LOCUS       NM_000789               4962 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens angiotensin I converting enzyme (ACE), transcript
            variant 1, mRNA.
ACCESSION   NM_000789
VERSION     NM_000789.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4962)
  AUTHORS   Zhang,Q., Zhuang,Y., Zhang,X., Lin,G., Wu,H., He,Z., Wang,Z.,
            Xu,W., Yin,X., Su,L., Jia,X. and Gong,A.
  TITLE     Association between a single-nucleotide polymorphism of the
            angiotensin-converting enzyme gene and susceptibility to systemic
            lupus erythematosus in the Hainanese population of China
  JOURNAL   Int J Immunogenet 51 (5), 319-329 (2024)
   PUBMED   39044325
  REMARK    GeneRIF: Association between a single-nucleotide polymorphism of
            the angiotensin-converting enzyme gene and susceptibility to
            systemic lupus erythematosus in the Hainanese population of China.
REFERENCE   2  (bases 1 to 4962)
  AUTHORS   Chae,J.H., Eom,S.H., Lee,S.K., Jung,J.H. and Kim,C.H.
  TITLE     Association between Complex ACTN3 and ACE Gene Polymorphisms and
            Elite Endurance Sports in Koreans: A Case-Control Study
  JOURNAL   Genes (Basel) 15 (9), 1110 (2024)
   PUBMED   39336701
  REMARK    GeneRIF: Association between Complex ACTN3 and ACE Gene
            Polymorphisms and Elite Endurance Sports in Koreans: A Case-Control
            Study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4962)
  AUTHORS   Elnaggar,B.M.M.A., Abd Elbaky,N.M., Albeltagy,E.S. and El
            Zomor,H.M.
  TITLE     Interaction between angiotensin-converting enzyme gene rs4343
            polymorphism, environment factors, and angiotensin II level on
            susceptibility to knee osteoarthritis
  JOURNAL   Reumatol Clin (Engl Ed) 20 (7), 372-379 (2024)
   PUBMED   39160009
  REMARK    GeneRIF: Interaction between angiotensin-converting enzyme gene
            rs4343 polymorphism, environment factors, and angiotensin II level
            on susceptibility to knee osteoarthritis.
REFERENCE   4  (bases 1 to 4962)
  AUTHORS   Liu,J.Y., Yi,Y.Z., Guo,Q.W., Jia,K.X., Li,X.C., Cai,J.J.,
            Shen,Y.L., Su,G.M., Chen,X., Zhang,X.Y., Fang,D.Z., Hong,H. and
            Lin,J.
  TITLE     Associations of ACE I/D and AGTR1 rs5182 polymorphisms with
            diabetes and their effects on lipids in an elderly Chinese
            population
  JOURNAL   Lipids Health Dis 23 (1), 231 (2024)
   PUBMED   39080710
  REMARK    GeneRIF: Associations of ACE I/D and AGTR1 rs5182 polymorphisms
            with diabetes and their effects on lipids in an elderly Chinese
            population.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4962)
  AUTHORS   Oosthuizen,D., Ganief,T.A., Bernstein,K.E. and Sturrock,E.D.
  TITLE     Proteomic Analysis of Human Macrophages Overexpressing
            Angiotensin-Converting Enzyme
  JOURNAL   Int J Mol Sci 25 (13), 7055 (2024)
   PUBMED   39000163
  REMARK    GeneRIF: Proteomic Analysis of Human Macrophages Overexpressing
            Angiotensin-Converting Enzyme.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4962)
  AUTHORS   Ghafouri-Fard,S., Noroozi,R., Omrani,M.D., Branicki,W.,
            Pospiech,E., Sayad,A., Pyrc,K., Labaj,P.P., Vafaee,R., Taheri,M.
            and Sanak,M.
