LOCUS       NM_032592               2383 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens 1-aminocyclopropane-1-carboxylate synthase homolog
            (inactive) (ACCS), transcript variant 1, mRNA.
ACCESSION   NM_032592
VERSION     NM_032592.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2383)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   2  (bases 1 to 2383)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2383)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2383)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 2383)
  AUTHORS   Liu,C.Y., Wu,M.C., Chen,F., Ter-Minassian,M., Asomaning,K.,
            Zhai,R., Wang,Z., Su,L., Heist,R.S., Kulke,M.H., Lin,X., Liu,G. and
            Christiani,D.C.
  TITLE     A Large-scale genetic association study of esophageal
            adenocarcinoma risk
  JOURNAL   Carcinogenesis 31 (7), 1259-1263 (2010)
   PUBMED   20453000
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2383)
  AUTHORS   Koch,K.A., Capitani,G., Gruetter,M.G. and Kirsch,J.F.
  TITLE     The human cDNA for a homologue of the plant enzyme
            1-aminocyclopropane-1-carboxylate synthase encodes a protein
            lacking that activity
  JOURNAL   Gene 272 (1-2), 75-84 (2001)
   PUBMED   11470512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC390076.1, DA406116.1, BC020197.1 and AC134775.8.
            
            On May 17, 2019 this sequence version replaced NM_032592.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057649.1, BC020197.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263776.9/ ENSP00000263776.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DC390076.1         9-10
            3-18                DA406116.1         1-16
            19-1302             BC020197.1         1-1284
            1303-1303           AC134775.8         39109-39109         c
            1304-1693           BC020197.1         1286-1675
            1694-1694           AC134775.8         35246-35246         c
            1695-2165           BC020197.1         1677-2147
            2166-2383           AC134775.8         34440-34657         c
FEATURES             Location/Qualifiers
     source          1..2383
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..2383
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /note="1-aminocyclopropane-1-carboxylate synthase homolog
                     (inactive)"
                     /db_xref="GeneID:84680"
                     /db_xref="HGNC:HGNC:23989"
                     /db_xref="MIM:608405"
     exon            1..432
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /inference="alignment:Splign:2.1.0"
     CDS             433..1938
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /note="ACC synthase-like protein 1"
                     /codon_start=1
                     /product="1-aminocyclopropane-1-carboxylate synthase-like
                     protein 1"
                     /protein_id="NP_115981.1"
                     /db_xref="CCDS:CCDS7907.1"
                     /db_xref="GeneID:84680"
                     /db_xref="HGNC:HGNC:23989"
                     /db_xref="MIM:608405"
                     /translation="MFTLPQKDFRAPTTCLGPTCMQDLGSSHGEDLEGECSRKLDQKL
                     PELRGVGDPAMISSDTSYLSSRGRMIKWFWDSAEEGYRTYHMDEYDEDKNPSGIINLG
                     TSENKLCFDLLSWRLSQRDMQRVEPSLLQYADWRGHLFLREEVAKFLSFYCKSPVPLR
                     PENVVVLNGGASLFSALATVLCEAGEAFLIPTPYYGAITQHVCLYGNIRLAYVYLDSE
                     VTGLDTRPFQLTVEKLEMALREAHSEGVKVKGLILISPQNPLGDVYSPEELQEYLVFA
                     KRHRLHVIVDEVYMLSVFEKSVGYRSVLSLERLPDPQRTHVMWATSKDFGMSGLRFGT
                     LYTENQDVATAVASLCRYHGLSGLVQYQMAQLLRDRDWINQVYLPENHARLKAAHTYV
                     SEELRALGIPFLSRGAGFFIWVDLRKYLPKGTFEEEMLLWRRFLDNKVLLSFGKAFEC
                     KEPGWFRFVFSDQVHRLCLGMQRVQQVLAGKSQVAEDPRPSQSQEPSDQRR"
     exon            433..720
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /inference="alignment:Splign:2.1.0"
     exon            721..780
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /inference="alignment:Splign:2.1.0"
     exon            781..851
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /inference="alignment:Splign:2.1.0"
