LOCUS       NM_001010887            2773 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens alkaline ceramidase 2 (ACER2), mRNA.
ACCESSION   NM_001010887 XM_294540
VERSION     NM_001010887.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2773)
  AUTHORS   Chen,X., Lu,T., Ding,M., Cai,Y., Yu,Z., Zhou,X. and Wang,X.
  TITLE     Targeting YTHDF2 inhibits tumorigenesis of diffuse large B-cell
            lymphoma through ACER2-mediated ceramide catabolism
  JOURNAL   J Adv Res 63, 17-33 (2024)
   PUBMED   37865189
  REMARK    GeneRIF: Targeting YTHDF2 inhibits tumorigenesis of diffuse large
            B-cell lymphoma through ACER2-mediated ceramide catabolism.
REFERENCE   2  (bases 1 to 2773)
  AUTHORS   Zheng,J., Jiang,X., Jiang,K., Yan,Y., Pan,J., Liu,F., Wen,Y. and
            Li,P.
  TITLE     miR-196a-5p Correlates with Chronic Atrophic Gastritis Progression
            to Gastric Cancer and Induces Malignant Biological Behaviors of
            Gastric Cancer Cells by Targeting ACER2
  JOURNAL   Mol Biotechnol 65 (8), 1306-1317 (2023)
   PUBMED   36513872
  REMARK    GeneRIF: miR-196a-5p Correlates with Chronic Atrophic Gastritis
            Progression to Gastric Cancer and Induces Malignant Biological
            Behaviors of Gastric Cancer Cells by Targeting ACER2.
REFERENCE   3  (bases 1 to 2773)
  AUTHORS   Zhang,S., Huang,P., Dai,H., Li,Q., Hu,L., Peng,J., Jiang,S., Xu,Y.,
            Wu,Z., Nie,H., Zhang,Z., Yin,W., Zhang,X. and Lu,J.
  TITLE     TIMELESS regulates sphingolipid metabolism and tumor cell growth
            through Sp1/ACER2/S1P axis in ER-positive breast cancer
  JOURNAL   Cell Death Dis 11 (10), 892 (2020)
   PUBMED   33093451
  REMARK    GeneRIF: TIMELESS regulates sphingolipid metabolism and tumor cell
            growth through Sp1/ACER2/S1P axis in ER-positive breast cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2773)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2773)
  AUTHORS   Xu,R., Garcia-Barros,M., Wen,S., Li,F., Lin,C.L., Hannun,Y.A.,
            Obeid,L.M. and Mao,C.
  TITLE     Tumor suppressor p53 links ceramide metabolism to DNA damage
            response through alkaline ceramidase 2
  JOURNAL   Cell Death Differ 25 (5), 841-856 (2018)
   PUBMED   29229990
  REMARK    GeneRIF: These results suggest that p53 mediates DDR and exerts its
            tumor suppressive role in part by regulating the expression of
            ACER2, which in turn regulates the bioactive sphingolipid lipids.
REFERENCE   6  (bases 1 to 2773)
  AUTHORS   Sun,W., Jin,J., Xu,R., Hu,W., Szulc,Z.M., Bielawski,J., Obeid,L.M.
            and Mao,C.
  TITLE     Substrate specificity, membrane topology, and activity regulation
            of human alkaline ceramidase 2 (ACER2)
  JOURNAL   J Biol Chem 285 (12), 8995-9007 (2010)
   PUBMED   20089856
  REMARK    GeneRIF: ACER2 has broad substrate specificity and requires Ca(2+)
            for its activity; ACER2 has the cytosolic C terminus and luminal N
            terminus, which are essential for its activity, correct cellular
            localization, and regulation for protein glycosylation
REFERENCE   7  (bases 1 to 2773)
  AUTHORS   Sun,W., Hu,W., Xu,R., Jin,J., Szulc,Z.M., Zhang,G., Galadari,S.H.,
            Obeid,L.M. and Mao,C.
  TITLE     Alkaline ceramidase 2 regulates beta1 integrin maturation and cell
            adhesion
  JOURNAL   FASEB J 23 (2), 656-666 (2009)
   PUBMED   18945876
  REMARK    GeneRIF: ACER2/sphingosine pathway plays an important role in
            regulating beta1 maturation and cell adhesion mediated by beta1
            integrins
REFERENCE   8  (bases 1 to 2773)
  AUTHORS   Xu,R., Jin,J., Hu,W., Sun,W., Bielawski,J., Szulc,Z., Taha,T.,
            Obeid,L.M. and Mao,C.