  TITLE     Angiotensin converting enzyme: A review on expression profile and
            its association with human disorders with special focus on
            SARS-CoV-2 infection
  JOURNAL   Vascul Pharmacol 130, 106680 (2020)
   PUBMED   32423553
  REMARK    Review article
REFERENCE   7  (bases 1 to 4962)
  AUTHORS   Cambien,F., Poirier,O., Lecerf,L., Evans,A., Cambou,J.P.,
            Arveiler,D., Luc,G., Bard,J.M., Bara,L., Ricard,S. et al.
  TITLE     Deletion polymorphism in the gene for angiotensin-converting enzyme
            is a potent risk factor for myocardial infarction
  JOURNAL   Nature 359 (6396), 641-644 (1992)
   PUBMED   1328889
REFERENCE   8  (bases 1 to 4962)
  AUTHORS   Wei,L., Clauser,E., Alhenc-Gelas,F. and Corvol,P.
  TITLE     The two homologous domains of human angiotensin I-converting enzyme
            interact differently with competitive inhibitors
  JOURNAL   J Biol Chem 267 (19), 13398-13405 (1992)
   PUBMED   1320019
REFERENCE   9  (bases 1 to 4962)
  AUTHORS   Erdos,E.G., Johnson,A.R. and Boyden,N.T.
  TITLE     Hydrolysis of enkephalin by cultured human endothelial cells and by
            purified peptidyl dipeptidase
  JOURNAL   Biochem Pharmacol 27 (5), 843-848 (1978)
   PUBMED   656131
REFERENCE   10 (bases 1 to 4962)
  AUTHORS   Sancho,J., Re,R., Burton,J., Barger,A.C. and Haber,E.
  TITLE     The role of the renin-angiotensin-aldosterone system in
            cardiovascular homeostasis in normal human subjects
  JOURNAL   Circulation 53 (3), 400-405 (1976)
   PUBMED   174834
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK296566.1, AB208971.1 and
            AC113554.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000789.3.
            
            Summary: This gene encodes an enzyme involved in blood pressure
            regulation and electrolyte balance. It catalyzes the conversion of
            angiotensin I into a physiologically active peptide angiotensin II.
            Angiotensin II is a potent vasopressor and aldosterone-stimulating
            peptide that controls blood pressure and fluid-electrolyte balance.
            This angiotensin converting enzyme (ACE) also inactivates the
            vasodilator protein, bradykinin. Accordingly, the encoded enzyme
            increases blood pressure and is a drug target of ACE inhibitors,
            which are often prescribed to reduce blood pressure. This enzyme
            additionally plays a role in fertility through its ability to
            cleave and release GPI-anchored membrane proteins in spermatozoa.
            Many studies have associated the presence or absence of a 287 bp
            Alu repeat element in this gene with the levels of circulating
            enzyme. This polymorphism, as well as mutations in this gene, have
            been implicated in a wide variety of diseases including
            cardiovascular pathophysiologies, psoriasis, renal disease, stroke,
            and Alzheimer's disease. Regulation of the homologous ACE2 gene may
            be involved in progression of disease caused by several human
            coronaviruses, including SARS-CoV and SARS-CoV-2. Alternative
            splicing results in multiple transcript variants encoding both
            somatic (sACE) and male-specific testicular (tACE) isoforms.
            [provided by RefSeq, Sep 2020].