     exon            852..921
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /inference="alignment:Splign:2.1.0"
     exon            922..988
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1086
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1164
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1265
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1355
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1401
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1543
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1686
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1840
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2383
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2144..2149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /note="hexamer: ATTAAA"
     polyA_site      2165
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /note="major polyA site"
     regulatory      2358..2363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /note="hexamer: AATAAA"
     polyA_site      2383
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /note="major polyA site"
ORIGIN      
        1 acacgtgatg ggcgcccacc gagtgccagc accgcctcct ccagctccgc caagtaggtg
       61 ggatccacta ctttgcagag gaggaagccg ttcaggcctc cctctgtgca ctttgcaaaa
      121 gcctctgccc ttccatctcg aatcccttgg cgccgatcac acttcctctg cctggaaacc
      181 tggagccgtc tctcgcgaga cgtcctccgc cctgtagaag gccgtttcgg ttcttcgtgc
      241 gcggtagccg ccccacttgc gggattccaa ggcctcatcg agtgcgggta tctggctgtg
      301 gattcgccgc cgtcctgctg gacgcctgga ggctcgaacc ccgccgcccc cctaccccag
      361 gctttactcc caccccggct tccgcccact gtgctgccct tcctcggacc tgggctgtcg
      421 ggagagctgg agatgttcac ccttcctcaa aaggacttca gggctcccac cacctgtctg
      481 ggccccacct gcatgcagga cctgggcagt agccatgggg aagatctgga aggagaatgc
      541 tccagaaaac tggaccagaa gctgccagag ctccgtggag tgggtgatcc tgccatgatc
      601 tcctctgata cctcctacct gtcctctaga ggaagaatga ttaaatggtt ctgggattca
      661 gctgaggagg gctacaggac ctaccacatg gatgagtatg atgaggacaa gaaccccagt
      721 ggcatcatta acttgggcac cagtgagaac aaactctgct ttgacctgct gtcctggcgg
      781 ctgagtcagc gcgacatgca gagggtggag ccatccctgc tgcagtatgc tgactggagg
      841 ggacatctgt tcctccggga ggaagtggcc aagttcctgt ctttctactg caagagccca
      901 gtacccctca gaccagagaa tgtggttgtc ctgaatggtg gtgcctcgct cttctctgct
      961 ctggccacgg tgctgtgtga ggccggggag gctttcctga tccccacccc ttactatggc
     1021 gctatcacac agcacgtgtg tctctatggc aacatccggc tggcctatgt ctacctggac
     1081 agtgaggtca ctgggctaga cacacgcccc ttccagctca cagtggagaa gctggagatg
     1141 gccctgagag aagctcactc tgagggtgtg aaggtcaaag gcctcatcct catcagcccc
     1201 cagaaccctc tgggtgatgt atactcccct gaagagctac aggagtacct ggtatttgcc
     1261 aagaggcaca ggctgcatgt gattgtggat gaggtctaca tgctgtccgt gtttgagaag
     1321 tctgttgggt accgcagtgt cctaagcctg gaaaggctcc ctgaccccca gaggacccat
     1381 gtgatgtggg caaccagcaa ggacttcggg atgtctgggc tccgctttgg cacgctgtac
     1441 acagaaaacc aggatgtggc cactgccgtg gcttccctct gccgctacca cggcctcagt
     1501 ggcttggtcc agtaccagat ggcacagctg ctccgggacc gtgactggat caaccaggtg
     1561 tacctgccgg aaaaccatgc ccggctcaag gctgcccaca cctatgtctc agaagagctt
     1621 agggcattgg ggatcccctt cttgagtcgt ggggctggct tcttcatctg ggttgacttg
     1681 agaaagtacc tgcccaaggg cacctttgag gaggaaatgc tgctctggcg ccgctttttg
     1741 gacaacaagg tgctgctgtc ctttggcaag gccttcgagt gtaaagagcc tggttggttt
     1801 cgctttgtct tctcagacca ggtccaccgg ctttgcctgg ggatgcagag ggtccagcag
     1861 gtgcttgcag gcaaatccca agtggcagaa gacccccgtc cctctcagag ccaggagcca
     1921 agtgaccaac gcaggtgagc tggtcattgt ctcgtggcca gagggcccag cagccactgt
     1981 ggacctgggg cgttctgggg ctgcagaaga ctgactgtgg atgtgccatt tgccaggaag
     2041 gtatctaact tggctttgtg cctgaagaac tgtttcttgt ctttcgctgt agcagtggga
     2101 aactccttaa gctgtggttc agcctgggcc ctccctctct cctattaaac aaaactagga
     2161 gagtccatat gtctccattg tgagttattt agaatggagg agtcgtgact gcttctaacc
     2221 agagcctcag cccccctgag gatgtgaaaa gaaaacaaac aacttgtacc ttctttctga
     2281 tatcaccgtc attcctcttt ctttgtcacc aaggaaacga gtcaaaggaa cagcacatac
     2341 aggagagttt gtagaaaaat aaaaaaaagt gataacttcc aaa
//