  TITLE     Golgi alkaline ceramidase regulates cell proliferation and survival
            by controlling levels of sphingosine and S1P
  JOURNAL   FASEB J 20 (11), 1813-1825 (2006)
   PUBMED   16940153
REFERENCE   9  (bases 1 to 2773)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   10 (bases 1 to 2773)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK123581.1, AY312516.1, BC092487.1 and AL158206.8.
            
            On Nov 23, 2018 this sequence version replaced NM_001010887.2.
            
            Summary: The sphingolipid metabolite sphingosine-1-phosphate
            promotes cell proliferation and survival, whereas its precursor,
            sphingosine, has the opposite effect. The ceramidase ACER2
            hydrolyzes very long chain ceramides to generate sphingosine (Xu et
            al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.78002.1,
                                           SRR1660805.128610.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340967.3/ ENSP00000342609.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AK123581.1         83-158
            77-896              AY312516.1         1-820
            897-1874            BC092487.1         1030-2007
            1875-2770           AK123581.1         1957-2852
            2771-2773           AL158206.8         19383-19385
FEATURES             Location/Qualifiers
     source          1..2773
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p22.1"
     gene            1..2773
                     /gene="ACER2"
                     /gene_synonym="ALKCDase2; ASAH3L"
                     /note="alkaline ceramidase 2"
                     /db_xref="GeneID:340485"
                     /db_xref="HGNC:HGNC:23675"
                     /db_xref="MIM:613492"
     exon            1..184
                     /gene="ACER2"
                     /gene_synonym="ALKCDase2; ASAH3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..904
                     /gene="ACER2"
                     /gene_synonym="ALKCDase2; ASAH3L"
                     /EC_number="3.5.1.23"
                     /note="ceramide hydrolase; haCER2; alkCDase 2; alkaline
                     CDase 2"
                     /codon_start=1
                     /product="alkaline ceramidase 2"
                     /protein_id="NP_001010887.2"
                     /db_xref="CCDS:CCDS34992.1"
                     /db_xref="GeneID:340485"
                     /db_xref="HGNC:HGNC:23675"
                     /db_xref="MIM:613492"
                     /translation="MGAPHWWDQLQAGSSEVDWCEDNYTIVPAIAEFYNTISNVLFFI
                     LPPICMCLFRQYATCFNSGIYLIWTLLVVVGIGSVYFHATLSFLGQMLDELAVLWVLM
                     CALAMWFPRRYLPKIFRNDRGRFKVVVSVLSAVTTCLAFVKPAINNISLMTLGVPCTA
                     LLIAELKRCDNMRVFKLGLFSGLWWTLALFCWISDRAFCELLSSFNFPYLHCMWHILI
                     CLAAYLGCVCFAYFDAASEIPEQGPVIKFWPNEKWAFIGVPYVSLLCANKKSSVKIT"
     exon            185..299
                     /gene="ACER2"
                     /gene_synonym="ALKCDase2; ASAH3L"
                     /inference="alignment:Splign:2.1.0"
     exon            300..441
                     /gene="ACER2"
                     /gene_synonym="ALKCDase2; ASAH3L"
                     /inference="alignment:Splign:2.1.0"
     exon            442..579
                     /gene="ACER2"
                     /gene_synonym="ALKCDase2; ASAH3L"
                     /inference="alignment:Splign:2.1.0"
     exon            580..717
                     /gene="ACER2"
                     /gene_synonym="ALKCDase2; ASAH3L"
                     /inference="alignment:Splign:2.1.0"
     exon            718..2773
                     /gene="ACER2"
                     /gene_synonym="ALKCDase2; ASAH3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2752..2757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACER2"