            
            Transcript Variant: This variant (1), also known as the endothelial
            or somatic form, represents the longest transcript and encodes the
            longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04144.1, AB208971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: relevant for disease process
            MANE Ensembl match     :: ENST00000290866.10/ ENSP00000290866.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AK296566.1         1-10
            11-3752             AB208971.1         1-3742
            3753-4962           AC113554.9         107372-108581       c
FEATURES             Location/Qualifiers
     source          1..4962
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3"
     gene            1..4962
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /note="angiotensin I converting enzyme"
                     /db_xref="GeneID:1636"
                     /db_xref="HGNC:HGNC:2707"
                     /db_xref="MIM:106180"
     exon            1..283
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..3955
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /EC_number="3.4.15.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; kininase II; CD143 antigen; peptidase P;
                     carboxycathepsin; dipeptidyl carboxypeptidase 1;
                     dipeptidyl carboxypeptidase I; angiotensin I converting
                     enzyme (peptidyl-dipeptidase A) 1"
                     /codon_start=1
                     /product="angiotensin-converting enzyme isoform 1
                     precursor"
                     /protein_id="NP_000780.1"
                     /db_xref="CCDS:CCDS11637.1"
                     /db_xref="GeneID:1636"
                     /db_xref="HGNC:HGNC:2707"
                     /db_xref="MIM:106180"
                     /translation="MGAASGRRGPGLLLPLPLLLLLPPQPALALDPGLQPGNFSADEA
                     GAQLFAQSYNSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAK
                     ELYEPIWQNFTDPQLRRIIGAVRTLGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPN
                     KTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQD
                     GFTDTGAYWRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGP
                     IPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWNATHMFRVAEEFFTSLE
                     LSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEM
                     GHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGLLDRVTNDTESD
                     INYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTR
                     NETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAG
                     AKLRKVLQAGSSRPWQEVLKDMVGLDALDAQPLLKYFQPVTQWLQEQNQQNGEVLGWP
                     EYQWHPPLPDNYPEGIDLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTET
                     SKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEY
                     NKILLDMETTYSVATVCHPNGSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAI
                     LQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYV
                     RRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQG
                     WTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRI
                     KQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPK
                     HLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQ
                     EWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAA
                     GHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPL
                     LDWLRTENELHGEKLGWPQYNWTPNSARSEGPLPDSGRVSFLGLDLDAQQARVGQWLL
                     LFLGIALLVATLGLSQRLFSIRHRSLHRHSHGPQFGSEVELRHS"
     exon            284..451
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            452..545
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..689
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..881
