggtacataa tgcatgaaaa tctttaaatg cctgcaaaaa ttaagttctg ttataatacc
     3961 agccaattct gaattagcca atgccctaaa agcatctaac aatttaaggt tatcttatga
     4021 gtcctatgaa aacaattatt tgttgctaaa tttgagtttt agctaccaac gccatgttta
     4081 cgtgacaaga aattgttttg gccctgtggt ttatgacgtg ctgctggata agcatttatg
     4141 taaaactgag tatttcaaag agaaccattt acaattggaa tttccacctg tgtggctgtt
     4201 tgcagaccta cctctgtctt ccattttgca tcctgtcagt gctataatta gtttgatcac
     4261 tttgtcttgt ttttcagtgt ctacaattat agcttattca ctatgttcta actatttaaa
     4321 aataatgggc cgggcgcggt ggctcatgcc tgtaatccca gcactttggg aggccgaggt
     4381 gagcagatca caaggtcagg agatcgagac catcctggct aacacagtga aaccccgtct
     4441 ctactaaaaa tacaaaaaaa ttagtcgggc atggtggcgg gcgcctgtag tcccagctac
     4501 tcgggaggct gaggcaggag aatggcgtga acctgggagg cagagcttgc agtgagccaa
     4561 gattgtgcca ctgcactcca gcctgggcaa cagagcgaga ctctgtctca aaaaaaaaaa
     4621 aaaaaaaaaa aaaaaaagac taaaatttga tttaaagtag ttaaacccct ttatggaagg
     4681 agctgcaaaa tgaaaaaaaa aaaaaaaagg aatcatgtca tcttgaccca gctgactgga
     4741 aattttcaat actgtctttt aactgttgta ctccagccag cctgggcaac agagtgagac
     4801 cctgtctcaa aaaaaaaaaa aaaaaaaaaa aaaaaaagaa ttaggaaata cttgttaaaa
     4861 tatctaacta cgtaattgct acatggggga gctgctggtg ttgttgaggt ccttgggagc
     4921 attccactgg acttcaccat ttctccaaaa ttatcagccc agtcagcttc atatacccag
     4981 atatggacac ttctacacgt gaaattcaaa ctgaagataa aactctgact ttggagtata
     5041 aacttttgcc ttgagtatga aaccttgaca ttgctgaaag aaaagtggaa actgtaaggg
     5101 acaacaagtt tcaccaaggc acagtcttct ctgataggcc agcagagcag ctaaggagaa
     5161 gacagatcat tcaagaactt aagtcgtttg ttagctacag catttccatt gctgtgatac
     5221 acattcagcc attttggagg aaagctaagc aggttctgac cacccatttt catgtacttt
     5281 aaataacaaa tattatttct caaggtcttc attttatcat taaattcagc taattactac
     5341 ctgatttcaa aggcagctag tgtagaagac tggtcacaag aatttttttt taaatagaaa
     5401 accctaaaat gcaaatcaag aaattcagtt acaggctgca agtgacctaa aattccccta
     5461 ctctagctca gcagccatca gtcagtatag catcagccac aggtcactgc tctgcataca
     5521 gttccttttc aacccttaca agacctgctt cattgcttta aaaatgtagt gttgatactt
     5581 gaactgaatt tagtcattgg taacttaaat attcacaaaa ttgtcataaa gcttctgaaa
     5641 catctggcaa tgccagatct gtaatcatca cttttaaatt gaatttgcag aattaactct
     5701 aaagttgcag caaccatatt tattagagaa atctttaagc atatacatat ggttccctat
     5761 aagcattcat tcagagatca tctgtgccta aaagaaaatg ataaaaatgt gtcataatat
     5821 caaaggggtc tagatcaggg gttggtaaac tacaacccat gggccaaatt caggctgcgt
     5881 tgtatggcct gcaaggtaag aatggttatt ttattttatt ttattcttta tatatatata
     5941 tatatattta tttatttttt tgagacagag tctctctctg tcacccacgc tggagtgcag
     6001 tggcaggatc tcaactcatt gcaacctccg cctcccaagg ttcaagcgat tctcctgcct
     6061 cagcctcccg agtagctggg actacaggca catgccacca tgccaccatg cctggctgat
     6121 ttttgtattt ttagtagagc tgggttggcc aggctggtct tgaactcctg acctcaagtg
     6181 attcacctgc cttggcctcc caaagtcctg gaattacagg cgtgagctac cgtgcccagc
     6241 tggtttttac attttaaaaa cgtttagaga aagaagaata tgcaacagaa actgtatgta
     6301 gcctgcaaag cctaaaatgt ttactctctg gcttgggagt ttgtctcccc tgctctagac
     6361 tgtcagcaag tggtacagtg gtacagtaca gtggtactgc ccaactgcac ttctctgcaa
     6421 ggtgattcta gtgtgcactt gtcagaatga aaatatgtta ttcatttaag acatctcatg
     6481 tctttgaatg taatcacatg atttgtattt aatatttaca tgacctaatt attttttcac
     6541 gtcagttttt ctagattggc aatagcctgt tgcaaagtgc ctaaaccttt gagaaaaatt
     6601 actatgagca aggtccatga tttagttttc aatataaagg gaattccatt ctatactgta
     6661 aaatccaaaa atgctagttg ccctcagctt ttgagttgac ttccagaaag ttgagatctt
     6721 ttgaccattt tttctcatgt catataaaat gtgccacatg gtagttgtca agctgtggta
     6781 gtcatgtaca ctttttttct tttttttaac tttctaaaag gaaaagttca aagtcctttc
     6841 cacagttagt cttcgcttct tttggatttt tctttttaga gctaaattat tcataccaat
     6901 gaataagtga gtctgttcta agatataggg gccattatct atttttgctt aatggactca
     6961 tgtggcattg ttcactatca tgcctttcca tacttgtaat atttctgagt cacttattaa
     7021 tgtgaccaac agataaactg ttcaagctaa tacagcattt cctaacttca tagttgtcgc
     7081 agatgtttgt tctagtagcg attatttaat aaacatacat tgtactgaat cttactagca
     7141 actaactatt ttcaggtaat ctcagtctgc ttattcactt tttccatttg atttgctaat
     7201 gccacaatca tttttctaga aaatagtagg ataatgtatt ttttcctgtc tgctataatg
     7261 gagactatat ttctgcattc attacctctc ataggtgaaa atattaaatt aaataatatt
     7321 gttttgaata aga
//