                     /gene_synonym="ALKCDase2; ASAH3L"
                     /note="hexamer: ATTAAA"
     polyA_site      2773
                     /gene="ACER2"
                     /gene_synonym="ALKCDase2; ASAH3L"
                     /note="major polyA site"
ORIGIN      
        1 gccgcgtttt gcctccgcag cagctctggg ctcttctcag ctgcgcgagc agctgctcca
       61 atgccccgga gtggccatgg gcgccccgca ctggtgggac cagctgcagg ctggtagctc
      121 ggaggtggac tggtgcgagg acaactacac catcgtgcct gctatcgccg agttctacaa
      181 cacgatcagc aatgtcttat ttttcatttt accgcccatc tgcatgtgct tgtttcgtca
      241 gtatgcaaca tgcttcaaca gtggcatcta cttaatctgg actcttttgg ttgtagtggg
      301 aattggatcc gtctacttcc atgcaaccct tagtttcttg ggtcagatgc ttgatgaact
      361 tgcagtcctt tgggttctga tgtgtgcttt ggccatgtgg ttccccagaa ggtatctacc
      421 aaagatcttt cggaatgacc ggggtaggtt caaggtggtg gtcagtgtcc tgtctgcggt
      481 tacgacgtgc ctggcatttg tcaagcctgc catcaacaac atctctctga tgaccctggg
      541 agttccttgc actgcactgc tcatcgcaga gctaaagagg tgtgacaaca tgcgtgtgtt
      601 taagctgggc ctcttctcgg gcctctggtg gaccctggcc ctgttctgct ggatcagtga
      661 ccgagctttc tgcgagctgc tgtcatcctt caacttcccc tacctgcact gcatgtggca
      721 catcctcatc tgccttgctg cctacctggg ctgtgtatgc tttgcctact ttgatgctgc
      781 ctcagagatt cctgagcaag gccctgtcat caagttctgg cccaatgaga aatgggcctt
      841 cattggtgtc ccctatgtgt ccctcctgtg tgccaacaag aaatcatcag tcaagatcac
      901 gtgatggcaa gatggtggct ggcttctctg cttatcgccc ctcatgcagt gggcttcctt
      961 tgctaggaag acagccaagg gagttcgaat agttggggtg tgggctatct tttcaaaaat
     1021 ctatttgctg gggctcttaa tttctttagt gttctttgta tgtagggatt taaactttgt
     1081 catatggtac aaatattccc tgcccccctg cagtttccca tttgtctttc agtatgttaa
     1141 tatttttgtg ccatactggt tttaaacttt catgttgtca catctgttaa tcttttcttt
     1201 aggatttctg gattttgtgt aatttttaaa aaggtcccct cctcctccct aatgtgtctg
     1261 tggaccacct ggattccact gtacaagggg aaaagtgtct attcctttcc caaagatgga
     1321 aaatggaggg cttagggaca ctagatgcat ctttctcagc atcacttcca gatgcagtga
     1381 cttgttgggc tgcgtcctta atggccatgg cagagcagtc ccttggggga tccagccctg
     1441 tacaatgcat ctcttcctgg agaaagctgg cctgctccag accccaccat tcccaggcgc
     1501 ccttggagtg gactctactg atgacagaca gaccctctga gagacaagac cctctgactc
     1561 tgtgatggaa gatgccagag attttccttt ggggtaattg tccttaaaca aaaccaaaca
     1621 gatgaaacac acacaggact tgtggctaaa aaggctagtt tttcacttgc atttctcaac
     1681 taacccaggt tttacatgca tctgtgaatc cttttactac tacctctgtg gagagatgga
     1741 gagacttcag ataaacgtga agctaatgag taaaaccctc tctgccaaaa cctacactcc
     1801 actttaggcc cttcttgaag atgagcacaa tttttaaata ctgagcacaa tttttaaata
     1861 ctgacatcac ttcctcttcc ccctcccacc ccagctcagc agcctcaaat ctacagagaa
     1921 gaagaattat ggcatgaaca ttcccacaga cccaccatct ttaagacttg acctctgtaa
     1981 gtttaccaaa gggctcctca caattgtggt gggggttctg gttcaaaatt tggagcaaac
     2041 atgaagtttt tggaaacgtt ttctcatttg aagcctccag tatgctgtac tattctggaa
     2101 attaccttca agagtctcac ttcttgtttc tgttgtgttt tctgtgggca tcatgttctt
     2161 cacgcttgca gtagaaggtg ctttctcggt ttcccagagt atccaacggc tcacctttct
     2221 caagtgctgg cagtagctat gcactcacgg gctggtttgg gtcgctggtg cagcagcgca
     2281 aatctgttgc cttctgaatt tttctcacct aatgtgacac tggctacaat gaatcttctc
     2341 ttcatcgggc tgaatgaaag attcaagaac catcttcaag gtgcatggtg ggaattatca
     2401 acctcaggga tactcatttt aactcaggcg tgtcctgctt tgtaacattc cattgttggg
     2461 agagggcagg acaggtgtgt tcttctgtgg gcaggagtca tgtcactgtc ctacatatgt
     2521 aagagttggg aaggtgacga tttttgacac atccaggaac tcttactcta gttagaattt
     2581 gtaccagatc caaggtgaaa accccaataa gcaactgaat ttagagttta aaaatgaatg
     2641 actttatgct acatctgtgg ttatcaaatt atataggttg ttgagaagca gaacgctgtt
     2701 tgtagtaaga aatctttgtg gaaccccagt gtgtgaagta aattgtatgt tattaaattt
     2761 atttaaggtt aaa
//