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..979
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1152
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1376
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1521
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1620
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1743
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1955
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2092
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2251
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2339
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2483
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2675
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2773
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2946
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3170
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..3315
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3414
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3537
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3725
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3726..4962
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4188..4193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /note="hexamer: ATTAAA"
     polyA_site      4209
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /note="major polyA site"
     regulatory      4936..4941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /note="hexamer: AATAAA"
     polyA_site      4962
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
ORIGIN      
        1 agaaggggca gagccgagca ccgcgcaccg cgtcatgggg gccgcctcgg gccgccgggg
       61 gccggggctg ctgctgccgc tgccgctgct gttgctgctg ccgccgcagc ccgccctggc
      121 gttggacccc gggctgcagc ccggcaactt ttctgctgac gaggccgggg cgcagctctt
      181 cgcgcagagc tacaactcca gcgccgaaca ggtgctgttc cagagcgtgg ccgccagctg
      241 ggcgcacgac accaacatca ccgcggagaa tgcaaggcgc caggaggaag cagccctgct
      301 cagccaggag tttgcggagg cctggggcca gaaggccaag gagctgtatg aaccgatctg
      361 gcagaacttc acggacccgc agctgcgcag gatcatcgga gctgtgcgca ccctgggctc
      421 tgccaacctg cccctggcta agcggcagca gtacaacgcc ctgctaagca acatgagcag
      481 gatctactcc accgccaagg tctgcctccc caacaagact gccacctgct ggtccctgga
      541 cccagatctc accaacatcc tggcttcctc gcgaagctac gccatgctcc tgtttgcctg
      601 ggagggctgg cacaacgctg cgggcatccc gctgaaaccg ctgtacgagg atttcactgc
      661 cctcagcaat gaagcctaca agcaggacgg cttcacagac acgggggcct actggcgctc
      721 ctggtacaac tcccccacct tcgaggacga tctggaacac ctctaccaac agctagagcc
      781 cctctacctg aacctccatg ccttcgtccg ccgcgcactg catcgccgat acggagacag
      841 atacatcaac ctcaggggac ccatccctgc tcatctgctg ggagacatgt gggcccagag
      901 ctgggaaaac atctacgaca tggtggtgcc tttcccagac aagcccaacc tcgatgtcac
      961 cagtactatg ctgcagcagg gctggaacgc cacgcacatg ttccgggtgg cagaggagtt
     1021 cttcacctcc ctggagctct cccccatgcc tcccgagttc tgggaagggt cgatgctgga
     1081 gaagccggcc gacgggcggg aagtggtgtg ccacgcctcg gcttgggact tctacaacag
     1141 gaaagacttc aggatcaagc agtgcacacg ggtcacgatg gaccagctct ccacagtgca
     1201 ccatgagatg ggccatatac agtactacct gcagtacaag gatctgcccg tctccctgcg
     1261 tcggggggcc aaccccggct tccatgaggc cattggggac gtgctggcgc tctcggtctc
     1321 cactcctgaa catctgcaca aaatcggcct gctggaccgt gtcaccaatg acacggaaag
     1381 tgacatcaat tacttgctaa aaatggcact ggaaaaaatt gccttcctgc cctttggcta
     1441 cttggtggac cagtggcgct ggggggtctt tagtgggcgt accccccctt cccgctacaa
     1501 cttcgactgg tggtatcttc gaaccaagta tcaggggatc tgtcctcctg ttacccgaaa
     1561 cgaaacccac tttgatgctg gagctaagtt tcatgttcca aatgtgacac catacatcag
     1621 gtactttgtg agttttgtcc tgcagttcca gttccatgaa gccctgtgca aggaggcagg
     1681 ctatgagggc ccactgcacc agtgtgacat ctaccggtcc accaaggcag gggccaagct
     1741 ccggaaggtg ctgcaggctg gctcctccag gccctggcag gaggtgctga aggacatggt
     1801 cggcttagat gccctggatg cccagccgct gctcaagtac ttccagccag tcacccagtg
     1861 gctgcaggag cagaaccagc agaacggcga ggtcctgggc tggcccgagt accagtggca
     1921 cccgccgttg cctgacaact acccggaggg catagacctg gtgactgatg aggctgaggc
     1981 cagcaagttt gtggaggaat atgaccggac atcccaggtg gtgtggaacg agtatgccga
     2041 ggccaactgg aactacaaca ccaacatcac cacagagacc agcaagattc tgctgcagaa
     2101 gaacatgcaa atagccaacc acaccctgaa gtacggcacc caggccagga agtttgatgt
     2161 gaaccagttg cagaacacca ctatcaagcg gatcataaag aaggttcagg acctagaacg
     2221 ggcagcactg cctgcccagg agctggagga gtacaacaag atcctgttgg atatggaaac
     2281 cacctacagc gtggccactg tgtgccaccc gaatggcagc tgcctgcagc tcgagccaga
     2341 tctgacgaat gtgatggcca cgtcccggaa atatgaagac ctgttatggg catgggaggg
     2401 ctggcgagac aaggcgggga gagccatcct ccagttttac ccgaaatacg tggaactcat
     2461 caaccaggct gcccggctca atggctatgt agatgcaggg gactcgtgga ggtctatgta
     2521 cgagacacca tccctggagc aagacctgga gcggctcttc caggagctgc agccactcta
     2581 cctcaacctg catgcctacg tgcgccgggc cctgcaccgt cactacgggg cccagcacat
     2641 caacctggag gggcccattc ctgctcacct gctggggaac atgtgggcgc agacctggtc
     2701 caacatctat gacttggtgg tgcccttccc ttcagccccc tcgatggaca ccacagaggc
     2761 tatgctaaag cagggctgga cgcccaggag gatgtttaag gaggctgatg atttcttcac
     2821 ctccctgggg ctgctgcccg tgcctcctga gttctggaac aagtcgatgc tggagaagcc
     2881 aaccgacggg cgggaggtgg tctgccacgc ctcggcctgg gacttctaca acggcaagga
     2941 cttccggatc aagcagtgca ccaccgtgaa cttggaggac ctggtggtgg cccaccacga
     3001 aatgggccac atccagtatt tcatgcagta caaagactta cctgtggcct tgagggaggg
     3061 tgccaacccc ggcttccatg aggccattgg ggacgtgcta gccctctcag tgtctacgcc
     3121 caagcacctg cacagtctca acctgctgag cagtgagggt ggcagcgacg agcatgacat
     3181 caactttctg atgaagatgg cccttgacaa gatcgccttt atccccttca gctacctcgt
     3241 cgatcagtgg cgctggaggg tatttgatgg aagcatcacc aaggagaact ataaccagga
     3301 gtggtggagc ctcaggctga agtaccaggg cctctgcccc ccagtgccca ggactcaagg
     3361 tgactttgac ccaggggcca agttccacat tccttctagc gtgccttaca tcaggtactt
     3421 tgtcagcttc atcatccagt tccagttcca cgaggcactg tgccaggcag ctggccacac
     3481 gggccccctg cacaagtgtg acatctacca gtccaaggag gccgggcagc gcctggcgac
     3541 cgccatgaag ctgggcttca gtaggccgtg gccggaagcc atgcagctga tcacgggcca
     3601 gcccaacatg agcgcctcgg ccatgttgag ctacttcaag ccgctgctgg actggctccg
     3661 cacggagaac gagctgcatg gggagaagct gggctggccg cagtacaact ggacgccgaa
     3721 ctccgctcgc tcagaagggc ccctcccaga cagcggccgc gtcagcttcc tgggcctgga
     3781 cctggatgcg cagcaggccc gcgtgggcca gtggctgctg ctcttcctgg gcatcgccct
     3841 gctggtagcc accctgggcc tcagccagcg gctcttcagc atccgccacc gcagcctcca
     3901 ccggcactcc cacgggcccc agttcggctc cgaggtggag ctgagacact cctgaggtga
     3961 cccggctggg tcggccctgc ccaagggcct cccaccagag actgggatgg gaacactggt
     4021 gggcagctga ggacacaccc cacaccccag cccaccctgc tcctcctgcc ctgtccctgt
     4081 ccccctcccc tcccagtcct ccagaccacc agccgcccca gccccttctc ccagcacacg
     4141 gctgcctgac actgagcccc acctctccaa gtctctctgt gaatacaatt aaaggtcctg
     4201 ccctccccat ctgagtctgt gtccctcaca gggaagccag ggacagggac aggctgcttt
     4261 cctgcctcct ggcagtcaag tgggtcccgt tactaggttt gttcctccat cctccttcag
     4321 gagccgggga ggatccccag agctctgccc cagcacctcc tggcgctggc gcctgtcttc
     4381 cctccagccc aggcagcccg ccactgtcct gccaccgcag gcagcccctg tctggcccaa
     4441 gcactgaccc acgcggactc tgggaagcag acatcctggg ctgctggcct cacatttcca
     4501 ctggcagtgg agcctttccc tgctccacaa atggccaggt ccccccaggg gaaggcttcc
     4561 ggctgttatc ggctgcctca gggggcgagt accttggagg gcctgcttca aggagggtgc
     4621 cccctggagg gcacacacca gcctagtgct taccttggct cctgcctgta ccagctccat
     4681 gactctgctc gggtgaacag ccttggctct cagacagcca ttctaacact gccagtgcag
     4741 aggggcctca gacgctggag tgtagcagtg gctgcacctg cacagggatt agctgccagc
     4801 agccaccctg ctggcgtccc agcacacacc tcctcactcc ctgcattgga gggagtgtca
     4861 ttttaaggga catttttatg acttttatgt gtatgtttat gtagaaattt ggaaaataca
     4921 gaaaactgta aagaaaataa aagcccttta tatcaacgtc aa
//
